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1. 发明授权

US5788977A Method of making controlled release devices 失效
标题翻译：制造控释装置的方法
公开(公告)号：US5788977A
公开(公告)日：1998-08-04
申请号：US803739
申请日：1997-02-21
申请人： Louis Aguadisch , Magali Barbaroux , Frederic Dalle
发明人： Louis Aguadisch , Magali Barbaroux , Frederic Dalle
IPC分类号： A61M37/00 , A61K9/00 , A61K9/52 , C08L83/04 , C08L83/06 , A61F13/00
CPC分类号： A61K9/0092 , A61K9/0024 , A61K9/0036 , A61K9/0039 , A61K9/0085
摘要： A process is disclosed for making devices which release active material, e.g. a drug, at a controlled rate, which device comprises a closed container and the active material. The device is made by first making a hollow envelope, e.g. by extrusion or moulding, followed by introducing the active material into the void of the envelope. The device may have a ring or cylindrical form.
摘要翻译：公开了一种制造释放活性材料的装置的方法，例如，药物，以受控的速率，该装置包括密闭容器和活性物质。该装置通过首先制造中空包络线，例如通过挤出或模制，然后将活性材料引入到信封的空隙中。该装置可以具有环形或圆柱形形式。

2. 发明申请

US20130161229A1 SINGLE-USE BIOPHARMACEUTICAL DEVICE FOR PRODUCING, STORING, AND TRANSPORTING A BIOPHARMACEUTICAL MATERIAL, AND CORRESPONDING MULTILAYER TUBE 有权
标题翻译：用于生产，储存和运输生物材料和相应多层管的单一生物制药装置
公开(公告)号：US20130161229A1
公开(公告)日：2013-06-27
申请号：US13817190
申请日：2011-08-10
申请人： Magali Barbaroux , Maréva Gueneron
发明人： Magali Barbaroux , Maréva Gueneron
IPC分类号： A61J1/20
CPC分类号： C12M23/20 , A61B10/0096 , A61J1/20 , B32B1/08 , B32B27/08 , B32B27/302 , B32B27/304 , B32B27/306 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B2307/41 , B32B2307/412 , B32B2307/536 , B32B2307/546 , B32B2307/7163 , B32B2307/72 , B32B2307/7242 , B32B2439/80 , B32B2535/00 , B32B2597/00 , F16L11/045
摘要： A device including: a bag, a tube section having a wall defining a free longitudinal space, and a plastic connector, which are all fused together, the wall including a contact layer made of a material other than PVC, selected from PE, EVA, PP, ETFE, and PVDF, and a functional layer including at least one basic functional layer of a material selected for the function thereof (flexibility, sturdiness, handling, opacity or transparence, gas barrier) and selected from the family including PE, PET, a PA, EVA, EVOH, SEBS, PETG, and PVDF, a bag, another tube section, and/or a connector fused to the biopharmaceutical tube and including a contact layer made of a material capable of being in contact with the biopharmaceutical material, which is capable of being fused onto itself, and which is identical or similar to the material of the contact layer of the biopharmaceutical tube.
摘要翻译：一种装置，包括：袋子，具有限定自由纵向空间的壁的管部分和塑料连接器，所有塑料连接器都熔合在一起，所述壁包括由不同于PVC的材料制成的接触层，所述接触层选自PE，EVA， PP，ETFE和PVDF，以及功能层，其包括至少一种选自其功能的材料的基本功能层（柔韧性，坚固性，操作性，不透明度或透明性，气体屏障），并且选自包括PE，PET， PA，EVA，EVOH，SEBS，PETG和PVDF，袋，另一管段和/或熔接到生物药物管的连接器，并且包括由能够与生物药物材料接触的材料制成的接触层，其能够熔合在其自身上，并且与生物药剂管的接触层的材料相同或相似。

3. 发明授权

US09044718B2 Mixing vessel 有权
标题翻译：混合容器
公开(公告)号：US09044718B2
公开(公告)日：2015-06-02
申请号：US12918351
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/22 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/00 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.
摘要翻译：混合容器包括柔性容器，用于混合其内容物的元件，曝气元件，具有设置有排水通道的刚性凸缘的排水/下轴承端口，紧密地附接到容器壁的下部，与排水通道相邻的轴承。容器包括用于分配曝气气体的延伸元件，并且与排放/承载端口基本上径向间隔开; 用于分配曝气气体的至少一个管状元件沿着内部空间中的延伸的分配元件沿容器的下部和内侧面的内表面延伸，并从容器的上部在容器的外侧延伸一部分; 至少一个混合元件基本上与容器壁的下部，下部轴承以及用于分配曝气的至少一个延伸元件间隔开。

4. 发明授权

US08746515B2 Closure for a container 有权
标题翻译：关闭集装箱
公开(公告)号：US08746515B2
公开(公告)日：2014-06-10
申请号：US13132572
申请日：2009-11-17
申请人： Shahmir Fatherazi , Gerhard Greller , Oscar-Werner Reif , Magali Barbaroux , Michael Bates
发明人： Shahmir Fatherazi , Gerhard Greller , Oscar-Werner Reif , Magali Barbaroux , Michael Bates
IPC分类号： B65D47/24
CPC分类号： B65D75/5877 , B01J19/0053 , B01J19/2415 , B01L3/523 , B01L2300/049 , B01L2300/0672 , C12M23/26 , C12M23/28 , C12M23/38
摘要： A closure for a container has an upper part (1) that can be connected to the container. The upper part (1) has an opening (2) and an outer hollow body (3). An inner hollow body (4) is arranged coaxially in the outer hollow body (3) with an intermediate space therebetween. A lower part (7) in the form of a hollow body can be displaced longitudinally in the intermediate space. A plug (5) is held coaxially in the lower part (7) and opens or closes the opening as the lower part (7) is displaced longitudinally in the intermediate space.
摘要翻译：容器的盖子具有可连接到容器的上部（1）。上部（1）具有开口（2）和外部空心体（3）。内空心体（4）同轴地设置在外空心体（3）中，其间具有中间空间。中空体形式的下部（7）可以在中间空间中纵向移位。当下部（7）在中间空间中纵向移位时，插头（5）同轴地保持在下部（7）中并打开或关闭开口。

5. 发明申请

US20110233210A1 CLOSURE FOR A CONTAINER 有权
标题翻译：集装箱封闭
公开(公告)号：US20110233210A1
公开(公告)日：2011-09-29
申请号：US13132572
申请日：2009-11-17
申请人： Shahmir Fatherazi , Gerhard Greller , Oscar-Werner Reif , Magali Barbaroux , Michael Bates
发明人： Shahmir Fatherazi , Gerhard Greller , Oscar-Werner Reif , Magali Barbaroux , Michael Bates
IPC分类号： B65D51/18 , B65D39/00
CPC分类号： B65D75/5877 , B01J19/0053 , B01J19/2415 , B01L3/523 , B01L2300/049 , B01L2300/0672 , C12M23/26 , C12M23/28 , C12M23/38
摘要： A closure for a container has an upper part (1) that can be connected to the container. The upper part (1) has an opening (2) and an outer hollow body (3). An inner hollow body (4) is arranged coaxially in the outer hollow body (3) with an intermediate space therebetween. A lower part (7) in the form of a hollow body can be displaced longitudinally in the intermediate space. A plug (5) is held coaxially in the lower part (7) and opens or closes the opening as the lower part (7) is displaced longitudinally in the intermediate space.
摘要翻译：容器的盖子具有可连接到容器的上部（1）。上部（1）具有开口（2）和外部空心体（3）。内空心体（4）同轴地设置在外空心体（3）中，其间具有中间空间。中空体形式的下部（7）可以在中间空间中纵向移位。当下部（7）在中间空间中纵向移位时，插头（5）同轴地保持在下部（7）中并打开或关闭开口。

6. 发明授权

US09896654B2 Single—use biopharmaceutical device for producing, storing, and transporting a biopharmaceutical material, and corresponding multilayer tube 有权
公开(公告)号：US09896654B2
公开(公告)日：2018-02-20
申请号：US13817190
申请日：2011-08-10
申请人： Magali Barbaroux , Mareva Gueneron
发明人： Magali Barbaroux , Mareva Gueneron
IPC分类号： C12M1/00 , A61J1/20 , B32B27/30 , B32B27/32 , B32B27/08 , B32B27/34 , B32B27/36 , B32B1/08 , A61B10/00 , F16L11/04
CPC分类号： C12M23/20 , A61B10/0096 , A61J1/20 , B32B1/08 , B32B27/08 , B32B27/302 , B32B27/304 , B32B27/306 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B2307/41 , B32B2307/412 , B32B2307/536 , B32B2307/546 , B32B2307/7163 , B32B2307/72 , B32B2307/7242 , B32B2439/80 , B32B2535/00 , B32B2597/00 , F16L11/045
摘要： A device including: a bag, a tube section having a wall defining a free longitudinal space, and a plastic connector, which are all fused together, the wall including a contact layer made of a material other than PVC, selected from PE, EVA, PP, ETFE, and PVDF, and a functional layer including at least one basic functional layer of a material selected for the function thereof (flexibility, sturdiness, handling, opacity or transparence, gas barrier) and selected from the family including PE, PET, a PA, EVA, EVOH, SEBS, PETG, and PVDF, a bag, another tube section, and/or a connector fused to the biopharmaceutical tube and including a contact layer made of a material capable of being in contact with the biopharmaceutical material, which is capable of being fused onto itself, and which is identical or similar to the material of the contact layer of the biopharmaceutical tube.

7. 发明申请

US20120208039A1 MULTILAYER FILM OF A WALL OF A BAG HAVING SEAMS AND INTENDED FOR A BIOPHARMACEUTICAL PRODUCT 审中-公开
标题翻译：一个有海绵的袋子的多层薄膜，并用于生物制品
公开(公告)号：US20120208039A1
公开(公告)日：2012-08-16
申请号：US13501912
申请日：2010-10-29
申请人： Magali Barbaroux , Eric Chevalier , Steve Wasterlain
发明人： Magali Barbaroux , Eric Chevalier , Steve Wasterlain
IPC分类号： B32B37/18 , B32B27/08 , B29C47/06
CPC分类号： B32B27/08 , B32B2307/7242 , B32B2439/46 , B65D65/40 , Y10T428/31913
摘要： Monolayer contact film, designed, once made integral with a multilayer functional film, to constitute a final multilayer film of a pouch wall; the pouch having seams, and designed to be filled with biopharmaceutical product, and composed of a selected material that can be part of the composition of the final multilayer film, be in contact with the biopharmaceutical product, without degradation of the film and biopharmaceutical product, be sealable on itself, with a thickness that is less than the thickness of a single contact layer of the final multilayer film suitable for the production of seams of the single contact layer on itself, of which one surface functions as an interface for interlocking with a first interface for making the multilayer functional film integral, and whose other surface has as its final function to constitute the contact surface of the final multilayer film with the biopharmaceutical product.
摘要翻译：设计成与多层功能膜一体形成的单层接触膜构成袋壁的最终多层膜; 设计成填充有生物制药产品的袋，并且由可以作为最终多层膜的组合物的一部分的选定材料组成的袋与生物药物产物接触，而不会降解膜和生物药物产品，可以自身密封，其厚度小于最终多层膜的单个接触层的厚度，其适用于生产单个接触层本身的接缝，其中一个表面用作与互锁的接口用于使多层功能膜成为一体的第一界面，并且其另一表面具有构成最终多层膜与生物药物产品的接触表面的最终功能。

8. 发明申请

US20120193264A1 PRODUCTION OF A BIOPHARMACEUTICAL PRODUCT 审中-公开
标题翻译：生产生物制品
公开(公告)号：US20120193264A1
公开(公告)日：2012-08-02
申请号：US13499738
申请日：2010-09-29
申请人： Magali Barbaroux , Samuel Dorey , Mareva Gueneron , Oscar Reif
发明人： Magali Barbaroux , Samuel Dorey , Mareva Gueneron , Oscar Reif
IPC分类号： B65D85/84 , B65B1/04
CPC分类号： C12M23/14 , C12M29/00 , C12M29/04
摘要： Process of producing a biopharmaceutical product includes providing a pouch unit including a pouch and at least one port, and optionally, a functional device; filling the pouch with the product; carrying out the production process, and at at least one stage thereof, using or generating a liquid or small solid incident body within the biopharmaceutical product; the pouch unit incorporating a support and replacement element formed by or integrated in the pouch wall, or in the port or functional device so as to be accessible from the inside space and be in direct physical contact with the contents of the pouch, arranged so as to be able to be loaded with the incident body and pass between the support and replacement element and the contents, such that the incident body is loaded on the support and replacement element when it is not or should not be within the biopharmaceutical product.
摘要翻译：生产生物药物产品的方法包括提供包括袋和至少一个端口的袋单元，以及任选的功能性装置; 用产品填充袋子; 进行生产过程，并在其至少一个阶段，在生物药物产品内使用或产生液体或小固体入口体; 所述袋单元包括由所述袋壁形成或集成在所述袋壁中的所述支撑和替换元件，或所述端口或功能装置中，以便能够从所述内部空间接近并与所述袋的内容物直接物理接触，能够装载入射体并在支撑和更换元件与内容物之间通过，使得当不是或不应该在生物药物产品内时，入射体被装载在支撑和替换元件上。

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