专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070208024A1 HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES 有权
标题翻译：组胺H3受体代谢物，制剂和治疗用途
公开(公告)号：US20070208024A1
公开(公告)日：2007-09-06
申请号：US10599488
申请日：2005-03-25
申请人： Lisa Beavers , Don Finley , Terry Finn , Robert Gadski , Philip Hipskind , William Hornback , Cynthia Jesudason , Richard Pickard , Takako Takakuwa , Grant Vaught
发明人： Lisa Beavers , Don Finley , Terry Finn , Robert Gadski , Philip Hipskind , William Hornback , Cynthia Jesudason , Richard Pickard , Takako Takakuwa , Grant Vaught
IPC分类号： A61K31/495 , A61K31/4025 , C07D207/04 , C07D401/08 , C07D247/00 , A61K31/44
CPC分类号： C07D207/09 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , C07D471/04
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases
摘要翻译：本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式（I）的新化合物或其药学上可接受的盐，以及制备这些化合物的方法。在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物以及使用它们治疗肥胖，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法

2. 发明申请

US20060167046A1 Histamine h3 receptor antagonists, preparation and therapeutic uses 审中-公开
标题翻译：组胺h3受体拮抗剂，制剂和治疗用途
公开(公告)号：US20060167046A1
公开(公告)日：2006-07-27
申请号：US10525315
申请日：2003-09-12
申请人： Lisa Beavers , Don Finley , Robert Gadski , Philip Hipskind , Cynthia Jesudason , Richard Pickard , Freddie Stevens
发明人： Lisa Beavers , Don Finley , Robert Gadski , Philip Hipskind , Cynthia Jesudason , Richard Pickard , Freddie Stevens
IPC分类号： A61K31/4709 , A61K31/454 , A61K31/405 , C07D401/02 , C07D403/02
CPC分类号： C07D215/227 , C07D209/04 , C07D209/22 , C07D209/24 , C07D209/26 , C07D209/32 , C07D215/06 , C07D215/08 , C07D215/20 , C07D215/26 , C07D215/58 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06
摘要： The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-II3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods or using them to treat obesity and other histamine II3 receptor-related diseases.
摘要翻译：本发明公开了具有组胺-II3受体拮抗剂活性的式（I）的新化合物或其药学上可接受的盐以及其制备方法。在另一个实施方案中，本发明公开了包含式（I）化合物的药物组合物，以及用于治疗肥胖症和其他组胺II3受体相关疾病的方法或用它们。

3. 发明申请

US20070197604A1 Oxazole derivatives as histamine h3 receptor agents,preparation and therapeutic uses 有权
标题翻译：恶唑衍生物作为组胺h3受体剂，制备和治疗用途
公开(公告)号：US20070197604A1
公开(公告)日：2007-08-23
申请号：US11572283
申请日：2005-07-14
申请人： Lisa Beavers , Serge Boulet , Terry Finn , Robert Gadski , Willaim Hornback , Cynthia Jesudason , Richard Pickard , Freddie Stevens , Grant Vaught
发明人： Lisa Beavers , Serge Boulet , Terry Finn , Robert Gadski , Willaim Hornback , Cynthia Jesudason , Richard Pickard , Freddie Stevens , Grant Vaught
IPC分类号： A61K31/421 , A61K31/44 , C07D413/10
CPC分类号： C07D413/14 , C07D263/32 , C07D413/06 , C07D417/14
摘要： The present invention discloses novel aryl oxazole compounds of Formula I (I), or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing and using such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases. Formula I (I) or a pharmaceutically acceptable salt thereof, wherein: m is independenlly at each occurrence 1, 2, or 3, Z independently represents carbon (substituted with hydrogen or the optional substituents indicated herein) or nitrogen, provided that when Z is nitrogen then R6 is not attached to Z; R1 and R2 are independently —(C1—C7) alkyl (optionally substituted with one to three halogens), or R1 and R2 and the nitrogen to which they are attached form an azetidinyl ring, a pyrrolidinyl ring, or a piperidinyl ring, wherein further the azetidinyl, pyrrolidinyl, or piperidinyl ring so formed may be optionally substituted one to three times with R5; R6 is independently at each occurrence —H, -halogen, or —CH3.
摘要翻译：本发明公开了具有组胺H3受体拮抗剂或反向激动剂活性的式I（I）的新型芳基恶唑化合物或其药学上可接受的盐，以及制备和使用这些化合物的方法。在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用这些组合物治疗肥胖症，认知缺陷，发作性睡病和其他组胺H3受体相关疾病的方法。式I（I）或其药学上可接受的盐，其中：m在每次出现时独立地为1,2或3，Z独立地表示碳（被氢或本文所示的任选取代基）或氮，条件是当Z为氮，然后R6不连接到Z; R 1和R 2独立地为 - （C 1 -C 7 -C 7）烷基（任选被一至三个卤素取代），或R 1和R 2以及与它们相连的氮形成氮杂环丁烷基环，吡咯烷基环或哌啶基环，其中如此形成的氮杂环丁烷基，吡咯烷基或哌啶基环可以任选地被R 5取代一至三次; R 6在每次出现时独立地为-H， - 卤素或-CH 3。

4. 发明申请

US20070155754A1 Histamine h3 receptor antagonists, preparation and therapeutic uses 失效
标题翻译：组胺h3受体拮抗剂，制剂和治疗用途
公开(公告)号：US20070155754A1
公开(公告)日：2007-07-05
申请号：US10598262
申请日：2005-02-22
申请人： Lisa Beavers , Robert Gadski , Philip Hipskind , Cynthia Jesudason , Karen Lobb , Richard Pickard , Craig Lindsley
发明人： Lisa Beavers , Robert Gadski , Philip Hipskind , Cynthia Jesudason , Karen Lobb , Richard Pickard , Craig Lindsley
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4025 , C07D403/14
CPC分类号： C07D295/125 , C07D207/09 , C07D295/02 , C07D295/096 , C07D295/155 , C07D295/192 , C07D487/04
摘要： The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.
摘要翻译：本发明公开了具有组胺H3受体拮抗剂活性的式I化合物或其药学上可接受的盐以及其制备方法。在另一个实施方案中，本发明公开了包含式I化合物的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法。

5. 发明申请

US20060089347A1 Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses 审中-公开
标题翻译：取代的吖庚因作为组胺h3受体拮抗剂，制剂和治疗用途
公开(公告)号：US20060089347A1
公开(公告)日：2006-04-27
申请号：US10523071
申请日：2003-08-15
申请人： Robert Gadski , Phillip Hipskind , Cynthia Jesudason , Richard Pickard , Lisa Beavers , Christopher Sledem , Alay Singh
发明人： Robert Gadski , Phillip Hipskind , Cynthia Jesudason , Richard Pickard , Lisa Beavers , Christopher Sledem , Alay Singh
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D403/06 , C07D223/16
摘要： The present invention discloses novel substituted azepine compounds of Formula (I) or pharmaceutically acceptable salts thereof which have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such azepines as well as methods of using them to treat obesity and other histamine H3 receptor-related diseases.
摘要翻译：本发明公开了具有选择性组胺-H 3受体拮抗剂活性的新颖的式（I）取代的吖庚因化合物或其药学上可接受的盐以及制备这些化合物的方法。在另一个实施方案中，本发明公开了包含这种吖庚因的药物组合物以及使用它们治疗肥胖症和其他组胺H3受体相关疾病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式