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1. 发明申请

US20100166859A1 NOVEL NUTRACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：新型营养组合物及其用途
公开(公告)号：US20100166859A1
公开(公告)日：2010-07-01
申请号：US12160823
申请日：2006-12-29
申请人： Luppo Edens , Regina Goralczyk , Adrian Wyss
发明人： Luppo Edens , Regina Goralczyk , Adrian Wyss
IPC分类号： A61K38/06 , C07K4/00 , A61P25/24 , A61P25/28 , A61K9/28
CPC分类号： A61K45/06 , A23L33/18 , A61K38/06
摘要： The invention relates to a novel nutraceutical composition containing at least one tripeptide as active ingredient. The term “nutraceutical' as used herein denotes a usefulness in both the nutritional and pharmaceutical field of application. Thus, the novel nutraceutical compositions can find use as supplement to food and beverages, and as pharmaceutical formulations for enteral or parenteral application which may be solid formulations such as capsules or tablets, or liquid formulations, such as solutions or suspensions. As will he evident from the foregoing, the term nutraceutical composition also comprises food and beverages containing the above-specified active ingredients, for example protein hydrolysates which are rich in tripeptides according to the invention. The compositions are useful to improve cognitive functions such as learning, memory and alertness and for the treatment of a disorder connected to impaired neurotransmission and of conditions resulting from hypoxia and for alleviating neuropathic pain.
摘要翻译：本发明涉及含有至少一种三肽作为活性成分的新型营养组合物。本文所用的术语“营养制品”表示在营养和制药领域中的有用性。因此，新型营养食品组合物可以用作食品和饮料的补充剂，以及用作肠内或肠胃外应用的药物制剂，其可以是固体制剂如胶囊或片剂，或液体制剂，例如溶液或悬浮液。从上文可以看出，术语营养药物组合物还包含含有上述活性成分的食品和饮料，例如富含根据本发明的三肽的蛋白质水解产物。该组合物可用于改善认知功能，例如学习，记忆和警觉性，以及治疗与受损的神经传递相关的病症以及由缺氧引起的疾病和减轻神经性疼痛。

2. 发明授权

US08802088B2 Mixture of peptide-bound tryptophan and polypeptide-bound tryptophan 有权
标题翻译：肽结合的色氨酸和多肽结合的色氨酸的混合物
公开(公告)号：US08802088B2
公开(公告)日：2014-08-12
申请号：US12989869
申请日：2009-04-27
申请人： Cinderalla C. Gerhardt , Luppo Edens
发明人： Cinderalla C. Gerhardt , Luppo Edens
IPC分类号： A61K38/48 , C12Q1/34 , C12Q1/37 , A61K38/01 , A61K38/05 , A61K38/06 , A61K38/00 , C07K14/00 , C07K16/02 , A61K47/34 , C12Q1/06 , G01N33/68 , A61K38/47 , A61K38/02 , A61P25/00
CPC分类号： A61K38/47 , A23J3/341 , A23L33/18 , A61K31/405 , C12P21/06 , C12Y302/01017
摘要： The present invention relates to a composition which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
摘要翻译：本发明涉及一种组合物，其包含色氨酸，由此存在色氨酸的10至90％，优选20至80％的游离色氨酸或肽结合的色氨酸，并且存在10至90％，优选20至80％的色氨酸存在作为多肽结合的色氨酸。

3. 发明申请

US20080113896A1 Blood Pressure Lowering Peptides in a Single Enzymatic Step 有权
标题翻译：血压降低单个酶步骤中的肽
公开(公告)号：US20080113896A1
公开(公告)日：2008-05-15
申请号：US11793390
申请日：2005-12-21
申请人： Luppo Edens , Andre de Roos , Olaf Leonardus Schouten , Philippus Antonius Deen
发明人： Luppo Edens , Andre de Roos , Olaf Leonardus Schouten , Philippus Antonius Deen
IPC分类号： A61K38/02 , A61P9/12 , C12P21/06
CPC分类号： C12P21/06 , A23J3/344 , A23L33/11 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K38/00 , A23V2200/3262 , A23V2200/332 , A23V2200/326 , A23V2250/54246 , A23V2250/2136 , A23V2250/7052 , A23V2250/706 , A23V2250/7056
摘要： A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino-peptidase preferably in a single enzymatic step.
摘要翻译：从其蛋白质序列中包含-IPP-和-VPP-序列的蛋白质源产生IPP和VPP的过程，并且其中存在于蛋白质源中的-IPP-序列的至少40％被转化为肽IPP，并且在存在于蛋白质源中的-VPP序列的至少40％被转化为肽VPP，其包括优选在单个酶促步骤中使用脯氨酸特异性内切蛋白酶和氨基肽酶。

4. 发明授权

US07323327B2 Genes encoding novel proteolytic enzymes 失效
标题翻译：编码新型蛋白水解酶的基因
公开(公告)号：US07323327B2
公开(公告)日：2008-01-29
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Albertus Van Dijk , Philipp Krubasik , Kaj Albermann , Alexander Stock , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Wilk Von Gustedt , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
IPC分类号： C12N9/62 , C12N15/00 , C12N1/00 , C07H21/04
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译：本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。

5. 发明申请

US20050064403A1 Novel Genes Encoding Novel Proteolytic Enzymes 失效
标题翻译：编码新型蛋白水解酶的新基因
公开(公告)号：US20050064403A1
公开(公告)日：2005-03-24
申请号：US10469204
申请日：2002-02-22
申请人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
发明人： Luppo Edens , Dijk Alard , Philipp Krubasik , Kaj Albermann , Stock Alexander , Erik Kimpel , Sabine Klugbauer , Christian Wagner , Andreas Fritz , Gustedt Wilk , Oliver Heinrich , Dieter Maier , Fabio Spreafico , Ulrike Folkers , Sylvia Hopper , Wolfram Kemmner , Pamela Tan , Josephine Stiebler , Richard Albang
IPC分类号： A23J3/16 , A23J3/34 , A23L1/29 , A23L1/305 , A23L2/02 , A23L2/84 , C07K16/40 , C12H1/00 , C12N9/62 , C12N15/57 , C12N15/63 , C12Q1/37 , G01N33/569 , G01N33/573 , C12Q1/68 , C07H21/04 , C12N9/64
CPC分类号： A23J3/16 , A23J3/343 , A23J3/344 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C07K2319/00 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to newly identified gene sequences that encode novel proteases obtainable from Aspergillus niger. The invention features the full length gene sequence of the novel genes, their cDNA sequences as well as the full-length functional protein and fragments thereof. The invention also relates to methods of using these enzymes in industrial processes and methods of diagnosing fungal infections. Also included in the invention are cells transformed with DNA according to the invention and cells wherein a protease according to the invention is genetically modified to enhance or reduce its activity and/or level of expression.
摘要翻译：本发明涉及新鉴定的编码从黑曲霉获得的新型蛋白酶的基因序列。本发明的特征在于新基因的全长基因序列，其cDNA序列以及全长功能蛋白及其片段。本发明还涉及在工业过程中使用这些酶的方法和诊断真菌感染的方法。本发明还包括用根据本发明的DNA转化的细胞和其中根据本发明的蛋白酶被遗传修饰以增强或降低其活性和/或表达水平的细胞。

6. 发明授权

US06368595B2 Topical application of enzymes using a peelable film 失效
标题翻译：使用可剥离膜局部应用酶
公开(公告)号：US06368595B2
公开(公告)日：2002-04-09
申请号：US09380805
申请日：1999-10-25
申请人： Luppo Edens , Bertus Noordam
发明人： Luppo Edens , Bertus Noordam
IPC分类号： A61K3846
CPC分类号： A61K8/0208 , A61K8/66 , A61K8/8129 , A61K9/7007 , A61Q7/02 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： The present invention discloses a method for topical application of an enzyme, wherein the enzyme becomes incorporated in a peelable film, for instance a polyvinyl alcohol film, after its application. In this way, the release of enzyme-containing dust particles from the site of application is prevented.
摘要翻译：本发明公开了一种局部施用酶的方法，其中在施用之后将酶并入可剥离膜，例如聚乙烯醇膜中。以这种方式，防止了从施用部位释放含酶粉尘颗粒。

7. 发明授权

US4891316A DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles, etc. 失效
标题翻译：编码成熟的马蹄拟糖的各种等位基因形式的DNA序列和克隆载体等
公开(公告)号：US4891316A
公开(公告)日：1990-01-02
申请号：US742139
申请日：1985-06-07
申请人： Cornelis T. Verrips , Adrianus M. Ledeboer , Luppo Edens , Robert Klok , Jan Maat
发明人： Cornelis T. Verrips , Adrianus M. Ledeboer , Luppo Edens , Robert Klok , Jan Maat
IPC分类号： C12N15/09 , C07H21/04 , C07K14/43 , C12N1/20 , C12N1/21 , C12N15/31 , C12N15/66 , C12N15/70 , C12P19/34 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/43 , C12N15/66 , C12N15/70
摘要： The invention relates to DNA sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles comprising said DNA sequences and their use in transforming microorganisms.
摘要翻译：本发明涉及编码成熟的马蹄拟糖的各种等位基因形式的DNA序列，以及包含所述DNA序列的克隆载体及其在转化微生物中的用途。

8. 发明授权

US08524225B2 Use of proline specific endoproteases to hydrolyse peptides and proteins 有权
标题翻译：使用脯氨酸特异性内切蛋白酶水解肽和蛋白质
公开(公告)号：US08524225B2
公开(公告)日：2013-09-03
申请号：US10572811
申请日：2004-09-23
申请人： Luppo Edens , Melissa Harvey , Robertus Antonius Mijndert Van Der Hoeven , Andre Leonardus De Roos
发明人： Luppo Edens , Melissa Harvey , Robertus Antonius Mijndert Van Der Hoeven , Andre Leonardus De Roos
IPC分类号： A61K38/48
CPC分类号： C12P21/06 , A23J3/346 , A61K38/482
摘要： The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and said peptide or polypeptide is not hydrolysable by subtilisin whereby said peptide or polypeptide is hydrolysed by a proline specific endo protease at a pH of 6.5 or lower, preferably 5.5 or lower and more preferably 5.0 or lower to hydrolyse said peptide or polypeptide.
摘要翻译：本发明涉及肽或多肽的蛋白水解水解方法，所述肽或多肽包含4至40个，优选5至35个氨基酸残基，并且所述肽或多肽不能被枯草杆菌蛋白酶水解，因此所述肽或多肽由pH6.5或更低，优选5.5或更低，更优选5.0或更低的脯氨酸特异性内切蛋白酶水解，以水解所述肽或多肽。

9. 发明申请

US20120141628A1 METHOD FOR THE PREVENTION OR REDUCTION OF HAZE IN BEVERAGES 审中-公开
标题翻译：在饮料中防止或减少烟雾的方法
公开(公告)号：US20120141628A1
公开(公告)日：2012-06-07
申请号：US13349930
申请日：2012-01-13
申请人： Michel LOPEZ , Luppo Edens
发明人： Michel LOPEZ , Luppo Edens
IPC分类号： C12H1/15 , C12G1/00 , A23L2/02 , C12N9/62 , C12N1/15 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , A23L2/84 , C12N15/57
CPC分类号： A23J3/344 , A23J3/16 , A23J3/343 , A23J3/346 , A23L2/02 , A23L2/84 , A23L33/18 , A23L33/40 , C12H1/003 , C12N9/62 , C12Q1/37 , G01N33/56961 , G01N33/573 , G01N2333/38
摘要： The invention relates to a method for the prevention or reduction of haze in a beverage by the addition of an prolyl-specific endoprotease and to new beverages obtainable by the method according to the invention. It also relates to new endoproteases. Sequence information of a genomic DNA, cDNA as well as protein sequences.
摘要翻译：本发明涉及通过添加脯氨酰特异性内切蛋白酶来预防或减少饮料中的雾度的方法以及通过本发明的方法获得的新饮料。它还涉及新的内切蛋白酶。基因组DNA，cDNA以及蛋白质序列的序列信息。

10. 发明申请

US20110166085A1 COMPOSITION COMPRISING CARBOHYDRATES AND PEPTIDES WHICH COMPRISE TRYPTOPHAN 审中-公开
标题翻译：包含碳水化合物和包含TRYPTOPHAN的肽的组合物
公开(公告)号：US20110166085A1
公开(公告)日：2011-07-07
申请号：US12989858
申请日：2009-04-09
申请人： Rudolf Beck-hoven Van , Alexander Duchateau , Luppo Edens , Franciscus Kleinherenbrink , Joris Kloek , Andre L. Ross De
发明人： Rudolf Beck-hoven Van , Alexander Duchateau , Luppo Edens , Franciscus Kleinherenbrink , Joris Kloek , Andre L. Ross De
IPC分类号： A61K38/06 , A61K38/05 , A61P25/00
CPC分类号： A23J3/34 , A23L2/52 , A23L5/00 , A23L27/33 , A23L27/34 , A23L29/274 , A23L29/30 , A23L29/35 , A23L33/125 , A23L33/18 , A23V2002/00 , A23V2200/322 , A23V2250/065
摘要： An edible composition comprising peptides rich in tryptophan, which edible composition further comprises a rapidly available glucose composition and a slowly available glucose composition.
摘要翻译：一种包含富含色氨酸的肽的可食用组合物，其食用组合物还包含快速可用的葡萄糖组合物和缓慢可用的葡萄糖组合物。

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