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1. 发明授权

US10091985B2 Perfusing an organ with an in situ generated gas 有权
公开(公告)号：US10091985B2
公开(公告)日：2018-10-09
申请号：US12803083
申请日：2010-06-18
申请人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
发明人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
IPC分类号： A01N1/02
摘要： Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The preserving gas used to perfuse the organ may be dissolved in a liquid and then administered to the organ as a gas/liquid solution or may be mixed with one or more other gases and then administered to the organ as a gas/gas mixture. The preserving gas may be, for example, oxygen gas generated in situ using an electrochemical oxygen concentrator. According to another aspect, an organ preservation system may include an electrochemical oxygen concentrator having a water vapor feed, as well as auxiliary equipment to control and measure delivery pressure, flow, temperature and humidity.

2. 发明申请

US20100330547A1 Perfusing an organ with an in situ generated gas 审中-公开
标题翻译：用原位产生的气体灌注器官
公开(公告)号：US20100330547A1
公开(公告)日：2010-12-30
申请号：US12803083
申请日：2010-06-18
申请人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
发明人： Linda A. Tempelman , Klearchos K. Papas , Simon G. Stone , William Earl Scott, III , Thomas M. Suszynski , Shuichiro Matsumoto , Joana Ferrer Fabrega , Michael D. Rizzari
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0226
摘要： Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The preserving gas used to perfuse the organ may be dissolved in a liquid and then administered to the organ as a gas/liquid solution or may be mixed with one or more other gases and then administered to the organ as a gas/gas mixture. The preserving gas may be, for example, oxygen gas generated in situ using an electrochemical oxygen concentrator. According to another aspect, an organ preservation system may include an electrochemical oxygen concentrator having a water vapor feed, as well as auxiliary equipment to control and measure delivery pressure, flow, temperature and humidity.
摘要翻译：器官保存方法与系统根据一个方面，可以通过用原位产生的保存气体灌注来保存器官。器官可以是例如人或猪胰腺，并且胰腺的灌注可以是前列腺，逆行，导管，前列腺/导管或逆行/导管。用于灌注器官的保存气体可以溶解在液体中，然后作为气体/液体溶液施用于器官，或者可以与一种或多种其它气体混合，然后作为气体/气体混合物施用于器官。保存气体可以是例如使用电化学氧浓缩器原位产生的氧气。根据另一方面，器官保存系统可以包括具有水蒸汽进料的电化学氧浓缩器，以及用于控制和测量输送压力，流量，温度和湿度的辅助设备。

3. 发明申请

US20110097678A1 Method of heating and heating apparatus 审中-公开
标题翻译：加热和加热装置的方法
公开(公告)号：US20110097678A1
公开(公告)日：2011-04-28
申请号：US12924808
申请日：2010-10-05
申请人： Keith D. Patch , Linda A. Tempelman , Simon G. Stone , Craig Thompson
发明人： Keith D. Patch , Linda A. Tempelman , Simon G. Stone , Craig Thompson
IPC分类号： F24C15/00
CPC分类号： F23C13/08 , A61F7/12 , A61F2007/126 , A61M5/44 , A61M2205/364 , F23D91/04
摘要： Method of heating and heating apparatus. According to one embodiment, the heating apparatus is designed for warming infusion fluids and includes a pair of catalytic heaters positioned around a cartridge containing the infusion fluid. Each catalytic heater includes a pair of frames jointly defining a cavity. One of the frames per heater is positioned proximate to the cartridge and includes an input port for receiving a liquid solution of methanol. The other frame per heater is positioned distal to the cartridge and includes an input port for receiving oxygen gas and an output port for exhaust gases. A first fluid diffusion medium is positioned within the methanol frame, and a second fluid diffusion medium is positioned within the oxygen frame. Sandwiched between the two diffusion media are a pervaporation membrane facing the first diffusion medium and a porous metal catalyst facing the second diffusion medium. Methanol in liquid form is supplied to the pervaporation membrane, which then transports the methanol in vapor form to the catalyst, where combustion occurs. Heat from the combustion reaction is then conducted through the heater to the cartridge containing the infusion fluid.
摘要翻译：加热和加热装置的方法根据一个实施例，加热装置被设计用于加温输液，并且包括位于围绕包含输注液体的药筒的一对催化加热器。每个催化加热器包括共同限定空腔的一对框架。每个加热器的框架中的一个定位成靠近墨盒，并且包括用于接收甲醇液体溶液的输入端口。每个加热器的另一个框架位于盒的远侧，并且包括用于接收氧气的输入端口和用于废气的输出端口。第一流体扩散介质位于甲醇框架内，第二流体扩散介质位于氧气框架内。在两个扩散介质之间夹有面向第一扩散介质的渗透蒸发膜和面向第二扩散介质的多孔金属催化剂。将液体形式的甲醇供应到渗透蒸发膜，然后将蒸气形式的甲醇输送到发生燃烧的催化剂中。然后将来自燃烧反应的热量通过加热器传导到含有输注流体的药筒。

4. 发明申请

US20120178150A1 SYSTEM FOR FLUID PERFUSION OF BIOLOGICAL MATTER COMPRISING TISSUE 有权
标题翻译：包含组织的生物物质的流体灌注系统
公开(公告)号：US20120178150A1
公开(公告)日：2012-07-12
申请号：US13341565
申请日：2011-12-30
申请人： Linda A. Tempelman , Simon G. Stone
发明人： Linda A. Tempelman , Simon G. Stone
IPC分类号： C12M1/04 , C12M1/38
CPC分类号： A01N1/0226 , A01N1/0247
摘要： System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled to the gas generator and insertable into tissue for delivering the preserving gas to the biological matter, and a process controller for controlling the operation of the gas generator and the thermal control device. The gas generator, in turn, may include an electrochemical oxygen concentrator and/or a water electrolyzer for generating the preserving gas. The system may further include a liquid perfusion system that includes a reservoir of liquid perfusate, a fluid delivery conduit for delivering liquid perfusate from the reservoir to the biological matter, and a fluid draining conduit for draining liquid perfusate from the biological matter.
摘要翻译：包括组织在内的生物物质的流体灌注系统。根据一个实施例，系统可以包括用于存储生物物质的存储容器，用于冷却存储容器的内容物的热控制装置，用于产生保存气体的气体发生器，连接到气体发生器的流体导管和可插入的用于将保存气体输送到生物物质的组织中，以及用于控制气体发生器和热控制装置的操作的过程控制器。气体发生器又可以包括用于产生保存气体的电化学氧浓缩器和/或水电解器。该系统还可以包括液体灌注系统，其包括液体灌注液的储存器，用于将液体灌注液从储存器输送到生物物质的流体输送管道，以及用于从生物物质排出液体灌注液的流体排放导管。

5. 发明授权

US09357764B2 System for fluid perfusion of biological matter comprising tissue 有权
标题翻译：包含组织的生物物质的流体灌注系统
公开(公告)号：US09357764B2
公开(公告)日：2016-06-07
申请号：US13341565
申请日：2011-12-30
申请人： Linda A. Tempelman , Simon G. Stone
发明人： Linda A. Tempelman , Simon G. Stone
IPC分类号： A01N1/00 , A01N1/02 , C12M1/36 , C12M1/38 , C12M3/00 , C12M1/00
CPC分类号： A01N1/0226 , A01N1/0247
摘要： System for fluid perfusion of biological matter that includes tissue. According to one embodiment, the system may include a storage container for storing the biological matter, a thermal control device for cooling the contents of the storage container, a gas generator for generating a preserving gas, a fluid conduit coupled to the gas generator and insertable into tissue for delivering the preserving gas to the biological matter, and a process controller for controlling the operation of the gas generator and the thermal control device. The gas generator, in turn, may include an electrochemical oxygen concentrator and/or a water electrolyzer for generating the preserving gas. The system may further include a liquid perfusion system that includes a reservoir of liquid perfusate, a fluid delivery conduit for delivering liquid perfusate from the reservoir to the biological matter, and a fluid draining conduit for draining liquid perfusate from the biological matter.
摘要翻译：包括组织在内的生物物质的流体灌注系统。根据一个实施例，系统可以包括用于存储生物物质的存储容器，用于冷却存储容器的内容物的热控制装置，用于产生保存气体的气体发生器，连接到气体发生器的流体导管和可插入的用于将保存气体输送到生物物质的组织中，以及用于控制气体发生器和热控制装置的操作的过程控制器。气体发生器又可以包括用于产生保存气体的电化学氧浓缩器和/或水电解器。该系统可以进一步包括液体灌注系统，其包括液体灌注液的储存器，用于将液体灌注液从储存器输送到生物物质的流体输送管道，以及用于从生物物质排出液体灌注液的流体排放导管。

6. 发明授权

US08361308B2 Electrochemical carbon dioxide sensor 有权
标题翻译：电化学二氧化碳传感器
公开(公告)号：US08361308B2
公开(公告)日：2013-01-29
申请号：US12878504
申请日：2010-09-09
申请人： Mourad Manoukian , Anthony B. Laconti , Linda A. Tempelman , John Forchione
发明人： Mourad Manoukian , Anthony B. Laconti , Linda A. Tempelman , John Forchione
IPC分类号： G01N27/417
CPC分类号： G01N27/4074
摘要： A method for the detection of carbon dioxide gas using an electrochemical sensor. The method includes exposing a gas to a sensor, which includes a non-conductive solid substrate and at least one each of a metal oxide sensing electrode, a reference electrode and a counter electrode positioned on the substrate. A solid polymer electrolyte anion-exchange membrane is in intimate contact with the sensing electrode, reference electrode and counter electrode. The method is highly sensitive and selective to carbon dioxide with a very rapid response time.
摘要翻译：一种使用电化学传感器检测二氧化碳气体的方法。该方法包括将气体暴露于传感器，该传感器包括非导电固体基底和位于基底上的金属氧化物感测电极，参考电极和对置电极中的至少一个。固体聚合物电解质阴离子交换膜与感测电极，参比电极和对电极紧密接触。该方法对二氧化碳具有高度敏感性和选择性，反应时间非常快。

7. 发明申请

US20080282653A1 System for modifying the atmosphere within an enclosed space and incubator system including the same 有权
标题翻译：用于改变封闭空间内的气氛的系统和包括其的培养箱系统
公开(公告)号：US20080282653A1
公开(公告)日：2008-11-20
申请号：US12082975
申请日：2008-04-14
申请人： Linda A. Tempelman , Monjid Hamdan , Matthew P. Steinbroner
发明人： Linda A. Tempelman , Monjid Hamdan , Matthew P. Steinbroner
IPC分类号： B01D59/50
CPC分类号： C25B1/10 , A61G10/04 , A61G11/00 , A61G2203/46 , H01M8/184 , H01M2008/1095 , Y02E60/366 , Y02E60/528
摘要： System for modifying the chemical composition of atmosphere within an enclosed space and incubator system including such a system. The concentration of oxygen within the enclosed space may be either increased or decreased using an electrochemical device. The concentration of carbon dioxide within the enclosed space may be increased using an electrochemical or chemical device. As necessary, purging of the system with ambient air can be a part of the process of controlling the chemical composition of the atmosphere. The present invention obviates the need to use pressurized gas cylinders to supply atmospheric gases to the enclosed space.
摘要翻译：用于改变封闭空间内的气氛的化学成分和包括这种系统的培养箱系统的系统。封闭空间内的氧浓度可以使用电化学装置增加或减少。封闭空间内二氧化碳的浓度可以使用电化学或化学装置来增加。根据需要，用环境空气清洗系统可以是控制大气化学成分的过程的一部分。本发明避免了使用加压气瓶向封闭空间供应大气的需要。

8. 发明授权

US08083821B2 System for modifying the atmosphere within an enclosed space and incubator system including the same 有权
标题翻译：用于改变封闭空间内的气氛的系统和包括其的培养箱系统
公开(公告)号：US08083821B2
公开(公告)日：2011-12-27
申请号：US12082975
申请日：2008-04-14
申请人： Linda A. Tempelman , Monjid Hamdan , Matthew P. Steinbroner
发明人： Linda A. Tempelman , Monjid Hamdan , Matthew P. Steinbroner
IPC分类号： H01M8/18
CPC分类号： C25B1/10 , A61G10/04 , A61G11/00 , A61G2203/46 , H01M8/184 , H01M2008/1095 , Y02E60/366 , Y02E60/528
摘要： System for modifying the chemical composition of atmosphere within an enclosed space and incubator system including such a system. The concentration of oxygen within the enclosed space may be either increased or decreased using an electrochemical device. The concentration of carbon dioxide within the enclosed space may be increased using an electrochemical or chemical device. As necessary, purging of the system with ambient air can be a part of the process of controlling the chemical composition of the atmosphere. The present invention obviates the need to use pressurized gas cylinders to supply atmospheric gases to the enclosed space.
摘要翻译：用于改变封闭空间内的气氛的化学成分和包括这种系统的培养箱系统的系统。封闭空间内的氧浓度可以使用电化学装置增加或减少。封闭空间内二氧化碳的浓度可以使用电化学或化学装置来增加。根据需要，用环境空气清洗系统可以是控制大气化学成分的过程的一部分。本发明避免了使用加压气瓶向封闭空间供应大气的需要。

9. 发明授权

US08366894B2 Multi-gas microsensor assembly 失效
标题翻译：多气体微传感器组件
公开(公告)号：US08366894B2
公开(公告)日：2013-02-05
申请号：US12660197
申请日：2010-02-22
申请人： Mourad Manoukian , Anthony B. LaConti , W. Michael Krebs , Linda A. Tempelman , John W. Forchione, Jr. , Erich Muehlanger, Jr.
发明人： Mourad Manoukian , Anthony B. LaConti , W. Michael Krebs , Linda A. Tempelman , John W. Forchione, Jr. , Erich Muehlanger, Jr.
IPC分类号： G01N27/26 , G01N27/407
CPC分类号： G01N27/404
摘要： A multi-gas microsensor assembly for simultaneously detecting carbon dioxide and oxygen in real time. According to one embodiment, the assembly comprises a non-conductive, solid substrate. A plurality of sensing electrodes, a single reference electrode, and a single counter electrode are positioned on one side of the non-conductive, solid substrate. In addition, all of the electrodes are in intimate contact with the same side of a solid-polymer electrolyte anion-exchange membrane, the solid polymer electrolyte membrane having at least one gas diffusion opening aligned with each sensing electrode. The sensor is operated in a three-electrode potentiostatic mode, in which a constant potential is maintained between the sensing and reference electrodes, and the current is measured between the sensing and counter electrodes. Control of the electrodes is achieved with a small bi-potentiostat. The design of the bi-potentiostat allows at least two different sensing electrodes to share the same counter and reference electrodes.
摘要翻译：用于同时检测二氧化碳和氧气的多气体微量传感器组件。根据一个实施例，组件包括非导电固体衬底。多个感测电极，单个参考电极和单个对电极位于非导电固体衬底的一侧。此外，所有电极与固体聚合物电解质阴离子交换膜的同一侧紧密接触，固体聚合物电解质膜具有与每个感测电极对准的至少一个气体扩散开口。传感器在三电极恒电位模式下工作，其中在感测和参考电极之间保持恒定电位，并且在感测和对电极之间测量电流。电极的控制通过小型双电位稳定器实现。双电位器的设计允许至少两个不同的感测电极共享相同的计数器和参考电极。

10. 发明申请

US20110005928A1 ELECTROCHEMICAL CARBON DIOXIDE SENSOR 有权
标题翻译：电化学二氧化碳传感器
公开(公告)号：US20110005928A1
公开(公告)日：2011-01-13
申请号：US12878504
申请日：2010-09-09
申请人： Mourad Manoukian , Anthony B. LaConti , Linda A. Tempelman , John Forchione
发明人： Mourad Manoukian , Anthony B. LaConti , Linda A. Tempelman , John Forchione
IPC分类号： G01N27/26
CPC分类号： G01N27/4074
摘要： A method for the detection of carbon dioxide gas using an electrochemical sensor. The method includes exposing a gas to a sensor, which includes a non-conductive solid substrate and at least one each of a metal oxide sensing electrode, a reference electrode and a counter electrode positioned on the substrate. A solid polymer electrolyte anion-exchange membrane is in intimate contact with the sensing electrode, reference electrode and counter electrode. The method is highly sensitive and selective to carbon dioxide with a very rapid response time.
摘要翻译：一种使用电化学传感器检测二氧化碳气体的方法。该方法包括将气体暴露于传感器，该传感器包括非导电固体基底和位于基底上的金属氧化物感测电极，参考电极和对置电极中的至少一个。固体聚合物电解质阴离子交换膜与感测电极，参比电极和对电极紧密接触。该方法对二氧化碳具有高度敏感性和选择性，反应时间非常快。

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