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1. 发明公开

EP1574180A3 Drug delivery stent 有权
标题翻译：一种用于递送药物支架
公开(公告)号：EP1574180A3
公开(公告)日：2005-12-07
申请号：EP05251292.8
申请日：2005-03-03
申请人： LUCENT TECHNOLOGIES INC.
发明人： Arney, Susanne , Kroupenkine, Timofei Nikita
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61F2/92 , A61F2210/0076 , A61F2250/0002 , A61F2250/001 , A61F2250/0035 , A61F2250/0039 , A61F2250/0056 , A61F2250/0067 , A61F2250/0068
摘要： An implantable stent (60) comprises a tubular member having an interior surface and an exterior surface, with a region of at least one of the surfaces being hydrophobic. The region is provided with an array (62) of microstructures or nanostructures that covers first portions of the surface but leaves second portions exposed in the interstices of the array. These structures cause the region to have a dynamically controllable hydrophobicity. In one embodiment, a control device, which is affixed to the tubular member, varies the hydrophobicity of the region. In another embodiment, which is particularly applicable to the delivery of a medicinal substance (69) to fluids in body vessels, the stent also includes such a medicinal substance that adheres to the exposed portions until the control device alters the hydrophobicity of the region and causes the substance to be released into a body fluid in contact with the stent. Various ways to load the stent are described. In yet another embodiment, the tubular member is provided with a mechanism that enables the shape of the stent (e.g., its diameter) in vivo to be controlled dynamically, again by means of external wireless communication. In one more embodiment, sensors are affixed to the tubular member to enable fluid parameters (e.g., pressure, flow rate) to be monitored remotely.

2. 发明授权

EP1574180B1 Drug delivery stent 有权
标题翻译：一种用于递送药物支架
公开(公告)号：EP1574180B1
公开(公告)日：2010-10-20
申请号：EP05251292.8
申请日：2005-03-03
申请人： LUCENT TECHNOLOGIES INC.
发明人： Arney, Susanne , Kroupenkine, Timofei Nikita
IPC分类号： A61L31/14 , A61F2/92
CPC分类号： A61L31/14 , A61F2/92 , A61F2210/0076 , A61F2250/0002 , A61F2250/001 , A61F2250/0035 , A61F2250/0039 , A61F2250/0056 , A61F2250/0067 , A61F2250/0068

3. 发明授权

EP1584375B1 Dynamically controllable biological/chemical detectors having nanostructured surfaces 有权转让
标题翻译：动态控制的生物/化学检测器与纳米结构表面
公开(公告)号：EP1584375B1
公开(公告)日：2008-07-02
申请号：EP05251553.3
申请日：2005-03-15
申请人： Lucent Technologies Inc.
发明人： Arney, Susanne , Kroupenkine, Timofei N. , Lyons, Alan M. , Mandich, Mary L. , Schabel, Michael J. , Taylor, Joseph A.
IPC分类号： B01L3/00
CPC分类号： B01L3/5088 , B01L3/508 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0421 , B01L2400/0427 , B01L2400/0436

4. 发明公开

EP1584375A1 Dynamically controllable biological/chemical detectors having nanostructured surfaces 有权转让
标题翻译： Dynamisch steuerbarer biologisch / chemischer Detektor mit nanostrukturiertenOberflächen
公开(公告)号：EP1584375A1
公开(公告)日：2005-10-12
申请号：EP05251553.3
申请日：2005-03-15
申请人： LUCENT TECHNOLOGIES INC.
发明人： Arney, Susanne , Kroupenkine, Timofei N. , Lyons, Alan M. , Mandich, Mary L. , Schabel, Michael J. , Taylor, Joseph A.
IPC分类号： B01L3/00
CPC分类号： B01L3/5088 , B01L3/508 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0421 , B01L2400/0427 , B01L2400/0436
摘要： A biological/chemical detector is disclosed that is capable of manipulating liquids, such as reagent droplets, without relying on microchannels. In a first embodiment, fluid flow is passed through the detector, thus causing particles wholly or partially containing an illustrative chemical compound or biological species to be collected on the tips of nanostructures in the detector. A droplet of liquid is moved across the tips of the nanostructures, thus absorbing the particles into the liquid. The droplet is caused to penetrate the nanostructures in a desired location, thus causing the chemical compound or biological species in said liquid droplet to come into contact with, for example, a reagent. In another embodiment, a fluid flow is passed through the nanostructured surfaces of the detector such that the chemical compound and/or biological species are deposited between the nanoposts of a desired pixel. A droplet of liquid is moved across the surface to that desired pixel and is caused to penetrate the nanostructures of the pixel, thus contacting a reagent.
摘要翻译：公开了一种生物/化学检测器，其能够在不依赖微通道的情况下操纵诸如试剂液滴的液体。在第一实施例中，流体流动通过检测器，从而使完全或部分含有说明性化学化合物或生物物质的颗粒收集在检测器中的纳米结构的尖端上。液滴流过纳米结构的尖端，从而将颗粒吸收到液体中。导致液滴在期望的位置穿透纳米结构，从而使所述液滴中的化合物或生物物质与例如试剂接触。在另一个实施例中，流体流动通过检测器的纳米结构化表面，使得化学化合物和/或生物物质沉积在所需像素的纳米孔之间。一滴液体通过表面移动到期望的像素，并且使其渗透像素的纳米结构，从而接触试剂。

5. 发明公开

EP1574180A2 Drug delivery stent 有权
标题翻译：药物输送支架
公开(公告)号：EP1574180A2
公开(公告)日：2005-09-14
申请号：EP05251292.8
申请日：2005-03-03
申请人： LUCENT TECHNOLOGIES INC.
发明人： Arney, Susanne , Kroupenkine, Timofei Nikita
IPC分类号： A61F2/06
CPC分类号： A61L31/14 , A61F2/92 , A61F2210/0076 , A61F2250/0002 , A61F2250/001 , A61F2250/0035 , A61F2250/0039 , A61F2250/0056 , A61F2250/0067 , A61F2250/0068
摘要： An implantable stent (60) comprises a tubular member having an interior surface and an exterior surface, with a region of at least one of the surfaces being hydrophobic. The region is provided with an array (62) of microstructures or nanostructures that covers first portions of the surface but leaves second portions exposed in the interstices of the array. These structures cause the region to have a dynamically controllable hydrophobicity. In one embodiment, a control device, which is affixed to the tubular member, varies the hydrophobicity of the region. In another embodiment, which is particularly applicable to the delivery of a medicinal substance (69) to fluids in body vessels, the stent also includes such a medicinal substance that adheres to the exposed portions until the control device alters the hydrophobicity of the region and causes the substance to be released into a body fluid in contact with the stent. Various ways to load the stent are described. In yet another embodiment, the tubular member is provided with a mechanism that enables the shape of the stent (e.g., its diameter) in vivo to be controlled dynamically, again by means of external wireless communication. In one more embodiment, sensors are affixed to the tubular member to enable fluid parameters (e.g., pressure, flow rate) to be monitored remotely.
摘要翻译：植入式支架（60）包括具有内表面和外表面的管状构件，其中至少一个表面的区域是疏水性的。该区域设有微结构或纳米结构的阵列（62），其覆盖表面的第一部分但留下暴露在阵列的空隙中的第二部分。这些结构使该区域具有可动态控制的疏水性。在一个实施例中，固定到管状构件上的控制装置改变该区域的疏水性。在另一个特别适用于将药用物质（69）输送到身体血管中的流体的实施方式中，支架还包括粘附到暴露部分的药物，直到控制装置改变该区域的疏水性并引起待释放到与支架接触的体液中的物质。描述了加载支架的各种方式。在又一个实施例中，管状构件设置有能够再次借助外部无线通信动态地控制体内支架的形状（例如，其直径）的机构。在又一个实施例中，传感器被固定到管状构件上以能够远程监测流体参数（例如，压力，流量）。

6. 发明公开

EP1043849A2 Splitter for use with an optical amplifier 有权
标题翻译： Verzweiger zur Verwendung mit einem optischenVerstärker
公开(公告)号：EP1043849A2
公开(公告)日：2000-10-11
申请号：EP00302506.1
申请日：2000-03-28
申请人： LUCENT TECHNOLOGIES INC.
发明人： Arney, Susanne , Legrange, Jane Deborah
IPC分类号： H04B10/17
CPC分类号： G02B6/3512 , G02B6/2817 , G02B6/3514 , G02B6/3548 , G02B6/357 , H01S3/06708 , H01S3/06716 , H01S3/06754 , H01S3/094003
摘要： An optical communication system which conserves electrical power is disclosed. Electrical power is conserved in the optical communication system by coupling a splitter to an optical amplifier. The optical amplifier is configured to receive optical signals as well as pump light. The splitter provides a portion of the pump light used in the optical amplifier to other devices (e. g., optical amplifiers, filters, modulators) of the optical communication system. Providing a portion of the pump light used in the optical amplifier to other devices in the optical communication systems conserves electric power by reducing the total electrical power needed to operate the optical communication system.
摘要翻译：公开了一种节省电力的光通信系统。在光通信系统中通过将分离器耦合到光放大器来节省电力。光放大器被配置为接收光信号以及泵浦光。分路器将光放大器中使用的泵浦光的一部分提供给光通信系统的其它设备（例如，光放大器，滤波器，调制器）。将光放大器中使用的泵浦光的一部分提供给光通信系统中的其他设备，通过减少操作光通信系统所需的总电功率来节省电力。

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