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1. 发明授权

US07670798B2 Automated method and reagent therefor assaying body fluid samples such as cerebrospinal fluid (CSF) 有权
标题翻译：自动化方法和试剂用于测定体液样品如脑脊液（CSF）
公开(公告)号：US07670798B2
公开(公告)日：2010-03-02
申请号：US10442706
申请日：2003-05-20
申请人： Leonard Ornstein , Gena Fischer , David Zelmanovic , Pamela Elsins , Jolanta Kunicka , Michael J. Malin
发明人： Leonard Ornstein , Gena Fischer , David Zelmanovic , Pamela Elsins , Jolanta Kunicka , Michael J. Malin
IPC分类号： G01N1/00 , G01N7/00 , G01N31/00 , G01N33/48 , G01N33/546
CPC分类号： G01N33/96 , A01N1/00 , G01N15/1459 , G01N2015/0073 , G01N2015/1486 , Y10T436/10 , Y10T436/11 , Y10T436/2525
摘要： The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid (CSF) samples. The reagent compositions sphere and fix all cells in the sample in suspension. Reported results can include red blood cell (RBC) and white blood cell (WBC) counts, WBC differential values, cell-by-cell volumes and dry-mass concentrations.
摘要翻译：本发明描述了用于体液样品，特别是非血液样品的测定和分析的半自动和全自动化方法和试剂。方法和试剂对于脑脊液（CSF）样品的测定和分析特别有用。试剂组合物球体并将悬浮液中的样品中的所有细胞固定。报告的结果可以包括红细胞（RBC）和白血球（WBC）计数，WBC差异值，逐个细胞体积和干质量浓度。

2. 发明授权

US06468732B1 METHOD AND LONG-TERM STABLE BICARBONATE-CONTAINING DILUENT COMPOSITION, AND STORAGE MEANS THEREFOR, FOR REDUCING OR REVERSING AERATION INDUCED CELL SHRINKAGE AND STORAGE INDUCED CELL SWELLING OF A WHOLE BLOOD SAMPLE 有权
标题翻译：方法和长期稳定的含二碳酸酯的稀释剂组合物及其储存方法，用于减少或逆转诱导的细胞收缩和储存诱导的全血样品的细胞裂解
公开(公告)号：US06468732B1
公开(公告)日：2002-10-22
申请号：US09819263
申请日：2001-03-28
申请人： Michael J. Malin , Leonard Ornstein
发明人： Michael J. Malin , Leonard Ornstein
IPC分类号： A01N102
CPC分类号： A01N1/02 , A01N1/0226 , Y10T436/107497 , Y10T436/108331
摘要： The invention provides a bicarbonate-containing, crosslinker-free reagent composition which reverses and/or reduces sample handling effects, such as aeration-induced shrinkage and storage-induced swelling of cells in a whole blood sample, particularly for a blood sample requiring repeated sampling and/or subjected to long-term storage. The reagent composition serves as a diluent medium for a blood sample, or an aliquot or portion thereof. The pH of the reagent is in the range of about 7.2 to about 7.5, preferably 7.3. The stability of the pH 7.2-7.5 bicarbonate-containing reagent over time is maintained by storing the reagent in a flexible collapsible container which is impermeable to carbon dioxide and is comprised of a multilayered flexible material, preferably plastic, and attachable to a hematology analyzer.
摘要翻译：本发明提供了一种含碳酸氢盐的不含交联剂的试剂组合物，其反转和/或降低样品处理效果，例如通气诱导的收缩和储存诱导的全血样品中的细胞肿胀，特别是需要重复取样的血液样品和/或经受长期储存。试剂组合物用作血液样品或等分试样或其部分的稀释介质。试剂的pH在约7.2至约7.5的范围内，优选7.3。通过将试剂储存在二氧化碳不可渗透的柔性可折叠容器中并由多层柔性材料（优选塑料）组成并且可连接到血液分析仪来维持pH 7.2-7.5含碳酸氢盐试剂随时间的稳定性。

3. 发明授权

US4744968A Stabilized aqueous hydrogen peroxide solution 失效
标题翻译：稳定的过氧化氢水溶液
公开(公告)号：US4744968A
公开(公告)日：1988-05-17
申请号：US772114
申请日：1985-09-03
申请人： Michael J. Malin , Louis D. Sclafani
发明人： Michael J. Malin , Louis D. Sclafani
IPC分类号： C01B15/037
CPC分类号： C01B15/037
摘要： This invention relates to a novel stabilized aqueous hydrogen peroxide solution which comprises hydrogen peroxide in admixture with an aromatic polysulfonic acid, or a salt thereof.
摘要翻译：本发明涉及一种新颖的稳定的过氧化氢水溶液，其包含与芳族聚磺酸混合的过氧化氢或其盐。

4. 发明授权

US5858794A Cyanide-containing hemoglobin reagent composition and method providing acceptable precision, accuracy and freedom from white cell interference on automated hematology analyzers 失效
标题翻译：含氰化物的血红蛋白试剂组合物和方法在自动血液分析仪上提供可接受的精确度，准确度和免受白细胞干扰的自由
公开(公告)号：US5858794A
公开(公告)日：1999-01-12
申请号：US854914
申请日：1997-05-13
申请人： Michael J. Malin
发明人： Michael J. Malin
IPC分类号： G01N33/483 , G01N33/50 , G01N33/72
CPC分类号： G01N33/721 , G01N33/5094 , Y10T436/10 , Y10T436/107497 , Y10T436/108331 , Y10T436/25125
摘要： The invention describes an improved stable reagent composition and method for the determination of hemoglobin (Hb) using whole blood samples and automated hematology analyzers. The Hb reagent contains an inorganic cyanide salt, at least one surfactant and a base and has a final pH of about 10.0 to about 11.2, preferably about 10.4 to about 11.2 or less and more preferably about 10.8 to about 11.2 or less. This reagent is intended for use as a universal Hb determination reagent for all of the instruments in the aforementioned series and will provide accurate and precise results without accompanying interference from elevated numbers of white blood cells, especially as found in abnormal blood specimens, and without system-to-system variation in the results obtained.
摘要翻译：本发明描述了使用全血样品和自动血液分析仪测定血红蛋白（Hb）的改进的稳定试剂组合物和方法。 Hb试剂含有无机氰化物盐，至少一种表面活性剂和碱，其最终pH为约10.0至约11.2，优选约10.4至约11.2或更小，更优选约10.8至约11.2或更低。该试剂适用于上述系列中所有仪器的通用Hb测定试剂，可提供准确，精确的结果，无需附加白细胞数量增加的干扰，特别是异常血液标本中无发现，无系统所得结果的系统变化。

5. 发明授权

US4565688A Quaternized phthalocyanin derivatives 失效
标题翻译：季铵化酞菁衍生物
公开(公告)号：US4565688A
公开(公告)日：1986-01-21
申请号：US551242
申请日：1983-11-14
申请人： Michael J. Malin , Bernard Loev , Deng R. Hwang
发明人： Michael J. Malin , Bernard Loev , Deng R. Hwang
IPC分类号： C09B47/26 , C09B47/32 , G01N33/48 , G01N33/50 , C09B47/04 , C09B47/30
CPC分类号： C09B47/32 , G01N33/5094
摘要： New phthalocyanin derivatives which can be used to differentiate basophils from other blood cells are disclosed. The compounds to which the present invention are quaternary salts of a substituted phthalocyanin structure wherein the substitutions are each independently hydrogen, sulfonate, or a C.sub.1 -C.sub.7 hydrocarbon, optionally containing at least one heteroatom, with the proviso that at least one of them is ##STR1## in which R.sub.1 -R.sub.3 are each independently lower alkyls, cycloalkyls or olefins of which at least one is C.sub.2 -C.sub.4 and two may join to form a ring; R.sub.4 is hydrogen or a C.sub.1 -C.sub.3 alkyl; n is an integer from 1 to 6; M is a polyvalent metal ion. It is preferred that at least two and especially at least three substitutions have the structure so set forth.
摘要翻译：公开了可用于将嗜碱性粒细胞与其他血细胞区分开的新的酞菁衍生物。本发明的化合物是取代的酞菁结构的季盐，其中取代各自独立地为氢，磺酸盐或任选含有至少一个杂原子的C 1 -C 7烃，条件是它们中的至少一个为 IMAGE>其中R 1 -R 3各自独立地为具有至少一个为C 2 -C 4的低级烷基，环烷基或烯烃，并且两个可以连接形成环; R4是氢或C1-C3烷基; n是1至6的整数; M是多价金属离子。优选至少两个，特别是至少三个取代具有如此阐述的结构。

6. 发明授权

US5888752A Universal rinse reagent and method for use in hematological analyses of whole blood samples 失效
标题翻译：通用冲洗试剂和全血样品血液分析中使用的方法
公开(公告)号：US5888752A
公开(公告)日：1999-03-30
申请号：US442363
申请日：1995-05-16
申请人： Michael J. Malin , Phyllis Shapiro
发明人： Michael J. Malin , Phyllis Shapiro
IPC分类号： G01N33/49 , C11D1/722 , C11D3/37 , G01N15/14 , G01N33/50 , C11D3/48 , G01N33/53
CPC分类号： C11D3/3707 , C11D1/722 , Y10S435/962 , Y10T436/10 , Y10T436/114998
摘要： The present invention provides a heretofore unknown use for a aqueous reagent composition that serves as a universal rinse for performing and/or improving a variety of hematological analyses on automated analyzers. The universal rinse reagent comprises a phosphate buffer to maintain the rinse solution pH at from about 7.0 to about 7.6; a nonhemolytic nonionic surfactant, such as a Pluronic.RTM. an alkali metal salt, such as NaCi; antimicrobial and anti-oxidant compounds; and has an osmolality of about 285 to 305 mOsmol/kg. The universal rinse reagent composition is highly suitable for use in the rinse phases or cycles of all types of blood cell analysis methods and processes performed on semi- and fully-automated systems. The invention allows the replacement of mutiple and specific rinse solutions with the disclosed universal rinse to obtain accurate and acceptable results, independent of the types of blood cell analyses that are performed. The universal rinse is most particularly useful for automated systems having intricate hardware and a number of different input and output channels. The universal rinse composition serves to economize, streamline, and simplify the design and operation of such systems.
摘要翻译：本发明提供了用于水性试剂组合物的迄今为止未知的用途，其用作用于在自动分析仪上进行和/或改进各种血液学分析的通用冲洗液。通用冲洗试剂包括磷酸盐缓冲液，以将漂洗溶液的pH保持在约7.0至约7.6; 非溶解性非离子表面活性剂，例如Pluronic TM的碱金属盐，例如NaCi; 抗菌和抗氧化剂; 并且具有约285至305mOsmol / kg的重量克分子渗透压浓度。通用冲洗试剂组合物非常适合用于在半自动和全自动化系统中进行的所有类型血细胞分析方法和过程的漂洗阶段或循环。本发明允许用所公开的通用冲洗液替换多种和特定的漂洗溶液以获得准确和可接受的结果，而与执行的血细胞分析的类型无关。通用冲洗对于具有复杂硬件和多个不同输入和输出通道的自动化系统最为特别有用。通用冲洗组合物用于节约，简化和简化这些系统的设计和操作。

7. 发明授权

US4801549A Method for the determination of a differential white blood cell count 失效
标题翻译：确定差异白细胞计数的方法
公开(公告)号：US4801549A
公开(公告)日：1989-01-31
申请号：US9423
申请日：1987-02-02
申请人： John F. Cremins , Young R. Kim , Michael J. Malin , Louis D. Sclafani
发明人： John F. Cremins , Young R. Kim , Michael J. Malin , Louis D. Sclafani
IPC分类号： G01N1/30 , G01N33/50 , G01N15/10 , G01N15/14
CPC分类号： G01N33/5094 , G01N1/30 , G01N2001/305 , Y10T436/101666 , Y10T436/107497
摘要： This invention relates to a method for the rapid determination of a differential white blood cell count in a sample, which method comprises:(a) preparing a reagent solution comprising;formaldehyde or paraformaldehyde;a surfactant;a sugar or sugar alcohol; anda buffer; and(b) rapidly mixing the reagent solution with the sample to be analyzed to form a reaction mixture, wherein both the reagent solution and the sample are initially at room temperature; and(c) rapidly heating the reaction mixture to a temperature of from about 62.degree. C. to about 72.degree. C. in order to lyse the red blood cells in the sample and fix the white blood cells in the sample.
摘要翻译：本发明涉及一种用于快速测定样品中差异白细胞计数的方法，该方法包括：（a）制备试剂溶液，其包含：甲醛或多聚甲醛; 表面活性剂; 糖或糖酒; 和缓冲区; 和（b）将试剂溶液与要分析的样品快速混合以形成反应混合物，其中试剂溶液和样品都开始在室温下; 和（c）将反应混合物快速加热至约62℃至约72℃的温度，以溶解样品中的红细胞并固定样品中的白细胞。

8. 发明授权

US4463117A Heat stable, polymer-forming composition 失效
标题翻译：热稳定，聚合物形成组合物
公开(公告)号：US4463117A
公开(公告)日：1984-07-31
申请号：US369486
申请日：1982-04-19
申请人： Michael J. Malin
发明人： Michael J. Malin
IPC分类号： C09D4/00 , G01N1/36 , C08K5/32
CPC分类号： G01N1/36 , C09D4/00
摘要： A heat-stable, polymer-forming composition of a polymerizable material, a transition metal compound, a polymer chain terminator, and, optionally, a preventive antioxidant is disclosed as well as particular uses of such composition.
摘要翻译：公开了可聚合材料，过渡金属化合物，聚合物链终止剂和任选的预防性抗氧化剂的热稳定的聚合物形成组合物以及这种组合物的具体用途。

9. 发明授权

US06623972B2 Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum 有权
公开(公告)号：US06623972B2
公开(公告)日：2003-09-23
申请号：US09861069
申请日：2001-05-18
申请人： Michael J. Malin , Phyllis Shapiro
发明人： Michael J. Malin , Phyllis Shapiro
IPC分类号： G01N3372
CPC分类号： G01N33/721 , G01N33/726
摘要： The invention provides a new method and system for detecting and monitoring extracellular or exogenously added hemoglobin, i.e., a cell-free hemoglobin substitute or derivative, in a blood, plasma, or serum sample of an individual, particularly a whole blood sample. The invention further describes the use of automated hematology analyzers to determine and quantify at the same time the concentration of total, cellular and exogenous hemoglobin in a blood, plasma, or serum sample, and is particularly advantageous for medical use during or after patient trauma or surgery, as well as for monitoring hemoglobin levels during patient recovery.

10. 发明授权

US5468640A Cyanide-free hemoglobin reagent 失效
标题翻译：无氰化物血红蛋白试剂
公开(公告)号：US5468640A
公开(公告)日：1995-11-21
申请号：US192940
申请日：1994-02-07
申请人： Jeffrey Benezra , Michael J. Malin
发明人： Jeffrey Benezra , Michael J. Malin
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , Y10T436/105831
摘要： A novel method and reagent useful therein are cyanide-free and capable of providing a rapid indication, e.g., less than 30 seconds, of total hemoglobin in a blood sample, so as to find particular application in automated hematological instrumentation. The novel reagent comprises an ionic surfactant, a pH of at least about 11.3 and is free of ionic cyanide. The ionic surfactant itself can impart the required pH or a strong base independent of such surfactant may be included.
摘要翻译：其中有用的新型方法和试剂是无氰化物，能够提供血液样品中总血红蛋白的快速指示，例如少于30秒，以便在自动血液仪器中发现特别的应用。新型试剂包含离子表面活性剂，pH至少约11.3，不含离子氰化物。离子表面活性剂本身可以赋予所需的pH或可以包括独立于这种表面活性剂的强碱。

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