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1. 发明申请

WO2009023877A2 FORMULATIONS FOR TREATMENT OF OCULAR DISEASES OR CONDITIONS 审中-公开
标题翻译：治疗眼部疾病或病症的配方
公开(公告)号：WO2009023877A2
公开(公告)日：2009-02-19
申请号：PCT/US2008073520
申请日：2008-08-18
申请人： MACUSIGHT INC , DOR PHILIPPE JM , MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ , TAKHAR SUDEEP KAUR
发明人： DOR PHILIPPE JM , MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ , TAKHAR SUDEEP KAUR
IPC分类号： A61K31/436 , A61K39/395 , A61P27/02
CPC分类号： A61K31/436 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/10 , A61K9/1075 , A61K9/7007 , A61K31/4184 , A61K31/575 , A61K39/3955 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/34 , A61K47/38 , A61K2300/00
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non- dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.
摘要翻译：包括但不限于眼睛中的组织的疾病和病症可被有效治疗，预防，抑制，发作延迟或由给予这些组织的治疗剂引起的回归。本文描述的是液体制剂，其将多种治疗剂（包括但不限于雷帕霉素）递送给受试者较长时间; 当被置于受试者的水性介质中时形成非分散物质的液体制剂; 在水性介质中形成凝胶或凝胶状物质的非分散质量形成液体制剂; 液体制剂，包含治疗剂和多种聚合物; 以及使用液体制剂将治疗剂递送给受试者较长时间的方法。液体制剂可以放置在受试者的水性介质中，包括但不限于通过眼内或眼周内施用，或靠近受试者待治疗的疾病或病症的位置放置。可以使用方法来施用雷帕霉素以治疗或预防受试者的血管生成，脉络膜新生血管形成或年龄相关性黄斑变性或湿性年龄相关性黄斑变性。液体制剂可以包含雷帕霉素或其它治疗剂。

2. 发明申请

WO2006102378A3 DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASES OR CONDITIONS 审中-公开
标题翻译：用于治疗疾病或病症的药物输送系统
公开(公告)号：WO2006102378A3
公开(公告)日：2007-03-29
申请号：PCT/US2006010336
申请日：2006-03-21
申请人： MACUSIGHT INC , MUDUMBA SREENIVASU , DOR PHILIPPE JM , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ
发明人： MUDUMBA SREENIVASU , DOR PHILIPPE JM , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ
IPC分类号： A61K31/436 , A61K9/00 , A61P27/02
CPC分类号： A61K9/0051 , A61K31/436 , A61K31/4745
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are solid drug delivery systems and methods for providing extended delivery of therapeutic agents to such tissues. A solid drug delivery system may be placed in a subject, including but not limited to placement between the sclera and the conjunctiva or transscleral placement. Described methods may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, age-related macular degeneration, or wet age- related macular degeneration in a subject. The solid drug delivery devices may comprise rapamycin or other therapeutic agents. Also described are methods of treating ocular diseases or disorders by administering an antiproliferative agent, including but not limited to rapamycin, proximal to an ocular device.
摘要翻译：包括但不限于眼睛中的组织的疾病和病症可被有效治疗，预防，抑制，发作延迟或由给予这些组织的治疗剂引起的回归。本文描述的是用于向这些组织提供治疗剂的延长递送的固体药物递送系统和方法。固体药物递送系统可以放置在受试者中，包括但不限于在巩膜和结膜之间的放置或经巩膜放置。描述的方法可用于施用雷帕霉素以治疗或预防受试者的血管生成，脉络膜新生血管形成，年龄相关性黄斑变性或湿性年龄相关性黄斑变性。固体药物递送装置可以包含雷帕霉素或其它治疗剂。还描述了通过在近视眼装置上施用抗增生剂（包括但不限于雷帕霉素）来治疗眼部疾病或病症的方法。

3. 发明专利

CA2602525A1 DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASES OR CONDITIONS 未知
公开(公告)号：CA2602525A1
公开(公告)日：2006-09-28
申请号：CA2602525
申请日：2006-03-21
申请人： MACUSIGHT INC
发明人： FAROOQ SIDIQ , NIVAGGIOLI THIERRY , WEBER DAVID A , MUDUMBA SREENIVASU , DOR PHILIPPE J M
IPC分类号： A61K31/436 , A61K9/00 , A61P27/02
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are solid drug delivery systems and methods for providing extended delivery of therapeutic agents to such tissues. A solid drug delivery system may be placed in a subject, including but not limited to placement between the sclera and the conjunctiva or transscleral placement. Described methods may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, age-related macular degeneration, or wet age-related macular degeneration in a subject. The solid drug delivery devices may comprise rapamycin or other therapeutic agents. Also described are methods of treating ocular diseases or disorders by administering an antiproliferative agent, including but not limited to rapamycin, proximal to an ocular device.

4. 发明公开

EP2187743A4 FORMULATIONS FOR TREATMENT OF OCULAR DISEASES OR CONDITIONS 有权
标题翻译：配方治疗眼疾OR的悲伤
公开(公告)号：EP2187743A4
公开(公告)日：2010-10-27
申请号：EP08827362
申请日：2008-08-18
申请人： MACUSIGHT INC
发明人： DOR PHILIPPE JM , MUDUMBA SREENIVASU , NIVAGGIOLI THIERRY , WEBER DAVID A , FAROOQ SIDIQ , TAKHAR SUDEEP KAUR
IPC分类号： A61K9/00 , A61K31/4184 , A61K31/575 , A61K39/395 , A61P27/02
CPC分类号： A61K31/436 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/10 , A61K9/1075 , A61K9/7007 , A61K31/4184 , A61K31/575 , A61K39/3955 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/34 , A61K47/38 , A61K2300/00

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