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1. 发明授权

US07582764B2 Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids 有权
标题翻译：由双功能甜菜碱生物碱催化的不对称碳 - 碳键形成反应
公开(公告)号：US07582764B2
公开(公告)日：2009-09-01
申请号：US11442742
申请日：2006-05-26
申请人： Li Deng , Hongming Li , Yi Wang , Fanghui Wu
发明人： Li Deng , Hongming Li , Yi Wang , Fanghui Wu
IPC分类号： C07D453/04
CPC分类号： C07F9/6561 , B01J31/0204 , B01J31/0237 , B01J31/0244 , B01J31/0271 , B01J2231/348 , C07B2200/07 , C07C45/69 , C07C253/30 , C07C269/06 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D453/04 , C07C255/19 , C07C255/23 , C07C255/31 , C07C255/41 , C07C255/46 , C07C255/47 , C07C271/18 , C07C271/22
摘要： One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an O-aryl group or an O-aroyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an optionally substituted O-diazene group or an optionally substituted O-benzoyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain a thiourea at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an NH(═S)NH-aryl group at the C9 position. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or prochiral imine, comprising the step of: reacting a prochiral alkene or imine with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. In certain embodiments, the nucleophile is a malonate or β-ketoester. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate.Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic aldehyde or racemic ketone with a nucleophile in the presence of a derivatized quinine or quinidine, thereby producing a non-racemic, chiral compound. In certain embodiments, the kinetic resolution is dynamic.
摘要翻译：本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。在某些实施方案中，基于奎宁和奎尼丁的催化剂在6'位置含有羟基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有O-芳基或O-芳酰基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有任选取代的O-二氮烯基或任选取代的O-苯甲酰基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有硫脲。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有NH（-S）NH-芳基。本发明的另一方面涉及从前手性电子缺乏烯烃或前手性亚胺制备手性非外消旋化合物的方法，其包括以下步骤：在催化剂存在下使前手性烯烃或亚胺与亲核试剂反应 ; 从而产生手性，非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。在某些实施方案中，亲核试剂是丙二酸酯或β-酮酯。在某些实施方案中，亲核试剂是烷基或芳基或2-氰基-2-烷基乙酸烷基酯。在某些实施方案中，亲核试剂是烷基或芳基或2-氰基-2-烷基乙酸烷基酯。本发明的另一方面涉及一种动力学拆分方法，其包括以下步骤：在衍生化的奎宁或奎尼丁存在下，使外消旋醛或外消旋酮与亲核试剂反应，从而产生非外消旋的手性化合物。在某些实施方案中，动力学分辨率是动态的。

2. 发明申请

US20070083049A1 Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids 有权
标题翻译：由双功能甜菜碱生物碱催化的不对称碳 - 碳键形成反应
公开(公告)号：US20070083049A1
公开(公告)日：2007-04-12
申请号：US11442742
申请日：2006-05-26
申请人： Li Deng , Hongming Li , Yi Wang , Fanghui Wu
发明人： Li Deng , Hongming Li , Yi Wang , Fanghui Wu
IPC分类号： C07F9/60 , C07F7/02 , C07D453/04 , C07C45/00 , C07C253/30 , C07C67/36
CPC分类号： C07F9/6561 , B01J31/0204 , B01J31/0237 , B01J31/0244 , B01J31/0271 , B01J2231/348 , C07B2200/07 , C07C45/69 , C07C253/30 , C07C269/06 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D453/04 , C07C255/19 , C07C255/23 , C07C255/31 , C07C255/41 , C07C255/46 , C07C255/47 , C07C271/18 , C07C271/22
摘要： One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an O-aryl group or an O-aroyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an optionally substituted O-diazene group or an optionally substituted O-benzoyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain a thiourea at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an NH(═S)NH-aryl group at the C9 position. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or prochiral imine, comprising the step of: reacting a prochiral alkene or imine with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. In certain embodiments, the nucleophile is a malonate or β-ketoester. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate. Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic aldehyde or racemic ketone with a nucleophile in the presence of a derivatized quinine or quinidine, thereby producing a non-racemic, chiral compound. In certain embodiments, the kinetic resolution is dynamic.
摘要翻译：本发明的一个方面涉及基于奎宁和奎尼丁的催化剂。在某些实施方案中，基于奎宁和奎尼丁的催化剂在6'位置含有羟基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有O-芳基或O-芳酰基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有任选取代的O-二氮烯基或任选取代的O-苯甲酰基。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有硫脲。在某些实施方案中，基于奎宁和奎尼丁的催化剂在C 9位含有NH（-S）NH-芳基。本发明的另一方面涉及从前手性电子缺乏烯烃或前手性亚胺制备手性非外消旋化合物的方法，其包括以下步骤：在催化剂存在下使前手性烯烃或亚胺与亲核试剂反应 ; 从而产生手性，非外消旋化合物; 其中所述催化剂是衍生的奎宁或奎尼丁。在某些实施方案中，亲核试剂是丙二酸酯或β-酮酯。在某些实施方案中，亲核试剂是烷基或芳基或2-氰基-2-烷基乙酸烷基酯。在某些实施方案中，亲核试剂是烷基或芳基或2-氰基-2-烷基乙酸烷基酯。本发明的另一方面涉及一种动力学拆分方法，其包括以下步骤：在衍生化的奎宁或奎尼丁存在下，使外消旋醛或外消旋酮与亲核试剂反应，从而产生非外消旋的手性化合物。在某些实施方案中，动力学分辨率是动态的。

3. 发明申请

US20210298596A1 CORNEA PROJECTION DEVICE FOR OPHTHALMIC SLIT LAMP MICROSCOPE 有权
公开(公告)号：US20210298596A1
公开(公告)日：2021-09-30
申请号：US16827761
申请日：2020-03-24
申请人： Yi Wang
发明人： Yi Wang
IPC分类号： A61B3/135
摘要： An additional cornea projection device for ophthalmic slit lamp microscope, comprising: a cornea projection device, a slit lamp microscope optical body, a curved arm and the connecting part. The cornea projection device is connected to the upper or lower part of the optical body of the slit lamp microscope, or to the left or right side of the curved arm. When the cornea projection device is not in use, it can be rotated to a non-working position while being kept connected, and there is no obstacle to the normal use of the slit light source projection device of the ophthalmic slit lamp microscope. An ophthalmic slit lamp microscope with a cornea projection device has a simple overall structure, reliable performance, low cost, obvious advantages, convenient for production, debugging and maintenance.

4. 发明授权

US10760391B2 Method for recovering hydrocarbons from low permeability formations 有权
公开(公告)号：US10760391B2
公开(公告)日：2020-09-01
申请号：US15776139
申请日：2016-11-16
申请人： NEXEN ENERGY ULC , Roberto Aguilera , Alfonso Fragoso , Yi Wang , Guicheng Jing
发明人： Roberto Aguilera , Alfonso Fragoso , Yi Wang , Guicheng Jing , Karthikeyan Selvan , Thomas Harding , Faisal Qureshi
IPC分类号： E21B43/40 , E21B43/16 , E21B43/25 , E21B43/18 , E21B43/12 , E21B47/06
摘要： There is provided a method of producing hydrocarbon material. A first hydrocarbon material is produced from the formation, the first hydrocarbon material including a gaseous hydrocarbon material originally in place in the formation. At least a portion of the produced gaseous hydrocarbon material is injected into the formation to increase the formation pressure. A second hydrocarbon material is produced from the formation.

5. 发明授权

US10172202B2 Circuit arrangement for controlling a LED unit and method of operating the same 有权
公开(公告)号：US10172202B2
公开(公告)日：2019-01-01
申请号：US14241489
申请日：2012-08-29
申请人： Dennis Johannes Antonius Claessens , Jascha Van Pommeren , Jan Wojciech Obrebski , Yi Wang , Philip Louis Zulma Vael , Sait Izmit
发明人： Dennis Johannes Antonius Claessens , Jascha Van Pommeren , Jan Wojciech Obrebski , Yi Wang , Philip Louis Zulma Vael , Sait Izmit
IPC分类号： H05B33/08
摘要： A circuit arrangement for controlling the brightness of at least one LED unit is described by the disclosure. The circuit arrangement, in one example, includes an input for receiving a phase-cut operating voltage from a power supply, a signal processor, connected with the input and adapted to provide a dimming signal for the at least one LED unit from the operating voltage. To allow an efficient reduction of noise in the dimming signal but simultaneously to allow an improved dimming of the LED unit, the signal processor are configured to operate at least in a noise suppression mode and a dimming mode. A control device is provided, connected with the signal processor and configured to set the mode of the signal processor in dependence of the variation in the operating voltage.

6. 发明授权

US10150876B2 Paint coating material for producing an imitation ceramic effect and its application method thereof 有权
公开(公告)号：US10150876B2
公开(公告)日：2018-12-11
申请号：US15169289
申请日：2016-05-31
申请人： Yi Wang
发明人： Yi Wang
IPC分类号： C09D5/28 , C09D133/08 , B05D5/06 , B05D7/00 , B44F11/06 , C09D5/02 , C09D133/06 , C09D7/47 , B05D7/02 , C08L1/28
摘要： A coating material with a primer layer, a middle layer and a surface layer and its method of application which includes the steps: (1) spraying the primer layer material onto an article; (2) spraying or brushing the middle layer material with a first color until satisfactorily coated; (3) repeating step (2) with the middle layer material having a second color and allowing drying; and (4) spraying the surface layer material of PU imitation porcelain material and allow drying to obtain the article with superior imitation ceramic effect. The present invention can be applied to any plastic and poly articles with a contoured body, making a highly imitative ceramic article such as pot or vase to replacing the existing authentic ceramic articles. Since the material being used is biodegradable, therefore effectively decreasing the level of pollution and damages to the environment and hence lessening the health hazards to human.

7. 发明申请

US20180311345A1 A METHOD OF INHIBITING EXACERBATIONS OF T CELL-MEDIATED ALLOGRAFT VASCULOPATHY 审中-公开
公开(公告)号：US20180311345A1
公开(公告)日：2018-11-01
申请号：US15771835
申请日：2016-10-28
申请人： Jordan POBER , Daniel JANE-WIT , Lingfeng QIN , Yi WANG , Alexion Pharmaceuticals, Inc. , Yale University
发明人： Jordan Pober , Daniel Jane-Wit , Lingfeng Qin , Yi Wang
IPC分类号： A61K39/395 , C07K16/28 , A61P37/06 , C07K16/40 , A61P9/00
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/76
摘要： The disclosure provides a method of reducing the likelihood of forming a T cell-mediated allograft vasculopathy lesion in a mammalian transplant recipient comprising transplanting an allograft from a donor to a recipient and administering a therapeutically effective amount of an anti-C5 antibody, or antigen-binding fragment thereof, to the recipient, wherein the anti-C5 antibody, or antigen-binding fragment thereof reduces the likelihood of forming an allograft vasculopathy lesion in the allograft, compared to the absence of treatment with an anti-C5 antibody, or antigen-binding fragment thereof.

8. 发明申请

US20180168109A1 Flower Pot 审中-公开
公开(公告)号：US20180168109A1
公开(公告)日：2018-06-21
申请号：US15584407
申请日：2017-05-02
申请人： Yi Wang
发明人： Yi Wang
IPC分类号： A01G9/04 , A01G9/02
CPC分类号： A01G9/042 , A01G9/021
摘要： A flower pot includes a main body and a water collection basin. The main body has a receiving cavity and at least one opening formed on a bottom portion thereof. The opening communicates the receiving cavity with an exterior of the main body. The water collection basin is formed underneath the main body, and is integrally extended from the bottom portion of the main body to act as a base for the flower pot.

9. 发明授权

US09771904B2 Self-cleaning air filtering material and preparation method therefor 有权
公开(公告)号：US09771904B2
公开(公告)日：2017-09-26
申请号：US14396530
申请日：2012-04-25
申请人： Jian Hu , Yun Liang , Yi Wang , Jingshan Zeng
发明人： Jian Hu , Yun Liang , Yi Wang , Jingshan Zeng
IPC分类号： B01D46/00 , F02M35/08 , B01D39/16
CPC分类号： F02M35/086 , B01D39/1607 , B01D46/0067 , B01D2239/025 , B01D2239/0654
摘要： Provided are a self-cleaning air filtering material and a preparation method therefor. The air filtering material comprises: a submicron fiber layer (2) at an inflow surface for surface filtration, a supporting area (3) for supporting and a mixed area (5) between the submicron fiber layer (2) and the supporting area (3), wherein the mixed area (5) is formed by contacting and mixing part of the fibers in the submicron fiber layer (2) and the supporting area (3) with each other during the one-step formation of the submicron fiber layer (2) and the supporting area (3) by passing through a double-layer headbox.

10. 发明授权

US09572514B2 Magnetic resonance imaging concepts 有权
标题翻译：磁共振成像概念
公开(公告)号：US09572514B2
公开(公告)日：2017-02-21
申请号：US13584367
申请日：2012-08-13
申请人： Yi Wang , He Zhu
发明人： Yi Wang , He Zhu
IPC分类号： A61B5/055 , G01R33/561 , G01R33/48 , G01R33/56 , G01R33/563 , G01R33/567
CPC分类号： A61B5/055 , G01R33/4824 , G01R33/5602 , G01R33/5607 , G01R33/561 , G01R33/5614 , G01R33/5635 , G01R33/5676
摘要： A method for producing multiple temporal frames of a time-resolved contrast enhanced magnetic resonance angiogram from a subject using an MR contrast agent by repeatedly applying RF pulses and sampling data in the corresponding image k-space along spiral trajectories that start at the k-space center and spiral outward toward the k-space edge.
摘要翻译：一种用于通过重复地施加RF脉冲并且沿着从k空间开始的螺旋轨迹在相应图像k空间中采样数据来产生来自使用MR造影剂的对象的时间分辨对比增强磁共振血管造影图的多个时间帧的方法中心并朝向k空间边缘向外螺旋。

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