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1. 发明申请

US20140135497A1 SYNTHESIS OF 2,4-DICHLORO-5-TRIFLUOROMETHYL-PYRIMIDINE 审中-公开
标题翻译： 2,4-二氯-5-三氟甲基吡啶的合成
公开(公告)号：US20140135497A1
公开(公告)日：2014-05-15
申请号：US14072146
申请日：2013-11-05
申请人： Li Liu , Deniz Akalay , Weitong Dong , Jianqing Feng , Christian Wolfgang Hemp , Jun Lu , Le Xie , Jinsong Yang
发明人： Li Liu , Deniz Akalay , Weitong Dong , Jianqing Feng , Christian Wolfgang Hemp , Jun Lu , Le Xie , Jinsong Yang
IPC分类号： C07D239/30 , C07D239/54
CPC分类号： C07D239/30 , C07D239/54
摘要： This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.
摘要翻译：本发明涉及一种合成2,4-二氯-5-三氟甲基 - 嘧啶的新方法，其用作制备药物活性成分的中间体。

2. 外观设计

USD995854S1 Mini computer 有权
公开(公告)号：USD995854S1
公开(公告)日：2023-08-15
申请号：US29817548
申请日：2021-12-02
申请人： Li Liu
设计人： Li Liu , Lirui Tian , Weifeng Huang , Pian Wang
摘要： FIG. 1 is a top, front and right side perspective view of a mini computer showing our new design;
FIG. 2 is a bottom, rear and left side perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines in the drawings illustrate portions of the mini computer which form no part of the claimed design.

3. 发明授权

US11491544B2 Preparation method of metal powder material 有权
公开(公告)号：US11491544B2
公开(公告)日：2022-11-08
申请号：US16771148
申请日：2020-01-19
申请人： Li Liu
发明人： Li Liu
IPC分类号： B22F9/16 , B22F1/05 , B22F1/065
摘要： The present disclosure provides a preparation method of a metal powder material. An alloy sheet composed of a matrix phase and a dispersive phase with different chemical reactivities is prepared by the rapid solidification technique of alloy melt. Metal powder is prepared by the reaction of the alloy sheet and an acid solution. Please refer to the description for the detailed preparation method. This method is simple in operation, can be used to prepare many kinds of metal powder materials of different shapes and at the nanometer scale, the submicron scale and the micron scale, and has a good application prospect in the fields of catalysis, powder metallurgy and 3D printing.

4. 发明授权

US09987247B2 Drugs for treating diseases of cervical and/or lumbar vertebrae 有权
公开(公告)号：US09987247B2
公开(公告)日：2018-06-05
申请号：US15039635
申请日：2014-11-28
申请人： Li Liu
发明人： Li Liu , Lifang Hu
IPC分类号： A61K31/343
CPC分类号： A61K31/343 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059
摘要： The present invention relates to a benzbromarone or different pharmaceutically acceptable crystals thereof, or pharmaceutically acceptable solvates, salts, esters, ethers or clathrates thereof, or use of a pharmaceutical composition comprising any of the above in preparation of drugs, application thereof being for preparation of drugs for treating and preventing vertebrae cervicales diseases or lumbar disk herniation (LDH) in human.

5. 发明授权

US09344100B2 Reconfigurable local oscillator for optimal noise performance in a multi-standard transceiver 有权
标题翻译：可重构本地振荡器，可在多标准收发器中实现最佳噪声性能
公开(公告)号：US09344100B2
公开(公告)日：2016-05-17
申请号：US12898104
申请日：2010-10-05
申请人： Li Liu , Chiewcharn Narathong , Prasad Srinivasa Siva Gudem
发明人： Li Liu , Chiewcharn Narathong , Prasad Srinivasa Siva Gudem
IPC分类号： H04B7/216 , H03L7/197 , H03L7/093 , H03L7/099 , H03L7/10 , H03B5/12 , H04B1/00
CPC分类号： H03L7/1976 , H03B5/1212 , H03B5/1228 , H03B5/1243 , H03L7/093 , H03L7/099 , H03L7/104 , H04B1/0057
摘要： A transceiver for multi-standard operation (usable, for example, to communicate signals both of a first wireless communication standard and of a second wireless communication standard) has a mixer that receives a local oscillator signal generated by a local oscillator. A PLL of the local oscillator involves a VCO, a digitally programmable analog loop filter, a digitally programmable VCO supply voltage circuit, and a digitally programmable VCO varactor bias control circuit. In one aspect, the bandwidth of the analog loop filter is adjusted depending on the communication standard of the signal being communicated. In other aspects, the VCO supply voltage circuit and/or the varactor bias control circuit are configured in different ways to optimize PLL performance depending on the communication standard of the signal being communicated.
摘要翻译：用于多标准操作的收发器（例如可用于传送第一无线通信标准和第二无线通信标准的信号）具有接收由本地振荡器产生的本地振荡器信号的混合器。本地振荡器的PLL包括VCO，数字可编程模拟环路滤波器，数字可编程VCO电源电压电路和数字可编程VCO变容二极管偏置控制电路。在一个方面，模拟环路滤波器的带宽根据正在传送的信号的通信标准来调节。在其他方面，VCO电源电压电路和/或变容二极管偏置控制电路以不同的方式配置，以根据正在通信的信号的通信标准优化PLL性能。

6. 发明申请

US20150306567A1 CHITOSAN-FUNCTIONALIZED CORDIERITE MONOLITHS AS HEAVY METAL SORBENTS 审中-公开
标题翻译：作为重金属分子的CHITOSAN官能化的CORDIERITE单体
公开(公告)号：US20150306567A1
公开(公告)日：2015-10-29
申请号：US14647840
申请日：2013-11-26
申请人： Benedict Yorke JOHNSON , Li LIU , Samuel Odei OWUSU , CORNING INCORPORATED
发明人： Benedict Yorke Johnson , Li Liu , Samuel Odei Owusu
IPC分类号： B01J20/24 , B01J20/32 , B01J20/28 , C02F1/28 , B01J20/10
CPC分类号： B01J20/24 , B01J20/103 , B01J20/28042 , B01J20/28045 , B01J20/3204 , B01J20/3234 , B01J20/3236 , B01J20/3274 , B01J20/3289 , C02F1/281 , C02F1/286 , C02F1/288 , C02F2101/20 , C02F2101/206 , C02F2101/22
摘要： Embodiments of a method of making a sorbent comprise providing a monolith having a plurality of internal channels, providing at least one silica coating onto walls of the plurality of internal channels by applying a silica coating solution, and providing at least one chitosan coating on the silica coating by applying a chitosan coating solution.
摘要翻译：制备吸附剂的方法的实施方案包括提供具有多个内部通道的整料，通过施加二氧化硅涂覆溶液在多个内部通道的壁上提供至少一种二氧化硅涂层，并在二氧化硅上提供至少一种壳聚糖涂层通过涂覆壳聚糖涂层溶液进行涂布。

7. 发明申请

US20140329244A1 APPARATUS FOR AMPLIFICATION OF NUCLEIC ACIDS 有权
标题翻译：用于放大核酸的装置
公开(公告)号：US20140329244A1
公开(公告)日：2014-11-06
申请号：US14128486
申请日：2012-06-25
申请人： Zhimin Ding , Fang Wu , Li Liu
发明人： Zhimin Ding , Fang Wu , Li Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L7/52 , B01L2200/028 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/043 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827
摘要： Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification of nucleic acids. More specifically, this invention provides integrated semiconductor chip, manufactured with standard semiconductor manufacturing process, with on-chip circuitry to perform thermal management and optical sensing necessary for amplification of nucleic acids. The apparatus and methods embodied in this invention makes it possible to build a disease diagnosis and prognosis tool that is easy to use, portable and disposable.
摘要翻译：本文描述了用于扩增核酸的基于芯片的装置，容纳该装置的盒和使用用于扩增核酸的装置的方法。更具体地，本发明提供了具有标准半导体制造工艺制造的集成半导体芯片，具有片上电路以执行核酸扩增所需的热管理和光学感测。本发明实施的装置和方法使得构建易于使用，便携和一次性的疾病诊断和预后工具成为可能。

8. 发明授权

US08842582B2 Reducing power consumption by taking advantage of superior in-circuit duplexer performance 有权
标题翻译：通过利用卓越的在线双工器性能来降低功耗
公开(公告)号：US08842582B2
公开(公告)日：2014-09-23
申请号：US12794195
申请日：2010-06-04
申请人： Prasad S. Gudem , Soon-Seng Lau , Li Liu
发明人： Prasad S. Gudem , Soon-Seng Lau , Li Liu
IPC分类号： H04B7/005 , H04B3/36 , H04B1/10 , H04W52/02 , H04B1/52
CPC分类号： H04B1/525 , H04B1/109 , H04W52/0238 , Y02D70/1242 , Y02D70/164 , Y02D70/40
摘要： Although the duplexer in a full-duplex transceiver circuit may only be guaranteed by the duplexer manufacturer to have a transmit band rejection from its TX port to its RX port of a certain amount, and may only be guaranteed to have a receive band rejection of another amount, the actual transmit band rejection and the actual receive band rejection of a particular instance of the duplexer may be better than specified. Rather than consuming excess power in the receiver and/or transmitter in order to meet performance requirements assuming the duplexer only performs as well as specified, the duplexer's in-circuit performance is measured as part of a transmitter-to-receiver isolation determination. Transmitter and/or receiver power settings are reduced where possible to take advantage of the measured better-than-specified in-circuit duplexer performance, while still meeting transceiver performance requirements. Power settings are not changed during normal transmit and receive mode operation.
摘要翻译：虽然全双工收发器电路中的双工器可能只能由双工器制造商保证从其TX端口到其一定数量的RX端口的发射波段抑制，并且只能保证具有另一个的接收频带抑制数量，双工器的特定实例的实际发射频带抑制和实际接收频带抑制可能优于指定的。假设双工器仅执行指定，而不是在接收机和/或发射机中消耗多余的功率，以满足性能要求，则双工器的在线性能是作为发射机到接收机隔离确定的一部分进行测量的。发射机和/或接收机功率设置在可能的情况下可以减少，以便在仍然满足收发器性能要求的同时利用测得的优于指定的在线双工器性能。在正常的发送和接收模式操作期间，电源设置不会改变。

9. 发明申请

US20130331345A1 PUERARIN HYDRATES, PREPARATION METHODS AND USES THEREOF 审中-公开
标题翻译： PUERARIN水合物，其制备方法及其用途
公开(公告)号：US20130331345A1
公开(公告)日：2013-12-12
申请号：US13993837
申请日：2010-12-17
申请人： Li Liu
发明人： Li Liu
IPC分类号： A61K31/7048
CPC分类号： A61K31/7048 , A61K9/0019 , A61K9/0048 , A61K9/06 , A61K9/08 , A61K9/1623 , A61K9/2054 , A61K9/4866 , C07D407/04
摘要： The present invention pertains to the field of pharmaceutical and chemical engineering, and relates to a puerarin hydrate, the preparation method and use thereof. Specifically, said puerarin hydrate has a molecular formula of C21H20O9.n H2O, in which n is a value of 0.8-1.3. The present invention further relates to a pharmaceutical composition comprising said puerarin hydrate, and a method for the treatment of cardiovascular diseases or eye diseases. The puerarin hydrate of the present invention is more stable than puerarin without water of crystallization, convenient for storage and transportation, and has good fluidity at room temperature thereby easy for the manufacture of preparations.
摘要翻译：本发明涉及药物和化学工程领域，涉及葛根素水合物，其制备方法和用途。具体地说，所述葛根素水合物具有C 21 H 20 O 9·n H 2 O的分子式，其中n为0.8-1.3的值。本发明还涉及包含所述葛根素水合物的药物组合物和用于治疗心血管疾病或眼睛疾病的方法。本发明的葛根素水合物比没有结晶水的葛根素更稳定，便于储存和运输，并且在室温下具有良好的流动性，从而易于制备制剂。

10. 发明申请

US20130231346A1 METHODS OF TREATING CANCER 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：US20130231346A1
公开(公告)日：2013-09-05
申请号：US13988054
申请日：2011-11-17
申请人： Tona M. Gilmer , Peter F. Lebowitz , Li Liu , Jolly Mazumdar
发明人： Tona M. Gilmer , Peter F. Lebowitz , Li Liu , Jolly Mazumdar
IPC分类号： A61K31/519 , A61K31/415 , A61K45/06 , A61K31/501 , A61K31/439
CPC分类号： A61K31/519 , A61K31/415 , A61K31/436 , A61K31/439 , A61K31/501 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
摘要： Methods for treating a human with cancer comprise administering a therapeutically effective amount of at least one MEK inhibitor and at least one mTOR inhibitor to said patient, wherein said patient has at least one mutation in at least one Ras protein or gene encoding at least one Ras protein and/or wherein said patient has at least one mutation, deletion or insertion in LKB1/STK11.
摘要翻译：用癌症治疗人的方法包括向所述患者施用治疗有效量的至少一种MEK抑制剂和至少一种mTOR抑制剂，其中所述患者在至少一种Ras蛋白或编码至少一种Ras的基因中具有至少一个突变蛋白质和/或其中所述患者在LKB1 / STK11中具有至少一个突变，缺失或插入。

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