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1. 发明专利

JP2013063986A Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy 审中-公开
标题翻译：白蛋白的分离，吡咯烷酸衍生物的合成及其用途及其衍生物用于治疗原发性高血压，前列腺癌和脊髓灰质炎病毒
公开(公告)号：JP2013063986A
公开(公告)日：2013-04-11
申请号：JP2012243244
申请日：2012-11-05
申请人： Lts Lohmann Therapie-Systeme Ag , エルテーエスローマンテラピー−ジステーメアーゲー
发明人： HANS-RAINER HOFFMANN , MATUSCH RUDOLF , ARIA BANIAHMAD
IPC分类号： A61K31/235 , A61K36/00 , A61K36/09 , A61K36/18 , A61P13/08 , A61P21/00 , A61P35/00 , C07C51/47 , C07C65/03 , C07C67/08 , C07C67/56 , C07C69/84
CPC分类号： C07C311/17 , C07C67/56 , C07C69/84
摘要： PROBLEM TO BE SOLVED: To provide a method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for the treatment of or the production of a medicament for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy.SOLUTION: The biomaterial is a bark of African plum tree P. africana, or lichenes viable on the bark of the P. africana. Stirring of the atraric acid in the chemical synthesis is performed in a primary aliphatic alcohol solution together with an equimolar amount of alkali hydroxide or alkaline earth hydroxide. The atraric acid is used as a basic substance for development of the other agents used for the treatment of the benign prostatic hyperplasia, prostate malignant tumor, or spinobulbar muscular atrophy.
摘要翻译：待解决的问题：提供一种从生物材料，阿曲酸衍生物，其化学合成，以及使用阿曲酸及其衍生物分离生物材料的方法，用于治疗或产生药物的方法治疗良性前列腺增生，前列腺癌或旋生肌肉肌肉萎缩。
解决方案：生物材料是非洲梅花树的非常野生树皮，或地衣在非洲野豌豆的树皮上生存。在化学合成中搅拌无水酸与脂族醇溶液一起等量的碱金属氢氧化物或碱土金属氢氧化物一起进行。阿曲酸用作用于治疗良性前列腺增生，前列腺恶性肿瘤或旋涡状肌肉萎缩的其它药物的发展的碱性物质。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2014050738A Disposable syringe having at least one pulling hook 有权
标题翻译：具有至少一个抽屉的可点击的注射器
公开(公告)号：JP2014050738A
公开(公告)日：2014-03-20
申请号：JP2013221697
申请日：2013-10-25
申请人： Lts Lohmann Therapie-Systeme Ag , エルテーエスローマンテラピー−ジステーメアーゲー
发明人： BODO ASMUSSEN , HANS-RAINER HOFFMANN , RUDOLF MATUSCH , WORTMANN UWE
IPC分类号： A61M5/30 , A61M5/315
CPC分类号： A61M5/30 , A61M5/2033 , A61M5/24 , A61M5/3007 , A61M5/31515 , A61M2005/2073 , A61M2005/2488 , A61M2005/2492 , A61M2005/312
摘要： PROBLEM TO BE SOLVED: To provide a disposable syringe of a module design having a small whole size, including only a small number of structure parts, easily handled, and on the other hand, ensuring safe storage and reliable operation.SOLUTION: A disposable syringe includes: at least one mechanical spring energy storing part 50; at least one piston-cylinder unit 100 for enabling effective filling at least at a certain time; at least one piston operation shaft 60; and an enclosure 10 in which at least one starting unit 80 is disposed. The spring energy storage part includes at least one spring element to which tension is previously applied. The piston-operation shaft worked by a spring includes at least one pull-out rod which can move in the lateral direction at least in a certain area, and supports the spring energy storage part in which tension is applied to the surface of at least one still surface of the enclosure by a support part 65. When the operation occurs, a starting element 82 opens a support part, and separates from the still surface to move it.
摘要翻译：要解决的问题：提供具有小尺寸的模块设计的一次性注射器，其仅包括少量结构部件，容易处理，另一方面确保安全储存和可靠的操作。解决方案：一次性注射器包括：至少一个机械弹簧能量存储部分50; 至少一个活塞缸单元100，用于至少在一定时间有效地填充; 至少一个活塞操作轴60; 以及设置有至少一个起动单元80的机壳10。弹簧储能部分包括至少一个预先施加张力的弹簧元件。由弹簧加工的活塞操作轴至少包括至少一个可在至少一定面积上沿横向方向移动的拉出杆，并支撑弹簧能量储存部分，其中张力施加到至少一个的表面上当操作发生时，启动元件82打开支撑部分，并从静止表面分离以使其移动。

3. 发明专利

JP2014055162A Autodestructive transdermal therapeutic system 有权
标题翻译：自动化转导治疗系统
公开(公告)号：JP2014055162A
公开(公告)日：2014-03-27
申请号：JP2013234507
申请日：2013-11-13
申请人： Lts Lohmann Therapie-Systeme Ag , エルテーエスローマンテラピー−ジステーメアーゲー
发明人： HANS-RAINER HOFFMANN , HILLE THOMAS
IPC分类号： A61K9/70 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/485 , A61K47/02 , A61P25/04 , A61P39/02
CPC分类号： A61K9/7061 , A61K9/703 , A61K31/485 , B09B3/0075 , B09B2220/14
摘要： PROBLEM TO BE SOLVED: To provide a transdermal therapeutic system (TTS), also called a transdermal patch, which is self-destroying after use.SOLUTION: The invention relates to a transdermal therapeutic system (TTS) which is a transdermal patch, preferably in the form of a transdermal plaster comprising: an active substance and an agent which can destroy the active substance; and means of bringing the active substance, e.g., buprenorphine, into contact with the agent, e.g., potassium permanganate, when the TTS is removed from skin of a patient, so that the contact causes the active substance to be destroyed.
摘要翻译：要解决的问题：提供一种也称为透皮贴片的透皮治疗系统（TTS），其在使用后自毁。解决方案：本发明涉及一种透皮贴剂，其为透皮贴剂，优选为透皮膏药的形式包括：活性物质和可破坏活性物质的药剂; 以及当TTS从患者皮肤上除去时使活性物质例如丁丙诺啡与药剂例如高锰酸钾接触的方法，使得接触导致活性物质被破坏。

4. 发明专利

BRPI0711858B1 sistema terapêutico transdérmico autodestrutivo 未知
公开(公告)号：BRPI0711858B1
公开(公告)日：2020-04-22
申请号：BRPI0711858
申请日：2007-05-22
申请人： LTS LOHMANN THERAPIE SYSTEME AG
发明人： HANS-RAINER HOFFMANN , THOMAS HILLE
IPC分类号： A61K9/70 , A61K31/485
摘要： sistema terapêutico transdérmico autodestrutivo. a presente invenção refere-se a um sistema terapêutico transdermal (tts), preferencialmente na forma de um emplastro transdermal, que contém uma substância ativa, um agente que torna inutilizável a substância ativa e um meio que faz com que ao retirar o tts da pele do paciente, a substância ativa, por exemplo, buprenorfina, e o agente, por exemplo, permanganato de potássio, entrem em contato um com o outro e que através deste contato a substância ativa é destruída.

5. 发明专利

AU2006331121B2 One-way injector with continuously charged spring energy store 未知
公开(公告)号：AU2006331121B2
公开(公告)日：2011-12-01
申请号：AU2006331121
申请日：2006-12-07
申请人： LTS LOHMANN THERAPIE SYSTEME AG
发明人： HANS-RAINER HOFFMANN
IPC分类号： A61M5/315 , A61M5/20
摘要： The invention relates to a one-way injector having a housing in which at least one mechanical spring energy store, at least one piston/cylinder unit, which can be at least temporarily filled with an active substance, at least one piston-actuating plunger and at least one tripping unit are arranged. To this end, the spring energy store comprises a preloaded spring element. The spring element is held in the preloaded position by a tension means surrounding at least a region of the spring. The tripping unit comprises a cutting tool which, in order to release the energy of the spring energy store, severs or weakens the tension means at at least one point, the weakening immediately tearing the tension means. With the present invention, a one-way injector is developed which, with a small overall size, has only a few components and ensures reliable mounting and functioning with simple manipulation.

6. 发明专利

BR112014016176A2 sistema terapêutico transdérmico com uma baixa tendência de cristalização espontânea 未知
公开(公告)号：BR112014016176A2
公开(公告)日：2017-06-13
申请号：BR112014016176
申请日：2012-12-28
申请人： LTS LOHMANN THERAPIE SYSTEME AG , UCB PHARMA GMBH
发明人： HANS-RAINER HOFFMANN , HORST DZEKAN , MICHAEL HORSTMANN , SANDRA WIEDERSBERG , WALTER MÜLLER
IPC分类号： A61K9/70
摘要： resumo patente de invenção: "sistema terapêutico transdérmico com uma baixa tendência de cristalização espontânea". a presente invenção refere-se aos sistemas terapêuticos transdérmicos para a dispensação de um produto farmacêutico, em particular um produto farmacêutico com uma baixa tendência de se cristalizar espontaneamente. a camada de matriz ou pelo menos uma das camadas de matriz em dito sistema contém um adesivo de fusão a quente de silicona, um produto farmacêutico, e partículas produzidas de polivinilpirrolidona reticulada. a invenção também se refere a um método para a produção de ditos sistemas terapêuticos transdérmicos.

7. 发明专利

AU2006210043B2 Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma, and spinobulbar muscular atrophy 未知
公开(公告)号：AU2006210043B2
公开(公告)日：2011-09-01
申请号：AU2006210043
申请日：2006-01-28
申请人： LTS LOHMANN THERAPIE SYSTEME AG
发明人： HANS-RAINER HOFFMANN , RUDOLF MATUSCH , ARIA BANIAHMAD
IPC分类号： C07C69/88 , A61K31/618 , C07C311/17
摘要： The invention relates to a method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for the treatment of or the production of a medicament for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy and as a basic substance for the development of other agents used for the treatment of benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy.

8. 发明专利

HK1047037B 含聚殼糖的蘭諾索爾(毫微溶膠)藥物製劑及其製備未知
公开(公告)号：HK1047037B
公开(公告)日：2005-03-24
申请号：HK02108480
申请日：2002-11-22
申请人： LTS LOHMANN THERAPIE-SYSTEME AG
发明人： HANS-RAINER HOFFMANN , BODO ASMUSSEN
IPC分类号： A61K20060101 , A61K47/48 , A61J3/00 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/51 , A61K31/722 , A61K47/30 , A61K47/36 , B01J13/00

9. 发明专利

BRPI0711858B8 sistema terapêutico transdérmico autodestrutivo 未知
公开(公告)号：BRPI0711858B8
公开(公告)日：2021-05-25
申请号：BRPI0711858
申请日：2007-05-22
申请人： LTS LOHMANN THERAPIE SYSTEME AG
发明人： HANS-RAINER HOFFMANN , THOMAS HILLE
IPC分类号： A61K9/70 , A61K31/485
摘要： sistema terapêutico transdérmico autodestrutivo. a presente invenção refere-se a um sistema terapêutico transdermal (tts), preferencialmente na forma de um emplastro transdermal, que contém uma substância ativa, um agente que torna inutilizável a substância ativa e um meio que faz com que ao retirar o tts da pele do paciente, a substância ativa, por exemplo, buprenorfina, e o agente, por exemplo, permanganato de potássio, entrem em contato um com o outro e que através deste contato a substância ativa é destruída.

10. 发明专利

BR112014016176A8 sistema terapêutico transdérmico com uma baixa tendência de cristalização espontânea 未知
公开(公告)号：BR112014016176A8
公开(公告)日：2017-07-04
申请号：BR112014016176
申请日：2012-12-28
申请人： LTS LOHMANN THERAPIE SYSTEME AG , UCB PHARMA GMBH
发明人： HANS-RAINER HOFFMANN , HORST DZEKAN , MICHAEL HORSTMANN , SANDRA WIEDERSBERG , WALTER MÜLLER
IPC分类号： A61K9/70
摘要： resumo patente de invenção: "sistema terapêutico transdérmico com uma baixa tendência de cristalização espontânea". a presente invenção refere-se aos sistemas terapêuticos transdérmicos para a dispensação de um produto farmacêutico, em particular um produto farmacêutico com uma baixa tendência de se cristalizar espontaneamente. a camada de matriz ou pelo menos uma das camadas de matriz em dito sistema contém um adesivo de fusão a quente de silicona, um produto farmacêutico, e partículas produzidas de polivinilpirrolidona reticulada. a invenção também se refere a um método para a produção de ditos sistemas terapêuticos transdérmicos.

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