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1. 发明申请

WO2006110593A2 BIOLOGICAL TARGETS FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER 审中-公开
标题翻译：用于诊断，治疗和预防癌症的生物学目标
公开(公告)号：WO2006110593A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013172
申请日：2006-04-07
申请人： MACROGENICS, INC. , VON HALLER, Priska, D. , SCHUMMER, Michèl , MEYER, David, W. , SCHUBERT, Lisa, A. , TJOELKER, Larry, W.
发明人： VON HALLER, Priska, D. , SCHUMMER, Michèl , MEYER, David, W. , SCHUBERT, Lisa, A. , TJOELKER, Larry, W.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to methods for detecting, diagnosing, monitoring and prognosing cancer by detecting differences in the expression of one or more, or any combination of the following genes: SLC12A2, FLJ23375, GRM5, TAS2R1, NRXN2, C14orfl60, MGC15668, MGC33486, TMEM16F, FAT, KIAA0195, LRFN, NFASC, BAT2D1, MGC2963, KIAA0685, EDG3, GGTL3, PLVAP, FLJ31528, FLJ90709, VEZATIN, TMPRSS9, ATP13A5, PKHDlLl, C2orfl8, ANKRD22, FAM62B, LOC57168, CDKALl, SLC39A3vl, SLC39A3v2, BAT5, TM9SF4, DC2, VAPB, XTP3TPB, TACSTD2, FNDC3A, GKOOl, OCIAD2, PRO1855, C20orf3, SDFRl, FLJ20481, LENG4, FLJ12443, ARP5 Long, ARP5 Short, TMD0645, NGEP, ILlRAPl, PLXNBl, ATP2B2, FLJl 1848, ENTPD2, PPMlH, KRTKAP3, KCNC3, TM9SF1, ULBPl, C19orf26, KIAA830, KIAA1244, KIAA1797, MGC26856, NETO2, SUSD2, FOLR2, EMR2, ENTPDl, ATPlOB, PTK7, FLJ14681, C20orf22, FLJ14281, FAM8A1, TMED7, C20orfl08, ATADl, GPR154, C14orf27, OSAP, FAD104, FLJ90492, SLC27A3, RON, ATP13A1, DKFZP564D166, ESSPL, EXTL3, KAIl, KIAA0960, MTRNL, SLC27A1, GRIA4, 0R4M1, KIAA1679 or UPK-Ib. The present invention also relates to methods for screening and identifying compounds that modulate the expression of one or more, or any combination of such genes. The invention further relates to the use of such compounds in the prevention, treatment, management and amelioration of cancer. The methods of the invention also comprise the administration of an effective amount of one or more therapies that modulate the expression and/or activity of one or more cancer targets disclosed herein for the prevention, treatment, management and amelioration of cancer.
摘要翻译：本发明涉及检测，诊断，监测和预测癌症的方法，该方法通过检测以下基因中的一种或多种或任何组合的表达差异：SLC12A2，FLJ23375，GRM5，TAS2R1，NRXN2，C14orfl60，MGC15668，MGC33486， TMEM16F，FAT，KIAA0195，LRFN，NFASC，BAT2D1，MGC2963，KIAA0685，EDG3，GGTL3，PLVAP，FLJ31528，FLJ90709，VEZATIN，TMPRSS9，ATP13A5，PKHD1L1，C2orf18，ANKRD22，FAM62B，LOC57168，CDKAL1，SLC39A3v1，SLC39A3v2，BAT5， TM9SF4，DC2，VAPB，XTP3TPB，TACSTD2，FNDC3A，GK001，OCIAD2，PRO1855，C20orf3，SDFR1，FLJ20481，LENG4，FLJ12443，ARP5 Long，ARP5 Short，TMD0645，NGEP，IL1RAP1，PLXNB1，ATP2B2，FLJ1848，ENTPD2，PPM1H ，KRTKAP3，KCNC3，TM9SF1，ULBP1，C19orf26，KIAA830，KIAA1244，KIAA1797，MGC26856，NETO2，SUSD2，FOLR2，EMR2，ENTPD1，ATP10B，PTK7，FLJ14681，C20orf22，FLJ14281，FAM8A1，TMED7，C20orfl08，ATAD1，GPR154，C14orf27 ，OSAP，FAD104，FLJ90492，SLC27A3，RON，ATP13A1，DKFZP564D166，ESSPL，EXTL3，KAI1，KIAA0960，MTRNL，SLC27 A1，GRIA4,0R4M1，KIAA1679或UPK-Ib。本发明还涉及筛选和鉴定调节这些基因的一种或多种或任何组合的表达的化合物的方法。本发明还涉及这些化合物在预防，治疗，治疗和改善癌症中的用途。本发明的方法还包括施用有效量的一种或多种治疗剂，其调节本文公开的一种或多种癌症靶标的表达和/或活性以预防，治疗，治疗和改善癌症。

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