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1. 发明申请

US20080261256A1 Methods of assaying receptor activity and constructs useful in such methods 审中-公开
标题翻译：测定受体活性的方法和在这些方法中有用的构建体
公开(公告)号：US20080261256A1
公开(公告)日：2008-10-23
申请号：US11875581
申请日：2007-10-19
申请人： Lawrence S. Barak , Marc G. Caron , Steven S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Steven S. Ferguson , Jie Zhang
IPC分类号： C12Q1/48 , C12Q1/02
CPC分类号： G01N33/5008 , C07K14/47 , C07K2319/00 , C07K2319/60 , C12N15/62 , G01N2333/726 , G01N2333/91
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.
摘要翻译：描述了体内和体外检测G蛋白偶联受体（GPCR）活性的方法; 测定GPCR活性的方法; 和筛选GPCR配体，G蛋白偶联受体激酶（GRK）活性和与GPCR调节过程的组分相互作用的化合物的方法。描述在这些方法中有用的构造。

2. 发明授权

US07572888B2 Methods of assaying receptor activity and constructs useful in such methods 有权
公开(公告)号：US07572888B2
公开(公告)日：2009-08-11
申请号：US10785841
申请日：2004-02-24
申请人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
IPC分类号： C07K14/00 , C07K17/00 , G01N33/53 , G01N33/567
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A01K2267/0393 , C07K14/47 , C07K14/4702 , C07K2319/00 , C07K2319/60 , C12N15/62
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.

3. 发明授权

US06770449B2 Methods of assaying receptor activity and constructs useful in such methods 有权
公开(公告)号：US06770449B2
公开(公告)日：2004-08-03
申请号：US09772644
申请日：2001-01-30
申请人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
IPC分类号： G01N33567
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A01K2267/0393 , C07K14/47 , C07K14/4702 , C07K2319/00 , C07K2319/60 , C12N15/62
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.

4. 发明授权

US6110693A Methods of assaying receptor activity and constructs useful in such methods 有权
标题翻译：测定受体活性的方法和在这些方法中有用的构建体
公开(公告)号：US6110693A
公开(公告)日：2000-08-29
申请号：US233530
申请日：1999-01-20
申请人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
IPC分类号： C07K14/47 , C12N15/62 , G01N33/52 , C07H21/04 , C07K14/00 , C12N15/12
CPC分类号： G01N33/5008 , C07K14/47 , C12N15/62 , C07K2319/00 , C07K2319/60 , G01N2333/726 , G01N2333/91
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.
摘要翻译：描述了体内和体外检测G蛋白偶联受体（GPCR）活性的方法; 测定GPCR活性的方法; 和筛选GPCR配体，G蛋白偶联受体激酶（GRK）活性和与GPCR调节过程的组分相互作用的化合物的方法。描述在这些方法中有用的构造。

5. 发明授权

US5891646A Methods of assaying receptor activity and constructs useful in such methods 失效
公开(公告)号：US5891646A
公开(公告)日：1999-04-06
申请号：US869568
申请日：1997-06-05
申请人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
IPC分类号： C07K14/47 , C12N15/62 , G01N33/52 , C07H21/04 , C07K14/00 , C12N15/12
CPC分类号： G01N33/5008 , C07K14/47 , C12N15/62 , C07K2319/00 , C07K2319/60 , G01N2333/726 , G01N2333/91
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.

6. 发明授权

US07138240B2 Methods of assaying receptor activity 有权
标题翻译：测定受体活性的方法
公开(公告)号：US07138240B2
公开(公告)日：2006-11-21
申请号：US10141725
申请日：2002-05-09
申请人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
发明人： Lawrence S. Barak , Marc G. Caron , Stephen S. Ferguson , Jie Zhang
IPC分类号： G01N33/566 , G01N21/76 , G01N33/53
CPC分类号： G01N33/5008 , C07K14/47 , C07K2319/00 , C07K2319/60 , C12N15/62 , G01N2333/726 , G01N2333/91
摘要： Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process.
摘要翻译：描述了体内和体外检测G蛋白偶联受体（GPCR）活性的方法; 测定GPCR活性的方法; 和筛选GPCR配体，G蛋白偶联受体激酶（GRK）活性和与GPCR调节过程的组分相互作用的化合物的方法。

7. 发明申请

US20160345828A1 SYSTEM AND METHOD FOR MULTI-SCALE CLOSED-LOOP EYE TRACKING WITH REAL-TIME IMAGE MONTAGING 有权
标题翻译：用于实时图像聚合的多尺度闭环眼跟踪的系统和方法
公开(公告)号：US20160345828A1
公开(公告)日：2016-12-01
申请号：US15158803
申请日：2016-05-19
申请人： Qiang Yang , Jie Zhang
发明人： Qiang Yang , Jie Zhang
IPC分类号： A61B3/15 , G02B26/10 , A61B3/12 , A61B3/113 , A61B3/00
CPC分类号： A61B3/152 , A61B3/0025 , A61B3/113 , A61B3/1225 , G02B26/105
摘要： A system for multi-scale closed-loop eye tracking to compensate for translation and rotation motion while imaging in vivo a surface area of an internal structure of an eye of a subject includes a narrow field imaging device optically coupled to an optical path to receive light reflected from the surface area of the structure of the eye. A wide field camera is optically coupled to the optical path by a beam splitter disposed in the optical path. A tracking mirror is disposed in the optical path between the beam splitter and the structure of the eye. A control process algorithm actively compensates substantially in real time for both translational and rotational movements of the eye. A system where a torsional correction device causes a rotating movement of a subject's head and a method for multi-scale closed-loop eye tracking are also described.
摘要翻译：一种用于多尺度闭环眼睛跟踪的系统，用于补偿平移和旋转运动，同时在体内成像对象的眼睛的内部结构的表面区域包括光学耦合到光路以接收光的窄场成像装置从眼睛结构的表面积反射出来。通过设置在光路中的分束器将宽视场摄像机光耦合到光路。跟踪镜设置在分束器和眼睛结构之间的光路中。控制过程算法主动地实时补偿眼睛的平移和旋转运动。还描述了一种系统，其中扭转校正装置引起受试者的头部的旋转运动以及用于多尺度闭环眼睛跟踪的方法。

8. 发明授权

US09346245B2 Laminar composite toilet lid and seat 有权
标题翻译：层压复合马桶盖和座椅
公开(公告)号：US09346245B2
公开(公告)日：2016-05-24
申请号：US13083161
申请日：2011-04-08
申请人： Chengdong Wu , Jie Zhang
发明人： Chengdong Wu , Jie Zhang
IPC分类号： A47K13/14 , B32B21/02 , A47K13/02 , B32B27/30
CPC分类号： B32B21/02 , A47K13/02 , B32B27/308 , B32B2307/412 , B32B2317/12 , B32B2317/16 , B32B2333/12 , B32B2509/00 , Y10T428/24802
摘要： Embodiments of the present disclosure include a laminate composite toilet lid and seat and a method of manufacturing thereof. The toilet lid includes a core structural layer having a shape and size associated with the toilet lid. The toilet lid also includes a first decorative graphic layer disposed on a first surface of the core structural layer. The toilet lid further includes a plurality of exterior layers disposed on exterior surfaces of the core structural layer and the first decorative graphic layer, the exterior layers configured to envelop the toilet lid.
摘要翻译：本公开的实施例包括层压复合马桶盖和座椅及其制造方法。马桶盖包括具有与马桶盖相关联的形状和尺寸的芯结构层。马桶盖还包括设置在芯结构层的第一表面上的第一装饰图形层。马桶盖还包括设置在芯结构层和第一装饰图形层的外表面上的多个外层，外层构造成包封马桶盖。

9. 发明授权

US09205180B2 Method and device for loading medical appliance with medicaments and/or polymers 有权
标题翻译：用药物和/或聚合物装载医疗器具的方法和装置
公开(公告)号：US09205180B2
公开(公告)日：2015-12-08
申请号：US13522819
申请日：2011-01-19
申请人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
发明人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
IPC分类号： A61L33/00 , A61L31/06 , A61L31/16 , A61F2/91
CPC分类号： A61F2/82 , A61F2/91 , A61F2240/001 , A61F2250/0068 , A61L31/06 , A61L31/16 , A61L2300/416 , B05C21/00 , C08L67/04
摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.
摘要翻译：一种用于装载具有药物和/或聚合物的医疗器具的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。

10. 发明授权

US08869383B2 Method of making magnetics assembly 有权
标题翻译：制作磁性装配的方法
公开(公告)号：US08869383B2
公开(公告)日：2014-10-28
申请号：US13523076
申请日：2012-06-14
申请人： Yong-Chun Xu , Jie Zhang
发明人： Yong-Chun Xu , Jie Zhang
IPC分类号： H01F7/06 , H01F17/06 , H01F27/28
CPC分类号： H01F17/062 , H01F27/2823 , H01F27/2828 , H01F41/07 , H01F41/08 , Y10T29/4902 , Y10T29/49069 , Y10T29/49071 , Y10T29/49073 , Y10T29/49075
摘要： A magnetics assembly (100) including a transformer (1) made of litz wire. The transformer includes a toroid core (2) and a bundle of wires (3) winding around the toroid core. The bundle of wires includes first to eighth wires, and has a central portion with all eight wires twisted together and winding around the toroid core. First and second ends of the bundle of wires oppositely extend out from the toroidal core. The ends of the first to eighth wires are connected to form a primary and a secondary coils of the transformer, wherein the second ends of the first wire and the second wire, and the first ends of the third wire and the fourth wire are sorted out to form central taps (35, 36) of the primary and secondary coils, respectively.
摘要翻译：磁性组件（100）包括由绞合线制成的变压器（1）。变压器包括环形磁芯（2）和缠绕在环形磁芯周围的电线束（3）。电线束包括第一至第八导线，并且具有中心部分，所有八条线绞合在一起并围绕环形芯线缠绕。线束的第一和第二端从环形芯相对地延伸出来。连接第一至第八导线的端部以形成变压器的初级线圈和次级线圈，其中第一线和第二线的第二端以及第三线和第四线的第一端被整理以分别形成初级和次级线圈的中心抽头（35,36）。

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