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1. 发明授权

US08209013B2 Therapeutic electrical stimulation that avoids undesirable activation 有权
标题翻译：避免不良活化的治疗电刺激
公开(公告)号：US08209013B2
公开(公告)日：2012-06-26
申请号：US11520879
申请日：2006-09-14
申请人： M. Jason Brooke , Alok S. Sathaye , Yanting Dong , Scott Walczak
发明人： M. Jason Brooke , Alok S. Sathaye , Yanting Dong , Scott Walczak
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3712
摘要： Energy parameters for electrical stimulation pulses that produce a desired activation, and avoid an undesirable activation, are determined. A strength-duration relationship for at least one desired activation produced by therapeutic electrical stimulation is measured. A strength-duration relationship for at least one undesirable activation produced by the therapeutic electrical stimulation is provided. A medical device selects, based on the desired and undesirable strength-duration relationships, one or more energy parameters for the therapeutic electrical stimulation that produce the desired activation and avoid the undesirable activation.
摘要翻译：确定产生所需激活的电刺激脉冲的能量参数，并避免不期望的激活。测量通过治疗性电刺激产生的至少一种所需活化的强度 - 持续时间关系。提供了由治疗性电刺激产生的至少一种不期望的激活的强度 - 持续时间关系。医疗设备基于期望的和不期望的强度 - 持续时间关系选择产生所需激活的治疗性电刺激的一个或多个能量参数，并避免不期望的激活。

2. 发明申请

US20080071318A1 Therapeutic electrical stimulation that avoids undesirable activation 有权
标题翻译：避免不良活化的治疗电刺激
公开(公告)号：US20080071318A1
公开(公告)日：2008-03-20
申请号：US11520879
申请日：2006-09-14
申请人： M. Jason Brooke , Alok S. Sathaye , Yanting Dong , Scott Walczak
发明人： M. Jason Brooke , Alok S. Sathaye , Yanting Dong , Scott Walczak
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3712
摘要： Approaches for determining energy parameters for electrical stimulation pulses that produce a desired activation and avoid an undesirable activation are described. A strength-duration relationship for at least one desired activation produced by therapeutic electrical stimulation is measured. A strength-duration relationship for at least one undesirable activation produced by the therapeutic electrical stimulation is provided. A medical device selects, based on the desired and undesirable strength-duration relationships, one or more energy parameters for the therapeutic electrical stimulation that produce the desired activation and avoid the undesirable activation.
摘要翻译：描述了用于确定产生期望的激活并避免不期望的激活的电刺激脉冲的能量参数的方法。测量通过治疗性电刺激产生的至少一种所需活化的强度 - 持续时间关系。提供了由治疗性电刺激产生的至少一种不期望的激活的强度 - 持续时间关系。医疗设备基于期望和不期望的强度 - 持续时间关系选择产生所需激活的治疗性电刺激的一个或多个能量参数，并避免不期望的激活。

3. 发明申请

US20080228093A1 Systems and methods for enhancing cardiac signal features used in morphology discrimination 审中-公开
标题翻译：用于增强形态学鉴别中使用的心脏信号特征的系统和方法
公开(公告)号：US20080228093A1
公开(公告)日：2008-09-18
申请号：US11717482
申请日：2007-03-13
申请人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
发明人： Yanting Dong , Jeremy J. Maniak , Scott A. Meyer , Kevin John Stalsberg , Alok S. Sathaye , Benjamin Ettori
IPC分类号： A61B5/0464
CPC分类号： A61B5/04525 , A61B5/0464 , A61B5/7203 , A61B5/7264 , A61N1/371
摘要： Methods and devices used to classify cardiac events based on morphological analysis of sensed signals are described. A signal comprising a cardiac signal component and a noise signal component is sensed. The sensed signal is processed to preferentially alter morphology of the cardiac signal component. The altered morphology of the cardiac signal component enhances detection of one or more features of the cardiac signal component. The features of the cardiac signal component are detected and the cardiac event is classified using the detected features. Processing the sensed signal may involve the use of adaptable signal processing parameters. For example, the signal processing parameters may be selected to accentuate one or more desirable features of the cardiac signal component or to mitigate one or more undesirable features of the cardiac signal component.
摘要翻译：描述了基于感测信号的形态学分析来分类心脏事件的方法和装置。检测包括心脏信号分量和噪声信号分量的信号。处理感测到的信号以优先改变心脏信号分量的形态。心脏信号分量改变的形态增强了对心脏信号分量的一个或多个特征的检测。检测心脏信号分量的特征，并使用检测到的特征对心脏事件进行分类。处理感测信号可能涉及使用适应性信号处理参数。例如，可以选择信号处理参数以强调心脏信号分量的一个或多个期望特征或减轻心脏信号分量的一个或多个不期望的特征。

4. 发明申请

US20100023082A1 INDIVIDUALIZED MORPHOLOGY FEATURE EVALUATION AND SELECTION FOR DISCRIMINATION IN IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可移植医疗设备中的个体化形态学特征评估与选择
公开(公告)号：US20100023082A1
公开(公告)日：2010-01-28
申请号：US12507436
申请日：2009-07-22
申请人： Yanting Dong , M. Jason Brooke , Dan Li , Kevin J. Stalsberg
发明人： Yanting Dong , M. Jason Brooke , Dan Li , Kevin J. Stalsberg
IPC分类号： A61N1/365 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0002 , A61B5/04525 , A61N1/365 , A61N1/3702
摘要： An apparatus comprises an implantable sensor, which provides a plurality of physiologic sensor signals of a subject, and a processor. The processor includes a feature module and a detection module. The feature module is configured to identify a feature in the sensor signals and to determine a measure of quality of the feature in the sensor signals. The detection module is configured to perform a morphology analysis of a subsequent portion of at least one of the sensor signals using the feature when the measure of quality of the feature satisfies a quality measure threshold.
摘要翻译：一种装置包括可植入传感器，其提供对象的多个生理传感器信号和处理器。处理器包括特征模块和检测模块。特征模块被配置为识别传感器信号中的特征并且确定传感器信号中的特征的质量的度量。所述检测模块被配置为当所述特征的质量度量满足质量测量阈值时，使用所述特征来对所述传感器信号中的至少一个的后续部分进行形态分析。

5. 发明授权

US09993205B2 Cardiac response classification using retriggerable classification windows 有权
公开(公告)号：US09993205B2
公开(公告)日：2018-06-12
申请号：US12818066
申请日：2010-06-17
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/08 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

6. 发明授权

US09020596B2 Management of fusion beat detection during capture threshold determination 有权
标题翻译：捕获阈值确定期间融合搏动检测的管理
公开(公告)号：US09020596B2
公开(公告)日：2015-04-28
申请号：US13546820
申请日：2012-07-11
申请人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
发明人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： An improved technique is described for dealing with the detection of fusion beats when capture verification is performed by a cardiac pacing device such as during a capture threshold determination procedure. Schemes for classifying heart beats may misclassify beats as fusion beats due to feature/morphology changes in the test electrogram waveform that may occur even when capture is achieved.
摘要翻译：描述了一种改进的技术，用于处理在心脏起搏装置执行捕获验证时，例如在捕获阈值确定过程期间的融合节拍的检测。分类心脏跳动的方案可能由于测试电描记图波形中的特征/形态变化而将节拍错误分类为融合节拍，即使实现捕获也可能发生。

7. 发明授权

US08805497B2 Titrated intermittent pacing therapy 有权
标题翻译：滴定间歇起搏治疗
公开(公告)号：US08805497B2
公开(公告)日：2014-08-12
申请号：US12573533
申请日：2009-10-05
申请人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
发明人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's heart rate or exertion level to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。这里描述了一种方法和系统，其使用患者心率或运动水平的测量来控制间歇性预激发起搏的占空比。

8. 发明授权

US08725255B2 Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
标题翻译：心脏再同步治疗优化使用心脏激活序列信息
公开(公告)号：US08725255B2
公开(公告)日：2014-05-13
申请号：US11601216
申请日：2006-11-17
申请人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
发明人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

9. 发明申请

US20130261688A1 DETERMINATION OF PHRENIC NERVE STIMULATION THRESHOLD 有权
标题翻译：确定神经刺激阈值
公开(公告)号：US20130261688A1
公开(公告)日：2013-10-03
申请号：US13781042
申请日：2013-02-28
申请人： Yanting Dong , Sunipa Saha , Holly Rockweiler
发明人： Yanting Dong , Sunipa Saha , Holly Rockweiler
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/1107 , A61B5/4029 , A61B5/7264 , A61B5/7282 , A61B2562/0219 , A61N1/36542
摘要： In an example of a method, the method includes testing for phrenic nerve stimulation (PS) threshold. If PS beats are detected at the pacing output level, analyzing the detected PS beats using criteria to determine if the pacing output level can be declared to be the PS threshold. If the pacing output level cannot be declared to be the PS threshold based on the analysis of the PS beat at the pacing output level, performing a PS beat confirmation procedure. The PS beat confirmation procedure may include delivering additional cardiac paces at the pacing output level to generate additional PS beats, and analyzing the detected PS beats using other criteria to determine if the pacing output level can be confirmed as the PS threshold.
摘要翻译：在方法的示例中，该方法包括测试膈神经刺激（PS）阈值。如果在起搏输出电平检测到PS节拍，则使用标准分析检测到的PS节拍，以确定起搏输出电平是否可以声明为PS阈值。如果起搏输出电平不能根据起搏输出电平下PS搏动的分析声明为PS阈值，则执行PS跳动确认程序。 PS节拍确认程序可以包括在起搏输出电平上递送额外的心脏搏动以产生额外的PS节拍，并且使用其他标准来分析检测到的PS节拍，以确定起搏输出电平是否可以被确认为PS阈值。

10. 发明授权

US08403830B2 Rhythm discrimination enhancement—AV drive 有权
标题翻译：节奏辨别增强 - AV驱动
公开(公告)号：US08403830B2
公开(公告)日：2013-03-26
申请号：US13196491
申请日：2011-08-02
申请人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
发明人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
IPC分类号： A61B1/00
CPC分类号： A61N1/3621 , A61B5/0464 , A61N1/3622 , A61N1/3624 , A61N1/3704 , A61N1/3962
摘要： An apparatus comprises an implantable cardiac signal sensing circuit and a controller circuit. The implantable cardiac signal sensing circuit provides a sensed depolarization signal from a ventricle and a sensed depolarization signal from an atrium. The controller circuit includes a one-to-one detector circuit and a tachyarrhythmia discrimination circuit. The one-to-one detector circuit measures cardiac depolarization intervals of the atrium and the ventricle and determines whether a relationship of atrial depolarizations to ventricular depolarizations is substantially one-to-one. The tachyarrhythmia discrimination circuit increments a counter when detecting a shortening or prolonging of a V-V interval that immediately precedes the same shortening or prolonging of an A-A interval, classifies the episode as VT according to the counter, and provides the classification of the tachyarrhythmia episode to a user or process.
摘要翻译：一种装置包括可植入心脏信号感测电路和控制器电路。可植入心脏信号感测电路提供来自心室的感测去极化信号和来自心房的感测去极化信号。控制器电路包括一对一检测器电路和快速心律失常鉴别电路。一对一检测器电路测量心房和心室的心脏去极化间隔，并确定心房去极化与心室去极化的关系是否基本上是一对一的。快速性心律失常辨别电路在检测到在AA间隔的相同缩短或延长之前的VV间期的缩短或延长时增加计数器，根据计数器将发作分类为VT，并将快速性心律失常发作的分类提供给用户或进程。

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