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1. 发明授权

US07993567B2 Method and system for aligning fibers during electrospinning 有权
标题翻译：静电纺丝时纤维对准的方法和系统
公开(公告)号：US07993567B2
公开(公告)日：2011-08-09
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译：提供了一种用于在静电纺丝过程中对准纤维的方法和系统。可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。可以使用分配器，收集器和电极的数字和几何形状的各种组合。

2. 发明申请

US20090108503A1 Method and System for Aligning Fibers During Electrospinning 有权
标题翻译：静电纺丝方法和系统
公开(公告)号：US20090108503A1
公开(公告)日：2009-04-30
申请号：US12131420
申请日：2008-06-02
申请人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
发明人： Lisa A. Scott-Carnell , Ralph M. Stephens , Nancy M. Holloway , Caroline Rhim , Laura Niklason , Robert L. Clark , Emilie J. Siochi
IPC分类号： B29C35/00
CPC分类号： D01D5/0092 , D01D5/0084 , D04H3/02
摘要： A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
摘要翻译：提供了一种用于在静电纺丝过程中对准纤维的方法和系统。可纤化材料的射流从与收集器间隔开的分配位置被引向不带电的收集器。当可纤化材料被引向集电器时，通过带电分配器和相对充电的控制位置产生椭圆形电场。该场在分配位置和处于分配位置的视线内的控制位置之间跨越，并且撞击在收集器的至少一部分上。可以使用分配器，收集器和电极的数字和几何形状的各种组合。

3. 发明授权

US08198245B2 Compositions and methods for soft tissue augmentation 有权
标题翻译：软组织增生的组成和方法
公开(公告)号：US08198245B2
公开(公告)日：2012-06-12
申请号：US12220420
申请日：2008-07-24
申请人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
发明人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
IPC分类号： A61K38/39 , A61K31/726 , A61K38/18 , C07K14/78
CPC分类号： A61K38/39 , A61K8/00 , A61K8/64 , A61K8/65 , A61K8/735 , A61K2300/00 , A61K2800/86 , A61K2800/91
摘要： The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
摘要翻译：本发明提供包含分离的人胶原，分离的人弹性蛋白和药学上可接受的载体的组合物，其中人弹性蛋白基本上不溶于分子量大于100kDa的水中。本发明还提供了用于软组织增强的方法和试剂盒。

4. 发明申请

US20090028817A1 Compositions and methods for soft tissue augmentation 有权
标题翻译：软组织增生的组成和方法
公开(公告)号：US20090028817A1
公开(公告)日：2009-01-29
申请号：US12220420
申请日：2008-07-24
申请人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
发明人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
IPC分类号： A61K38/39 , A61K38/20 , A61P17/00 , A61K35/12
CPC分类号： A61K38/39 , A61K8/00 , A61K8/64 , A61K8/65 , A61K8/735 , A61K2300/00 , A61K2800/86 , A61K2800/91
摘要： The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
摘要翻译：本发明提供包含分离的人胶原，分离的人弹性蛋白和药学上可接受的载体的组合物，其中人弹性蛋白基本上不溶于分子量大于100kDa的水中。本发明还提供了用于软组织增强的方法和试剂盒。

5. 发明申请

US20060073590A1 Decellularized tissue engineered constructs and tissues 审中-公开
公开(公告)号：US20060073590A1
公开(公告)日：2006-04-06
申请号：US11252993
申请日：2005-10-19
申请人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
发明人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
IPC分类号： C12N5/00
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.

6. 发明申请

US20120230950A1 Compositions and Methods for Soft Tissue Augmentation 审中-公开
标题翻译：软组织增强的组成和方法
公开(公告)号：US20120230950A1
公开(公告)日：2012-09-13
申请号：US13476406
申请日：2012-05-21
申请人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
发明人： Laura Niklason , Yuling Li , Juliana Blum , Shannon Dahl , Geoffrey Erickson , Frank Zeigler
IPC分类号： A61K38/39 , A61K35/36 , A61K38/18 , A61K38/19 , B65D65/00 , A61K38/21 , A61P17/00 , A61P27/00 , A61P17/10 , A61P17/02 , A61K35/12 , A61K38/20
CPC分类号： A61K38/39 , A61K8/00 , A61K8/64 , A61K8/65 , A61K8/735 , A61K2300/00 , A61K2800/86 , A61K2800/91
摘要： The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
摘要翻译：本发明提供包含分离的人胶原，分离的人弹性蛋白和药学上可接受的载体的组合物，其中人弹性蛋白基本上不溶于分子量大于100kDa的水中。本发明还提供了用于软组织增强的方法和试剂盒。

7. 发明申请

US20080248080A1 Decelluarlized Tissue Engineered Constructs and Tissues 审中-公开
标题翻译：减速组织工程结构和组织
公开(公告)号：US20080248080A1
公开(公告)日：2008-10-09
申请号：US12124521
申请日：2008-05-21
申请人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
发明人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
IPC分类号： A61F2/00 , C12N5/06 , A61K35/34 , G01N33/53 , C07K1/00 , A61P19/00
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了用于生产组织工程化构建体和工程化天然组织的新方法。所述方法包括通过在基质上体外培养细胞产生组织工程化构建体，然后使构建体脱细胞化以产生主要由细胞外基质组分组成的脱细胞结构。该结构可以立即使用或存储直到需要。脱细胞化构建体可用于进一步的组织工程，其可以包括使用从构建体的预期接受者获得的细胞接种构建体。在制造结构所需的任何生长阶段期间，显影构件可以经受各种组织工程步骤，例如施加包括脉动力的机械刺激。所述方法还包括通过从动物或人收集组织来产生工程化的天然组织，在组织上执行一个或多个组织工程步骤，以及对组织进行脱细胞化。然后可以将脱细胞化的工程化天然组织进行进一步的组织工程步骤。

8. 发明授权

US06962814B2 Decellularized tissue engineered constructs and tissues 有权
标题翻译：脱细胞组织工程构建体和组织
公开(公告)号：US06962814B2
公开(公告)日：2005-11-08
申请号：US09931506
申请日：2001-08-16
申请人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
发明人： Shannon Mitchell , Jennifer Koh , Vikas Prabhakar , Laura Niklason
IPC分类号： A61L27/38 , C12N5/00 , A61F2/02 , A61K48/00 , C12P21/00 , A01N38/00
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了用于生产组织工程化构建体和工程化天然组织的新方法。所述方法包括通过在基质上体外培养细胞产生组织工程化构建体，然后使构建体脱细胞化以产生主要由细胞外基质组分组成的脱细胞结构。该结构可以立即使用或存储直到需要。脱细胞化构建体可用于进一步的组织工程，其可以包括使用从构建体的预期接受者获得的细胞接种构建体。在制造结构所需的任何生长阶段期间，显影构件可以经受各种组织工程步骤，例如施加包括脉动力的机械刺激。所述方法还包括通过从动物或人收集组织来产生工程化的天然组织，在组织上执行一个或多个组织工程步骤，以及对组织进行脱细胞化。然后可以将脱细胞化的工程化天然组织进行进一步的组织工程步骤。

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