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1. 发明申请

US20120135046A1 CORTICOSTEROID PARTICLES AND METHOD OF PRODUCTION 失效
标题翻译：角质细胞颗粒和生产方法
公开(公告)号：US20120135046A1
公开(公告)日：2012-05-31
申请号：US13237792
申请日：2011-09-20
申请人： Libo WU , Wiwik WATANABE , Jian ZHANG
发明人： Libo WU , Wiwik WATANABE , Jian ZHANG
IPC分类号： A61K31/58 , C07J71/00 , A61K9/14
CPC分类号： A61K9/0078 , A61K9/14 , A61K31/58 , A61K47/26 , Y10T428/2982
摘要： A new particle morphology of glucocorticosteroids is described. The forms have a particle morphology that is particularly well suited for use in an inhaled corticosteroid drug suspension formulation for delivery from a next generation nebulizer device. Use of the new glucocorticosteroid particles enables enhanced drug delivery efficiency and increased residence time of the delivered drug in the lungs. New methods for producing glucocorticosteroid particles having these specific particle morphologies are also described. The methods provide a simplified, reproducible and scalable particle formation process that can produce glucocorticosteroid particles having a narrow particle size and shape distribution, a low surface energy, a low aspect ratio, uniform particle morphology and a reduced specific surface area.
摘要翻译：描述了糖皮质激素的新的颗粒形态。这些形式具有特别适合用于从下一代雾化器装置递送的吸入皮质类固醇药物悬浮液制剂中的颗粒形态。使用新的糖皮质激素颗粒使得能够提高药物递送效率并增加递送的药物在肺中的停留时间。还描述了产生具有这些特定颗粒形态的糖皮质激素颗粒的新方法。该方法提供了一种简化的，可重现的和可伸缩的颗粒形成过程，其可以产生具有窄粒度和形状分布，低表面能，低纵横比，均匀颗粒形态和降低的比表面积的糖皮质激素颗粒。

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