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1. 发明授权

US07693698B2 Method for identifying or designing a candidate agent that interacts with LINGO-1 polypeptide using a LINGO-1 three-dimensional structure 失效
标题翻译：使用LINGO-1三维结构识别或设计与LINGO-1多肽相互作用的候选试剂的方法
公开(公告)号：US07693698B2
公开(公告)日：2010-04-06
申请号：US11701635
申请日：2007-02-01
申请人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
发明人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
IPC分类号： G06G7/58 , G01N31/00
CPC分类号： C07K14/4703 , C07K14/705 , C07K2299/00
摘要： This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.
摘要翻译：本公开涉及LINGO-1多肽，LINGO-1多肽/配体复合物，LINGO-1多肽的晶体，LINGO-1多肽/配体复合物的晶体，以及相关方法和软件系统。

2. 发明授权

US07496489B2 Design of progesterone receptor ligands 失效
标题翻译：孕酮受体配体设计
公开(公告)号：US07496489B2
公开(公告)日：2009-02-24
申请号：US11208303
申请日：2005-08-19
申请人： Andrea M. Olland , James M. Wilhelm , Karl Malakian , Rayomand J. Unwalla
发明人： Andrea M. Olland , James M. Wilhelm , Karl Malakian , Rayomand J. Unwalla
IPC分类号： G06G7/48 , G01N33/50 , G06F19/00
CPC分类号： C07K14/721 , C07K2299/00
摘要： This invention relates to progesterone receptor/ligand complex, and related methods and software systems. Methods for designing and/or selecting ligands of the progesterone receptor using the three-dimensional structural coordinates of the progesterone receptor and/or nonsteroidal ligands are disclosed.
摘要翻译：本发明涉及孕酮受体/配体复合物，以及相关方法和软件系统。公开了使用孕酮受体和/或非甾体配体的三维结构坐标设计和/或选择孕酮受体配体的方法。

3. 发明授权

US4702843A Control system for an adverse terrain vehicle 失效
标题翻译：不利地形车辆的控制系统
公开(公告)号：US4702843A
公开(公告)日：1987-10-27
申请号：US747669
申请日：1985-06-21
申请人： Norman D. Oswald , Harry S. Mankey , Carl M. Franklin , James M. Wilhelm , Ronnie M. Osborn
发明人： Norman D. Oswald , Harry S. Mankey , Carl M. Franklin , James M. Wilhelm , Ronnie M. Osborn
IPC分类号： B60C23/00 , B60G17/016 , B60G17/018 , B60G17/027 , B62D49/08 , B62D55/116 , B62D61/10 , B60G11/26
CPC分类号： B60C23/003 , B60G17/016 , B60G17/018 , B60G17/0272 , B62D49/08 , B62D55/116 , B62D61/10 , B60G2204/13 , B60G2300/07 , B60G2300/28
摘要： An adverse terrain vehicle is provided which includes a system for controlling a number of vehicular functions. The vehicle includes at least two variable displacement hydraulic motors, each for driving at least one wheel member on one side of the vehicle independently of the wheel members on the opposing side thereof. At least two variable displacement hydraulic pumps are mounted on the vehicle for supplying pressurized hydraulic fluid to the hydraulic motor on one side of the vehicle independently of the hydraulic motor on the opposing side thereof. The hydraulic pumps are driven by an engine. A sensor detects a decrease in the power output of the vehicle below that selected by the vehicle operator. Overload protection circuitry is responsive to the overload sensor and adjusts the displacement of the hydraulic motors and pumps to increase the power output capacity of the vehicle. Braking control circuitry coordinates with braking of the vehicle steering to effect turning of the vehicle while braking. Control circuitry also adjusts the vertical positions of the wheels on opposing sides of the vehicle during a turn to facilitate skid-steering. Control circuitry also varies the displacement of the hydraulic motors to prevent their operation at excessive speeds and to facilitate acceleration of the vehicle at slow speeds. A tire inflation system is utilized to control the pressure within the tires of the vehicle.
摘要翻译：提供了一种不利的地形车辆，其包括用于控制多个车辆功能的系统。车辆包括至少两个可变排量液压马达，每个用于在车辆的相对侧上与轮构件无关地驱动车辆一侧的至少一个车轮构件。至少两个可变排量的液压泵安装在车辆上，用于将加压液压流体供应到车辆一侧的液压马达，而与液压马达相对的侧面无关。液压泵由发动机驱动。传感器检测到低于由车辆操作者选择的车辆的动力输出的减小。过载保护电路响应于过载传感器并调节液压马达和泵的位移以增加车辆的动力输出能力。制动控制电路与车辆转向制动协调，以在制动时实现车辆转向。控制电路还在转弯期间调整车辆相对两侧的车轮的垂直位置，以便于滑行转向。控制电路还可以改变液压马达的位移，以防止它们在过快的速度下操作并且有助于以低速加速车辆。轮胎充气系统用于控制车辆轮胎内的压力。

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