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1. 发明授权

US08582846B2 Method and system for validating image registration 有权
标题翻译：验证图像配准的方法和系统
公开(公告)号：US08582846B2
公开(公告)日：2013-11-12
申请号：US13161656
申请日：2011-06-16
申请人： Guyu Li , Li Zhang , Christophe Chefd'hotel , Christoph Guetter
发明人： Guyu Li , Li Zhang , Christophe Chefd'hotel , Christoph Guetter
IPC分类号： G06K9/32
CPC分类号： G06T7/37 , G06T2207/20056
摘要： A method for validating non-rigid image registration includes acquiring a source image and a target image. Registration is performed from source image to target image using a non-rigid registration technique to produce forward transformation map. Registration is performed from the target image back to the source image using the non-rigid registration technique to produce a backward transformation map. Consistency registration error is measured as an indication of a change in local volume of the source with respect to the target image using the produced forward transformation map and the produced backward transformation map. The non-rigid registration technique is validated based on the measured consistency registration error.
摘要翻译：用于验证非刚性图像配准的方法包括获取源图像和目标图像。使用非刚性注册技术从源图像到目标图像进行注册以产生正向变换图。使用非刚性登记技术从目标图像返回到源图像，从而产生反向变换图。使用所产生的正向变换图和所产生的向后变换图，测量一致性登记误差作为相对于目标图像的源的局部体积的变化的指示。基于测量的一致性注册误差验证非刚性注册技术。

2. 发明申请

US20110311115A1 METHOD AND SYSTEM FOR VALIDATING IMAGE REGISTRATION 有权
标题翻译：用于验证图像注册的方法和系统
公开(公告)号：US20110311115A1
公开(公告)日：2011-12-22
申请号：US13161656
申请日：2011-06-16
申请人： Guyu Li , Li Zhang , Christophe Chefd'hotel , Christoph Guetter
发明人： Guyu Li , Li Zhang , Christophe Chefd'hotel , Christoph Guetter
IPC分类号： G06K9/32
CPC分类号： G06T7/37 , G06T2207/20056
摘要： A method for validating non-rigid image registration includes acquiring a source image and a target image. Registration is performed from source image to target image using a non-rigid registration technique to produce forward transformation map. Registration is performed from the target image back to the source image using the non-rigid registration technique to produce a backward transformation map. Consistency registration error is measured as an indication of a change in local volume of the source with respect to the target image using the produced forward transformation map and the produced backward transformation map. The non-rigid registration technique is validated based on the measured consistency registration error.
摘要翻译：用于验证非刚性图像配准的方法包括获取源图像和目标图像。使用非刚性注册技术从源图像到目标图像进行注册以产生正向变换图。使用非刚性登记技术从目标图像返回到源图像，从而产生反向变换图。使用所产生的正向变换图和所产生的向后变换图，测量一致性登记误差作为相对于目标图像的源的局部体积的变化的指示。基于测量的一致性注册误差验证非刚性注册技术。

3. 发明授权

US08553964B2 Unifying reconstruction and motion estimation in first pass cardiac perfusion imaging 有权
标题翻译：一次心脏灌注显像统一重建和运动估计
公开(公告)号：US08553964B2
公开(公告)日：2013-10-08
申请号：US13273410
申请日：2011-10-14
申请人： Christophe Chefd'hotel , Mathews Jacob , Sajan Goud Lingala , Mariappan S. Nadar , Li Zhang
发明人： Christophe Chefd'hotel , Mathews Jacob , Sajan Goud Lingala , Mariappan S. Nadar , Li Zhang
IPC分类号： G06K9/00 , A61B5/00 , A61B8/00
CPC分类号： G01R33/56366 , G01R33/5611 , G01R33/56509
摘要： Methods and a system to unify reconstruction and motion estimation steps in first pass cardiac perfusion MRI include a global objective function that meets data consistency, spatial smoothness, motion and contrast dynamics constraints. The global objective decomposed into simpler sub-problems which include low pass filtering of a deformed object, TV shrinkage, analytical Fourier replacement and an l2 minimizing problem. A registration tool based on the local cross-correlation similarity measure and enabled to perform both rigid and flexile deformations, is applied. Registration parameters are tuned by rigid, semi rigid and flexible models at different stages of iterations. A system to perform the methods is also disclosed.
摘要翻译：在第一次心脏灌注MRI中统一重建和运动估计步骤的方法和系统包括满足数据一致性，空间平滑度，运动和对比度动力学约束的全局目标函数。全局目标分解为更简单的子问题，包括变形对象的低通滤波，电视收缩，分析傅立叶置换和最小二乘问题。应用基于局部互相关相似性测量并且能够执行刚性和柔性变形的注册工具。注册参数通过刚性，半刚性和柔性模型在不同的迭代阶段进行调整。还公开了执行方法的系统。

4. 发明授权

US08483464B2 System and method for detecting and correcting registration misalignment of MR perfusion images 有权
标题翻译：用于检测和纠正MR灌注图像的配准失准的系统和方法
公开(公告)号：US08483464B2
公开(公告)日：2013-07-09
申请号：US12897849
申请日：2010-10-05
申请人： Li Zhang , Christophe Chefd'hotel
发明人： Li Zhang , Christophe Chefd'hotel
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： G06T7/35 , G06T2207/10076 , G06T2207/10096 , G06T2207/30016
摘要： A method for correcting registration misalignment in magnetic resonance perfusion images includes receiving a time series of magnetic resonance images of an anatomical organ, each image comprising a plurality of intensities defined on an N-dimensional domain of points, performing a first group-wise registration of all images in the time series of images using a pair-wise registration as an initialization, detecting a misaligned image from the group-wise registration by analyzing a total variation of intensity differences between consecutive images, and correcting the misaligned image by optimizing a second group-wise energy function over registration parameters of the misaligned image.
摘要翻译：用于校正磁共振灌注图像中的配准未对准的方法包括接收解剖器官的磁共振图像的时间序列，每个图像包括在点的N维域上限定的多个强度，执行第一次分组注册使用成对注册的图像的时间序列中的所有图像作为初始化，通过分析连续图像之间的强度差的总变化来检测来自分组注册的未对齐图像，并且通过优化第二组来校正未对准图像对于不对准图像的记录参数，

5. 发明申请

US20110311121A1 SYSTEM AND METHOD FOR DETECTING AND CORRECTING REGISTRATION MISALIGNMENT OF MR PERFUSION IMAGES 有权
标题翻译：用于检测和校正MR灌注图像的注册缺失的系统和方法
公开(公告)号：US20110311121A1
公开(公告)日：2011-12-22
申请号：US12897849
申请日：2010-10-05
申请人： Li Zhang , Christophe Chefd'hotel
发明人： Li Zhang , Christophe Chefd'hotel
IPC分类号： G06K9/00
CPC分类号： G06T7/35 , G06T2207/10076 , G06T2207/10096 , G06T2207/30016
摘要： A method for correcting registration misalignment in magnetic resonance perfusion images includes receiving a time series of magnetic resonance images of an anatomical organ, each image comprising a plurality of intensities defined on an N-dimensional domain of points, performing a first group-wise registration of all images in the time series of images using a pair-wise registration as an initialization, detecting a misaligned image from the group-wise registration by analyzing a total variation of intensity differences between consecutive images, and correcting the misaligned image by optimizing a second group-wise energy function over registration parameters of the misaligned image.
摘要翻译：用于校正磁共振灌注图像中的配准未对准的方法包括接收解剖器官的磁共振图像的时间序列，每个图像包括在点的N维域上限定的多个强度，执行第一次分组注册使用成对注册的图像的时间序列中的所有图像作为初始化，通过分析连续图像之间的强度差的总变化来检测来自分组注册的未对齐图像，并且通过优化第二组来校正未对准图像对于不对准图像的记录参数，

6. 发明申请

US20120148128A1 UNIFYING RECONSTRUCTION AND MOTION ESTIMATION IN FIRST PASS CARDIAC PERFUSION IMAGING 有权
标题翻译：第一次心脏灌注成像中的统一重建和运动估计
公开(公告)号：US20120148128A1
公开(公告)日：2012-06-14
申请号：US13273410
申请日：2011-10-14
申请人： Christophe Chefd'hotel , Mathews Jacob , Sajan Goud Lingala , Mariappan S. Nadar , Li Zhang
发明人： Christophe Chefd'hotel , Mathews Jacob , Sajan Goud Lingala , Mariappan S. Nadar , Li Zhang
IPC分类号： G06K9/00
CPC分类号： G01R33/56366 , G01R33/5611 , G01R33/56509
摘要： Methods and a system to unify reconstruction and motion estimation steps in first pass cardiac perfusion MRI include a global objective function that meets data consistency, spatial smoothness, motion and contrast dynamics constraints. The global objective decomposed into simpler sub-problems which include low pass filtering of a deformed object, TV shrinkage, analytical Fourier replacement and an l2 minimizing problem. A registration tool based on the local cross-correlation similarity measure and enabled to perform both rigid and flexile deformations, is applied. Registration parameters are tuned by rigid, semi rigid and flexible models at different stages of iterations. A system to perform the methods is also disclosed.
摘要翻译：在第一次心脏灌注MRI中统一重建和运动估计步骤的方法和系统包括满足数据一致性，空间平滑度，运动和对比度动力学约束的全局目标函数。全局目标分解为更简单的子问题，包括变形对象的低通滤波，电视收缩，分析傅立叶置换和最小二乘问题。应用基于局部互相关相似性测量并且能够执行刚性和柔性变形的注册工具。注册参数通过刚性，半刚性和柔性模型在不同的迭代阶段进行调整。还公开了执行方法的系统。

7. 发明授权

US08848990B2 Automatic registration of image series with varying contrast based on synthetic images derived from intensity behavior model 有权
标题翻译：基于从强度行为模型导出的合成图像，自动配准具有不同对比度的图像序列
公开(公告)号：US08848990B2
公开(公告)日：2014-09-30
申请号：US13237198
申请日：2011-09-20
申请人： Hui Xue , Saurabh Shah , Jens Gühring , Andreas Greiser , Christophe Chefd'hotel , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff
发明人： Hui Xue , Saurabh Shah , Jens Gühring , Andreas Greiser , Christophe Chefd'hotel , Christoph Guetter , Marie-Pierre Jolly , Sven Zuehlsdorff
IPC分类号： G06K9/00 , G06T5/50 , G06T7/00 , G01R33/44 , G01R33/565
CPC分类号： G06T5/50 , G01R33/448 , G01R33/56509 , G06T7/30 , G06T2207/10088 , G06T2207/20201 , G06T2207/30048
摘要： A method for performing motion compensation in a series of magnetic resonance (MR) images includes acquiring a set of MR image frames spanning different points along an MR recovery curve. A motion-free synthetic image is generated for each of the acquired MR image frames using prior knowledge pertaining to an MR recovery curve. Each of the acquired MR images is registered to its corresponding generated synthetic images. Motion within each of the acquired MR image is corrected based on its corresponding generated synthetic image that has been registered thereto.
摘要翻译：用于在一系列磁共振（MR）图像中执行运动补偿的方法包括获取沿着MR恢复曲线横跨不同点的一组MR图像帧。使用与MR恢复曲线相关的先前知识，为每个所获取的MR图像帧生成无运动合成图像。所获取的MR图像中的每一个被注册到其对应的生成的合成图像。基于其对应的生成的已经被注册的合成图像来校正所获取的MR图像的每一个内的运动。

8. 发明申请

US20130070995A1 2D/3D IMAGE REGISTRATION METHOD 有权
标题翻译： 2D / 3D图像注册方法
公开(公告)号：US20130070995A1
公开(公告)日：2013-03-21
申请号：US13597963
申请日：2012-08-29
申请人： Chen-Rui Chou , Atilla Peter Kiraly , Christophe Chefd'hotel , David Thivierge-gaulin
发明人： Chen-Rui Chou , Atilla Peter Kiraly , Christophe Chefd'hotel , David Thivierge-gaulin
IPC分类号： G06K9/32
CPC分类号： G06T7/344 , G06K2209/057 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/10121 , G06T2207/10124 , G06T2207/30048
摘要： A method (100) that registers a 3D heart volume (112, 114) obtained from either a pre-operative MR image or CT image (102) to an intra-operative fluoroscopic image using a mesh of the heart structure (106) as the basis for the registration.
摘要翻译：一种方法（100），其使用心脏结构（106）的网格将从手术前MR图像或CT图像（102）获得的3D心脏体积（112,114）登记到手术中透视图像，作为注册基础。

9. 发明申请

US20130051647A1 Automatic Initialization for 2D/3D Registration 有权
标题翻译： 2D / 3D注册自动初始化
公开(公告)号：US20130051647A1
公开(公告)日：2013-02-28
申请号：US13591752
申请日：2012-08-22
申请人： Shun Miao , Christophe Chefd'hotel , Rui Liao
发明人： Shun Miao , Christophe Chefd'hotel , Rui Liao
IPC分类号： G06K9/62
CPC分类号： G06T7/344 , G06T2207/10081 , G06T2207/10121
摘要： A method for automatic initialization of 2D to 3D image registration includes acquiring a 3D model. A plurality of shape descriptor features is calculated from the acquired 3D model representing a plurality of poses of the 3D model. A 2D image is acquired. The plurality of shape descriptors is matched to the acquired 2D model. An optimum pose of the 3D model is determined based on the matching of the plurality of shape descriptors to the acquired 2D model. An initial registration is generated, in an image processing system, between the 3D model and the 2D image based on the determined optimum pose.
摘要翻译：用于2D到3D图像配准的自动初始化的方法包括获取3D模型。从所获取的3D模型中计算出多个形状描述符特征，该3D模型表示3D模型的多个姿态。获取2D图像。多个形状描述符与获取的2D模型相匹配。基于多个形状描述符与所获取的2D模型的匹配来确定3D模型的最佳姿态。在图像处理系统中，基于确定的最佳姿态在3D模型和2D图像之间生成初始注册。

10. 发明申请

US20120140998A1 Deformable Motion Correction for Stent Visibility Enhancement 有权
标题翻译：用于支架可见度增强的可变形运动校正
公开(公告)号：US20120140998A1
公开(公告)日：2012-06-07
申请号：US13277312
申请日：2011-10-20
申请人： Ying Zhu , Christophe Chefd'hotel
发明人： Ying Zhu , Christophe Chefd'hotel
IPC分类号： G06K9/00
CPC分类号： G06T5/006 , G06T7/194 , G06T2207/10081 , G06T2207/10121 , G06T2207/10132 , G06T2207/30021 , G06T2207/30101 , G06T2207/30204
摘要： A method for enhancing stent visibility includes acquiring a set of image frames including multiple test frames. A set of measurement points uniformly distributed within an image of a stent is defined in the test frames. A local image context is defined around each measurement point. A non-rigid deformation field relating the local image contexts of the test frames to local image contexts of a reference image is calculated. The non-rigid deformation field is optimized by maximizing a similarity function between the local image contexts of the test frames and the local image contexts of the reference image. The optimized non-rigid deformation field is used to deform images of a stent in the multiple test frames and combine the non-rigidly deformed images of the stent from the test frames. An image frame with the combined image of the stents superimposed thereon is displayed.
摘要翻译：一种用于增强支架可见度的方法包括获取包括多个测试框架的一组图像帧。在测试框架中定义了在支架的图像内均匀分布的一组测量点。在每个测量点周围定义一个局部图像上下文。计算将测试帧的局部图像上下文与参考图像的局部图像上下文相关联的非刚性变形场。通过最大化测试帧的局部图像上下文与参考图像的局部图像上下文之间的相似度函数来优化非刚性变形场。优化的非刚性变形场用于在多个测试框架中变形支架的图像，并将来自测试框架的支架的非刚性变形图像组合。显示具有叠加在其上的支架的组合图像的图像帧。

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