专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08704155B2 Nanoscale object detection using a whispering gallery mode resonator 有权
标题翻译：使用耳语画廊模式谐振器进行纳米物体检测
公开(公告)号：US08704155B2
公开(公告)日：2014-04-22
申请号：US12966785
申请日：2010-12-13
申请人： Lina He , Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang , Da-Ren Chen
发明人： Lina He , Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang , Da-Ren Chen
IPC分类号： G01J9/00
CPC分类号： G01N21/7746
摘要： Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.
摘要翻译：使用光源和耳语画廊模式（WGM）谐振器检测各个物体。分析了来自耳语堂模式（WGM）谐振器的光。基于与由光电检测器接收的光相关联的模式分割来确定对象的存在。例如，可以基于两个耳语画廊模式之间的距离和/或发送频谱中的两种模式的线宽来确定对象的存在。或者，可以基于基于通过在来自WGM微腔激光器的接收光中组合分割激光模式而产生的外差拍频确定的拍频来确定对象的存在。

2. 发明申请

US20110139970A1 Nanoscale Object Detection Using A Whispering Gallery Mode Resonator 有权
标题翻译：使用耳语画廊模式谐振器的纳米级对象检测
公开(公告)号：US20110139970A1
公开(公告)日：2011-06-16
申请号：US12966785
申请日：2010-12-13
申请人： Lina He , Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang , Da-Ren Chen
发明人： Lina He , Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang , Da-Ren Chen
IPC分类号： G01J9/00
CPC分类号： G01N21/7746
摘要： Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.
摘要翻译：使用光源和耳语画廊模式（WGM）谐振器检测各个物体。分析了来自耳语堂模式（WGM）谐振器的光。基于与由光电检测器接收的光相关联的模式分割来确定对象的存在。例如，可以基于两个耳语画廊模式之间的距离和/或发送频谱中的两种模式的线宽来确定对象的存在。或者，可以基于基于通过在来自WGM微腔激光器的接收光中组合分割激光模式而产生的外差拍频确定的拍频来确定对象的存在。

3. 发明申请

US20120268731A1 SYSTEMS AND METHODS FOR PARTICLE DETECTION 有权
标题翻译：用于粒子检测的系统和方法
公开(公告)号：US20120268731A1
公开(公告)日：2012-10-25
申请号：US13460170
申请日：2012-04-30
申请人： Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang
发明人： Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang
IPC分类号： G01N15/02 , G01N21/59
CPC分类号： G01N21/7746 , B82Y35/00 , Y10S977/88
摘要： A particle detection system is provided. The particle detection system includes at least one tapered optical fiber, a light source configured to transmit light through the at least one tapered optical fiber, a photodetector configured to measure a characteristic of the light being transmitted through the at least one optical fiber, and a computing device coupled to the photodetector and configured to determine whether a nanoparticle is present within an evanescent field of the at least one tapered optical fiber based on the measured light characteristic.
摘要翻译：提供了一种粒子检测系统。粒子检测系统包括至少一个锥形光纤，被配置为通过至少一个锥形光纤透射光的光源，被配置为测量透过至少一个光纤的光的特性的光电检测器，以及耦合到所述光电检测器并且被配置为基于所测量的光特性来确定纳米颗粒是否存在于所述至少一个锥形光纤的消逝场内。

4. 发明授权

US09012830B2 Systems and methods for particle detection 有权
标题翻译：粒子检测系统和方法
公开(公告)号：US09012830B2
公开(公告)日：2015-04-21
申请号：US13460170
申请日：2012-04-30
申请人： Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang
发明人： Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang
IPC分类号： G01J9/00 , G01N21/17 , G01N21/77 , B82Y35/00
CPC分类号： G01N21/7746 , B82Y35/00 , Y10S977/88
摘要： A particle detection system is provided. The particle detection system includes at least one tapered optical fiber, a light source configured to transmit light through the at least one tapered optical fiber, a photodetector configured to measure a characteristic of the light being transmitted through the at least one optical fiber, and a computing device coupled to the photodetector and configured to determine whether a nanoparticle is present within an evanescent field of the at least one tapered optical fiber based on the measured light characteristic.
摘要翻译：提供了一种粒子检测系统。粒子检测系统包括至少一个锥形光纤，被配置为通过至少一个锥形光纤透射光的光源，被配置为测量透过至少一个光纤的光的特性的光电检测器，以及耦合到所述光电检测器并且被配置为基于所测量的光特性来确定纳米颗粒是否存在于所述至少一个锥形光纤的消逝场内。

5. 发明授权

US11637355B1 Fully integrated parity-time symmetric electronics 有权
公开(公告)号：US11637355B1
公开(公告)日：2023-04-25
申请号：US17446000
申请日：2021-08-26
申请人： Xuan Zhang , Lan Yang , Weidong Cao , Weijian Chen
发明人： Xuan Zhang , Lan Yang , Weidong Cao , Weijian Chen
IPC分类号： H01P1/32 , H01P1/38 , H01P1/36
摘要： An integrated circuit is disclosed. The integrated circuit includes a first resonator, a second resonator, and a coupling element. The first resonator has a first terminal and a second terminal, where the first resonator comprises a gain resistor, a gain capacitor, and a gain inductor in parallel and electrically coupling the first terminal with the second terminal. The second resonator has a third terminal and a fourth terminal, where the second resonator includes a loss resistor, a loss capacitor, and a loss inductor in parallel and electrically coupling the third terminal with the fourth terminal. The coupling element selectively couples the first terminal of the first resonator with the third terminal of the second resonator.

6. 发明授权

US08436158B2 Antibodies to IL-6 and their uses 失效
标题翻译： IL-6抗体及其用途
公开(公告)号：US08436158B2
公开(公告)日：2013-05-07
申请号：US13454296
申请日：2012-04-24
申请人： Arvind Rajpal , Madhav Narasimha Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
发明人： Arvind Rajpal , Madhav Narasimha Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
IPC分类号： C07H21/02 , C12N5/07 , C12N5/16
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
摘要翻译：提供了结合人IL-6的抗体及其抗原结合部分。还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。

7. 发明授权

US08399623B2 Human antibodies that bind mesothelin, and uses thereof 有权
标题翻译：结合间皮素的人抗体及其用途
公开(公告)号：US08399623B2
公开(公告)日：2013-03-19
申请号：US13587500
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.
摘要翻译：本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。优选地，所述抗体结合人间皮素。在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。

8. 发明授权

US08383779B2 Human antibodies that bind mesothelin, and uses thereof 有权
公开(公告)号：US08383779B2
公开(公告)日：2013-02-26
申请号：US13587572
申请日：2012-08-16
申请人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
发明人： Jonathan A. Terrett , Sarah L. Pogue , Kristopher Toy , Lan Yang , Chetana Rao-Naik , Bingliang Chen
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/30 , A61K39/39558 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K2039/505 , C07K2317/21 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/80 , C07K2317/92 , A61K2300/00
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

9. 发明授权

US08039596B2 Alpha 5-beta 1 antibodies and their uses 失效
标题翻译： Alpha 5-beta 1抗体及其用途
公开(公告)号：US08039596B2
公开(公告)日：2011-10-18
申请号：US12365638
申请日：2009-02-04
申请人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译：本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。

10. 发明申请

US20060254042A1 Mold-casting structure and improvement method for grounding of the same 审中-公开
标题翻译：铸造结构及其接地改良方法
公开(公告)号：US20060254042A1
公开(公告)日：2006-11-16
申请号：US11194542
申请日：2005-08-02
申请人： Wen Chou , Lan Yang
发明人： Wen Chou , Lan Yang
IPC分类号： B21B1/46 , B22D27/00
CPC分类号： B22D17/22 , Y10T29/4998 , Y10T29/49995
摘要： A mold-casting structure comprises at least one dishing and a plurality of micro-protrusions. The dishing(s) formed on the surface of a mold-casting body, the plurality of micro-protrusions sticking out of the surface of the dishing, and the tops of the micro-protrusions constitute on a plane, so that the grounding issue of the circuitry embedded in the mold-casting structure caused by the dishing can be resolved. The dishing can be verified by daubing paint and scrapping thereafter, the location of remaining paint is deemed the dishing. Moreover, a three-dimensional measurement instrument can be employed for more precise measurement. The micro-protrusions can be formed on the dishing by mechanical processing or electric discharge machining (EDM). Alternatively, a mold with a structure matching the micro-protrusions can be formed first, and consequently the micro-protrusions are formed directly by mold-filling, which is more suitable for mass production.
摘要翻译：模铸结构包括至少一个凹陷和多个微突起。在铸模体的表面上形成的凹陷，从凹部表面突出的多个微突起和微突起的顶部构成在平面上，使得接地问题可以解决由凹陷引起的嵌入铸模结构中的电路。可以通过涂抹油漆和报废来验证凹坑，剩余油漆的位置被认为是凹陷。此外，可以采用三维测量仪器进行更精确的测量。微型突起可以通过机械加工或放电加工（EDM）在凹陷上形成。或者，可以首先形成具有与微突起匹配的结构的模具，因此微型突起直接通过更适合批量生产的模具填充形成。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式