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1. 发明申请

US20120157825A1 Navigational Reference Dislodgement Detection Method and System 有权
标题翻译：导航参考检测方法与系统
公开(公告)号：US20120157825A1
公开(公告)日：2012-06-21
申请号：US12972253
申请日：2010-12-17
申请人： Lev A. Koyrakh , Jeffrey A. Schweitzer , Daniel R. Starks , Carlos Carbonera
发明人： Lev A. Koyrakh , Jeffrey A. Schweitzer , Daniel R. Starks , Carlos Carbonera
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/042 , A61B5/05 , A61B5/062 , A61B5/063 , A61B5/7207 , A61B5/7221 , A61B34/20 , A61B2034/2051 , A61B2034/2053 , A61B2034/2072
摘要： A method of detecting dislodgement of a navigational reference for a localization system includes securing a reference catheter, including at least one reference localization element, at an initial reference location within a localization field. The positions of one or more of the reference localization elements are monitored for a perceived displacement that suggests that the reference catheter has become dislodged from the initial reference location (e.g., a displacement above a certain threshold, such as about 4 mm). The direction of this perceived displacement may then be further analyzed (e.g., compared to a predicted or most likely direction of displacement) to determine whether there has been an actual dislodgement of the reference catheter, and, if so, an appropriate signal (e.g., an audible or visual warning) may be generated. Upon dislodgement, guidance may be provided to aid the practitioner in restoring the reference catheter to its initial location.
摘要翻译：检测用于定位系统的导航参考的移动的方法包括在定位区域内的初始参考位置处固定包括至少一个参考定位元件的参考导管。监测一个或多个参考定位元件的位置以感知到的位移，其表明参考导管已经从初始参考位置移除（例如，高于某个阈值的位移，例如约4mm）。然后可以进一步分析这种感知的位移的方向（例如，与预期的或最可能的位移方向相比较），以确定是否已经存在参考导管的实际移动，并且如果是，则适当的信号（例如，可能会产生声音或视觉警告）。在移动时，可以提供指导以帮助从业者将参考导管恢复到其初始位置。

2. 发明授权

US09585586B2 Navigational reference dislodgement detection method and system 有权
标题翻译：导航参考检测方法及系统
公开(公告)号：US09585586B2
公开(公告)日：2017-03-07
申请号：US12972253
申请日：2010-12-17
申请人： Lev A. Koyrakh , Jeffrey A. Schweitzer , Daniel R. Starks , Carlos Carbonera
发明人： Lev A. Koyrakh , Jeffrey A. Schweitzer , Daniel R. Starks , Carlos Carbonera
IPC分类号： A61B5/042 , A61B5/00
CPC分类号： A61B5/06 , A61B5/042 , A61B5/05 , A61B5/062 , A61B5/063 , A61B5/7207 , A61B5/7221 , A61B34/20 , A61B2034/2051 , A61B2034/2053 , A61B2034/2072
摘要： A method of detecting dislodgement of a navigational reference for a localization system includes securing a reference catheter, including at least one reference localization element, at an initial reference location within a localization field. The positions of one or more of the reference localization elements are monitored for a perceived displacement that suggests that the reference catheter has become dislodged from the initial reference location (e.g., a displacement above a certain threshold, such as about 4 mm). The direction of this perceived displacement may then be further analyzed (e.g., compared to a predicted or most likely direction of displacement) to determine whether there has been an actual dislodgement of the reference catheter, and, if so, an appropriate signal (e.g., an audible or visual warning) may be generated. Upon dislodgement, guidance may be provided to aid the practitioner in restoring the reference catheter to its initial location.
摘要翻译：检测用于定位系统的导航参考的移动的方法包括在定位区域内的初始参考位置处固定包括至少一个参考定位元件的参考导管。监测一个或多个参考定位元件的位置以感知到的位移，其表明参考导管已经从初始参考位置移除（例如，高于某个阈值的位移，例如约4mm）。然后可以进一步分析这种感知的位移的方向（例如，与预期的或最可能的位移方向相比较），以确定是否已经存在参考导管的实际移动，并且如果是，则适当的信号（例如，可能会产生声音或视觉警告）。在移动时，可以提供指导以帮助从业者将参考导管恢复到其初始位置。

3. 发明授权

US09560988B2 System and method for rendering an image of an elongate medical device 有权
标题翻译：用于渲染细长医疗装置的图像的系统和方法
公开(公告)号：US09560988B2
公开(公告)日：2017-02-07
申请号：US12980732
申请日：2010-12-29
申请人： Carlos Carbonera , Daniel R. Starks , Lev A. Koyrakh
发明人： Carlos Carbonera , Daniel R. Starks , Lev A. Koyrakh
IPC分类号： A61B5/05 , A61B5/06 , A61B5/00
CPC分类号： A61B5/065 , A61B5/6855
摘要： A system for visually rendering an elongate medical device in a body is provided. The system includes an electronic control unit configured to find a measured physical location for each of a plurality of position sensors on the elongate medical device. The electronic control unit is further configured to apply a spline function to each of the measured physical locations to determine a display location for each position sensor. The electronic control unit is further configured to interpolate between display locations of adjacent position sensors to identify display locations for portions of the elongate medical device between adjacent position sensors. The electronic control unit is further configured to generate image data for display of an image of the elongate medical device including the display locations of the position sensors and the display locations of the portions of the elongate medical device between adjacent position sensors.
摘要翻译：提供了一种用于在身体中视觉呈现细长医疗装置的系统。该系统包括电子控制单元，其配置成为细长医疗装置上的多个位置传感器中的每一个找到测量的物理位置。电子控制单元还被配置为向所测量的物理位置中的每一个施加样条函数，以确定每个位置传感器的显示位置。电子控制单元还被配置为在相邻位置传感器的显示位置之间插值，以识别相邻位置传感器之间的细长医疗设备的部分的显示位置。电子控制单元还被配置为产生用于显示细长医疗装置的图像的图像数据，其包括位置传感器的显示位置和细长医疗装置在相邻位置传感器之间的部分的显示位置。

4. 发明授权

US10918307B2 Catheter navigation using impedance and magnetic field measurements 有权
公开(公告)号：US10918307B2
公开(公告)日：2021-02-16
申请号：US13231284
申请日：2011-09-13
申请人： Eric S. Olson , Carlos Carbonera , Lev A. Koyrakh , Daniel R. Starks
发明人： Eric S. Olson , Carlos Carbonera , Lev A. Koyrakh , Daniel R. Starks
IPC分类号： A61B5/00 , A61B5/06 , A61B34/20 , A61B5/0538 , A61B90/00
摘要： A method of operating a positioning system by registering a first coordinate system of a first positioning system in a second coordinate system of a second positioning system includes determining an interpolation function configured to register the first, non-orthonormal coordinate system in the second, orthonormal coordinate system. Fiducial pairs are collected by the respective positioning systems, each of which contain a respective coordinate in the respective coordinate system, both of which refer to the same physical point in three dimensional space. Establishing a working interpolation function involves an analysis of the fiducial pairs using a thin-plate spline algorithm. The method further includes repeatedly obtaining a first coordinate in the first coordinate system and determining a corresponding second coordinate in the second coordinate system in accordance with the interpolation function.

5. 发明申请

US20130066193A1 CATHETER NAVIGATION USING IMPEDANCE AND MAGNETIC FIELD MEASUREMENTS 审中-公开
标题翻译：使用阻抗和磁场测量的导管导航
公开(公告)号：US20130066193A1
公开(公告)日：2013-03-14
申请号：US13231284
申请日：2011-09-13
申请人： Eric S. Olson , Carlos Carbonera , Lev A. Koyrakh , Daniel R. Starks
发明人： Eric S. Olson , Carlos Carbonera , Lev A. Koyrakh , Daniel R. Starks
IPC分类号： A61B5/05
CPC分类号： A61B5/063 , A61B5/0538 , A61B5/062 , A61B5/6852 , A61B5/7207 , A61B34/20 , A61B2034/2051 , A61B2034/2053 , A61B2090/0818
摘要： A method of operating a positioning system by registering a first coordinate system of a first positioning system in a second coordinate system of a second positioning system includes determining an interpolation function configured to register the first, non-orthonormal coordinate system in the second, orthonormal coordinate system. Fiducial pairs are collected by the respective positioning systems, each of which contain a respective coordinate in the respective coordinate system, both of which refer to the same physical point in three dimensional space. Establishing a working interpolation function involves an analysis of the fiducial pairs using a thin-plate spline algorithm. The method further includes repeatedly obtaining a first coordinate in the first coordinate system and determining a corresponding second coordinate in the second coordinate system in accordance with the interpolation function.
摘要翻译：一种通过在第二定位系统的第二坐标系中登记第一定位系统的第一坐标系来操作定位系统的方法包括确定配置成在第二正交坐标系中登记第一非正交坐标系的内插函数系统。基准对由相应的定位系统收集，每个定位系统在相应的坐标系中包含相应的坐标系，两者均指三维空间中相同的物理点。建立工作插值函数涉及使用薄板样条算法对基准对的分析。该方法还包括重复地获得第一坐标系中的第一坐标并根据插值函数确定第二坐标系中的对应的第二坐标。

6. 发明申请

US20120172713A1 SYSTEM AND METHOD FOR RENDERING AN IMAGE OF AN ELONGATE MEDICAL DEVICE 有权
标题翻译：用于呈现ELENATE医疗装置的图像的系统和方法
公开(公告)号：US20120172713A1
公开(公告)日：2012-07-05
申请号：US12980732
申请日：2010-12-29
申请人： Carlos Carbonera , Daniel R. Starks , Lev A. Koyrakh
发明人： Carlos Carbonera , Daniel R. Starks , Lev A. Koyrakh
IPC分类号： A61B5/05
CPC分类号： A61B5/065 , A61B5/6855
摘要： A system for visually rendering an elongate medical device in a body is provided. The system includes an electronic control unit configured to find a measured physical location for each of a plurality of position sensors on the elongate medical device. The electronic control unit is further configured to apply a spline function to each of the measured physical locations to determine a display location for each position sensor. The electronic control unit is further configured to interpolate between display locations of adjacent position sensors to identify display locations for portions of the elongate medical device between adjacent position sensors. The electronic control unit is further configured to generate image data for display of an image of the elongate medical device including the display locations of the position sensors and the display locations of the portions of the elongate medical device between adjacent position sensors.
摘要翻译：提供了一种用于在身体中视觉呈现细长医疗装置的系统。该系统包括电子控制单元，其配置成为细长医疗装置上的多个位置传感器中的每一个找到测量的物理位置。电子控制单元还被配置为向所测量的物理位置中的每一个施加样条函数，以确定每个位置传感器的显示位置。电子控制单元还被配置为在相邻位置传感器的显示位置之间插值，以识别相邻位置传感器之间的细长医疗设备的部分的显示位置。电子控制单元还被配置为产生用于显示细长医疗装置的图像的图像数据，其包括位置传感器的显示位置和细长医疗装置在相邻位置传感器之间的部分的显示位置。

7. 发明申请

US20140155721A1 CORRECTION OF SHIFT AND DRIFT IN IMPEDANCE-BASED MEDICAL DEVICE NAVIGATION USING MEASURED IMPEDANCES AT EXTERNAL PATCH ELECTRODES 有权
标题翻译：使用外部贴片电极测量的阻抗进行基于阻抗的医疗设备导航中的移位和移位校正
公开(公告)号：US20140155721A1
公开(公告)日：2014-06-05
申请号：US13690737
申请日：2012-11-30
申请人： John A. Hauck , Jeffrey A. Schweitzer , Lev A. Koyrakh
发明人： John A. Hauck , Jeffrey A. Schweitzer , Lev A. Koyrakh
IPC分类号： A61B5/06
CPC分类号： A61B5/063 , A61B5/053 , A61B5/6801 , A61B5/742
摘要： A system and method are provided for determining characteristics of a device electrode disposed on a medical device within a body. A plurality of measurement electrodes are coupled to an external surface of the body and establish transmission paths for current through the body. An electronic control unit (ECU) is configured to cause transmission of current between a pair of active electrodes selected from the measurement electrodes and thereby generate a voltage on the device electrode. The ECU receives impedance signals from a plurality of passive electrodes among the measurement electrodes other than the active electrodes. The ECU establishes a virtual reference electrode at a reference position within the body responsive to the impedance signals and computes a position of the device responsive to the voltage on the device electrode and the reference position of the reference electrode. The ECU may also compute impedances at the device and measurement electrodes.
摘要翻译：提供了一种用于确定设置在身体内的医疗装置上的装置电极的特性的系统和方法。多个测量电极耦合到身体的外表面并建立用于通过身体的电流的传输路径。电子控制单元（ECU）被配置为在从测量电极中选择的一对有源电极之间引起电流的传输，从而在器件电极上产生电压。 ECU从除了有源电极之外的测量电极中的多个无源电极接收阻抗信号。 ECU根据阻抗信号在主体内的参考位置建立虚拟参考电极，并根据器件电极上的电压和参考电极的参考位置计算器件的位置。 ECU还可以计算设备和测量电极处的阻抗。

8. 发明授权

US09125573B2 Electrically transparent introducer sheath 有权
标题翻译：电导透镜护套
公开(公告)号：US09125573B2
公开(公告)日：2015-09-08
申请号：US13339547
申请日：2011-12-29
申请人： Lev A. Koyrakh , Daniel J. Potter , Jeffrey A. Schweitzer , D. Curtis Deno , Anthony D. Hill , Dale Eric Just
发明人： Lev A. Koyrakh , Daniel J. Potter , Jeffrey A. Schweitzer , D. Curtis Deno , Anthony D. Hill , Dale Eric Just
IPC分类号： A61B5/04 , A61M25/06 , A61B5/053 , A61B5/145 , A61B5/024 , A61M25/00
CPC分类号： A61B5/04 , A61B5/02444 , A61B5/0538 , A61B5/14503 , A61B2560/06 , A61M25/005 , A61M25/0662
摘要： An introducer sheath for a medical device is provided. The sheath includes a deformable, elongate body disposed about a longitudinal axis. The body has proximal and distal ends and defines a lumen extending between the proximal and distal ends and configured to allow passage of the medical device therethrough. The body is configured to allow an electric current to pass radially between a space outside of the body and the lumen such that the position of the medical device within a patient can be monitored and electrogram readings from body tissues can be measured while the device is in the sheath. In some embodiments of the invention, the body may include a one or more apertures extending from the radially outer surface of the body to the lumen or a portion of the body may be made from a conductive and/or fluid permeable material.
摘要翻译：提供了一种用于医疗装置的引导器护套。护套包括围绕纵向轴线设置的可变形的细长体。主体具有近端和远端并且限定在近端和远端之间延伸的构造成允许医疗装置通过的内腔。身体构造成允许电流在身体外部的空间和内腔之间径向通过，使得可以监测患者体内的医疗装置的位置，并且可以在装置处于状态时测量来自身体组织的电描记图读数护套。在本发明的一些实施例中，主体可以包括从主体的径向外表面延伸到内腔的一个或多个孔，或者主体的一部分可以由导电和/或流体可渗透的材料制成。

9. 发明授权

US08849393B2 Correction of shift and drift in impedance-based medical device navigation using measured impedances at external patch electrodes 有权
标题翻译：使用测量的外部贴片电极的阻抗校正基于阻抗的医疗设备导航中的位移和漂移
公开(公告)号：US08849393B2
公开(公告)日：2014-09-30
申请号：US13690737
申请日：2012-11-30
申请人： John A. Hauck , Jeffrey A. Schweitzer , Lev A. Koyrakh
发明人： John A. Hauck , Jeffrey A. Schweitzer , Lev A. Koyrakh
IPC分类号： A61B5/00
CPC分类号： A61B5/063 , A61B5/053 , A61B5/6801 , A61B5/742
摘要： A system and method are provided for determining characteristics of a device electrode disposed on a medical device within a body. A plurality of measurement electrodes are coupled to an external surface of the body and establish transmission paths for current through the body. An electronic control unit (ECU) is configured to cause transmission of current between a pair of active electrodes selected from the measurement electrodes and thereby generate a voltage on the device electrode. The ECU receives impedance signals from a plurality of passive electrodes among the measurement electrodes other than the active electrodes. The ECU establishes a virtual reference electrode at a reference position within the body responsive to the impedance signals and computes a position of the device responsive to the voltage on the device electrode and the reference position of the reference electrode. The ECU may also compute impedances at the device and measurement electrodes.
摘要翻译：提供了一种用于确定设置在身体内的医疗装置上的装置电极的特性的系统和方法。多个测量电极耦合到身体的外表面并建立用于通过身体的电流的传输路径。电子控制单元（ECU）被配置为在从测量电极中选择的一对有源电极之间引起电流的传输，从而在器件电极上产生电压。 ECU从除了有源电极之外的测量电极中的多个无源电极接收阻抗信号。 ECU根据阻抗信号在主体内的参考位置建立虚拟参考电极，并根据器件电极上的电压和参考电极的参考位置计算器件的位置。 ECU还可以计算设备和测量电极处的阻抗。

10. 发明申请

US20130172712A1 ELECTRICALLY TRANSPARENT INTRODUCER SHEATH 有权
标题翻译：电动透明导板
公开(公告)号：US20130172712A1
公开(公告)日：2013-07-04
申请号：US13339547
申请日：2011-12-29
申请人： Lev A. Koyrakh , Daniel J. Potter , Jeffrey A. Schweitzer , D. Curtis Deno , Anthony D. Hill , Dale E. Just
发明人： Lev A. Koyrakh , Daniel J. Potter , Jeffrey A. Schweitzer , D. Curtis Deno , Anthony D. Hill , Dale E. Just
IPC分类号： A61B5/04
CPC分类号： A61B5/04 , A61B5/02444 , A61B5/0538 , A61B5/14503 , A61B2560/06 , A61M25/005 , A61M25/0662
摘要： An introducer sheath for a medical device is provided. The sheath includes a deformable, elongate body disposed about a longitudinal axis. The body has proximal and distal ends and defines a lumen extending between the proximal and distal ends and configured to allow passage of the medical device therethrough. The body is configured to allow an electric current to pass radially between a space outside of the body and the lumen such that the position of the medical device within a patient can be monitored and electrogram readings from body tissues can be measured while the device is in the sheath. In some embodiments of the invention, the body may include a one or more apertures extending from the radially outer surface of the body to the lumen or a portion of the body may be made from a conductive and/or fluid permeable material.
摘要翻译：提供了一种用于医疗装置的引导器护套。护套包括围绕纵向轴线设置的可变形的细长体。主体具有近端和远端并且限定在近端和远端之间延伸的构造成允许医疗装置通过的内腔。身体构造成允许电流在身体外部的空间和内腔之间径向通过，使得可以监测患者体内的医疗装置的位置，并且可以在装置处于状态时测量来自身体组织的电描记图读数护套。在本发明的一些实施例中，主体可以包括从主体的径向外表面延伸到内腔的一个或多个孔，或者主体的一部分可以由导电和/或流体可渗透材料制成。

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