专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080038717A1 ENRICHMENT METHOD FOR VARIANT PROTEINS WITH ALTERED BINDING PROPERTIES 审中-公开
标题翻译：具有改变的结合性质的变体蛋白的富集方法
公开(公告)号：US20080038717A1
公开(公告)日：2008-02-14
申请号：US11761180
申请日：2007-06-11
申请人： Lisa Garrard , Dennis Henner , Steven Bass , Ronald Greene , Henry Lowman , James Wells , David Matthews
发明人： Lisa Garrard , Dennis Henner , Steven Bass , Ronald Greene , Henry Lowman , James Wells , David Matthews
IPC分类号： C12Q1/70 , C07K14/00 , C12N7/00
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N15/1037 , C12N15/62 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N33/6845 , G01N33/74 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

2. 发明申请

US20060115874A1 Enrichment method for variant proteins with altered binding properties 审中-公开
公开(公告)号：US20060115874A1
公开(公告)日：2006-06-01
申请号：US11199062
申请日：2005-08-08
申请人： Lisa Garrard , Dennis Henner , Steven Bass , Ronald Greene , Henry Lowman , James Wells , David Matthews
发明人： Lisa Garrard , Dennis Henner , Steven Bass , Ronald Greene , Henry Lowman , James Wells , David Matthews
IPC分类号： C12P21/06 , C12N9/64 , C12N9/80 , C07K14/16 , C07K14/65 , C07K14/705 , C12N15/74
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N15/1037 , C12N15/62 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N33/6845 , G01N33/74 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.

3. 发明授权

US5750373A Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants 失效
标题翻译：具有改变的结合特性的变体蛋白质的富集方法，M13噬菌粒和生长激素变体
公开(公告)号：US5750373A
公开(公告)日：1998-05-12
申请号：US50058
申请日：1993-04-30
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12P21/06 , C12N15/63
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译： PCT No.PCT / US91 / 09133 Sec。 371日期：1993年04月30日 102（e）日期1993年4月30日PCT 1991年12月3日提交了一种选择具有改变其各自受体分子结合特性的生长激素和抗体片段变体的新蛋白质的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

4. 发明授权

US6040136A Enrichment method for variant proteins with altered binding properties 失效
标题翻译：具有改变的结合特性的变体蛋白质的富集方法
公开(公告)号：US6040136A
公开(公告)日：2000-03-21
申请号：US923854
申请日：1997-09-03
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12Q1/70 , C07H17/00 , C07K14/00 , C12P21/06
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

5. 发明申请

US20100035236A1 ENRICHMENT METHOD FOR VARIANT PROTEINS WITH ALTERED BINDING PROPERTIES 审中-公开
标题翻译：具有改变的结合性质的变体蛋白的富集方法
公开(公告)号：US20100035236A1
公开(公告)日：2010-02-11
申请号：US12508859
申请日：2009-07-24
申请人： Lisa J. GARRARD , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. GARRARD , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： C12Q1/70 , C07K14/61 , C12N7/00
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N15/1037 , C12N15/62 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N33/6845 , G01N33/74 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

6. 发明授权

US5821047A Monovalent phage display 失效
标题翻译：单价噬菌体展示
公开(公告)号：US5821047A
公开(公告)日：1998-10-13
申请号：US463587
申请日：1995-06-05
申请人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
发明人： Lisa J. Garrard , Dennis J. Henner , Steven Bass , Ronald Greene , Henry B. Lowman , James A. Wells , David J. Matthews
IPC分类号： A61K47/48 , C07K14/01 , C07K14/47 , C07K14/575 , C07K14/61 , C07K19/00 , C12N5/10 , C12N15/10 , C12N15/11 , C12N15/62 , C12N15/85 , C12Q1/68 , C40B40/02 , G01N33/554 , G01N33/566 , G01N33/74 , C12Q1/70 , C07K16/00 , C12N7/02 , C12N15/63
CPC分类号： C40B40/02 , C07K14/005 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , G01N33/6845 , G01N33/74 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , C12N2750/00011 , C12N2795/14022 , C12N2795/14122 , G01N2333/61 , Y10S436/802 , Y10S930/12
摘要： A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了选择新型蛋白质如生长激素和具有改变其各自受体分子的结合特性的抗体片段变体的方法。该方法包括将编码目的蛋白质的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。公开了优选的噬菌粒表达载体和选择的人生长激素变体。

7. 发明授权

US07418311B1 Portable dispensing device for refreshments and sundries 有权
标题翻译：用于茶点和杂物的便携式分配装置
公开(公告)号：US07418311B1
公开(公告)日：2008-08-26
申请号：US11440319
申请日：2006-05-22
申请人： Paul J Lagassey , Ben Junior Bush , Gary A. Crain , Ronald Greene
发明人： Paul J Lagassey , Ben Junior Bush , Gary A. Crain , Ronald Greene
IPC分类号： G06F17/00
CPC分类号： G07F9/105 , G07F9/026 , G07F11/42
摘要： A portable dispensing system comprising a vending machine including an upper snack-holding portion, an intermediate beverage-holding portion, a lower refrigeration portion, contained within a housing that fits within the basket of a golf cart. The snack-holding portion and the beverage-holding portion occupy a common cabinet being separated by an insulating wall, allowing a refrigeration mechanism within the refrigeration portion to refrigerate the beverage-holding portion without refrigerating the snack-holding portion. The cabinet is disposed above the basket within the golf cart, and may be provided with a pair of belts for fastening the dispensing system to the golf cart. Within the snack-holding portion, snacks are held in a plurality of snack-holding bins, with similar snacks being stored in a single bin, separated from one another by sliding platforms. When a sliding platform is pulled away, the snack product resting atop the sliding platform is released to fall downward into a lowest position within the bin, to be retrieved by the user through a door. Within the beverage-holding portion, cans are stored in a plurality of columns to be retrieved through doors. An inventory management system is disclosed for controlling and monitoring the dispensing of refreshments and sundries. The inventory management system including a systems for electronically accepting payment, a system for monitoring inventory levels, and a system for wirelessly communicating with a remote terminal.
摘要翻译：一种便携式分配系统，包括自动贩卖机，该自动售货机包括上部小吃保持部分，中间饮料保持部分，下部制冷部分，其容纳在装配在高尔夫球车的篮子内的壳体内。小吃保持部和饮料保持部占据由绝缘壁隔开的共用柜体，允许制冷部内的制冷机构冷冻饮料保持部而不使小吃保持部冷冻。机柜设置在高尔夫球车内的篮子上方，并且可以设置有一对用于将分配系统紧固到高尔夫球车上的皮带。在小吃保持部分内，小吃被保持在多个小吃保持箱中，类似的小食被储存在单个箱中，通过滑动平台彼此分开。当滑动平台被拉开时，休息在滑动平台顶部的零食产品被释放以向下落入箱内的最低位置，由用户通过门取回。在饮料保持部分内，罐被储存在多个列中以通过门取回。公开了一种库存管理系统，用于控制和监视点心和杂物的分配。库存管理系统包括用于电子接收支付的系统，用于监控库存水平的系统以及用于与远程终端进行无线通信的系统。

8. 发明授权

US5688666A Growth hormone variants with altered binding properties 失效
标题翻译：具有改变的结合特性的生长激素变体
公开(公告)号：US5688666A
公开(公告)日：1997-11-18
申请号：US182530
申请日：1994-01-14
申请人： Steven H. Bass , Ronald Greene , Henry B. Lowman , James A. Wells
发明人： Steven H. Bass , Ronald Greene , Henry B. Lowman , James A. Wells
IPC分类号： C07K14/575 , C07K14/61 , C12N15/10 , C12N15/62 , C40B40/02 , C12P21/06
CPC分类号： C40B40/02 , C07K14/575 , C07K14/61 , C12N15/1037 , C12N15/62 , C07K2319/00 , C07K2319/02 , C07K2319/735 , C07K2319/75 , G01N2333/61
摘要： A method for selecting novel proteins such as growth hormone variants having altered binding properties for a growth hormone receptor molecule is provided. The method comprises fusing a gene encoding a hormone to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disposed are preferred phagemid expression vectors and selected human growth hormone variants.
摘要翻译：提供了一种用于选择具有改变的生长激素受体分子结合特性的生长激素变体的新蛋白质的方法。该方法包括将编码激素的基因融合到丝状噬菌体M13的基因III外壳蛋白的羧基末端结构域上。基因融合突变以形成在噬菌粒粒子表面上以低量表达的结构相关融合蛋白的文库。使用生物选择和筛选来鉴定可用作候选药物的新型配体。优选的噬菌粒表达载体和选择的人生长激素变体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式