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1. 发明授权

US08231787B2 Tangential flow filtration system 有权
标题翻译：切向流过滤系统
公开(公告)号：US08231787B2
公开(公告)日：2012-07-31
申请号：US12435481
申请日：2009-05-05
申请人： Leon Mir , Gaston de los Reyes
发明人： Leon Mir , Gaston de los Reyes
IPC分类号： B01D61/00 , B01D63/00 , B01D35/00 , B01D21/30
CPC分类号： B01D61/22 , B01D61/145 , B01D61/147 , B01D61/16 , B01D2313/18 , B01D2315/14 , B01D2315/16
摘要： A system, method and device are disclosed for bio-processing a feed stream providing a constant output by operating a continuous single-pass tangential-flow process. Embodiments are operated without large circulation pumps. Other embodiments use components which can be disposed after a single use. The system, method and device can also be used to provide constant output diafiltration.
摘要翻译：公开了一种系统，方法和装置，用于通过运行连续的单程切向流程生物处理提供恒定输出的进料流。实施例在没有大循环泵的情况下操作。其他实施例使用可以在单次使用之后被布置的部件。系统，方法和装置也可用于提供恒定输出渗滤。

2. 发明申请

US20080161741A1 OCULAR IMPLANT AND METHODS FOR MAKING AND USING SAME 审中-公开
标题翻译： OCULAR植入物及其制备方法和使用方法
公开(公告)号：US20080161741A1
公开(公告)日：2008-07-03
申请号：US12050346
申请日：2008-03-18
申请人： Eric A. Bene , Tim J. Morrill , Margaret B. Mulhern , Thaddeus L. Wandel , Jon B. Taylor , Leon Mir
发明人： Eric A. Bene , Tim J. Morrill , Margaret B. Mulhern , Thaddeus L. Wandel , Jon B. Taylor , Leon Mir
IPC分类号： A61F9/00 , A61M27/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2210/0061 , A61F2250/0067 , A61F2250/0087 , A61M27/00
摘要： An ocular implant device that is insertable into either the anterior or posterior chamber of the eye to drain aqueous humor and/or to introduce medications. The implant can include a substantially cylindrical body with a channel member that regulates the flow rate of aqueous humor from the anterior chamber or introduces medications into the posterior chamber, and simultaneously minimizes the ingress of microorganisms into the eye.
摘要翻译：眼部植入装置，其可插入眼睛的前房或后房以排出房水和/或引入药物。植入物可以包括具有通道构件的基本上圆柱形的主体，该通道构件调节房水从前房的流速或将药物引入后室，同时使微生物进入眼睛最小化。

3. 发明授权

US06296751B1 Electrodeionization apparatus with scaling control 有权
标题翻译：具有缩放控制功能的电离装置
公开(公告)号：US06296751B1
公开(公告)日：2001-10-02
申请号：US09526658
申请日：2000-03-15
申请人： Leon Mir
发明人： Leon Mir
IPC分类号： B01D6148
CPC分类号： B01D61/48 , B01J47/08 , C02F1/42 , C02F1/4604 , C02F1/4695 , C02F2201/46115
摘要： First and second stages are used in electrodeionization to purify water including calcium and carbon dioxide and its hydrates. The diluting flow channels of the first stage include only anion exchange material or cation exchange material, and thus remove either carbon dioxide and its hydrates (and other anions) or calcium (and other cations) but not the other. The diluting flow channels of the second stage receive the diluting channel effluent from the first stage and include the other type of exchange resin (or a mixed resin) and remove the oppositely charged ions. The brine effluent from the concentrating flow channels in the first stage is isolated from the second stage, and calcium and total inorganic carbon tend to be removed in different stages so as to deter calcium carbonate precipitation in any of the concentrating flow channels. Also the concentrating channels can include cation exchange material next to the anion membrane, with pH being lowered at the surface of the anion so as to limit calcium carbonate precipitation in the concentrating flow channel. Also disclosed are using countercurrent flow in the diluting flow channels and the concentrating flow channels and flowing the feed to the concentrating compartment first through a region that renders it substantially acidic before it enters a region that contains calcium.
摘要翻译：第一和第二阶段用于去离子水以净化包括钙和二氧化碳及其水合物的水。第一阶段的稀释流动通道仅包括阴离子交换材料或阳离子交换材料，因此除去二氧化碳及其水合物（和其它阴离子）或钙（和其它阳离子）而不是另一种。第二阶段的稀释流动通道接收来自第一阶段的稀释通道流出物，并且包括另一种类型的交换树脂（或混合树脂）并除去带相反电荷的离子。来自第一阶段的浓缩流动通道的盐水流出物与第二阶段分离，并且钙和总无机碳倾向于在不同的阶段被去除，以便阻止任何浓缩流动通道中的碳酸钙沉淀。此外，浓缩通道可以包括在阴离子膜旁边的阳离子交换材料，其pH在阴离子的表面降低，以限制浓缩流动通道中的碳酸钙沉淀。还公开了在稀释流动通道和浓缩流动通道中使用逆流，并且将进料流经浓缩室首先通过使其在进入含钙的区域之前呈现基本上为酸性的区域。

4. 发明授权

US06187162B1 Electrodeionization apparatus with scaling control 有权
标题翻译：具有缩放控制功能的电离装置
公开(公告)号：US06187162B1
公开(公告)日：2001-02-13
申请号：US09395327
申请日：1999-09-13
申请人： Leon Mir
发明人： Leon Mir
IPC分类号： B01D6148
CPC分类号： C02F1/4695 , B01D61/48 , B01J47/08 , C02F1/42 , C02F1/4604 , C02F2201/46115
摘要： First and second stages are used in electrodeionization to purify water including calcium and carbon dioxide and its hydrates. The diluting flow channels of the first stage include only anion exchange material or cation exchange material, and thus remove either carbon dioxide and its hydrates (and other anions) or calcium (and other cations) but not the other. The diluting flow channels of the second stage receive the diluting channel effluent from the first stage and include the other type of exchange resin (or a mixed resin) and remove the oppositely charged ions. The brine effluent from the concentrating flow channels in the first stage is isolated from the second stage, and calcium and total inorganic carbon tend to be removed in different stages so as to deter calcium carbonate precipitation in any of the concentrating flow channels. Also the concentrating channels can include cation exchange material next the anion membrane, with pH being lowered at the surface of the anion so as to limit calcium carbonate precipitation in the concentrating flow channel.
摘要翻译：第一和第二阶段用于去离子水以净化包括钙和二氧化碳及其水合物的水。第一阶段的稀释流动通道仅包括阴离子交换材料或阳离子交换材料，因此除去二氧化碳及其水合物（和其它阴离子）或钙（和其它阳离子）而不是另一种。第二阶段的稀释流动通道接收来自第一阶段的稀释通道流出物，并且包括另一种类型的交换树脂（或混合树脂）并除去带相反电荷的离子。来自第一阶段的浓缩流动通道的盐水流出物与第二阶段分离，并且钙和总无机碳倾向于在不同的阶段被去除，以便阻止任何浓缩流动通道中的碳酸钙沉淀。此外，浓缩通道可以包括阴离子膜旁边的阳离子交换材料，pH在阴离子表面降低，以限制浓缩流动通道中的碳酸钙沉淀。

5. 发明申请

US20100133185A1 METHOD AND APPARATUS FOR THE FILTRATION OF BIOLOGICAL SOLUTIONS 有权
标题翻译：用于过滤生物解决方案的方法和装置
公开(公告)号：US20100133185A1
公开(公告)日：2010-06-03
申请号：US12685192
申请日：2010-01-11
申请人： Gaston de los Reyes , Leon Mir
发明人： Gaston de los Reyes , Leon Mir
IPC分类号： B01D61/14 , B01D61/22 , B01D61/32 , B01D61/18 , B01D61/24 , B01D61/28
CPC分类号： B01D61/18 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/22 , B01D63/02 , B01D63/06 , B01D63/066 , B01D63/08 , B01D63/10 , B01D63/103 , B01D2311/04 , B01D2313/08 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2319/022 , B01L3/50255 , B01L2200/12 , B01L2300/0829 , B01L2300/0858 , B01L2400/049 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , B01D2311/2649 , B01D2311/14 , B01D2311/25
摘要： A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
摘要翻译：公开了一种系统，方法和装置，用于对进料流进行生物处理，并通过运行连续的单程切向流程提供恒定的输出。单通过程在相对较低的进料流速下运行时提供高转化浓度，并且该方法也可用于提供恒定的输出渗滤。

6. 发明授权

US07682511B2 Method and apparatus for the filtration of biological solutions 有权
标题翻译：用于过滤生物溶液的方法和装置
公开(公告)号：US07682511B2
公开(公告)日：2010-03-23
申请号：US12114751
申请日：2008-05-03
申请人： Gaston de los Reyes , Leon Mir
发明人： Gaston de los Reyes , Leon Mir
IPC分类号： B01D61/00
CPC分类号： B01D61/18 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/22 , B01D63/02 , B01D63/06 , B01D63/066 , B01D63/08 , B01D63/10 , B01D63/103 , B01D2311/04 , B01D2313/08 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2319/022 , B01L3/50255 , B01L2200/12 , B01L2300/0829 , B01L2300/0858 , B01L2400/049 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , B01D2311/2649 , B01D2311/14 , B01D2311/25
摘要： A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
摘要翻译：公开了一种系统，方法和装置，用于对进料流进行生物处理，并通过运行连续的单程切向流程提供恒定的输出。单通过程在相对较低的进料流速下运行时提供高转化浓度，并且该方法也可用于提供恒定的输出渗滤。

7. 发明申请

US20090145845A1 METHOD AND APPARATUS FOR THE FILTRATION OF BIOLOGICAL SAMPLES 有权
标题翻译：用于过滤生物样品的方法和装置
公开(公告)号：US20090145845A1
公开(公告)日：2009-06-11
申请号：US12371611
申请日：2009-02-15
申请人： Leon Mir , Gaston de los Reyes
发明人： Leon Mir , Gaston de los Reyes
IPC分类号： B01D61/14 , B01D63/00 , B01D65/02
CPC分类号： B01D61/18 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/22 , B01D63/02 , B01D63/06 , B01D63/066 , B01D63/08 , B01D63/10 , B01D63/103 , B01D2311/04 , B01D2313/08 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2319/022 , B01L3/50255 , B01L2200/12 , B01L2300/0829 , B01L2300/0858 , B01L2400/049 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , B01D2311/2649 , B01D2311/14 , B01D2311/25
摘要： A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes two reservoirs and a hydrophobic vent. The single-pass process provides high conversion while operating with relatively low pressure sources.
摘要翻译：公开了用于处理液体样品并通过操作没有再循环回路的单程切向流程提供高转换的分离模块和方法。在一个实施例中，分离模块包括三个储存器，并且具有至少一个长通道，通道膜面积比大于：通道空隙体积; 样品进料槽的体积; 和饲料样品的体积。在另一个实施例中，分离模块包括两个储存器和疏水排气口。单通道过程在相对较低的压力源下运行时提供高转换率。

8. 发明申请

US20070151925A1 METHOD AND APPARATUS FOR THE FILTRATION OF BIOLOGICAL SOLUTIONS 有权
标题翻译：用于过滤生物解决方案的方法和装置
公开(公告)号：US20070151925A1
公开(公告)日：2007-07-05
申请号：US11615028
申请日：2006-12-22
申请人： Gaston de los Reyes , Leon Mir
发明人： Gaston de los Reyes , Leon Mir
IPC分类号： B01D61/00
CPC分类号： B01D61/18 , B01D61/14 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/22 , B01D63/02 , B01D63/06 , B01D63/066 , B01D63/08 , B01D63/10 , B01D63/103 , B01D2311/04 , B01D2313/08 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2319/022 , B01L3/50255 , B01L2200/12 , B01L2300/0829 , B01L2300/0858 , B01L2400/049 , G01N1/4005 , G01N1/4077 , G01N2001/4088 , B01D2311/2649 , B01D2311/14 , B01D2311/25
摘要： A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
摘要翻译：公开了一种系统，方法和装置，用于对进料流进行生物处理，并通过运行连续的单程切向流程提供恒定的输出。单通过程在相对较低的进料流速下运行时提供高转化浓度，并且该方法也可用于提供恒定的输出渗滤。

9. 发明授权

US06241867B1 Electrodeionization apparatus and packing therefor 有权
标题翻译：电动除菌装置及其包装
公开(公告)号：US06241867B1
公开(公告)日：2001-06-05
申请号：US09442525
申请日：1999-11-18
申请人： Leon Mir
发明人： Leon Mir
IPC分类号： B01D6148
CPC分类号： B01D61/48 , B01J47/08 , C02F1/42 , C02F1/4604 , C02F1/4695 , C02F2201/46115
摘要： Electrodeionization packing including one or more macrostructural elements made up of smaller, microstructural elements. The microstructural elements are in fixed, close contacting position with respect to each other in the macrostructural elements so as to provide porosity in the macrostructural elements. A majority of the microstructural elements have a characteristic dimension between 10 and 50 micrometers, and the macrostructural elements have a void fraction between about 25% and 50%.
摘要翻译：电离离子包装，包括由较小的微结构元素组成的一个或多个宏观结构元件。微结构元件在宏观结构元件中相对于彼此处于固定的紧密接触位置，以便在宏观结构元件中提供孔隙。大部分微结构元件具有10至50微米的特征尺寸，并且所述宏观结构元件具有约25％至50％之间的空隙率。

10. 发明授权

US06241866B1 Electrodeionization apparatus with fixed ion exchange materials 有权
标题翻译：具有固定离子交换材料的电离离子装置
公开(公告)号：US06241866B1
公开(公告)日：2001-06-05
申请号：US09394170
申请日：1999-09-13
申请人： Leon Mir
发明人： Leon Mir
IPC分类号： B01D6144
CPC分类号： C02F1/4695 , B01D61/48 , B01J47/08 , C02F1/42 , C02F1/4604 , C02F2201/46115
摘要： Electrodeionization apparatus for purifying water that includes a cathode, an anode, and a plurality of alternating anion permeable membranes and cation permeable membranes between the cathode and anode that define concentrating and diluting flow channels between adjacent pairs of membranes. The diluting channels include cation exchange materials and anion exchange materials that are fixed in close contacting position with respect to each other and provide conductive paths for cations and anions to the adjacent membranes and provide flow passages for water between the materials. The anion exchange materials and cation exchange materials each have a characteristic dimension that is smaller than the characteristic dimensions of the flow passages. The use of exchange materials with small dimensions and the fixed intimate contact of cation and anion exchange materials provides increased, uniform water splitting and resin regeneration, and a high rate of ion removal from the water flowing through the diluting channels compartments. An increased velocity can be provided in the diluting channels of by reintroducing a portion of the water from the diluting channel outlet to the diluting channel inlet or using flow diverters in the diluting channel to provide a tortuous path for the flowing water.
摘要翻译：用于净化水的电除去装置，其包括在阴极和阳极之间包括阴极，阳极和多个交替的阴离子可渗透膜和阳离子可渗透膜，其限定相邻膜对之间的浓缩和稀释流动通道。稀释通道包括阳离子交换材料和阴离子交换材料，其相对于彼此紧密接触地固定，并为邻近的膜提供用于阳离子和阴离子的导电路径，并为材料之间的水提供流动通道。阴离子交换材料和阳离子交换材料各自具有小于流动通道的特征尺寸的特征尺寸。使用具有小尺寸的交换材料和阳离子和阴离子交换材料的固定紧密接触提供了增加的均匀的水分解和树脂再生，以及从流过稀释通道隔室的水中离子去除的高速率。可以在稀释通道中提供增加的速度，通过将一部分水从稀释通道出口再次引入稀释通道入口或使用稀释通道中的流动分流器来为流动的水提供曲折的路径。

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