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1. 发明申请

US20100305054A1 CONCENTRATED AQUEOUS AZALIDE FORMULATIONS 审中-公开
标题翻译：浓缩水杨酸盐配方
公开(公告)号：US20100305054A1
公开(公告)日：2010-12-02
申请号：US12855096
申请日：2010-08-12
申请人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
发明人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
IPC分类号： A61K31/7052 , A61P33/02 , A61P31/04 , A61P29/00
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/351 , A61K31/573 , A61K31/7052 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
摘要翻译：本发明涉及浓氮ide啶抗生素的制剂及其制备和使用方法。具体地说，本发明涉及一种治疗感染的方法，其包括对有需要的患者施用有效量的根据包括将含有强酸的水溶液中的氮杂抗生素溶解的方法制备的浓氮唑类抗生素制剂。本发明还涉及用于制备用于肺部感染，鼻咽感染，耳部感染，眼部感染，皮肤或阴道感染的浓盐酸阿糖苷类抗生素制剂的方法。本发明还涉及通过将azalide抗生素溶解在包含强酸的水溶液中制备的浓氮唑类抗生素制剂。

2. 发明申请

US20090093449A1 Concentrated aqueous azalide formulations 有权
标题翻译：浓盐水配方
公开(公告)号：US20090093449A1
公开(公告)日：2009-04-09
申请号：US11905854
申请日：2007-10-04
申请人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
发明人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
IPC分类号： A61K31/351 , A61K31/573 , A61P31/04
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/351 , A61K31/573 , A61K31/7052 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
摘要翻译：本发明涉及浓氮ide啶抗生素的制剂及其制备和使用方法。具体地说，本发明涉及一种治疗感染的方法，其包括对有需要的患者施用有效量的根据包括将含有强酸的水溶液中的氮杂抗生素溶解的方法制备的浓氮唑类抗生素制剂。本发明还涉及用于制备用于肺部感染，鼻咽感染，耳部感染，眼部感染，皮肤或阴道感染的浓盐酸阿糖苷类抗生素制剂的方法。本发明还涉及通过将azalide抗生素溶解在包含强酸的水溶液中制备的浓氮唑类抗生素制剂。

3. 发明授权

US07795231B2 Concentrated aqueous azalide formulations 有权
标题翻译：浓盐水配方
公开(公告)号：US07795231B2
公开(公告)日：2010-09-14
申请号：US11905854
申请日：2007-10-04
申请人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
发明人： Lyle Bowman , S. Kumar Chandrasekaran , Roy Duane Archibald , Stephen Pham , David Mufson
IPC分类号： A61K31/00
CPC分类号： A61K9/0048 , A61K9/0014 , A61K9/0034 , A61K9/0043 , A61K9/0046 , A61K9/0051 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K9/0078 , A61K9/008 , A61K31/00 , A61K31/351 , A61K31/573 , A61K31/7052 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
摘要翻译：本发明涉及浓氮ide啶抗生素的制剂及其制备和使用方法。具体地说，本发明涉及一种治疗感染的方法，其包括对有需要的患者施用有效量的根据包括将含有强酸的水溶液中的氮杂抗生素溶解的方法制备的浓氮唑类抗生素制剂。本发明还涉及用于制备用于肺部感染，鼻咽感染，耳部感染，眼部感染，皮肤或阴道感染的浓盐酸阿糖苷类抗生素制剂的方法。本发明还涉及通过将azalide抗生素溶解在包含强酸的水溶液中制备的浓氮唑类抗生素制剂。

4. 发明申请

US20100226997A1 CONTROLLED-RELEASE OPHTHALMIC VEHICLES 有权
标题翻译：控制释放的眼动车
公开(公告)号：US20100226997A1
公开(公告)日：2010-09-09
申请号：US12398625
申请日：2009-03-05
申请人： Lyle Bowman , Stephen Pham
发明人： Lyle Bowman , Stephen Pham
IPC分类号： A61K9/14 , A61K47/32 , A61P27/02
CPC分类号： A61K9/0048 , A61K47/32 , A61K47/34 , A61K47/36
摘要： An ophthalmically acceptable vehicle includes an aqueous suspension having a first viscosity. The suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. The polymer has average particle size of not more than about 50 μm in equivalent spherical diameter. The vehicle includes a second polymer that allows the carboxyl-containing polymer to remain suspended. Upon contact with tear fluid, the vehicle gels to a second viscosity which is greater than the first viscosity. A method of administering a medicament to the eye of a subject includes applying a composition that includes this ophthalmically acceptable vehicle and a medicament contained for treatment of a disease or disorder for which ophthalmic delivery is indicated. The medicament is released from the vehicle in a sustained release manner.
摘要翻译：眼科可接受的载体包括具有第一粘度的水性悬浮液。悬浮液包含约0.1％至约6.5％重量的通过聚合一种或多种含羧基的单烯属不饱和单体和少于约5％重量的交联剂制备的含羧基聚合物。该聚合物的平均粒径在等效的球形直径上不超过约50μm。载体包括允许含羧基聚合物保持悬浮的第二聚合物。当与泪液接触时，车辆凝胶化到比第一粘度大的第二粘度。向受试者的眼睛施用药物的方法包括施用包含该眼科可接受载体的组合物和用于治疗指示眼科递送的疾病或病症的药物。药物以持续释放的方式从车辆释放。

5. 发明授权

US08778999B2 Non-steroidal anti-inflammatory ophthalmic compositions 有权
标题翻译：非甾体抗炎眼科组合物
公开(公告)号：US08778999B2
公开(公告)日：2014-07-15
申请号：US12398657
申请日：2009-03-05
申请人： Kamran Hosseini , Lyle Bowman , Erwin C. Si , Stephen Pham
发明人： Kamran Hosseini , Lyle Bowman , Erwin C. Si , Stephen Pham
IPC分类号： A61K31/196 , A61K31/192 , A61K9/00 , A61K45/06 , A61K47/32 , A61K47/34
CPC分类号： A61K31/192 , A61K9/0048 , A61K45/06 , A61K47/32 , A61K47/34 , A61K2300/00
摘要： The disclosure provides compositions and systems for topical ophthalmic application, which include an aqueous mixture of bromfenac and flowable mucoadhesive polymer, for treating inflammation and inflammatory conditions of the eye.
摘要翻译：本公开提供了用于局部眼用药的组合物和系统，其包括溴芬酸和可流动粘膜粘附聚合物的水性混合物，用于治疗眼睛的炎症和炎症状况。

6. 发明授权

US08501800B2 Controlled-release ophthalmic vehicles 有权
标题翻译：控制释放眼科车辆
公开(公告)号：US08501800B2
公开(公告)日：2013-08-06
申请号：US12398625
申请日：2009-03-05
申请人： Lyle Bowman , Stephen Pham
发明人： Lyle Bowman , Stephen Pham
IPC分类号： A61K38/00 , A61K38/28 , A61K31/40
CPC分类号： A61K9/0048 , A61K47/32 , A61K47/34 , A61K47/36
摘要： An ophthalmically acceptable vehicle includes an aqueous suspension having a first viscosity. The suspension includes about 0.1% to about 6.5% by weight of a carboxyl-containing polymer prepared by polymerizing one or more carboxyl-containing monoethylenically unsaturated monomers and less than about 5% by weight of a cross-linking agent. The polymer has average particle size of not more than about 50 μm in equivalent spherical diameter. The vehicle includes a second polymer that allows the carboxyl-containing polymer to remain suspended. Upon contact with tear fluid, the vehicle gels to a second viscosity which is greater than the first viscosity. A method of administering a medicament to the eye of a subject includes applying a composition that includes this ophthalmically acceptable vehicle and a medicament contained for treatment of a disease or disorder for which ophthalmic delivery is indicated. The medicament is released from the vehicle in a sustained release manner.
摘要翻译：眼科可接受的载体包括具有第一粘度的水性悬浮液。悬浮液包含约0.1％至约6.5％重量的通过聚合一种或多种含羧基的单烯属不饱和单体和少于约5％重量的交联剂制备的含羧基聚合物。该聚合物的平均粒径在等于球形直径的范围内不超过约50μm。载体包括允许含羧基聚合物保持悬浮的第二聚合物。当与泪液接触时，车辆凝胶化到比第一粘度大的第二粘度。向受试者的眼睛施用药物的方法包括施用包含该眼科可接受载体的组合物和用于治疗指示眼科递送的疾病或病症的药物。药物以持续释放的方式从车辆释放。

7. 发明授权

US08695850B2 Tip arrangement for a dropper bottle 有权
标题翻译：滴管瓶的提示布置
公开(公告)号：US08695850B2
公开(公告)日：2014-04-15
申请号：US12399596
申请日：2009-03-06
申请人： Lyle Bowman , Surendra Patel
发明人： Lyle Bowman , Surendra Patel
IPC分类号： B67D1/00 , B65D47/18
CPC分类号： B65D47/18 , A61F9/0008 , B65D25/48
摘要： A tip arrangement for a bottle used for dispensing viscous liquid, such as drops of medicine, is provided. Embodiments include a tip insert having an insert body and a piercing point at a lower end of the insert body, for piercing a top surface of the bottle and for retaining the tip insert on the top surface of the bottle after piercing. A passage extends from a distal end of the piercing point, through the insert body, to an opposing upper surface of the insert body. A dispensing tip at the insert body upper surface communicates with the passage for precisely forming drops of the liquid from the bottle.
摘要翻译：提供了用于分配粘性液体的瓶子的尖端装置，例如药液滴。实施例包括具有插入体和在插入体的下端处的刺穿点的尖端插入件，用于刺穿瓶子的顶部表面并且用于在刺穿之后将尖端插入物保持在瓶子的顶部表面上。通道从穿刺点的远端穿过插入体延伸到插入体的相对的上表面。插入体上表面的分配尖端与通道连通，用于从瓶中精确地形成液体液滴。

8. 发明授权

US08361492B2 Drug delivery system and methods of use 有权
标题翻译：药物输送系统及使用方法
公开(公告)号：US08361492B2
公开(公告)日：2013-01-29
申请号：US12490972
申请日：2009-06-24
申请人： Shachar Tauber , Randall Fuerst , Keela Davis , Lyle Bowman , Gary Wnek , Joseph J. Bango, Jr.
发明人： Shachar Tauber , Randall Fuerst , Keela Davis , Lyle Bowman , Gary Wnek , Joseph J. Bango, Jr.
IPC分类号： A61F13/00 , A61K9/00
CPC分类号： A61K9/0051 , A61K9/0092
摘要： Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.
摘要翻译：电纺纤维用于改善隐形眼镜的机械特性，降低通常形成透镜的聚合物的重量和机械强度。电纺纤维也被用作药物递送系统，通过直接使用在眼睛中并通过将纤维包含在隐形眼镜中。纤维通过各种方法装载治疗药物并通过涂布和交联纤维进行加工。

9. 发明申请

US20080103103A1 Reagents and methods to treat ocular diseases and infection 审中-公开
标题翻译：用于治疗眼部疾病和感染的试剂和方法
公开(公告)号：US20080103103A1
公开(公告)日：2008-05-01
申请号：US11590617
申请日：2006-10-30
申请人： Bahram Memarzadeh , Lyle Bowman
发明人： Bahram Memarzadeh , Lyle Bowman
IPC分类号： A61K31/7048 , A61K31/353 , A61K31/12 , A61K31/05
CPC分类号： A61K31/353 , A61K31/05 , A61K31/12 , A61K31/7048 , A61K31/7052 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions and methods of treating an ocular condition by administering to an eye of a patient having an ocular condition an effective amount of a catechin or polyphenol. The compositions and methods can be used to treat ocular conditions such as ocular infection, ocular inflammation, ocular cancer or benign eye tumors.
摘要翻译：本发明提供了通过给患有眼睛状况的患者的眼睛施用有效量的儿茶素或多酚来治疗眼部病症的组合物和方法。组合物和方法可用于治疗眼部疾病如眼部感染，眼部炎症，眼癌或良性眼肿瘤。

10. 发明申请

US20090269391A1 Drug Delivery System And Methods Of Use 有权
标题翻译：药物输送系统和使用方法
公开(公告)号：US20090269391A1
公开(公告)日：2009-10-29
申请号：US12416802
申请日：2009-04-01
申请人： Joseph J. Bango, JR. , Lyle Bowman , Gary Wnek , Shachar Tauber , Randall Fuerst
发明人： Joseph J. Bango, JR. , Lyle Bowman , Gary Wnek , Shachar Tauber , Randall Fuerst
IPC分类号： A61K9/00 , B29D11/00
CPC分类号： B29D11/00048 , A61K9/0051 , A61K9/0092
摘要： Electrospun fibers are utilized to improve the mechanical characteristics of a contact lens reducing the weight and mechanical strength of the polymers from which the lenses are typically formed. Electrospun fibers are also utilized as a drug delivery system, both through direct use in the eye and by inclusion of the fibers in a contact lens. The fibers are loaded with therapeutic drugs by a variety of methods and processed by coating and cross-linking the fibers.
摘要翻译：电纺纤维用于改善隐形眼镜的机械特性，降低通常形成透镜的聚合物的重量和机械强度。电纺纤维也被用作药物递送系统，通过直接使用在眼睛中并通过将纤维包含在隐形眼镜中。纤维通过各种方法装载治疗药物并通过涂布和交联纤维进行加工。

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