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1. 发明申请

US20050287212A1 Oral delivery system comprising a drug/polymer complex 审中-公开
标题翻译：包含药物/聚合物复合物的口服递送系统
公开(公告)号：US20050287212A1
公开(公告)日：2005-12-29
申请号：US11148673
申请日：2005-06-08
申请人： Liang-Chang Dong , Jasmine Han , Crystal Pollock-Dove , Patrick Wong
发明人： Liang-Chang Dong , Jasmine Han , Crystal Pollock-Dove , Patrick Wong
IPC分类号： A61K9/00 , A61K9/14 , A61K9/19 , A61K9/20 , A61K9/24 , A61K9/48 , A61K47/10 , A61K47/38
CPC分类号： A61K9/19 , A61K9/0004 , A61K9/146 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K47/10 , A61K47/38
摘要： This invention pertains to the enhanced delivery of orally administered pharmaceutical agents and methods, dosage forms and devices thereof. In particular, the invention is directed to methods including providing a low solubility drug having a pKa between about 6 and about 9; dissolving the low solubility drug in an aqueous solution, wherein a pH of the aqueous solution is less than about 6.0; dissolving a hydrophilic polymer in the aqueous solution, wherein the weight ratio of the hydrophilic polymer to the low solubility drug is less than or equal to about 0.15; lyophilizing the aqueous solution to obtain a lyophilized powder. Also disclosed are drug formulations made according to the method, and dosage forms that include the drug formulations.
摘要翻译：本发明涉及口服给药药剂的增强递送及其方法，剂型及其装置。特别地，本发明涉及包括提供具有约6至约9的pKa的低溶解度药物的方法; 将低溶解度药物溶解在水溶液中，其中水溶液的pH小于约6.0; 将亲水性聚合物溶解在水溶液中，其中亲水性聚合物与低溶解度药物的重量比小于或等于约0.15; 冻干该水溶液以获得冻干粉末。还公开了根据该方法制备的药物制剂以及包括药物制剂的剂型。

2. 发明申请

US20050186273A1 Controlled release dosage form including a banded engine 审中-公开
标题翻译：受控释放剂型，包括带状发动机
公开(公告)号：US20050186273A1
公开(公告)日：2005-08-25
申请号：US10950039
申请日：2004-09-24
申请人： Si-Hong Yum , Crystal Pollock-Dove , Liang-Chang Dong , Patrick Wong
发明人： Si-Hong Yum , Crystal Pollock-Dove , Liang-Chang Dong , Patrick Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22
CPC分类号： A61K9/0004
摘要： The present invention includes a dosage form configured to provide the controlled release of an active agent formulation. A dosage form according to the present invention includes a reservoir containing an active agent formulation and an engine positioned at least partially within the reservoir. In order to reduce the possibility that the engine included in a dosage form of the present invention will separate from the reservoir either during or after fabrication, the dosage form of the present invention includes a band that binds the engine to the reservoir. The band is provided over an outside surface of the both the engine and the reservoir at or near the interface formed where the engine enters the opening provided in the reservoir. The present invention also includes a method of fabricating controlled release dosage forms having banded engine.
摘要翻译：本发明包括配制成提供活性剂制剂的受控释放的剂型。根据本发明的剂型包括含有活性剂制剂的储存器和至少部分地位于储存器内的发动机。为了减少包含在本发明的剂型中的发动机在制造期间或之后与储存器分离的可能性，本发明的剂型包括将发动机结合到储存器的带。该带被设置在发动机进入设置在储存器中的开口所形成的界面处或附近的发动机和储存器两侧的外表面上。本发明还包括制造具有带状发动机的控释剂型的方法。

3. 发明申请

US20060057206A1 Controlled release nanoparticle active agent formulation dosage forms and methods 审中-公开
标题翻译：控制释放纳米粒子活性剂配方剂型及方法
公开(公告)号：US20060057206A1
公开(公告)日：2006-03-16
申请号：US11198717
申请日：2005-08-04
申请人： Patrick Wong , Liang-Chang Dong , Ruiping Zhao , Crystal Pollock-Dove
发明人： Patrick Wong , Liang-Chang Dong , Ruiping Zhao , Crystal Pollock-Dove
IPC分类号： A61K9/24
CPC分类号： A61K9/1075 , A61K9/0004 , A61K9/143 , A61K9/146 , A61K9/1611 , A61K9/2009 , A61K9/2013 , A61K9/2031
摘要： Controlled release of self-dispersing nanoparticle active agent formulations is provided by dispersing porous particles into which have been sorbed a self-dispersing nanoparticle active agent formulation in osmotic, push-layer dosage forms. The dosage forms may provide for continuous or pulsatile delivery of active agents.
摘要翻译：自分散纳米颗粒活性剂制剂的控制释放通过分散多孔颗粒提供，其中已经吸收了渗透型推层剂型中的自分散纳米颗粒活性剂制剂。剂型可以提供活性剂的连续或脉动递送。

4. 发明申请

US20050079220A1 Osmotic engine & dosage form for controlled release of a liquid active agent formulation 审中-公开
标题翻译：用于控制释放液体活性剂制剂的渗透引发剂和剂型
公开(公告)号：US20050079220A1
公开(公告)日：2005-04-14
申请号：US10902912
申请日：2004-07-30
申请人： Betty Yu , Liang-Chang Dong , Andrew Lam , Crystal Pollock-Dove
发明人： Betty Yu , Liang-Chang Dong , Andrew Lam , Crystal Pollock-Dove
IPC分类号： A61K9/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： The present invention relates to osmotic engines and dosage forms providing the controlled release of a liquid active agent formulation. More specifically, the present invention is directed to osmotic engines, dosage forms and methods that preserve osmotic engine functionality and reduce void volume formation in osmotically driven dosage form providing the controlled release of liquid active agent formulations.
摘要翻译：本发明涉及提供液体活性剂制剂的受控释放的渗透引发剂和剂型。更具体地，本发明涉及渗透引发剂，剂型和方法，其保持渗透引发剂功能并减少渗透驱动剂型中提供液体活性剂制剂的受控释放的空隙体积形成。

5. 发明申请

US20070048368A1 Dosage form comprising liquid formulation 失效
标题翻译：包含液体制剂的剂型
公开(公告)号：US20070048368A1
公开(公告)日：2007-03-01
申请号：US11589558
申请日：2006-10-30
申请人： Liang-Chang Dong , Steven Espinal , Patrick Wong
发明人： Liang-Chang Dong , Steven Espinal , Patrick Wong
IPC分类号： A61K9/52
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.
摘要翻译：持续释放剂型包括由软化点低于200℃的热塑性聚合物制成的胶囊，以及在胶囊内形成或可形成的孔，包含在胶囊内的乳剂，以及远离胶囊内的胶囊内的可膨胀组合物孔。乳液制剂包含药物，乳化表面活性剂和油。可膨胀组合物构造成通过孔膨胀和排出乳液制剂。

6. 发明申请

US20050003006A1 Pharmaceutical coating composition and method of use 失效
标题翻译：药用涂料组合物及其使用方法
公开(公告)号：US20050003006A1
公开(公告)日：2005-01-06
申请号：US10897669
申请日：2004-07-23
申请人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
发明人： David Edgren , Shu Li , Patrick Wong , Gurdish Bhatti , Liang-Chang Dong , Si-Hong Yum
IPC分类号： A61K9/00 , A61K9/28 , A61K9/36 , A61K9/50 , A61K9/24
CPC分类号： A61K9/2853 , A61K9/0004 , A61K9/282 , A61K9/284 , A61K9/2866
摘要： A composition is disclosed comprising a polymer and a surfactant in a solvent exhibiting a common solubility for the polymer and the surfactant. The composition provides a dosage form for administering a drug over time.
摘要翻译：公开的组合物在溶剂中显示出对聚合物和表面活性剂具有共同的溶解性的聚合物和表面活性剂。该组合物提供了随时间施用药物的剂型。

7. 发明申请

US20090130204A1 Dosage Form Comprising Therapeutic Formulation 审中-公开
标题翻译：包含治疗配方的剂型
公开(公告)号：US20090130204A1
公开(公告)日：2009-05-21
申请号：US12359235
申请日：2009-01-23
申请人： Liang-Chang Dong , Patrick S.L. Wong , Vincent Joseph Ferrari , Steven Espinal
发明人： Liang-Chang Dong , Patrick S.L. Wong , Vincent Joseph Ferrari , Steven Espinal
IPC分类号： A61K9/52
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.
摘要翻译：公开了一种剂型，其包含容纳胶囊的半透性壁容器，该胶囊包括药物制剂，活塞和渗透组合物。该剂型在持续释放的时间长达24小时内以可控的速率通过通道递送药物制剂。

8. 发明授权

US07147867B2 Dosage form comprising liquid formulation 失效
标题翻译：包含液体制剂的剂型
公开(公告)号：US07147867B2
公开(公告)日：2006-12-12
申请号：US09740191
申请日：2000-12-19
申请人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
发明人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
IPC分类号： A61K9/48 , A61K9/66
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A dosage form is disclosed comprising a drug formulation that self-emulsifies in the drug formulation.
摘要翻译：公开了一种剂型，其包含药物制剂中自乳化的药物制剂。

9. 发明授权

US06551613B1 Dosage form comprising therapeutic formulation 失效
标题翻译：包含治疗剂型的剂型
公开(公告)号：US06551613B1
公开(公告)日：2003-04-22
申请号：US09353519
申请日：1999-07-14
申请人： Liang-Chang Dong , Patrick S. L. Wong , Vincent Joseph Ferrari , Steven Espinal
发明人： Liang-Chang Dong , Patrick S. L. Wong , Vincent Joseph Ferrari , Steven Espinal
IPC分类号： A61K948
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a semipermeable walled container that houses a capsule, which capsule comprises a drug formulation, a piston, and an osmotic composition. The dosage form delivers the drug formulation through a passageway at a controlled rate over a sustained-release period of time up to 24 hours.
摘要翻译：公开了一种剂型，其包含容纳胶囊的半透性壁容器，该胶囊包括药物制剂，活塞和渗透组合物。该剂型在持续释放的时间长达24小时内以可控的速率通过通道递送药物制剂。

10. 发明授权

US07803401B2 Dosage form comprising liquid formulation 失效
标题翻译：包含液体制剂的剂型
公开(公告)号：US07803401B2
公开(公告)日：2010-09-28
申请号：US11589558
申请日：2006-10-30
申请人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
发明人： Liang-Chang Dong , Steven Espinal , Patrick S. L. Wong
IPC分类号： A61K9/48 , A61K9/66
CPC分类号： A61K9/4858 , A61K9/0004 , A61K9/1075 , A61K9/4866
摘要： A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.
摘要翻译：持续释放剂型包括由软化点低于200℃的热塑性聚合物制成的胶囊，以及在胶囊内形成或可形成的孔，包含在胶囊内的乳剂，以及远离胶囊内的胶囊内的可膨胀组合物孔。乳液制剂包含药物，乳化表面活性剂和油。可膨胀组合物构造成通过孔膨胀和排出乳液制剂。

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