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1. 发明申请

US20140349919A1 CHROMANE-LIKE CYCLIC PRENYLFLAVONOIDS FOR THE MEDICAL INTERVENTION IN NEUROLOGICAL DISORDERS 有权
标题翻译：用于神经病学医疗干预的色素样循环性抗原
公开(公告)号：US20140349919A1
公开(公告)日：2014-11-27
申请号：US14127029
申请日：2012-06-15
申请人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
发明人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： C07D493/04 , C07D311/32 , C07D407/06 , C07D311/70
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
摘要翻译：本发明涉及某些苯甲酰样环状异戊烯基类黄酮，特别是本文所述和定义的式（I），（II）和（III）化合物，用于治疗或预防神经障碍，以及它们用于促进神经元分化，神经突生长和神经保护。

2. 发明授权

US09527860B2 Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders 有权
标题翻译：用于医学干预神经系统疾病的类似异构体的环状异戊烯基黄酮
公开(公告)号：US09527860B2
公开(公告)日：2016-12-27
申请号：US14127029
申请日：2012-06-15
申请人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
发明人： Ludwig Aigner , Eleni Oberbauer-Hofmann , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： A61K31/35 , C07D493/04 , A61K31/352 , A61K31/353 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.
摘要翻译：本发明涉及某些苯甲酸样环状异戊烯黄酮，特别是本文所述和定义的式（I），（II）和（III）化合物，用于治疗或预防神经障碍，以及它们用于促进神经元分化，神经突生长和神经保护。

3. 发明授权

US08841430B2 Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US08841430B2
公开(公告)日：2014-09-23
申请号：US12894766
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

4. 发明申请

US20110016547A1 USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权
标题翻译：神经元测定细胞中特异性，瞬时表达的调节序列的使用
公开(公告)号：US20110016547A1
公开(公告)日：2011-01-20
申请号：US12894766
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： A61K48/00 , C07H21/04 , C12N5/10 , C12N15/09 , A01K67/027 , C12N15/63 , A61K35/12 , C12Q1/68 , A61P35/00
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元测定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异的早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

5. 发明授权

US08815505B2 Use of regulatory sequences for specific, transient expression in neuronal determined cells 有权
标题翻译：在神经元确定的细胞中使用调节序列用于特异性，瞬时表达
公开(公告)号：US08815505B2
公开(公告)日：2014-08-26
申请号：US12894884
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

6. 发明申请

US20110020790A1 USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS 有权
标题翻译：神经元测定细胞中特异性，瞬时表达的调节序列的使用
公开(公告)号：US20110020790A1
公开(公告)日：2011-01-27
申请号：US12894884
申请日：2010-09-30
申请人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
发明人： Sébastien Couillard-Despres , Claudia Karl , Hans-Georg Kuhn , Ludwig Aigner
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12N15/85 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0318 , A61K48/00 , C12N15/8509 , C12N2503/02 , C12N2510/00 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating proliferation of neuronally committed precursor cells and/or neuronal differentiation are provided and the invention also relates to methods for the detection and analysis of neuronal differentiation, neuronal migration and/or neuronal determination processes. Finally, the invention relates to diagnostic and pharmaceutical compositions comprising the regulatory sequences, recombinant nucleic acid molecules, host-cells or isolated neuronal determined cells described herein.
摘要翻译：本发明涉及调节序列用于介导增殖性神经元确定细胞中特异性，早期瞬时表达的用途。此外，公开了包含所述确定的调节序列的重组核酸分子在增殖性神经元确定的细胞中介导特异性早期瞬时表达以及产生非人转基因生物体和/或宿主细胞的用途。此外，本发明提供包含所述调节序列和/或重组核酸分子的转基因非人动物和/或宿主细胞。本发明还描述了制备这种载体，宿主细胞和转基因非人动物的方法以及用于检测和/或分离神经元确定的细胞的方法。另外，提供了用于筛选能够调节神经元确定的细胞活性，神经发生，刺激神经元定向的前体细胞的增殖和/或神经元分化的化合物的方法，本发明还涉及用于检测和分析神经元分化，神经元迁移和 /或神经元测定过程。最后，本发明涉及包含本文所述的调节序列，重组核酸分子，宿主细胞或分离的神经元确定的细胞的诊断和药物组合物。

7. 发明授权

US09956199B2 Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders 有权
公开(公告)号：US09956199B2
公开(公告)日：2018-05-01
申请号：US15354325
申请日：2016-11-17
申请人： Ludwig Aigner , Sébastien Couillard-Despres
发明人： Ludwig Aigner , Eleni Priglinger , Sébastien Couillard-Despres , Francisco Javier Rivera , Herbert Riepl , Corinna Urmann , Martin Biendl
IPC分类号： A61K31/35 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/355
CPC分类号： A61K31/352 , A61K31/35 , A61K31/353 , A61K31/355 , A61K31/36 , C07D311/32 , C07D311/70 , C07D407/06 , C07D493/04
摘要： The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (I), (II) and (III) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.

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