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1. 发明申请

US20080069893A1 Compositions for repair of defects in osseous tissues, and methods of making the same 有权
标题翻译：用于修复骨组织缺陷的组合物及其制备方法
公开(公告)号：US20080069893A1
公开(公告)日：2008-03-20
申请号：US11898053
申请日：2007-09-07
申请人： Leila Masinaei , Lloyd Wolfinbarger
发明人： Leila Masinaei , Lloyd Wolfinbarger
IPC分类号： A61K35/32 , A61P43/00
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/3604 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是含有软骨骨碎片和匀浆结缔组织的骨修复组合物及其制备方法。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

2. 发明申请

US20070083270A1 Orthopedic prosthetic devices containing compositions for repair of defects in osseous tissues 审中-公开
标题翻译：整形外科装置含有用于修复骨组织缺陷的组合物
公开(公告)号：US20070083270A1
公开(公告)日：2007-04-12
申请号：US11247249
申请日：2005-10-12
申请人： Leila Masinaei , Lloyd Wolfinbarger
发明人： Leila Masinaei , Lloyd Wolfinbarger
IPC分类号： A61F2/28 , A61F2/02
CPC分类号： A61L27/34 , A61F2/30767 , A61F2310/00958 , A61L27/3604 , A61L27/3608 , A61L27/365
摘要： Implantable orthopedic prosthetic devices containing tissue repair compositions that contain demineralized bone fragments and homogenized connective tissue.
摘要翻译：含有组织修复组合物的植入式矫形假体装置，其含有软化骨碎片和匀浆结缔组织。

3. 发明申请

US20070082058A1 Composition for repair of defects in osseous tissues 有权
标题翻译：用于修复骨组织缺陷的组合物
公开(公告)号：US20070082058A1
公开(公告)日：2007-04-12
申请号：US11247230
申请日：2005-10-12
申请人： Leila Masinaei , Lloyd Wolfinbarger
发明人： Leila Masinaei , Lloyd Wolfinbarger
IPC分类号： A61K35/32
CPC分类号： A61K35/32 , A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是骨修复组合物，其含有软化骨碎片和匀浆结缔组织。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

4. 发明申请

US20070082057A1 Compositions for repair of defects in osseous tissues, and methods of making the same 有权
标题翻译：用于修复骨组织缺陷的组合物及其制备方法
公开(公告)号：US20070082057A1
公开(公告)日：2007-04-12
申请号：US11247229
申请日：2005-10-12
申请人： Leila Masinaei , Lloyd Wolfinbarger
发明人： Leila Masinaei , Lloyd Wolfinbarger
IPC分类号： A61K35/32
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/3604 , A61L2400/06 , A61L2430/02
摘要： Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
摘要翻译：组织修复组合物，特别是含有软骨骨碎片和匀浆结缔组织的骨修复组合物及其制备方法。组合物可以以可注射凝胶，可注射糊剂，糊剂，油灰或可再水化的冷冻干燥形式的形式使用。

5. 发明申请

US20070105222A1 In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby 有权
标题翻译：适合于由此形成骨和骨形成组织的组织的体外生长
公开(公告)号：US20070105222A1
公开(公告)日：2007-05-10
申请号：US11518566
申请日：2006-09-11
申请人： Lloyd Wolfinbarger , Xiaofei Qin
发明人： Lloyd Wolfinbarger , Xiaofei Qin
IPC分类号： C12N5/02 , C12N5/00 , C12N5/08
CPC分类号： C12N5/0654 , A61L27/3608 , A61L27/3683 , A61L2430/02 , C12M21/08 , C12M25/14 , C12M29/16 , C12M35/02 , C12M35/04
摘要： The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.
摘要翻译：本发明涉及一种用于在体外细胞培养条件下生长新骨或骨样组织的装置。

6. 发明申请

US20050261767A1 Composite bone graft, method of making and using same 有权
标题翻译：复合骨移植物，制造和使用方法
公开(公告)号：US20050261767A1
公开(公告)日：2005-11-24
申请号：US10953881
申请日：2004-09-30
申请人： Billy Anderson , Lloyd Wolfinbarger
发明人： Billy Anderson , Lloyd Wolfinbarger
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/36 , A61L27/40 , A61L27/44 , A61L27/46 , A61L27/48
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30224 , A61F2002/30261 , A61F2002/30263 , A61F2002/3028 , A61F2002/30329 , A61F2002/30383 , A61F2002/30387 , A61F2002/30492 , A61F2002/30494 , A61F2002/30599 , A61F2002/30604 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30904 , A61F2002/30971 , A61F2210/0004 , A61F2220/0025 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2230/0084 , A61F2240/001 , A61F2250/0014 , A61F2250/0063 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00179 , A61F2310/00329 , A61L27/02 , A61L27/14 , A61L27/36 , A61L27/3608 , A61L27/365 , A61L27/40 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L2430/02
摘要： The invention is directed to a composite bone graft for implantation in a patient, and methods of making and using the composite bone graft, along with methods for treating patients by implanting the composite bone graft at a site in a patient. The composite bone graft includes two or more connected, discrete, bone portions, and includes one or more biocompatible connectors which hold together the discrete bone portions to form the composite bone graft. The composite bone graft may include one or more textured bone surfaces. The textured surface preferably includes a plurality of closely spaced protrusions, preferably closely spaced continuous protrusions. The composite bone graft is useful for repairing bone defects caused by congenital anomaly, disease, or trauma, in a patient, for example, for restoring vertical support of the anterior and/or posterior column. Implantation of the composite bone graft results in improved graft stability and osteoinductivity, without a decrease in mechanical strength. The composite bone graft does not shift, extrude or rotate, after implantation. The present composite bone graft can be appropriately sized for any application and can be used to replace traditional non-bone prosthetic implants.
摘要翻译：本发明涉及用于植入患者的复合骨移植物，以及制备和使用复合骨移植物的方法，以及通过将复合骨移植物植入患者的部位来治疗患者的方法。复合骨移植物包括两个或更多个连接的，离散的骨部分，并且包括一个或多个生物相容性连接器，其将离散的骨部分保持在一起以形成复合骨移植物。复合骨移植物可以包括一个或多个织构化的骨表面。纹理表面优选地包括多个紧密间隔的突起，优选地紧密间隔连续的突起。复合骨移植物可用于修复患者中由先天性异常，疾病或创伤引起的骨缺损，例如用于恢复前和/或后柱的垂直支撑。复合骨移植的植入导致改善的移植物稳定性和骨诱导性，而不降低机械强度。复合骨移植物在植入后不会移位，挤压或旋转。本发明的复合骨移植物可以适用于任何应用，并可用于替代传统的非骨修复植入物。

7. 发明申请

US20080077251A1 Cleaning and devitalization of cartilage 审中-公开
标题翻译：软骨的清洁和失活
公开(公告)号：US20080077251A1
公开(公告)日：2008-03-27
申请号：US11826522
申请日：2007-07-16
申请人： Silvia Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger
发明人： Silvia Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger
IPC分类号： A61F2/02 , C12N5/08
CPC分类号： A61F2/30756 , A01N1/02 , A01N1/0215 , A61F2/28 , A61F2/30749 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30751 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L2/0088 , A61L27/3612 , A61L27/3654 , A61L27/3683 , A61L27/38 , A61L2430/06 , A61L2430/40
摘要： The invention is further directed to producing a cleaned, disinfected, and devitalized cartilage graft by optionally cleaning and disinfecting the cartilage graft; treating the cartilage graft in a pretreatment solution; treating the cartilage graft in an extracting solution; washing the extracted cartilage graft with a rinsing solution; and subsequently soaking the devitalized cartilage graft in a storage solution. The devitalized cartilage graft is essentially free from metabolically viable and/or reproductively viable cells and the rinsing solution is hypotonic solution or isotonic solution. The present invention is further directed to a cleaned, disinfected, and devitalized cartilage graft and a process for cleaning, disinfecting, and devitalizing cartilage grafts. The invention also relates to a process for repairing a cartilage defect and implantation of a cartilage graft into a human or animal by crafting the cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps.
摘要翻译：本发明进一步旨在通过任选地清洁和消毒软骨移植物来生产清洁的，消毒的和失活的软骨移植物; 在预处理溶液中处理软骨移植物; 在提取液中处理软骨移植物; 用冲洗溶液洗涤提取的软骨移植物; 随后将失活的软骨移植物浸泡在储存溶液中。失活的软骨移植物基本上没有代谢活力和/或再生活细胞，冲洗溶液是低渗溶液或等渗溶液。本发明还涉及清洁，消毒和失活的软骨移植物以及用于清洁，消毒和失活软骨移植物的方法。本发明还涉及一种通过将软骨基质成形为单独的移植物，消毒和清洁软骨移植物，将预处理溶液施用于软骨移植物，去除细胞的方法来修复软骨缺损和软骨移植物植入人或动物的方法碎片使用提取溶液以产生失活的软骨移植物，将软骨移植物植入软骨缺损带有或不具有插入装置，以及用接受者组织密封植入的软骨移植物。灭活的软骨移植物任选地在体外，体内或原位与活细胞接触，以在植入之前或之后使组织至关重要。灭活的软骨移植物也任选地存储在去除细胞碎片和再结晶步骤之间。

8. 发明申请

US20050064041A1 Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby 审中-公开
标题翻译：用于生产骨诱导骨的连续酸化脱矿质过程; 和由此产生的骨诱导性骨
公开(公告)号：US20050064041A1
公开(公告)日：2005-03-24
申请号：US10855797
申请日：2004-05-28
申请人： Robert O'Leary , Jan Zajdowicz , Lloyd Wolfinbarger
发明人： Robert O'Leary , Jan Zajdowicz , Lloyd Wolfinbarger
IPC分类号： A61K35/32 , C12N5/08
CPC分类号： A61K35/32
摘要： The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by subjecting bone, including for example ground bone, bone cubes, chips, strips, or essentially intact bone, to a rapid continuous acid demineralization process. The process includes subjecting bone to a continuous exchange of demineralizing acid solution where the demineralizing acid solution is recirculated from the substantially closed container through an ion exchange media to remove calcium and phosphate thereby producing a regenerated acid, and returning the regenerated acid to the substantially closed container to produce osteoinductive demineralized bone. The process allows bone to be rapidly demineralized to a precise and specific desired residual calcium level, without sacrificing osteoinductivity.
摘要翻译：本发明涉及一种用于生产软化的骨诱导骨的方法和由此产生的软化的骨诱导骨。该方法通过使骨骼（包括例如研磨骨，骨块，切片，条或基本上完整的骨）经历快速连续的酸脱矿质过程来实现骨的脱矿质。该方法包括使骨骼连续交换软化酸溶液，其中软化酸溶液通过离子交换介质从基本上密封的容器再循环以除去钙和磷酸盐，从而产生再生酸，并将再生酸返回到基本上封闭的容器生产骨诱导的软骨。该过程允许骨快速脱矿质至精确和特定的所需残留钙水平，而不牺牲骨诱导能力。

9. 发明申请

US20050058726A1 Method for debriding bone and bone debrided thereby 审中-公开
标题翻译：从而清除骨骼和骨骼的方法
公开(公告)号：US20050058726A1
公开(公告)日：2005-03-17
申请号：US10855771
申请日：2004-05-28
申请人： Lloyd Wolfinbarger , Robert O'Leary , Louis Ford , Alyce Jones
发明人： Lloyd Wolfinbarger , Robert O'Leary , Louis Ford , Alyce Jones
IPC分类号： A61F2/46 , A61L27/36 , C12N5/08 , A61K33/00
CPC分类号： A61L27/3691 , A61F2/4644 , A61L27/3608 , A61L27/365 , A61L27/3687
摘要： The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one or more alkaline solutions. Incubation is optionally carried out with one or more debriding agents including inert dry granular or particulate material including for example beads, and the granular phase of an alkaline agent, including for example granular sodium hydroxide. The incubating may be carried out with agitation. In another embodiment, the medullary canal of the bone is subjected to a positive pressure stream of debriding solution under conditions sufficient to loosen the associated soft tissue from the bone at the interface of the soft tissue and bone. In a further embodiment, the debriding solution is provided as a gel.
摘要翻译：本发明涉及一种清除骨的方法，包括用一种或多种清创溶液孵育骨和相关的软组织，其中清创溶液可包括一种或多种碱性溶液。任选地，使用一种或多种包括惰性干燥颗粒或颗粒物质（包括例如珠粒）的清洁剂以及碱性试剂（包括例如颗粒状氢氧化钠）的颗粒相进行孵育。孵育可以在搅拌下进行。在另一个实施方案中，在足以在软组织和骨的界面处从骨骼松开相关联的软组织的条件下，使骨的髓管受到清除溶液的正压力流。在另一个实施方案中，清创溶液以凝胶形式提供。

10. 发明授权

US09125743B2 Devitalization and recellularization of cartilage 有权
公开(公告)号：US09125743B2
公开(公告)日：2015-09-08
申请号：US11826523
申请日：2007-07-16
申请人： Silvia Sihui Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger , Mark Moore , Rony Thomas , Alyce Linthurst Jones
发明人： Silvia Sihui Chen , Xiaofei Qin , Jingsong Chen , Lloyd Wolfinbarger , Mark Moore , Rony Thomas , Alyce Linthurst Jones
IPC分类号： A61F2/02 , A61F2/30 , A61F2/28 , A61F2/46 , A61L27/38 , A61L27/36 , A61F2/38
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/3094 , A61F2/38 , A61F2/3859 , A61F2/4644 , A61F2002/2817 , A61F2002/2839 , A61F2002/30004 , A61F2002/30224 , A61F2002/30751 , A61F2002/30759 , A61F2002/30764 , A61F2002/4646 , A61F2002/4648 , A61F2002/4649 , A61F2230/0069 , A61F2250/0014 , A61L27/3612 , A61L27/3683 , A61L27/3804 , A61L27/3852 , A61L2430/06
摘要： The present invention is directed toward recellularizing a devitalized cartilage graft with viable recellularizable cells in vivo, in situ, or in vitro to render the tissue vital. The present invention is also directed toward repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, disinfecting and cleaning the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, recellularizing the devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally stored between the removing cellular debris and the recellularizing steps. The present invention is directed to both recellularized cartilage grafts as well as a process for recellularizing cartilage grafts.

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