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1. 发明授权

US07829665B2 Macrocyclic inhibitors of hepatitis C virus replication 有权
标题翻译：丙型肝炎病毒复制的大环抑制剂
公开(公告)号：US07829665B2
公开(公告)日：2010-11-09
申请号：US11491126
申请日：2006-07-21
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07K7/50
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

2. 发明申请

US20090148407A1 Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication 审中-公开
标题翻译：丙型肝炎病毒复制的新型大环抑制剂
公开(公告)号：US20090148407A1
公开(公告)日：2009-06-11
申请号：US11996902
申请日：2006-07-17
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/21 , C07K5/12 , A61K38/12 , C07D209/18 , C12N9/99 , A61K39/395
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式（I）至通式（VIII）的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

3. 发明授权

US08299021B2 Macrocyclic inhibitors of hepatitis C virus replication 失效
标题翻译：丙型肝炎病毒复制的大环抑制剂
公开(公告)号：US08299021B2
公开(公告)日：2012-10-30
申请号：US13450885
申请日：2012-04-19
申请人： Lawrence M Blatt , Scott D Seiwert , Steven W Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M Blatt , Scott D Seiwert , Steven W Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/00
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

4. 发明申请

US20120208995A1 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 失效
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：US20120208995A1
公开(公告)日：2012-08-16
申请号：US13450885
申请日：2012-04-19
申请人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M. Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07D498/18
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

5. 发明申请

US20090169510A1 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：US20090169510A1
公开(公告)日：2009-07-02
申请号：US12106234
申请日：2008-04-18
申请人： Lawrence M Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence M Blatt , Scott D. Seiwert , Steven W. Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Todd Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： C07K5/12 , A61K38/12 , A61K38/21 , C12N9/99 , A61P31/12
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

6. 发明申请

US20070054842A1 Novel macrocyclic inhibitors of hepatitis C virus replication 有权
标题翻译：丙型肝炎病毒复制的新型大环抑制剂
公开(公告)号：US20070054842A1
公开(公告)日：2007-03-08
申请号：US11491126
申请日：2006-07-21
申请人： Lawrence Blatt , Scott Seiwert , Steven Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
发明人： Lawrence Blatt , Scott Seiwert , Steven Andrews , Pierre Martin , Andreas Schumacher , Bradley Barnett , C. Eary , Robert Kaus , Timothy Kercher , Weidong Liu , Michael Lyon , Paul Nichols , Bin Wang , Tarek Sammakia , April Kennedy , Yutong Jiang
IPC分类号： A61K38/12
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/1793 , A61K38/212 , A61K38/217 , A61K38/2292 , A61K38/55 , C07D471/04 , C07D487/04 , C07K5/0804 , A61K2300/00
摘要： The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供通式I至通式VIII的化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

7. 发明授权

US07732599B2 Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin 有权
标题翻译：四氢生物喋呤和四氢生物喋呤的类似物的制备方法
公开(公告)号：US07732599B2
公开(公告)日：2010-06-08
申请号：US10579106
申请日：2004-11-17
申请人： Rudolf Moser , Viola Groehn , Andreas Schumacher , Pierre Martin , Dirk Spielvogel
发明人： Rudolf Moser , Viola Groehn , Andreas Schumacher , Pierre Martin , Dirk Spielvogel
IPC分类号： C07D487/00 , C07D491/00
CPC分类号： C07D487/14 , C07D475/04
摘要： Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
摘要翻译：从新喋呤和/或6-取代蝶呤制备四氢生物喋呤的方法，其具有提高的产率和高立体选择性。本文还公开了在制备四氢生物蝶呤（例如可用于制备四氢生物蝶呤的选择性保护的新蝶呤）中制备的新的单个中间体。

8. 发明申请

US20070244322A1 Process for Preparing Tetrahydrobiopterin and Analogs of Tetrahydrobiopterin 有权
标题翻译：制备四氢生物蝶呤和四氢生物蝶呤类似物的方法
公开(公告)号：US20070244322A1
公开(公告)日：2007-10-18
申请号：US10579106
申请日：2004-11-17
申请人： Rudolf Moser , Viola Groehn , Andreas Schumacher , Pierre Martin , Dirk Spielvogel
发明人： Rudolf Moser , Viola Groehn , Andreas Schumacher , Pierre Martin , Dirk Spielvogel
IPC分类号： C07D475/04
CPC分类号： C07D487/14 , C07D475/04
摘要： Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
摘要翻译：从新喋呤和/或6-取代蝶呤制备四氢生物喋呤的方法，其具有提高的产率和高立体选择性。本文还公开了在制备四氢生物蝶呤（例如可用于制备四氢生物蝶呤的选择性保护的新蝶呤）中制备的新的单个中间体。

9. 发明申请

US20150368199A1 PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER OR THE BENZENE SULFONATE SALT THEREOF, AND COMPOUNDS USEFUL IN THAT PROCESS 有权
标题翻译：制备3 - [（4S）-8-溴-1-甲基-6-（2-吡啶基）-4H-咪唑并[1,2-A] [1,4]苯并噻吩并[4-y]]丙酸甲酯的方法 ESTER或其中的苯甲磺酸盐及其用途的化合物
公开(公告)号：US20150368199A1
公开(公告)日：2015-12-24
申请号：US14841899
申请日：2015-09-01
申请人： Gary Stuart Tilbrook , Andreas Schumacher , Rene Emmenegger
发明人： Gary Stuart Tilbrook , Andreas Schumacher , Rene Emmenegger
IPC分类号： C07D213/50
CPC分类号： C07D401/04 , C07D213/40 , C07D213/50 , C07D487/04 , C07F9/65586
摘要： The invention concerns a new process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]-propionic acid methyl ester or 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester benzene sulfonate (P) which comprises reacting 3-[(S)-7-bromo-2-((R and/or S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester of formula (EM) with an oxidizing agent and optionally treating the reaction product under acidic conditions, such as to produce the compound of formula (F) or the compound (P), and new compounds useful as starting material or as intermediate for performing that process.
摘要翻译：本发明涉及一种制备3 - [（4S）-8-溴-1-甲基-6-（2-吡啶基）-4H-咪唑并[1,2-a] [1,4]苯并二氮杂- 吡啶-3-基] - 丙酸甲酯或3 - [（4S）-8-溴-1-甲基-6-（2-吡啶基）-4H-咪唑并〔1,2-a〕〔1,4〕苯并二氮杂-4- 吡啶-2-基]丙酸甲酯苯磺酸盐（P），其包括使3 - [（S）-7-溴-2 - （（R和/或S）-2-羟基 - 丙基氨基） -3H-苯并[e] [1,4]二氮杂-3-基] - 丙酸甲酯与氧化剂反应，并在酸性条件下任选地处理反应产物，例如制备式（F）或化合物（P），以及可用作原料的新化合物或用于进行该方法的中间体。

10. 发明申请

US20100214724A1 POWER SWITCH FOR PREVENTING ACCIDENTAL ARCS 有权
标题翻译：用于防止意外ARCS的电源开关
公开(公告)号：US20100214724A1
公开(公告)日：2010-08-26
申请号：US12599224
申请日：2008-05-09
申请人： Samuel Dahl , Andreas Schumacher , Wolfgang Wagner
发明人： Samuel Dahl , Andreas Schumacher , Wolfgang Wagner
IPC分类号： H02B1/00
CPC分类号： H02H1/0023 , H02H3/023 , H02H3/08
摘要： A power switch disposed in a housing includes a contact breaker configured to connect and disconnect a low-voltage switchgear from a power source supplying the low-voltage switchgear, a triggering device configured to disconnect the low-voltage switchgear in an overload event, a current detection device, a control device, a first evaluation device configured to evaluate an accidental arc overcurrent, and a second evaluation device configured to evaluate the accidental arc overcurrent. The power switch is configured to be activated via an overcurrent signal generated by an arc monitoring system in response to the accidental arc overcurrent. The overcurrent signal is linked to the at least one triggering signal. The second evaluation has a threshold above a threshold of the first evaluation device. The triggering device is configured to be activated via a turn-off pulse when a signal from the current detection device is above the threshold of the second evaluation device.
摘要翻译：设置在壳体中的电源开关包括接触断路器，其被配置为将低压开关设备与供应低压开关设备的电源连接和断开;触发装置，其被配置为在过载事件中断开低压开关设备，电流检测装置，控制装置，被配置为评估意外的过电流的第一评估装置，以及被配置为评估意外的电弧过电流的第二评估装置。电源开关被配置为通过由电弧监视系统响应于意外的电弧过电流而产生的过电流信号而被激活。过电流信号与至少一个触发信号相连。第二评估具有高于第一评估装置的阈值的阈值。触发装置被配置为当来自当前检测装置的信号高于第二评估装置的阈值时通过关断脉冲被激活。

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