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1. 发明专利

JP2008148694A Method for producing (s)- or (r)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 有权
标题翻译：生产（S） - 或（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：JP2008148694A
公开(公告)日：2008-07-03
申请号：JP2007315256
申请日：2007-12-05
申请人： Lonza Ag , ロンザア−ゲ−
发明人： BRIEDEN WALTER , NAUGHTON ANDREW , ROBINS KAREN , SHAW NICHOLAS , TINSCHERT ANDREAS , ZIMMERMANN THOMAS
IPC分类号： C12N1/20 , C12N15/09 , C07B61/00 , C07C235/06 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/02 , C12P41/00 , C12R1/06
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： PROBLEM TO BE SOLVED: To provide a new microorganism utilizing the racemic form or optically active isomeric forms of propionic acid amide as a sole nitrogen source and a new enzyme, and to provide a method for producing (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid from a trifluoroacetoacetic acid ester. SOLUTION: This method for obtaining an optically active propionic acid amide form and optically active propionic acid form includes obtaining microorganism utilizing the racemic form or optical active isomeric forms of the propionic acid amide as the sole nitrogen source, and acting the microorganism on the racemic form of the propionic acid amide. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种利用外消旋形式或旋光异构形式的丙酸酰胺作为唯一氮源和新的酶的新微生物，并提供一种生产（S） - 或（R ）-3,3,3-三氟-2-羟基-2-甲基丙酸从三氟乙酰乙酸酯中得到。解决方案：用于获得光学活性丙酸酰胺形式和光学活性丙酸形式的方法包括使用外消旋形式的微生物或作为唯一氮源的丙酸酰胺的光学活性异构体形式，并将微生物作用于丙酰胺的外消旋形式。版权所有（C）2008，JPO＆INPIT

2. 发明申请

WO0229021A3 BIOTECHNOLOGICAL METHOD FOR PREPARING CARBOXYLIC ACIDS WITH A HYDROXY-NITROGEN HETEROCYCLE 审中-公开
标题翻译：生物技术用于生产羟基 - 氮杂环 - 碳氢酸
公开(公告)号：WO0229021A3
公开(公告)日：2002-09-19
申请号：PCT/EP0111624
申请日：2001-10-08
申请人： LONZA AG , MARILLEY LAURENT , SCHRAEDER THOMAS , THIEMER BARBARA , ANDEREESEN JAN R , BURGDORF KNUT , TINSCHERT ANDREAS , HAAS DIETER , ZIMMERMANN THOMAS
发明人： MARILLEY LAURENT , SCHRAEDER THOMAS , THIEMER BARBARA , ANDEREESEN JAN R , BURGDORF KNUT , TINSCHERT ANDREAS , HAAS DIETER , ZIMMERMANN THOMAS
IPC分类号： C07D213/80 , C07D241/24 , C12N9/06 , C12N15/53 , C12P17/12 , C07D487/04 , C07K14/195 , C07K14/21 , C12N1/21 , C12N15/31
CPC分类号： C07D213/80 , C07D241/24 , C12N9/0012 , C12P17/12
摘要： The invention relates to a novel enzyme that has 6-methyl nicotinic-2-dehydrogenase-activity, to a nucleotide sequence encoding said enzyme, and to novel methods for producing carboxylic acids with a hydroxy-nitrogen heterocycle of the general formulae (I), (II), (III) or the salts thereof, wherein R , R , R and R are the same or different and represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an arylalkyl group, a heteroaryl group or a carboxylic acid group, and X is a nitrogen atom or CR , wherein R represents a hydrogen or halogen atom. The substrate used is a carboxylic acid with a nitrogen heterocycle of the general formulae (IV), (V), (VI) or a salt thereof, wherein R , R , R and R and X are defined as above. The method according to the invention is carried out with the isolated polypeptide/enzyme, using genetically engineered microorganisms, or using wild strains of the genus Ralstonia/Burkholderia .
摘要翻译：公开的是一种新型的酶与6-甲基烟酸-2-脱氢酶活性的核苷酸序列，编码此酶，以及用于生产通式（I）的羟基 - 氮杂环羧酸新工艺，（II），（ III）或其盐，其中，R <1>，R <2>，R <3>和R <4>是相同的或不同的，是氢原子，卤素原子，烷基，芳基，芳基，杂芳基或羧酸基团和X是氮原子或CR <5>，其中R <5>是一个氢原子或卤原子，通式（IV），（V）的使用作为底物的含氮杂环羧酸，（VI）或其盐，其中，R <1>，R <2>，R <3>和R <4>和X具有所提到的含义被使用。该过程与分离的多肽/酶进行，通过遗传修饰的微生物，或通过属青枯/伯克霍尔德的“野生株”的手段。

3. 发明申请

WO02061094A2 MICROBIOLOGICAL METHOD FOR PRODUCING L-CARNITINE 审中-公开
标题翻译：微生物法生产L-肉碱
公开(公告)号：WO02061094A2
公开(公告)日：2002-08-08
申请号：PCT/EP0201009
申请日：2002-01-31
申请人： LONZA AG , BORNSCHEUER UWE , MUSIDLOWSKA ANNA , WERLEN JOSEF , ZIMMERMANN THOMAS , TSCHERRY RENATA HF
发明人： BORNSCHEUER UWE , MUSIDLOWSKA ANNA , WERLEN JOSEF , ZIMMERMANN THOMAS , TSCHERRY BENNO DI
IPC分类号： C12N1/21 , C12N9/18 , C12N15/55 , C12P13/00 , C12R1/01 , C12R1/41
CPC分类号： C12P13/007 , C12N9/18 , C12R1/01 , C12R1/41
摘要： The invention relates to a method for producing L-carnitine on the basis of a betaine ester of the general formula (I), wherein R and R represent either hydrogen or together form a bond, and R represents alkyl, aryl or arylalkyl, by means of hydrolases that convert said betaine ester to give the betaine. The betaine so obtained is then converted to L-carnitine by means of a microorganism capable of converting the betaine of formula (II) to L-carnitine. The invention further relates to hydrolases that convert 4-butyrobetaine methyl ester to 4-butyrobetaine and to microorganisms that contain such hydrolases.
摘要翻译：生产L-肉毒碱的方法所述，由通式（I）其中R <1>和R <2>是氢或一起形成一个键和的甜菜碱酯起始 - [R <3>是烷基，芳基或芳通过这些甜菜碱酯转化成甜菜碱水解酶的手段。甜菜碱是随后由微生物，其是能够将式（II）为L-肉碱的甜菜碱转换的装置，转换成L-肉碱。是描述进一步的水解酶，其将4- Butyronetain甲酯向4-甜菜碱和含有这样的水解酶的微生物。

4. 发明申请

WO9801568A3 METHOD OF PREPARING (S) - OR (R) -3,3,3-TRIFLUORO-2-HYDROXY-2- METHYLPROPIONIC ACID 审中-公开
标题翻译：制备（S） - （（R）-3,3,3-三氟-2-羟基-2-甲基丙酸的方法
公开(公告)号：WO9801568A3
公开(公告)日：1998-02-19
申请号：PCT/EP9703670
申请日：1997-07-10
申请人： LONZA AG , BRIEDEN WALTER , NAUGHTON ANDREW , ROBINS KAREN , SHAW NICHOLAS , TINSCHERT ANDREAS , ZIMMERMANN THOMAS
发明人： BRIEDEN WALTER , NAUGHTON ANDREW , ROBINS KAREN , SHAW NICHOLAS , TINSCHERT ANDREAS , ZIMMERMANN THOMAS
IPC分类号： C12N15/09 , C07C235/06 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/02 , C12P41/00 , C12R1/06 , C07C231/06 , C12N1/20 , C12P7/42
CPC分类号： C12N1/20 , C07C235/06 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/006
摘要： Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S) - or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.

5. 发明专利

CA2259954C PROCESS FOR THE PREPARATION OF (S)- OR (R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPIONIC ACID 未知
公开(公告)号：CA2259954C
公开(公告)日：2012-03-06
申请号：CA2259954
申请日：1997-07-10
申请人： LONZA AG
发明人： BRIEDEN WALTER , NAUGHTON ANDREW , ROBINS KAREN , SHAW NICHOLAS , TINSCHERT ANDREAS , ZIMMERMANN THOMAS
IPC分类号： C12N15/09 , C12N15/55 , C07C231/06 , C07C235/06 , C12N1/20 , C12N1/21 , C12N9/80 , C12P7/42 , C12P13/02 , C12P41/00 , C12R1/06
摘要： Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S) -or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.

6. 发明专利

DK0938584T3 未知
公开(公告)号：DK0938584T3
公开(公告)日：2008-09-22
申请号：DK97938817
申请日：1997-07-10
申请人： LONZA AG
发明人： ZIMMERMANN THOMAS , BRIEDEN WALTER , NAUGHTON ANDREW , ROBINS KAREN , SHAW NICHOLAS , TINSCHERT ANDREAS
IPC分类号： C12N15/09 , C12P41/00 , C07C235/06 , C12N1/21 , C12N9/80 , C12N15/55 , C12P13/02 , C12R1/06
摘要： The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.

7. 发明专利

ES2282399T3 PROCEDIMIENTO MICROBIOLOGICO PARA LA OBTENCION DE L-CARNITINA. 未知
公开(公告)号：ES2282399T3
公开(公告)日：2007-10-16
申请号：ES02712878
申请日：2002-01-31
申请人： LONZA AG
发明人： BORNSCHEUER UWE , MUSIDLOWSKA ANNA , WERLEN JOSEF , ZIMMERMANN THOMAS , TSCHERRY BENNO
IPC分类号： C12N15/55 , C12N1/21 , C12N9/18 , C12P13/00 , C12R1/01 , C12R1/41
摘要： Hidrolasa, que transforma el éster de metilo de la 4-butirobetaína como substrato en 4-butirobetaína, caracterizada porque tiene: a) un pI de 4, 15 ñ 0, 30 y b) un peso molecular de 22, 0 ñ 2, 0 kDa, determinado según SDS-PAGE.

8. 发明专利

AT356214T 未知
公开(公告)号：AT356214T
公开(公告)日：2007-03-15
申请号：AT02712878
申请日：2002-01-31
申请人： LONZA AG
发明人： BORNSCHEUER UWE , MUSIDLOWSKA ANNA , WERLEN JOSEF , ZIMMERMANN THOMAS , TSCHERRY BENNO
IPC分类号： C12N1/21 , C12N9/18 , C12N15/55 , C12P13/00 , C12R1/01 , C12R1/41
摘要： The invention relates to a method for producing L-carnitine on the basis of a betaine ester of the general formula (I), wherein R and R represent either hydrogen or together form a bond, and R represents alkyl, aryl or arylalkyl, by means of hydrolases that convert said betaine ester to betaine. The betaine so obtained is then converted to L-carnitine by means of a microorganism capable of converting the betaine of formula (II) to L-carnitine. The invention further relates to hydrolases that convert 4-butyrobetaine methyl ester to 4-butyrobetaine and to microorganisms that contain such hydrolases.

9. 发明专利

AT257515T 未知
公开(公告)号：AT257515T
公开(公告)日：2004-01-15
申请号：AT94929520
申请日：1994-10-07
申请人： LONZA AG
发明人： ZIMMERMANN THOMAS , WERLEN JOSEF
IPC分类号： C12N15/09 , C12N1/21 , C12N15/52 , C12N15/74 , C12P13/00 , C12R1/01 , C12R1/41
摘要： PCT No. PCT/EP94/03317 Sec. 371 Date Jul. 2, 1996 Sec. 102(e) Date Jul. 2, 1996 PCT Filed Oct. 7, 1994 PCT Pub. No. WO95/10613 PCT Pub. Date Apr. 20, 1995An isolated DNA fragment including the genes bcoC, bcoA/B, bcoD coding for the enzymes for L-carnitine biosynthesis in gamma -butyrobetaine/crotonobetaine metabolism and, additionally, including the gene bcoT coding for a potential transport protein in gamma -butyrobetaine/crotonobetaine metabolism. Also, any vector which includes an isolated DNA fragment including the genes bcoC, bcoA/B, bcoD coding for the enzymes for L-carnitine biosynthesis in gamma -butyrobetaine/crotonobetaine metabolism and, additionally, including the gene bcoT coding for a potential transport protein in gamma -butyrobetaine/crotonobetaine metabolism. Also, biotechnological process for the production of L-carnitine characterized in that crotonobetaine and/or gamma -butyrobetaine is fermented in the presence of a suitable carbon and nitrogen source using a microorgansim and L-carnitine is isolated.

10. 发明专利

PL170598B1 METHOD OF OBTAINING S-(+)-2,2-DIMETHYLCYCLOPROPANOCARBOXAMIDE BY A GENETIC ENGINEERING METHOD USING MICROORGANISM 未知
公开(公告)号：PL170598B1
公开(公告)日：1997-01-31
申请号：PL29540892
申请日：1992-07-24
申请人： LONZA AG
发明人： ZIMMERMANN THOMAS , ROBINS KAREN , BIRCH OLWEN M , BOEHLEN ELISABETH
IPC分类号： C12P13/02 , C07H21/00 , C07K14/195 , C12N1/00 , C12N1/20 , C12N1/21 , C12N9/80 , C12N11/06 , C12N15/09 , C12N15/10 , C12N15/55 , C12P7/40 , C12P19/34 , C12P41/00 , C12R1/19 , C12R1/38 , C12R1/41
摘要： A genetic engineering process for the preparation of S-(+)-2,2-dimethylcyclopropanecarboxamide is described. For this, a DNA which codes for a stereospecific hydrolase is isolated from a microorganism. This DNA is then ligated into an expression vector, resulting in a hybrid plasmid which is transformed into microorganisms. These microorganisms are then capable of the biotransformation of the R-(-) isomer in racemic R,S-(+/-)-2,2-dimethylcyclopropanecarboxamide to the R-(-)-2,2-dimethylcyclopropanecarboxylic acid, resulting in optically active S-(+)-2,2-dimethylcyclopropanecarboxamide.

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