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1. 发明授权

US07213474B2 Sampling apparatus 失效
标题翻译：取样装置
公开(公告)号：US07213474B2
公开(公告)日：2007-05-08
申请号：US11180198
申请日：2005-07-12
申请人： Lennart Björk , Staffan Folestad , Mats Johansson , Anders Klevensparr , Ingela Niklasson Björn
发明人： Lennart Björk , Staffan Folestad , Mats Johansson , Anders Klevensparr , Ingela Niklasson Björn
IPC分类号： G01N1/16 , G01N1/26
CPC分类号： G01N1/20 , G01N2001/1018 , G01N2001/1025
摘要： An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a colelcted sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).
摘要翻译：一种用于在工艺系统中在线采样材料的装置，包括用于接收材料样品的样品收集器（1），限定了承载测量探针（11）的通道（14）的细长轴（10）来自共焦样品的测量，连接到通道的加压流体供应器（31），用于将加压流体通过通道输送到样品收集器以移动收集的样品和设置在测量探针远端的喷嘴（33） 11），用于将加压流体分配到样品收集器，用于将收集的样品从样品收集器（1）移位。

2. 发明授权

US06918310B2 Sampling apparatus 失效
标题翻译：取样装置
公开(公告)号：US06918310B2
公开(公告)日：2005-07-19
申请号：US10466001
申请日：2002-01-29
申请人： Lennart Björk , Staffan Folestad , Mats Johansson , Anders Klevensparr , Ingela Niklasson Björn
发明人： Lennart Björk , Staffan Folestad , Mats Johansson , Anders Klevensparr , Ingela Niklasson Björn
IPC分类号： G01N23/223 , G01N1/00 , G01N1/04 , G01N1/10 , G01N1/20 , G01N21/21 , G01N21/27 , G01N21/35 , G01N21/65 , G01N22/00 , G01N23/225 , G01N24/00 , G01N1/16 , G01N1/26
CPC分类号： G01N1/20 , G01N2001/1018 , G01N2001/1025
摘要： An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a collected sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).
摘要翻译：一种用于在工艺系统中在线采样材料的装置，包括用于接收材料样品的样品收集器（1），限定了承载测量探针（11）的通道（14）的细长轴（10）来自收集的样品的测量，连接到通道的加压流体供应（31），用于将加压流体通过通道输送到样品收集器以移动收集的样品和设置在测量探针的远端处的喷嘴（33） 11），用于将加压流体分配到样品收集器，用于将收集的样品从样品收集器（1）移位。

3. 发明授权

US07329430B2 Method and device for coating pharmaceutical products 失效
标题翻译：制药产品涂敷方法及装置
公开(公告)号：US07329430B2
公开(公告)日：2008-02-12
申请号：US10483139
申请日：2002-07-09
申请人： Staffan Folestad , Ingela Niklasson Björn , Daniel Ström
发明人： Staffan Folestad , Ingela Niklasson Björn , Daniel Ström
IPC分类号： B05D1/02
CPC分类号： B05B17/0607 , A61K9/2893 , B01J2/006 , B01J2/16 , B05B7/0012
摘要： The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).
摘要翻译：本发明涉及药物包衣的方法。该方法包括用至少一个微分配器（1）产生受控尺寸，形状和组成的离散液滴（7）的步骤，并以受控的速度，飞行时间分布液滴（7）。此外，该方法包括控制液滴的生产频率和调制的步骤（7）。此外，该方法包括控制载气的流速，温度和组成并将液滴（7）引向经受涂覆的颗粒（10）的步骤。本发明还涉及一种用于涂覆药物的装置。该装置包括液滴产生单元（1）和液滴引导单元（8）。液滴产生单元（1）是用于产生离散液滴（7）并控制所述液滴（7）的尺寸，形状和组成的压电致动微型分配器（1）。

4. 发明授权

US06946157B2 Method and apparatus for monitoring the coating on particle during manufacturing of a pharmaceutical product 失效
标题翻译：用于在制造药物产品期间监测颗粒上的涂层的方法和装置
公开(公告)号：US06946157B2
公开(公告)日：2005-09-20
申请号：US09806795
申请日：2001-01-08
申请人： Staffan Folestad , Ingela Niklasson Björn , Anders Rasmuson , Daniel Ström
发明人： Staffan Folestad , Ingela Niklasson Björn , Anders Rasmuson , Daniel Ström
IPC分类号： G01N21/64 , B01J2/00 , B01J2/16 , G01N21/27 , G01N21/33 , G01N21/35 , G01N21/65 , G01N21/84 , G01N21/85 , B01J13/00 , B05C11/00
CPC分类号： G01N21/3563 , B01J2/006 , B01J2/16 , G01N21/359 , G01N2021/8427
摘要： In a method of monitoring the formation of a coating on a single particle (P), an apparatus is used which comprises means (2,5,6,9) for arranging said particle (P) at a given spatial location, and a fluid supply unit (3) adapted to apply a coating fluid to the particle (P) such that the coating is formed. Further, the apparatus has a measurement unit (4) which is adapted to perform a spectrometric measurement on the coating during formation thereof, and to derive a measurement value of at least one principle parameter related to the coating. This, such principle parameters, for example the thickness, thickness growth rate and physical and/or chemical properties related to the quality of the coating, as well as heat, mass and momentum transfer, can be continuously and non-invasively monitored during the coating process on the single particle (P). The results of such measurements can be used to understand the coating process on the single particle (P), and ultimately to control, up-scale and develop industrial full-scale coating plants.
摘要翻译：在监测单一颗粒（P）上的涂层形成的方法中，使用一种装置，其包括用于在给定空间位置排列所述颗粒（P）的装置（2,5,6,9），以及流体供应单元（3），适于将涂层流体施加到所述颗粒（P）上，使得形成所述涂层。此外，该装置具有测量单元（4），其适于在其形成期间对涂层进行光谱测量，并且导出与涂层相关的至少一个原理参数的测量值。这样的原理参数，例如厚度，厚度生长速率，与涂层质量有关的物理和/或化学性质，以及热，质量和动量传递，可以在涂层期间连续地和非侵入性地监测单个颗粒（P）上的过程。这些测量结果可用于了解单颗粒（P）上的涂布过程，并最终控制，扩大和开发工业全尺寸涂装设备。

5. 发明授权

US06633792B1 Method for controlling a coating process 失效
标题翻译：控制涂层工艺的方法
公开(公告)号：US06633792B1
公开(公告)日：2003-10-14
申请号：US09380937
申请日：1999-09-09
申请人： Staffan Folestad , Ingela Niklasson Björn
发明人： Staffan Folestad , Ingela Niklasson Björn
IPC分类号： G06F1900
CPC分类号： G01N21/65 , G01N21/25
摘要： This invention relates to a method for controlling the process of manufacturing a coating of a pharmaceutical product, comprising the steps of: performing a spectroscopic measurement on the coating; generating a sample vector of measurement values from the spectrometric measurement; condensing the measurement values into at least one principal parameter; comparing the principal parameter to a predetermined corresponding model parameter; determining deviations of the principal parameter from the corresponding model parameter and extracting information directly related to the quality of the coating; and controlling the process on the basis, at least partly, of the extracted information.
摘要翻译：本发明涉及一种用于控制制造药物制品的涂层的方法的方法，包括以下步骤：在涂层上进行光谱测量;从光谱测定产生测量值的样本载体测量; 将测量值凝结成至少一个主要参数; 将主参数与预定的相应模型参数进行比较;确定主参数与相应模型参数的偏差并提取信息直接关系到涂层的质量; 至少部分地基于提取的信息来控制该过程。

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