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1. 发明申请

US20060245990A1 Contact structures 有权
标题翻译：接触结构
公开(公告)号：US20060245990A1
公开(公告)日：2006-11-02
申请号：US11477003
申请日：2006-06-28
申请人： Lawrence Smith , Abraham Gelbein , John Adams
发明人： Lawrence Smith , Abraham Gelbein , John Adams
IPC分类号： B01J8/02 , B01J35/02
CPC分类号： B01J19/2495 , B01D3/009 , B01J19/32 , B01J35/04 , B01J2219/00006 , B01J2219/32213 , B01J2219/32227 , B01J2219/32231 , B01J2219/32286 , B01J2219/32289 , B01J2219/32408 , B01J2219/32416 , B01J2219/32441 , B01J2219/32466 , B01J2219/32483 , B01J2219/32491 , B01J2219/3306 , B01J2219/3322 , C10G29/205 , C10G50/00
摘要： An internal static mixing system such as a disperser of mesh wire or expanded metal co-knit with a multi filament material selected from inert polymers, catalytic polymers, catalytic metals or mixtures in combination with a vertical reactor having a reaction zone and the disperser disposed in said reaction zone, particularly for carrying out paraffin alkylation using acid catalyst is disclosed. The wire mesh provides the structural integrity of the system as well as the open space required in reactors for the movement of vapors and liquids though the system. The disperser may be in sheets, bundles or bales or positioned within a frame.
摘要翻译：内部静态混合系统，例如网状丝网或多孔金属分散机，与选自惰性聚合物，催化聚合物，催化金属或混合物的多丝材料共同编织，与具有反应区和分散器的立式反应器组合所述反应区，特别是用于使用酸催化剂进行烷基烷基化的反应区。丝网提供了系统的结构完整性以及反应器中通过系统运动蒸气和液体所需的开放空间。分散器可以是片材，束或捆包或定位在框架内。

2. 发明申请

US20050113624A1 Paraffin alkylation 有权
公开(公告)号：US20050113624A1
公开(公告)日：2005-05-26
申请号：US10973746
申请日：2004-10-26
申请人： Lawrence Smith , Mitchell Loescher , John Adams , Abraham Gelbein
发明人： Lawrence Smith , Mitchell Loescher , John Adams , Abraham Gelbein
IPC分类号： B01J27/053 , B01J35/12 , C07C2/06 , C07C2/54 , C07C2/56 , C07C2/58 , C07C2/62 , C10G35/04 , C10G50/00 , C10G63/02
CPC分类号： C07C2/62 , C07C11/02 , C07C2527/054 , C10G29/205 , C10G2300/1081 , C10G2300/1088
摘要： A process for the alkylation of alkane with olefin or olefin precursor such as an oligomer of tertiary olefin comprising contacting a liquid system comprising acid catalyst, isoparaffin and olefin in concurrent downflow into contact in a reaction zone with a disperser mesh under conditions of temperature and pressure to react said isoparaffin and said olefin to produce an alkylate product is disclosed. Preferably, the liquid system is maintained at about its boiling point in the reaction zone. Unexpectedly, the olefin oligomers have been found to function as olefin precursors and not as olefins in the reaction. Thus, for example, a cold acid alkylation using an oligomer of isobutene (principally dimer and trimer) with isobutane produces isooctane with the isobutane reacting with the constituent isobutene units of the oligomers on a molar basis. The product isooctane is essentially the same as that produced in the conventional cold acid process.

3. 发明申请

US20070289901A1 ENERGY EFFICIENT METHOD FOR EXOTHERMIC REACTIONS 有权
标题翻译：能量反应的能量有效方法
公开(公告)号：US20070289901A1
公开(公告)日：2007-12-20
申请号：US11845642
申请日：2007-08-27
申请人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
发明人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
IPC分类号： B01D3/00
CPC分类号： B01D3/009 , B01J19/0033 , B01J2219/00006 , Y10S203/08 , Y10S585/914
摘要： An energy efficient process scheme for a highly exothermic reaction-distillation system in which the reactor is external to the distillation column and the feed to the reactor is a mixture of at least one liquid product stream from the distillation column with or without other liquid/vapor reactants. The reactor is operated under adiabatic and boiling point conditions and at a pressure that results in vaporizing a portion of the liquid flow through the reactor due to the heat of reaction. Under these conditions, reaction temperature is controlled by reactor pressure. The pressure (and hence the temperature) is maintained at a sufficiently high level such that the reactor effluent can be efficiently used to provide reboil heat for the distillation column.
摘要翻译：用于高放热反应 - 蒸馏系统的能量效率方法，其中反应器在蒸馏塔外部和反应器的进料是来自蒸馏塔的至少一种液体产物流与有或没有其它液体/蒸气的混合物反应物。反应器在绝热和沸点条件下运行，并且在由于反应热导致部分液体流过反应器的压力下运行。在这些条件下，反应温度由反应器压力控制。压力（因此温度）保持在足够高的水平，使得反应器流出物可以有效地用于为蒸馏塔提供再沸腾热。

4. 发明申请

US20060157337A1 Energy efficient method and apparatus for exothermic reactions 有权
标题翻译：节能方法和放热反应装置
公开(公告)号：US20060157337A1
公开(公告)日：2006-07-20
申请号：US11038755
申请日：2005-01-19
申请人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
发明人： Arvids Judzis , Abraham Gelbein , John Adams , Christopher Boyer
IPC分类号： B01D3/00
CPC分类号： B01D3/009 , B01J19/0033 , B01J2219/00006 , Y10S203/08 , Y10S585/914
摘要： An energy efficient process scheme for a highly exothermic reaction-distillation system in which the reactor is external to the distillation column and the feed to the reactor comprises a mixture of at least one liquid product stream from the distillation column with or without other liquid/vapor reactants. The reactor is operated under adiabatic and boiling point conditions and at a pressure that results in vaporizing a portion of the liquid flow through the reactor due to the heat of reaction. Under these conditions, reaction temperature is controlled by reactor pressure. The pressure (and hence the temperature) is maintained at a sufficiently high level such that the reactor effluent can be efficiently used to provide reboil heat for the distillation column.
摘要翻译：用于高放热反应 - 蒸馏系统的能量有效的方法，其中反应器在蒸馏塔外部和反应器的进料包括来自蒸馏塔的至少一种液体产物流与有或没有其它液体/蒸气的混合物反应物。反应器在绝热和沸点条件下运行，并且在由于反应热导致部分液体流过反应器的压力下运行。在这些条件下，反应温度由反应器压力控制。压力（因此温度）保持在足够高的水平，使得反应器流出物可以有效地用于为蒸馏塔提供再沸腾热。

5. 发明申请

US20060235246A1 Etherification process 审中-公开
标题翻译：醚化过程
公开(公告)号：US20060235246A1
公开(公告)日：2006-10-19
申请号：US11455324
申请日：2006-06-19
申请人： Lawrence Smith , John Adams
发明人： Lawrence Smith , John Adams
IPC分类号： C07C41/00
CPC分类号： C07C41/06 , C07C41/42 , C07C43/046
摘要： A process for the etherification of C4, C5 and/or C6 tertiary olefins in a hydrocarbon feed with at least one C1 to C6 alcohol, preferably C1-C4 alcohols in a distillation column reactor, preferably where C4's and C5's ethers are co-produced, in which the amount of alcohol employed in the etherification is below that which will produce an azeotrope with hydrocarbons in the overheads from the distillation column reactor. The azeotrope results from the presence of unreacted alcohol in the reaction system in the distillation column reactor. The amount of alcohol is less than the stoichiometric amount, preferably less than 90%, more preferably 10 to 80%, of the stoichiometric amount and the overheads contain less than a stoichiometric of alcohol.
摘要翻译：一种烃原料中C 4 H 5，C 5和/或C 6 H 3叔烯烃的醚化与至少一种C _{4个和C 5个醚是共同生产的，其中在醚化中使用的醇的量低于将在塔顶馏出物中产生与烃的共沸物蒸馏塔反应器。共沸物是由蒸馏塔反应器中反应体系中未反应的醇的存在引起的。醇的量小于化学计量量的化学计量量，优选小于90％，更优选10至80％，并且塔顶馏出物含有小于化学计量的醇。}

6. 发明申请

US20060030741A1 Etherification process 失效
公开(公告)号：US20060030741A1
公开(公告)日：2006-02-09
申请号：US10926208
申请日：2004-08-25
申请人： Lawrence Smith , John Adams
发明人： Lawrence Smith , John Adams
IPC分类号： C07C41/06
CPC分类号： C07C41/06 , C07C41/42 , C07C43/046
摘要： A process for the etherification of C4, C5 and/or C6 tertiary olefins in a hydrocarbon feed with at least one C1 to C6 alcohol, preferably C1-C4 alcohols in a distillation column reactor, preferably where C4's and C5's ethers are co-produced, in which the amount of alcohol employed in the etherification is below that which will produce an azeotrope with hydrocarbons in the overheads from the distillation column reactor. The azeotrope results from the presence of unreacted alcohol in the reaction system in the distillation column reactor. The amount of alcohol is less than the stoichiometric amount, preferably less than 90%, more preferably 10 to 80%, of the stoichiometric amount and the overheads contain less than a stoichiometric of alcohol.

7. 发明授权

US09642673B2 Shock wave balloon catheter with multiple shock wave sources 有权
公开(公告)号：US09642673B2
公开(公告)日：2017-05-09
申请号：US13534658
申请日：2012-06-27
申请人： John Adams , Thomas G. Goff , Doug Hakala
发明人： John Adams , Thomas G. Goff , Doug Hakala
IPC分类号： A61B17/22 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B17/2202 , A61B17/22022 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B18/00 , A61B2017/22024 , A61B2017/22025 , A61B2017/22051 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062 , A61B2017/22098
摘要： An apparatus includes a balloon adapted to be placed adjacent a calcified region of a body. The balloon is inflatable with a liquid. The apparatus further includes a shock wave generator within the balloon that produces shock waves that propagate through the liquid for impinging upon the calcified region adjacent the balloon. The shock wave generator includes a plurality of shock wave sources distributed within the balloon.

8. 发明申请

US20070262180A1 Vehicle engine-driven pressure-washing system and method 审中-公开
标题翻译：汽车发动机驱动的压力清洗系统及方法
公开(公告)号：US20070262180A1
公开(公告)日：2007-11-15
申请号：US11434424
申请日：2006-05-12
申请人： John Adams
发明人： John Adams
IPC分类号： B08B3/00 , B08B3/12 , B05B3/00
CPC分类号： B08B3/026 , B08B2203/007 , B08B2203/0241 , B08B2203/027
摘要： Mobile pressure-washing systems are disclosed that can be coupled to a carrier vehicle's engine for receiving operational power and heat power from the engine. The system includes a pump that is driven by a driven member of the engine. The system captures heat from the engine, particularly while the engine is running, such as from liquid coolant used for cooling the engine and/or from hot exhaust gases produced by the running engine. The carrier vehicle can include a utility bay including hydraulic fittings connected to the pump and heat exchanger and connectable to a supply of pressure-washing liquid and to a conduit used for discharging the stream of heated and pressurized liquid. The supply can be a tank carried on the vehicle.
摘要翻译：公开了可连接到运载工具发动机的移动式压力清洗系统，用于从发动机接收操作功率和热功率。该系统包括由发动机的从动构件驱动的泵。该系统捕获来自发动机的热量，特别是在发动机运行时，例如用于冷却发动机的液体冷却剂和/或来自运行的发动机产生的热废气。运载工具可以包括一个公用设施，包括连接到泵和热交换器的液压配件，并可连接到供应的压力清洗液体和用于排出加热和加压液体流的导管。供应可以是车上携带的坦克。

9. 发明申请

US20070254903A1 Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof 审中-公开
标题翻译：新型螺二氢吲哚或螺异喹啉化合物，其使用方法和组合
公开(公告)号：US20070254903A1
公开(公告)日：2007-11-01
申请号：US10583839
申请日：2004-12-22
申请人： P. Boatman , John Adams , Jeanne Moody , Eric Babych , Thomas Schrader
发明人： P. Boatman , John Adams , Jeanne Moody , Eric Babych , Thomas Schrader
IPC分类号： A61K31/438 , A61P25/00 , A61P9/00 , C07D401/04 , C12N5/08 , G01N33/566
CPC分类号： G01N33/6893 , C07D471/10 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N33/6872 , G01N2500/00
摘要： The invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates and stereoisomers thereof, wherein A, B, E, G, W, X, Y, Z, o, and R1 are as disclosed herein (“Compound(s) of the Invention”), which are useful as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物和立体异构体，其中A，B，E，G，W，X，Y，Z，o和R 1是如本文所公开的（“本发明的化合物”），其可用作心脏保护和/或神经保护剂。本发明还提供了包含本发明化合物和治疗，预防和/或控制血管，心血管或神经疾病或病症的方法的药物组合物，其包括向有需要的患者施用本发明的化合物。

10. 发明申请

US20070231792A1 Human g protein-coupled receptor and modulators thereof for the treatment of cardiovascular disorders 有权
标题翻译：人类g蛋白偶联受体及其调节剂用于治疗心血管疾病
公开(公告)号：US20070231792A1
公开(公告)日：2007-10-04
申请号：US10561132
申请日：2004-06-17
申请人： John Adams , Daniel Connolly
发明人： John Adams , Daniel Connolly
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/55 , A01K67/027
CPC分类号： G01N33/74 , A01K67/027 , A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/705 , C07K14/723 , C07K2319/00 , C12N2799/022 , G01N33/6893 , G01N33/76 , G01N2333/726 , G01N2800/32 , G01N2800/325
摘要： The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardiomyocytes. In some embodiments, the GPCR is coupled to Gq. In some embodiments, the GPCR increases the intracellular level of inositol 1,4,5-triphosphate (IP3). In some embodiments, a modulator of the GPCR is a modulator of cardiomyocyte hypertrophy. The present invention further relates to methods of using a modulator of the GPCR. Preferred modulators are inverse agonists and antagonists. Inverse agonists and antagonists of the invention are useful as therapeutic agents for the prevention or treatment of heart disease, including hypertrophic cardiomyopathy and congestive heart failure, in particular hypertrophic cardiomyopathy resulting from post-myocardial infarction remodeling, cardiac valve disease, sustained cardiac afterload, myocarditis, and familial hypertrophic cardiomyopathy.
摘要翻译：本发明涉及鉴定候选化合物是G蛋白偶联受体（GPCR）的调节剂的方法。在一些实施方案中，GPCR是哺乳动物，优选人。在一些实施方案中，GPCR由心肌细胞内源性表达。在一些实施例中，GPCR耦合到Gq。在一些实施方案中，GPCR增加1,4,5-三磷酸肌醇（IP3）的细胞内水平。在一些实施方案中，GPCR的调节剂是心肌细胞肥大的调节剂。本发明还涉及使用GPCR调制器的方法。优选的调节剂是反向激动剂和拮抗剂。本发明的反向激动剂和拮抗剂可用作预防或治疗心脏病，包括肥厚性心肌病和充血性心力衰竭的治疗剂，特别是由心肌梗死后重建，心脏瓣膜疾病，持续的心脏后负荷，心肌炎引起的肥大性心肌病，和家族性肥厚型心肌病。

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