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1. 发明申请

US20110022162A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20110022162A1
公开(公告)日：2011-01-27
申请号：US12508092
申请日：2009-07-23
申请人： Rajesh Radhakishnan , Liliana Atanasoska , Daniel VanCamp
发明人： Rajesh Radhakishnan , Liliana Atanasoska , Daniel VanCamp
IPC分类号： A61F2/06 , B44C1/22 , C25D11/00
CPC分类号： C25D3/50 , A61F2/91 , C25D5/18 , C25D5/48 , C25D11/34
摘要： An endoprosthesis includes an endoprosthesis wall that includes a ceramic coating and a polymer coating containing a therapeutic agent. A ceramic coating can be formed on the wall by electrochemical deposition. Cyclic voltammetry can be conducted to modify the density of the hydroxyl groups on the surface of the ceramic coating.
摘要翻译：内置假体包括内置假体壁，其包括陶瓷涂层和含有治疗剂的聚合物涂层。可以通过电化学沉积在壁上形成陶瓷涂层。可以进行循环伏安法来改变陶瓷涂层表面上的羟基的密度。

2. 发明申请

US20090118823A1 ENDOPROSTHESIS WITH POROUS RESERVOIR 审中-公开
标题翻译：与多孔储层结合
公开(公告)号：US20090118823A1
公开(公告)日：2009-05-07
申请号：US11934421
申请日：2007-11-02
申请人： Liliana Atanasoska , Daniel VanCamp
发明人： Liliana Atanasoska , Daniel VanCamp
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/022 , A61L31/146 , A61L2300/00
摘要： An endoprosthesis such as a coronary stent includes a porous metal reservoir of drug, e.g. directly in the body of the stent. And a method of loading drug into the porous reservoir includes applying an electrical potential to the endoprosthesis.
摘要翻译：诸如冠状动脉支架的内假体包括药物的多孔金属储库，例如，直接在体内的支架。并且将药物装载到多孔容器中的方法包括向内假体施加电势。

3. 发明授权

US09526814B2 Medical balloons and methods of making the same 有权
标题翻译：医用气球及其制作方法
公开(公告)号：US09526814B2
公开(公告)日：2016-12-27
申请号：US11355392
申请日：2006-02-16
申请人： Jan Weber , Liliana Atanasoska , Alexey Kondyurin
发明人： Jan Weber , Liliana Atanasoska , Alexey Kondyurin
IPC分类号： A61M25/10 , A61L31/08 , A61L27/30
CPC分类号： A61L31/084 , A61L27/303
摘要： Medical balloons are provided that have enhanced properties, such as enhanced puncture and scratch resistance.
摘要翻译：提供具有增强性能的医疗气球，例如增强穿刺和耐划伤性。

4. 发明授权

US09314551B2 Block copolymer-coated endoprosthesis 有权
标题翻译：嵌段共聚物涂层内用假体
公开(公告)号：US09314551B2
公开(公告)日：2016-04-19
申请号：US13105473
申请日：2011-05-11
申请人： Liliana Atanasoska , Mourad Rahi , Robert W. Warner
发明人： Liliana Atanasoska , Mourad Rahi , Robert W. Warner
IPC分类号： A61F2/82 , A61L31/14 , A61L31/02 , A61L31/06 , A61L31/10 , A61L31/16
CPC分类号： A61L31/148 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L67/04
摘要： In embodiments, a stent includes a copolymer having a modulus of about 10 MPa or less and exhibiting hydrolytic degradation substantially by surface erosion. For example, the copolymer can include elastic segments formed of trimethyl carbonate polymer or copolymer, and rigid segments formed of a lactide, glycolide, ε-caprolactone polymer or copolymer.
摘要翻译：在实施方案中，支架包括模量为约10MPa或更低的共聚物，并且基本上通过表面侵蚀显示水解降解。例如，共聚物可以包括由碳酸三甲酯聚合物或共聚物形成的弹性链段，以及由丙交酯，乙交酯，ε-己内酯聚合物或共聚物形成的刚性链段。

5. 发明授权

US08815273B2 Drug eluting medical devices having porous layers 有权
标题翻译：具有多孔层的药物洗脱医学装置
公开(公告)号：US08815273B2
公开(公告)日：2014-08-26
申请号：US11881749
申请日：2007-07-27
申请人： Liliana Atanasoska , Robert W. Warner , Michael S. Arney , Jan Weber
发明人： Liliana Atanasoska , Robert W. Warner , Michael S. Arney , Jan Weber
IPC分类号： A61F13/00 , A61F2/06
CPC分类号： A61L31/16 , A61L31/022 , A61L31/082 , A61L31/10 , A61L31/146 , A61L31/148 , A61L2300/608 , Y10T428/13 , Y10T428/249994
摘要： In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包括（a）基底和（b）包含设置在基底上的紧密堆积的球形孔的多孔层。多孔层还可以包含治疗剂。在另一方面，本发明提供了形成可植入或可插入的医疗装置的方法。这些方法包括形成前身结构，其包括（i）在其上设置（ii）微球组件的基底。然后将该微球体组合物用作形成多孔层的模板，随后可以加入治疗剂。

6. 发明授权

US08538515B2 Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 有权
标题翻译：用于与电力源一起递送治疗剂的内部医疗装置
公开(公告)号：US08538515B2
公开(公告)日：2013-09-17
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

7. 发明授权

US08480729B2 Medical devices containing silicate and carbon particles 有权
标题翻译：包含硅酸盐和碳颗粒的医疗器械
公开(公告)号：US08480729B2
公开(公告)日：2013-07-09
申请号：US12205647
申请日：2008-09-05
申请人： Liliana Atanasoska , Jan Weber , John Jianhua Chen , Daniel J. Horn
发明人： Liliana Atanasoska , Jan Weber , John Jianhua Chen , Daniel J. Horn
IPC分类号： A61L29/02 , A61L29/16 , A61L31/02 , A61L31/16
CPC分类号： A61L31/026 , A61L29/02 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/02 , A61L31/024 , A61L31/084 , A61L31/126 , A61L31/16 , A61L2300/416
摘要： According to one aspect of the present invention, implantable and insertable medical devices are provided which contain one or more particle-containing regions that comprise silicate particles and carbon particles.
摘要翻译：根据本发明的一个方面，提供了可植入和可插入的医疗装置，其包含一个或多个包含硅酸盐颗粒和碳颗粒的含颗粒的区域。

8. 发明授权

US08277833B2 Medical devices having surface coatings 有权
标题翻译：具有表面涂层的医疗器械
公开(公告)号：US08277833B2
公开(公告)日：2012-10-02
申请号：US12489996
申请日：2009-06-23
申请人： Liliana Atanasoska , James Lee Shippy, III , Benjamin Arcand , Robert W. Warner
发明人： Liliana Atanasoska , James Lee Shippy, III , Benjamin Arcand , Robert W. Warner
IPC分类号： A61F2/00 , A61F13/00 , A61F2/06
CPC分类号： A61L31/022 , A61L31/08
摘要： According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.
摘要翻译：根据本发明的一个方面，提供了包括金属区域和包含多价酸的全部或部分金属区域上的涂层的医疗装置。

9. 发明授权

US08128689B2 Bioerodible endoprosthesis with biostable inorganic layers 有权
标题翻译：具有生物稳定无机层的生物蚀变内置假体
公开(公告)号：US08128689B2
公开(公告)日：2012-03-06
申请号：US11855542
申请日：2007-09-14
申请人： Jan Weber , Liliana Atanasoska , Scott Schewe
发明人： Jan Weber , Liliana Atanasoska , Scott Schewe
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/022 , A61L31/082 , A61L2300/416
摘要： Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed.
摘要翻译：公开了包含一个或多个生物稳定层（例如生物稳定无机层）和可生物降解的底层结构的内用假体（例如，支架）的医疗装置。

10. 发明申请

US20120022585A1 VASCULAR CLOSURE DEVICE WITH BIODEGRADABLE ANCHOR 有权
标题翻译：具有生物可降解锚固件的血管闭合装置
公开(公告)号：US20120022585A1
公开(公告)日：2012-01-26
申请号：US12841895
申请日：2010-07-22
申请人： Liliana Atanasoska , David J. Sogard , Robert W. Warner , Michael Root , Rajesh Radhakrishnan , Mourad Rahi , Scott R. Smith , Jan Weber , Eric Petersen
发明人： Liliana Atanasoska , David J. Sogard , Robert W. Warner , Michael Root , Rajesh Radhakrishnan , Mourad Rahi , Scott R. Smith , Jan Weber , Eric Petersen
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00411 , A61B2017/00654 , A61B2017/00659
摘要： This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof.
摘要翻译：本公开涉及可控制的生物可吸收装置，特别是用于血管闭塞塞的锚及其使用方法。

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