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1. 发明申请

US20070203111A1 Cycloalkylamines as monoamine reuptake inhibitors 审中-公开
标题翻译：环烷基胺作为单胺再摄取抑制剂
公开(公告)号：US20070203111A1
公开(公告)日：2007-08-30
申请号：US11649927
申请日：2007-01-05
申请人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Jianguo Ma , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , John Campbell
发明人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Jianguo Ma , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , John Campbell
IPC分类号： A61K31/55 , A61K31/445 , A61K31/40 , A61K31/397 , A61K31/396 , C07D211/06 , C07D203/04 , C07D207/04
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。

2. 发明申请

US20070197588A1 Tetralone-based monoamine reuptake inhibitors 有权
标题翻译：基于四氢萘酮的单胺再摄取抑制剂
公开(公告)号：US20070197588A1
公开(公告)日：2007-08-23
申请号：US11643190
申请日：2006-12-21
申请人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , Jianguo Ma
发明人： Liming Shao , Fengjiang Wang , Scott Malcolm , Michael Hewitt , Larry Bush , Mark Varney , Una Campbell , Sharon Engel , Larry Hardy , Patrick Koch , Jianguo Ma
IPC分类号： A61K31/4706 , A61K31/137 , A61K31/135
CPC分类号： C07C211/40 , C07C17/16 , C07C17/35 , C07C45/38 , C07C45/52 , C07C45/63 , C07C45/67 , C07C45/68 , C07C45/74 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/44 , C07C217/74 , C07C2601/14 , C07C2602/10 , C07D215/12 , C07C25/22 , C07C22/04 , C07C47/453 , C07C49/67 , C07C49/697 , C07C49/255 , C07C49/755 , C07C49/683
摘要： The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的四氢萘酮类胺及其用于治疗中枢神经系统（CNS）障碍，例如抑郁症，注意缺陷多动障碍（ADHD）和帕金森病。本发明还涉及含有本发明化合物和组合物的药物组合物以及抑制一种或多种单胺（例如多巴胺和去甲肾上腺素）从突触裂缝再摄取的方法，以及调节一种或多种单胺转运蛋白的方法。

3. 发明申请

US20100175699A1 RESPIRATORY SENSOR 审中-公开
标题翻译：呼吸传感器
公开(公告)号：US20100175699A1
公开(公告)日：2010-07-15
申请号：US12595536
申请日：2008-04-10
申请人： Mark Varney , Michael Garrett , Deryk Williams , John Beadle
发明人： Mark Varney , Michael Garrett , Deryk Williams , John Beadle
IPC分类号： A61M16/00 , A61B5/08 , A61B5/02
CPC分类号： A61B5/0816 , A61B5/087 , A61B5/4806 , A61B5/4818 , A61M16/024 , A61M16/0672 , A61M16/08 , A61M16/161 , A61M2016/0036 , A61M2202/062 , A61M2205/0233 , A61M2205/0244 , A61M2205/3317 , A61M2205/502 , A61M2205/8206 , A61M2230/30 , A61M2230/42 , A61M2230/435 , G01N27/121
摘要： A sensor assembly for monitoring the respiration pattern of a subject is disclosed, the sensor comprising a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour; a processor for determining the pattern of respiration of the subject; and means for displaying information relating to the determined respiration pattern to a user. The sensor assembly is particular suitable for measuring the respiration rate and/or depth of respiration of the subject. The sensor and method find particular application in the diagnosis and treatment of sleep apnea.
摘要翻译：公开了一种用于监测受试者的呼吸模式的传感器组件，该传感器包括用于暴露于受试者呼出的气流的传感器元件，包括第一电极，第二电极和在第一和第二电极之间延伸的有源层，在它们之间提供电气路径，所述传感器元件响应受试者呼出的气流中的水蒸气的浓度，由此电极之间的路径的导电性响应于水蒸汽浓度的变化而变化; 用于确定所述对象的呼吸模式的处理器; 以及用于向用户显示与确定的呼吸模式相关的信息的装置。传感器组件特别适于测量受试者的呼吸速率和/或呼吸深度。传感器和方法在睡眠呼吸暂停的诊断和治疗中有特别的应用。

4. 发明申请

US20080058395A1 Fused heterocyclic inhibitors of D-amino acid oxidase 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂
公开(公告)号：US20080058395A1
公开(公告)日：2008-03-06
申请号：US11825093
申请日：2007-07-02
申请人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
发明人： Michele Heffernan , James Dorsey , Qun Fang , Robert Foglesong , Seth Hopkins , Michael Jones , Steven Jones , Cyprian Ogbu , Joe Perales , Mustapha Soukri , Kerry Spear , Mark Varney
IPC分类号： A61K31/40 , A61K31/415 , A61K31/425 , A61K31/48 , A61P43/00 , C07D231/02 , C07D303/02 , C07D487/02 , C07D513/00
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.
摘要翻译：本发明提供了D-氨基酸氧化酶酶的新型抑制剂以及包含本发明化合物的药物组合物。还提供了治疗和预防神经系统疾病如神经精神和神经退行性疾病以及疼痛，共济失调和惊厥的方法。本发明的化合物具有以下通式结构：其中Q是选自O，S，CR 1和N中的一个，X和Y是独立地选自CR 2，，O，S，N和NR 3。

5. 发明申请

US20100133120A1 Electrochemical Sensor 审中-公开
标题翻译：电化学传感器
公开(公告)号：US20100133120A1
公开(公告)日：2010-06-03
申请号：US12531093
申请日：2008-03-17
申请人： Mark Varney , Micheal Garrett , Deryk Williams , Francis Marken
发明人： Mark Varney , Micheal Garrett , Deryk Williams , Francis Marken
IPC分类号： G01N27/26 , G01N27/30
CPC分类号： G01N33/497
摘要： An electrochemical sensor (40) is provided, the sensor comprising a working electrode (44); a counter electrode (46); and an ionic liquid medium extending between the working electrode and the counter electrode, the ionic liquid medium comprising an ionic liquid retained in a support material. The ionic liquid may comprise a cation selected from 1-alkyl-3-methylimidazolium ([CnMIM]), N-alkylpyridinium, tetraalkylammonium or tetraalkylphosphonium cations and an anion selected from hexafluorophosphate [PF6]; tetrafluoroborate [BF4]; trifluoromethylsulfonate [CF3SO3]; bis[(trifluoromethyl)sulfonyl]amide [(CF3SO2)2N]; trifluoroethanoate [CF3CO2]; acetate [CH3CO2]; nitrate, and halides, including fluoride [F] 1 chloride [Cl], and bromide [Br]. The sensor is particularly useful in the detection of gaseous components in the exhaled breath of a subject and for use in monitoring the lung function of the subject, for example to identify the onset of asthma and/or COPD.
摘要翻译：提供一种电化学传感器（40），该传感器包括工作电极（44）; 对电极（46）; 以及在工作电极和对电极之间延伸的离子液体介质，离子液体介质包含保留在支撑材料中的离子液体。离子液体可以包含选自1-烷基-3-甲基咪唑鎓（[CnMIM]），N-烷基吡啶鎓，四烷基铵或四烷基鏻阳离子的阳离子和选自六氟磷酸盐[PF6]的阴离子。四氟硼酸盐[BF4]; 三氟甲磺酸盐[CF 3 SO 3]; 双[（三氟甲基）磺酰基]酰胺[（CF 3 SO 2）2 N]; 三氟乙酸盐[CF 3 CO 2]; 乙酸酯[CH3CO2]; 硝酸盐和卤化物，包括氟化物[F] 1氯化物[Cl]和溴化物[Br]。传感器特别可用于检测受试者的呼出气中的气体组分并用于监测受试者的肺功能，例如用于鉴定哮喘和/或COPD的发作。

6. 发明申请

US20100050735A1 Gas Sensor 审中-公开
标题翻译：气体传感器
公开(公告)号：US20100050735A1
公开(公告)日：2010-03-04
申请号：US12374661
申请日：2007-07-20
申请人： Mark Varney , Michael Garrett
发明人： Mark Varney , Michael Garrett
IPC分类号： G01N33/497
CPC分类号： G01N27/407 , A61B5/0836 , G01N27/121 , G01N27/4045 , G01N33/497
摘要： A sensor for sensing a target substance in a gas stream is provided, the sensor comprising: a sensing element disposed to be exposed to the gas stream, the sensing element comprising: a working electrode; a counter electrode; and a layer of ion exchange material extending between the working electrode and the counter electrode; whereby contact of the ion exchange layer with the gas stream forms an electrical contact between the working and counter electrodes.
摘要翻译：提供了一种用于感测气流中的目标物质的传感器，该传感器包括：设置成暴露于气流的感测元件，该感测元件包括：工作电极; 对电极以及在工作电极和对电极之间延伸的一层离子交换材料; 由此离子交换层与气流的接触在工作电极和对电极之间形成电接触。

7. 发明申请

US20090272656A1 Gas Sensor 审中-公开
标题翻译：气体传感器
公开(公告)号：US20090272656A1
公开(公告)日：2009-11-05
申请号：US12446046
申请日：2007-10-17
申请人： Mark Varney , Michael Garrett , Deryk Williams
发明人： Mark Varney , Michael Garrett , Deryk Williams
IPC分类号： G01N27/26 , G01N27/28
CPC分类号： G01N27/4045 , A61B5/0836 , G01N33/004 , G01N33/497
摘要： A method for the determination of the carbon dioxide content of an exhaled gas stream is provided, the method comprising measuring the water vapour content of the exhaled gas stream, and determining the concentration of carbon dioxide in the exhaled gas stream from the measured water vapour content. A particular method comprises causing the gas stream to impinge on a sensing element comprising a working electrode and a counter electrode; applying an electric potential across the working electrode and counter electrode; measuring the current flowing between the working electrode and counter electrode as a result of the applied potential; and determining from the measured current flow an indication of the concentration of the water vapour in the gas stream. A sensor is also described.
摘要翻译：提供了一种用于确定呼出气体流的二氧化碳含量的方法，所述方法包括测量呼出气流的水蒸气含量，以及从测量的水蒸汽含量确定呼出气流中二氧化碳的浓度。一种特定的方法包括使气流冲击到包括工作电极和对电极的感测元件上; 在工作电极和对电极两端施加电位; 测量作为施加电位的结果在工作电极和对电极之间流动的电流; 并根据所测量的电流流量确定气流中水蒸气浓度的指示。还描述了传感器。

8. 发明授权

US08329950B2 Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine 有权
标题翻译：反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的制备方法
公开(公告)号：US08329950B2
公开(公告)日：2012-12-11
申请号：US13358155
申请日：2012-01-25
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
IPC分类号： C07C209/62
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

9. 发明申请

US20100264042A1 METHOD OF MONITORING GAS COMPOSITION 审中-公开
标题翻译：监测气体组成的方法
公开(公告)号：US20100264042A1
公开(公告)日：2010-10-21
申请号：US12740774
申请日：2008-10-24
申请人： Mark Varney , Michael Garrett
发明人： Mark Varney , Michael Garrett
IPC分类号： G01N33/497 , G01N27/26
CPC分类号： A61B5/0836 , A61B2562/0215 , G01N33/497
摘要： A method of determining the general or a specific condition of a subject is disclosed, the method comprising measuring the concentration of each of a plurality of components in a single sample of the gas stream exhaled by the subject; and generating information regarding the concentration of each of the plurality of components such that the concentrations of the components are directly comparable. The method is particularly suitable for assessing the condition of the respiratory system of a subject. The method preferably employs electrochemical sensors to measure the concentration of the target components in the exhaled gas stream.
摘要翻译：公开了一种确定受试者的一般或特定条件的方法，所述方法包括测量由受试者呼出的气流的单个样品中的多个组分中的每一个的浓度; 并且产生关于多个组分中的每一个的浓度的信息，使得组分的浓度直接可比。该方法特别适用于评估受试者呼吸系统的状况。该方法优选采用电化学传感器来测量呼出气流中目标组分的浓度。

10. 发明申请

US20050247574A1 Electrochemical gas detection apparatus and method comprising a permeable membrane and an aqueous electrolyte 审中-公开
标题翻译：电化学气体检测装置和方法，其包括可渗透膜和水性电解质
公开(公告)号：US20050247574A1
公开(公告)日：2005-11-10
申请号：US11058084
申请日：2004-12-09
申请人： Mark Varney
发明人： Mark Varney
IPC分类号： G01N27/28 , G01N27/30 , G01N27/416 , G01N33/00 , G01N27/26
CPC分类号： G01N27/4162 , G01N33/004
摘要： A method for the electrochemical detection of carbon dioxide, which comprises causing at least a portion of the carbon dioxide to pass through a permeable membrane and dissolve in an aqueous electrolyte containing a metal ion and an organic ligand to form in situ in the electrolyte an equilibrium between the dissolved carbon dioxide species, the metal ion and the ligand concentrations and measuring the varying metal ion concentration and hence calculating the corresponding carbon dioxide concentration by means of measuring a current passing between electrodes present in the electrolyte. Also a gas detection apparatus comprising a housing, a gas permeable membrane, an aqueous electrolyte inside the housing with electrodes. The concentration of the gas is determined amperometrically.
摘要翻译：一种用于电化学检测二氧化碳的方法，其包括使至少一部分二氧化碳通过可渗透膜并溶解在含有金属离子和有机配体的含水电解质中以在电解质中原位形成平衡在溶解的二氧化碳物质，金属离子和配体浓度之间，并测量不同的金属离子浓度，从而通过测量存在于电解质中的电极之间的电流来计算相应的二氧化碳浓度。还有一种气体检测装置，其包括壳体，透气膜，壳体内的含有电极的水性电解质。气体的浓度由电流计确定。

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