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1. 发明申请

US20120192872A1 REVERSIBLE TUBAL CONTRACEPTIVE DEVICE 有权
标题翻译：可逆的管状装置
公开(公告)号：US20120192872A1
公开(公告)日：2012-08-02
申请号：US13367338
申请日：2012-02-06
申请人： Leon Rudakov , Tanner J. Hargens , Phillip M. Leopold
发明人： Leon Rudakov , Tanner J. Hargens , Phillip M. Leopold
IPC分类号： A61F6/06
CPC分类号： A61F6/18 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/12159 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61B2017/1209 , A61F6/08 , A61F6/146 , A61F6/20 , A61F6/225
摘要： Described are apparatus and methods for preventing sperm passage through a reproductive structure of a patient, and also for subsequently reversing the preventative measure in order to restore fertility to the patient. In some embodiments, the apparatus includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the reproductive structure. The apparatus may also have a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially impedes, reduces, or totally obstructs passage of sperm through the lumen.
摘要翻译：描述了用于防止精子通过患者的生殖结构的装置和方法，并且还用于随后逆转预防措施以恢复对患者的生育能力。在一些实施例中，该装置包括细长构件，该细长构件布置成形成具有远侧和近侧开口并构造成定位在生殖结构内腔内的框架。该装置还可以具有联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上阻止，减少或完全阻碍精子通过内腔的通道。

2. 发明授权

US09247942B2 Reversible tubal contraceptive device 有权
标题翻译：可逆输卵管避孕器
公开(公告)号：US09247942B2
公开(公告)日：2016-02-02
申请号：US13367338
申请日：2012-02-06
申请人： Leon Rudakov , Tanner J. Hargens , Phillip M. Leopold
发明人： Leon Rudakov , Tanner J. Hargens , Phillip M. Leopold
IPC分类号： A61B17/12 , A61F6/14 , A61F6/18 , A61F6/20 , A61F6/22 , A61B17/00
CPC分类号： A61F6/18 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12109 , A61B17/12113 , A61B17/12145 , A61B17/12159 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61B2017/1209 , A61F6/08 , A61F6/146 , A61F6/20 , A61F6/225
摘要： Described are apparatus and methods for preventing sperm passage through a reproductive structure of a patient, and also for subsequently reversing the preventative measure in order to restore fertility to the patient. In some embodiments, the apparatus includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the reproductive structure. The apparatus may also have a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially impedes, reduces, or totally obstructs passage of sperm through the lumen.
摘要翻译：描述了用于防止精子通过患者的生殖结构的装置和方法，并且还用于随后逆转预防措施以恢复对患者的生育能力。在一些实施例中，该装置包括细长构件，该细长构件布置成形成具有远侧和近侧开口并构造成定位在生殖结构内腔内的框架。该装置还可以具有联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上阻止，减少或完全阻碍精子通过内腔的通道。

3. 发明申请

US20100063531A1 Medical Device with Non-Circumferential Surface Portion 审中-公开
标题翻译：具有非圆周表面部分的医疗器械
公开(公告)号：US20100063531A1
公开(公告)日：2010-03-11
申请号：US12093310
申请日：2005-11-09
申请人： Leon Rudakov , Michael O'Connor , Vimal Raj D
发明人： Leon Rudakov , Michael O'Connor , Vimal Raj D
IPC分类号： A61M29/00 , A61B5/00
CPC分类号： A61B17/12022 , A61B17/12118 , A61B2017/1205 , A61F2/07 , A61F2/89 , A61F2/958 , A61F2002/075 , A61F2002/077 , A61F2002/823 , A61F2220/0058
摘要： PCT A medical device (10) for insertion into a bodily vessel (4) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device expandable from a first position to a second position; the mechanically expandable device having an exterior circumferential surface at end portions (11, 12) of the mechanically expandable device such that the exterior circumferential surface engages with the inner surface of the vessel (4) so as to maintain a fluid pathway through said vessel (4) when the end portions (11, 12) of the mechanically expandable device are expanded radially outwardly to the second position; the mechanically expandable device having an exterior non-circumferential surface at a connecting portion (13) of the mechanically expandable device to connect the end portions (11, 12); and an expandable membrane (15) extending over a portion of the exterior non-circumferential surface, the membrane (15) is expanded in response to expansion of the mechanically expandable device; wherein the connecting portion (13) is positioned proximal to the aneurysm neck such that the expanded membrane (15) obstructs blood circulation to the aneurysm (5).
摘要翻译： PCT一种用于插入身体血管（4）以治疗具有动脉瘤颈部的动脉瘤（5）的医疗装置（10），所述装置（10）包括：可从第一位置扩展到第二位置的机械可扩张装置; 所述机械可扩张装置在所述机械可扩张装置的端部部分（11,12）处具有外周表面，使得所述外周表面与所述容器（4）的内表面接合，以便保持通过所述容器的流体路径（ 4）当机械可膨胀装置的端部部分（11,12）径向向外延伸到第二位置时; 所述机械可扩张装置在所述机械可扩张装置的连接部分（13）处具有外部非圆周表面，以连接所述端部部分（11,12）; 以及在所述外部非圆周表面的一部分上延伸的可膨胀膜（15），所述膜（15）响应于所述机械可扩张装置的膨胀而膨胀; 其中所述连接部分（13）位于所述动脉瘤颈部的近侧，使得所述扩张的膜（15）阻止血液循环到所述动脉瘤（5）。

4. 发明申请

US20090054966A1 ENDOVASCULAR DEVICE WITH MEMBRANE 审中-公开
标题翻译：具有膜的血管内装置
公开(公告)号：US20090054966A1
公开(公告)日：2009-02-26
申请号：US12279335
申请日：2006-02-13
申请人： Leon Rudakov , Tsui Ying Rachel Hong , Peir Fen Sung
发明人： Leon Rudakov , Tsui Ying Rachel Hong , Peir Fen Sung
IPC分类号： A61F2/06
CPC分类号： C08G18/283 , A61F2/07 , A61F2250/0023 , A61L31/06 , C08G18/2885 , C08G18/289 , C08G18/44 , C08L75/04
摘要： An endovascular device (10) for insertion into a bodily vessel (5) to treat a diseased, damaged or weakened portion of a vessel wall (50), the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (20) covering at least a portion of the circumferential surface of said mechanically expandable device (11), the membrane (20) comprising a plurality of pores (25), the porosity of the membrane (20) being defined by the ratio of the material surface area of the membrane (20) determined by the size of the pores (21) and the distance between adjacent pores (22, 23); wherein the mechanically expandable device (10) is positioned in the bodily vessel (5) such that the membrane (20) covers at least the diseased, damaged or weakened portion of the vessel wall (50), the porosity of the membrane (20) obstructing blood supply to the diseased, damaged or weakened portion of the vessel wall (50) and enhancing healing of the bodily vessel (5).
摘要翻译：一种用于插入身体血管（5）以治疗血管壁（50）的患病，受损或弱化部分的血管内装置（10），所述血管内装置（10）包括：机械可扩张装置（11），其可从第一位置到第二位置，所述机械可扩张装置（11）径向向外扩展到第二位置，使得所述机械可扩张装置（11）的圆周表面与容器（5）的内表面接合，以便保持通过所述容器（5）的流体通道; 以及覆盖所述机械可扩张装置（11）的所述圆周表面的至少一部分的膜（20），所述膜（20）包括多个孔（25），所述膜（20）的孔隙度由通过孔（21）的尺寸和相邻孔（22,23）之间的距离确定的膜（20）的材料表面积的比率; 其中所述机械可扩张装置（10）定位在所述身体容器（5）中，使得所述膜（20）至少覆盖所述血管壁（50）的患病，受损或弱化部分，所述膜（20）的孔隙率阻止对血管壁（50）的患病，受损或弱化部分的血液供应，并增强身体血管（5）的愈合。

5. 发明申请

US20090018636A1 Methods and apparatus for rapid endovascular vessel occlusion and blood flow interruption 失效
标题翻译：用于快速血管内血管闭塞和血流中断的方法和装置
公开(公告)号：US20090018636A1
公开(公告)日：2009-01-15
申请号：US11825956
申请日：2007-07-09
申请人： Philippe Gailloud , Leon Rudakov
发明人： Philippe Gailloud , Leon Rudakov
IPC分类号： A61F2/06 , A61B19/00 , A61M25/10
CPC分类号： A61B17/12031 , A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B17/1219 , A61B2017/00867 , A61B2017/00893 , A61B2017/1205
摘要： An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.
摘要翻译：描述了包括可扩展支架和限流部件的闭塞装置。在一些实施方案中，支架是可在导丝上传送的可扩张或自扩张支架。限流构件可以包括在展开之后可以关闭的阀。在展开时，支架和限流构件可以接合体腔内腔的内表面，阻止材料的流动。在一些实施例中，体腔是血管，并且该装置可用于阻止血液流动。在一些实施方案中，该装置包括生物活性剂。

6. 发明申请

US20070255388A1 Endovascular device with membrane 有权
标题翻译：带膜的血管内装置
公开(公告)号：US20070255388A1
公开(公告)日：2007-11-01
申请号：US11786023
申请日：2007-04-09
申请人： Leon Rudakov , Tsui Hong , Michael O'Connor
发明人： Leon Rudakov , Tsui Hong , Michael O'Connor
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/915 , A61F2002/065
摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.
摘要翻译：描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。在一些实施方案中，孔径范围为约10-100μm。在一些实施方案中，孔等距离地间隔开约40-100μm的范围内的孔隙。孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

7. 发明申请

US20070191924A1 Method for treating aneurysms 有权
标题翻译：治疗动脉瘤的方法
公开(公告)号：US20070191924A1
公开(公告)日：2007-08-16
申请号：US11547100
申请日：2004-10-15
申请人： Leon Rudakov
发明人： Leon Rudakov
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/1214 , A61B17/12186 , A61F2/07 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/075 , A61F2002/3008 , A61F2002/823 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0037 , A61F2250/0098
摘要： A method for treating a bifurcation aneurysm, the aneurysm having an aneurysm neck, by positioning a first mechanically expandable device in a first bifurcation branch proximate to the aneurysm neck; positioning a second mechanically expandable device in a second bifurcation branch proximate to the aneurysm neck; and expanding the mechanically expandable devices to constrict the aneurysm neck such that blood circulation to the bifurcation aneurysm is reduced.
摘要翻译：一种用于治疗分叉动脉瘤的方法，所述动脉瘤具有动脉瘤颈部，通过将第一机械可扩张装置定位在靠近所述动脉瘤颈部的第一分叉分支中; 将第二机械可扩张装置定位在靠近动脉瘤颈部的第二分叉分支中; 并且扩张机械可扩张装置以收缩动脉瘤颈部，使得分叉动脉瘤的血液循环减少。

8. 发明授权

US08715340B2 Endovascular device with membrane 有权
标题翻译：带膜的血管内装置
公开(公告)号：US08715340B2
公开(公告)日：2014-05-06
申请号：US11786023
申请日：2007-04-09
申请人： Leon Rudakov , Tsui Ying Rachel Hong , Michael O'Connor
发明人： Leon Rudakov , Tsui Ying Rachel Hong , Michael O'Connor
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/915 , A61F2002/065
摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.
摘要翻译：描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。在一些实施方案中，孔径范围为约10-100μm。在一些实施方案中，孔等距离地间隔开约40-100μm的孔隙。孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

9. 发明授权

US08328840B2 Methods and apparatus for rapid endovascular vessel occlusion and blood flow interruption 失效
标题翻译：用于快速血管内血管闭塞和血流中断的方法和装置
公开(公告)号：US08328840B2
公开(公告)日：2012-12-11
申请号：US11825956
申请日：2007-07-09
申请人： Philippe Gailloud , Leon Rudakov
发明人： Philippe Gailloud , Leon Rudakov
IPC分类号： A61M29/00
CPC分类号： A61B17/12031 , A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B17/1219 , A61B2017/00867 , A61B2017/00893 , A61B2017/1205
摘要： An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.
摘要翻译：描述了包括可扩展支架和限流部件的闭塞装置。在一些实施方案中，支架是可在导丝上传送的可扩张或自扩张支架。限流构件可以包括在展开之后可以关闭的阀。在展开时，支架和限流构件可以接合体腔内腔的内表面，阻止材料的流动。在一些实施例中，体腔是血管，并且该装置可用于阻止血液流动。在一些实施方案中，该装置包括生物活性剂。

10. 发明授权

US09017351B2 Reducing flow through a tubular structure 有权
标题翻译：减少通过管状结构的流动
公开(公告)号：US09017351B2
公开(公告)日：2015-04-28
申请号：US12826593
申请日：2010-06-29
申请人： Leon Rudakov , Phillipe Gailloud
发明人： Leon Rudakov , Phillipe Gailloud
IPC分类号： A61B17/08 , A61B17/12 , A61B17/00 , A61B17/22
CPC分类号： A61B17/12145 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12109 , A61B17/12113 , A61B17/1215 , A61B2017/00469 , A61B2017/00809 , A61B2017/1205 , A61B2017/12054 , A61B2017/1209 , A61B2017/22035
摘要： In some embodiments, an apparatus, for reducing or stopping flow through a tubular structure of a patient, includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the tubular structure. The frame includes a proximal, distal, and middle portion. The distal portion is tapered such that an outer cross sectional dimension (OCSD) of the distal opening is less than an OCSD of the middle portion. The frame is configured to be inverted such that the distal portion moves within and toward the middle portion for removing the frame from within the lumen. The apparatus also comprises a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially reduces or totally obstructs flow of at least one of emboli and fluid flowing through the lumen.
摘要翻译：在一些实施例中，用于减少或阻止穿过患者的管状结构的流动的装置包括细长构件，该细长构件布置成形成具有远端和近侧开口并被配置为定位在管状结构的内腔内的框架。框架包括近端，远端和中间部分。远侧部分是锥形的，使得远端开口的外横截面尺寸（OCSD）小于中间部分的OCSD。框架被构造成倒置，使得远端部分在中间部分内移动并朝向中间部分移动，以从框架内移除框架。该装置还包括联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上减少或完全阻碍栓塞和流过管腔的流体中的至少一个的流动。

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