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1. 发明申请

US20130259842A1 STABLE REPROGRAMMED CELLS 审中-公开
标题翻译：稳定的转录细胞
公开(公告)号：US20130259842A1
公开(公告)日：2013-10-03
申请号：US13698170
申请日：2011-05-18
申请人： Lee Rubin , Joel Blanchard , Kelvin Lam
发明人： Lee Rubin , Joel Blanchard , Kelvin Lam
IPC分类号： C12N5/071 , C12N5/0793 , C12N15/85 , A61K35/54 , C12Q1/68
CPC分类号： C12N5/0696 , A61K35/545 , C12N5/0619 , C12N5/0657 , C12N15/85 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/13 , C12N2510/00 , C12Q1/6809
摘要： The present invention relates to a stable pluripotent reprogrammed cells, and compositions and methods of isolation and uses thereof, wherein the stable pluripotent reprogrammed cells is derived from a somatic cell and has undergone incomplete remodeling of the epigenome. In some embodiments, the stable reprogrammed cell is a human stable reprogrammed cell. In some embodiments, the stable reprogrammed cell has a statistically significant lower level of expression of one or any combination of Nanog, Dnmt3b, Lefty2 as compared to an induced pluripotent stem cell. In some embodiments, the stable reprogrammed cell has a statistically significant higher level of expression of one or any combination of Tdgf1, Tert or endogenous Sox2 as compared to a somatic cell from which it was derived. In some embodiments, the stable reprogrammed cell has a statistically significant faster rate of doubling as compared to an induced pluripotent stem cell (iPSC) or an embryonic stem (ES) cell. Other aspects of the invention relate to compositions comprising the reprogrammed cell, method of isolation and method of use.
摘要翻译：本发明涉及稳定的多能重编程细胞，以及其分离及其用途的组合物和方法，其中所述稳定多能重编程细胞衍生自体细胞，并且已经进行表观遗传学的不完全重塑。在一些实施方案中，稳定的重编程细胞是人稳定的重编程细胞。在一些实施方案中，与诱导的多能干细胞相比，稳定的重编程细胞具有统计学上显着的较低水平的Nanog，Dnmt3b，Lefty2的一种或任何组合的表达。在一些实施方案中，稳定的重编程细胞与其衍生的体细胞相比具有统计学上显着更高水平的Tdgf1，Tert或内源性Sox2的一种或任何组合的表达。在一些实施方案中，与诱导的多能干细胞（iPSC）或胚胎干（ES）细胞相比，稳定的重编程细胞具有统计上显着更快的倍增速率。本发明的其它方面涉及包含重编程细胞，分离方法和使用方法的组合物。

2. 发明申请

US20120021519A1 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS 审中-公开
标题翻译：使用小分子化合物有效诱导大脑干细胞
公开(公告)号：US20120021519A1
公开(公告)日：2012-01-26
申请号：US13119848
申请日：2009-09-21
申请人： Justin Ichida , Joel Blanchard , Lee Rubin , Kevin Eggan , Kelvin Lam
发明人： Justin Ichida , Joel Blanchard , Lee Rubin , Kevin Eggan , Kelvin Lam
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2501/065 , C12N2501/15 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/727 , C12N2501/999
摘要： The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
摘要翻译：本公开特征在于从分化（例如体细胞）细胞产生重编程细胞（例如，诱导多能干细胞或未分化细胞）的方法。在一些实施方案中，所述方法包括使分化的（例如体细胞）与TGFBR1抑制剂或抗TGF-β抗体接触以产生重编程细胞（例如多能干细胞或未分化细胞）。本发明的实施方案涉及重编程细胞以及用于产生化学产生的重编程细胞或其群体的方法和组合物。

3. 发明授权

US06683192B2 Small organic molecule regulators of cell proliferation 有权
标题翻译：细胞增殖的小有机分子调节剂
公开(公告)号：US06683192B2
公开(公告)日：2004-01-27
申请号：US09964276
申请日：2001-09-26
申请人： Anthony David Baxter , Edward Andrew Boyd , Oivin M. Guicherit , Jeffrey Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Oivin M. Guicherit , Jeffrey Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： C07D32704
CPC分类号： A61K31/422 , A61K31/381 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： A compound represented in general formula (X) and (XI):
摘要翻译：通式（X）和（XI）表示的化合物：

4. 发明授权

US08129425B2 Small organic molecule regulators of cell proliferation 有权
标题翻译：细胞增殖的小有机分子调节剂
公开(公告)号：US08129425B2
公开(公告)日：2012-03-06
申请号：US11412424
申请日：2006-04-27
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： A61K31/381 , C07D333/52
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译：本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。

5. 发明申请

US20050019801A1 Stem cell-based methods for identifying and characterizing agents 审中-公开
标题翻译：用于识别和表征药剂的基于干细胞的方法
公开(公告)号：US20050019801A1
公开(公告)日：2005-01-27
申请号：US10861040
申请日：2004-06-04
申请人： Lee Rubin , Karen Kotkow , Cheng-Jung Lai
发明人： Lee Rubin , Karen Kotkow , Cheng-Jung Lai
IPC分类号： C12N5/08 , G01N33/50 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5073 , G01N33/5008 , G01N33/5023 , G01N33/5026 , G01N33/5058
摘要： The present invention provides methods of identifying and/or characterizing agents that promote differentiation of stem cells to a particular differentiated cell type. The invention further provides methods of treating injuries and degenerative diseases by administering agents that promote the differentiation of stem cells to particular differentiated cell types.
摘要翻译：本发明提供鉴定和/或表征促进干细胞分化为特定分化细胞类型的药剂的方法。本发明还提供了通过施用促进干细胞分化为特定分化细胞类型的药剂来治疗损伤和退行性疾病的方法。

6. 发明授权

US08852937B2 Small organic molecule regulators of cell proliferation 有权
标题翻译：细胞增殖的小有机分子调节剂
公开(公告)号：US08852937B2
公开(公告)日：2014-10-07
申请号：US11894557
申请日：2007-08-20
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： C12N5/00 , A01N43/12 , A01N43/06 , A01N43/64 , C07D409/14 , C07D333/70 , A61K31/4436 , A61K31/44 , A61K31/517 , A61K31/50 , A61K31/422 , A61K31/381 , C07D409/12
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译：本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。在某些实施方案中，可以使用方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。

7. 发明申请

US20080207740A1 Small organic molecule regulators of cell proliferation 有权
标题翻译：细胞增殖的小有机分子调节剂
公开(公告)号：US20080207740A1
公开(公告)日：2008-08-28
申请号：US11894557
申请日：2007-08-20
申请人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
发明人： Anthony David Baxter , Edward Andrew Boyd , Maria Frank-Kamenetsky , Oivin Guicherit , Jeffery Porter , Stephen Price , Lee Rubin , John Harry Alexander Stibbard
IPC分类号： A61K31/381 , C12N5/06
CPC分类号： A61K31/381 , A61K31/422 , A61K31/44 , A61K31/4436 , A61K31/50 , A61K31/517 , C07D333/70 , C07D409/12 , C07D409/14
摘要： The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
摘要翻译：本发明提供用于调节细胞或组织中的增殖或分化的可用方法和试剂，包括使细胞与刺猬激动剂接触，所述刺猬激动剂例如图1和图2所示的化合物。 32和33。在某些实施方案中，可以使用所述方法和试剂来校正或抑制异常或不想要的生长状态，例如通过拮抗正常的ptc途径或激动平滑的或刺猬活性。

8. 发明申请

US20050203014A1 Composition and methods for modulating CNS activity 审中-公开
标题翻译：调节CNS活性的组成和方法
公开(公告)号：US20050203014A1
公开(公告)日：2005-09-15
申请号：US11018739
申请日：2004-12-20
申请人： Lee Rubin
发明人： Lee Rubin
IPC分类号： A61K38/17 , A61K48/00 , C12Q1/68
CPC分类号： A61K38/1709
摘要： The present invention concerns the methods and compositions for treating depression and other behavioral and/or emotional disorders of the central nervous system by administering an agonist of hedgehog signaling. Other disorders amenable to treatment by the subject method include attention deficit hyperactive disorders, non-Alzheimer dementia, and various symptoms of memory loss. The present invention also concerns the methods and compositions for enhancing memory and/or cognitive functions, both in a patient suffering from ailment affecting these functions, and in a subject with no diagnosed deficit in memory or cognitive function. The methods and compositions of the present invention stimulate neurogenesis and differentiation, and enhance synaptic transmission of neurons.
摘要翻译：本发明涉及通过施用刺猬蛋白信号传导的激动剂来治疗中枢神经系统的抑郁症和其它行为和/或情绪障碍的方法和组合物。适用于本发明方法治疗的其它障碍包括注意缺陷多动障碍，非阿尔茨海默痴呆和记忆丧失的各种症状。本发明还涉及用于增强记忆和/或认知功能的方法和组合物，在患有影响这些功能的疾病的患者中，以及在记忆或认知功能中没有诊断出缺陷的受试者中。本发明的方法和组合物刺激神经发生和分化，并增强神经元的突触传递。

9. 发明授权

US06610535B1 Progenitor cells and methods and uses related thereto 有权
标题翻译：祖细胞及其相关的方法和用途
公开(公告)号：US06610535B1
公开(公告)日：2003-08-26
申请号：US09724632
申请日：2000-11-28
申请人： Kuanghui Lu , Kevin Pang , Lee Rubin
发明人： Kuanghui Lu , Kevin Pang , Lee Rubin
IPC分类号： C12N500
CPC分类号： C12N5/0676 , A61K35/12 , A61K48/00 , C12N5/0647 , C12N5/0678 , C12N2500/02 , C12N2500/34 , C12N2500/36 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/125 , C12N2501/148 , C12N2501/23 , C12N2501/26 , C12N2501/35 , C12N2501/39 , C12N2501/835 , C12N2510/02
摘要： The present invention relates to a substantially pure population of viable pancreatic progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
摘要翻译：本发明涉及基本上纯的存活胰腺祖细胞群，以及分离这些细胞的方法。本发明还涉及这些祖细胞及其后代的某些治疗用途。

10. 发明授权

US06552016B1 Mediators of hedgehog signaling pathways, compositions and uses related thereto 有权
公开(公告)号：US06552016B1
公开(公告)日：2003-04-22
申请号：US09688018
申请日：2000-10-13
申请人： Anthony David Baxter , Edward Andrew Boyd , Oivin M. Guicherit , Stephen Price , Lee Rubin
发明人： Anthony David Baxter , Edward Andrew Boyd , Oivin M. Guicherit , Stephen Price , Lee Rubin
IPC分类号： A61K31401
CPC分类号： A61K31/496 , A61K31/40 , A61K31/4025 , A61K2039/505 , C07K14/43581 , C07K14/461 , C07K14/465 , C07K14/47 , C07K16/18
摘要： The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

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