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1. 发明授权

US07514214B2 Selective functionalization of carbon nanotube tips allowing fabrication of new classes of nanoscale sensing and manipulation tools 有权
标题翻译：碳纳米管尖端的选择性功能化，允许制造新类型的纳米级感测和操作工具
公开(公告)号：US07514214B2
公开(公告)日：2009-04-07
申请号：US10783713
申请日：2004-02-20
申请人： Lawrence A. Wade , Ian R. Shapiro , Charles Patrick Collier , Maria J. Esplandiu , Vern Garrett Bittner, Jr. , Konstantinos P. Giapis
发明人： Lawrence A. Wade , Ian R. Shapiro , Charles Patrick Collier , Maria J. Esplandiu , Vern Garrett Bittner, Jr. , Konstantinos P. Giapis
IPC分类号： C12Q1/68
CPC分类号： G01Q70/12
摘要： Embodiments in accordance with the present invention relate to techniques for the growth and attachment of single wall carbon nanotubes (SWNT), facilitating their use as robust and well-characterized tools for AFM imaging and other applications. In accordance with one embodiment, SWNTs attached to an AFM tip can function as a structural scaffold for nanoscale device fabrication on a scanning probe. Such a probe can trigger, with nanometer precision, specific biochemical reactions or conformational changes in biological systems. The consequences of such triggering can be observed in real time by single-molecule fluorescence, electrical, and/or AFM sensing. Specific embodiments in accordance with the present invention utilize sensing and manipulation of individual molecules with carbon nanotubes, coupled with single-molecule fluorescence imaging, to allow observation of spectroscopic signals in response to mechanically induced molecular changes. Biological macromolecules such as proteins or DNA can be attached to nanotubes to create highly specific single-molecule probes for investigations of intermolecular dynamics, for assembling hybrid biological and nanoscale materials, or for developing molecular electronics. In one example, electrical wiring of single redox enzymes to carbon nanotube scanning probes allows observation and electrochemical control over single enzymatic reactions by monitoring fluorescence from a redox-active cofactor or the formation of fluorescent products. Enzymes “nanowired” to the tips of carbon nanotubes in accordance with embodiments of the present invention, may enable extremely sensitive probing of biological stimulus-response with high spatial resolution, including product-induced signal transduction.
摘要翻译：根据本发明的实施方案涉及用于生长和附着单壁碳纳米管（SWNT）的技术，便于将其用作用于AFM成像和其它应用的鲁棒且良好表征的工具。根据一个实施例，附接到AFM尖端的SWNT可以用作扫描探针上的纳米级器件制造的结构支架。这样的探针可以以纳米精度触发生物系统中的特定生化反应或构象变化。这种触发的后果可以通过单分子荧光，电学和/或AFM感测实时观察。根据本发明的具体实施方案利用与单分子荧光成像耦合的碳纳米管的单个分子的感测和操纵，以便响应于机械诱导的分子变化观察光谱信号。生物大分子如蛋白质或DNA可以连接到纳米管上，以产生用于分子间动力学研究的高度特异性单分子探针，用于组装混合生物和纳米级材料，或用于开发分子电子学。在一个实例中，单个氧化还原酶与碳纳米管扫描探针的电气配线允许通过监测来自氧化还原活性辅助因子的荧光或荧光产物的形成来观察和电化学控制单个酶反应。根据本发明的实施方案，“纳米线”纳米线对碳纳米管的尖端可以实现具有高空间分辨率（包括产物诱导的信号转导）的生物刺激反应的极度敏感的探测。

2. 发明申请

US20090114883A1 Metal-filled nanostructures 审中-公开
标题翻译：金属填充纳米结构
公开(公告)号：US20090114883A1
公开(公告)日：2009-05-07
申请号：US11545861
申请日：2006-10-11
申请人： Charles Patrick Collier , Konstantinos P. Giapis , Jinyu Chen , Oleksandr Kutana
发明人： Charles Patrick Collier , Konstantinos P. Giapis , Jinyu Chen , Oleksandr Kutana
IPC分类号： H01B1/04 , H01B1/02
CPC分类号： H01B1/04
摘要： A metal-filled nanostructure and fabrication methods thereof are discussed. A metal-filled nanostructure according to an embodiment of the present invention comprises a metal filling and a nanostructure shell, and may provide superior conductivity and contact resistance over those inherent in the nanostructure shell. In a preferred embodiment, the metal filled nanostructure comprises a continuous metal nanowire inserted into a single-walled carbon nanotube using an electrowetting technique.
摘要翻译：讨论了金属填充纳米结构及其制造方法。根据本发明实施方案的金属填充纳米结构包括金属填充物和纳米结构壳，并且可以提供优于纳米结构壳中固有的导电性和接触电阻的优异的导电性和接触电阻。在优选的实施方案中，金属填充的纳米结构包括使用电润湿技术插入到单壁碳纳米管中的连续金属纳米线。

3. 发明授权

US07211795B2 Method for manufacturing single wall carbon nanotube tips 失效
标题翻译：制造单壁碳纳米管尖端的方法
公开(公告)号：US07211795B2
公开(公告)日：2007-05-01
申请号：US11045240
申请日：2005-01-27
申请人： Charles Patrick Collier , Ma Ziyang , Stephen R. Quake , Ian R. Shapiro , Lawrence Wade
发明人： Charles Patrick Collier , Ma Ziyang , Stephen R. Quake , Ian R. Shapiro , Lawrence Wade
IPC分类号： G21K7/00 , G01B5/28
CPC分类号： C01B32/162 , C01B2202/02 , C01B2202/34 , C01B2202/36 , G01Q60/38 , G01Q70/12 , G01R3/00
摘要： A method for fabricating assembled structures. The method includes providing a tip structure, which has a first end, a second end, and a length defined between the first end and the second end. The second end is a free end. The method includes attaching a nano-sized structure along a portion of the length of the tip structure to extend a total length of the tip structure to include the length of the tip structure and a first length associated with the nano-sized structure. The method includes shortening the nano-sized structure from the first length to a second length. The method also includes pushing the nano-sized structure in a direction parallel to the second length to reduce the second length to a third length of the nano-sized structure along the direction parallel to the second length to cause the nano-sized structure to move along a portion of the length of the tip structure.
摘要翻译：一种组装结构的制造方法。该方法包括提供尖端结构，其具有第一端，第二端和限定在第一端和第二端之间的长度。第二端是自由端。该方法包括沿着尖端结构的长度的一部分附接纳米尺寸结构以延伸尖端结构的总长度以包括尖端结构的长度和与纳米尺寸结构相关联的第一长度。该方法包括将纳米尺寸结构从第一长度缩短到第二长度。该方法还包括沿平行于第二长度的方向推动纳米尺寸结构，以沿平行于第二长度的方向将纳米尺寸结构的第二长度减小到第三长度，以使纳米尺寸结构移动沿着尖端结构的长度的一部分。

4. 发明授权

US08492160B1 Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures 有权
标题翻译：生物标记传感器和多色成像和处理单分子生命特征的方法
公开(公告)号：US08492160B1
公开(公告)日：2013-07-23
申请号：US12720103
申请日：2010-03-09
申请人： Lawrence A. Wade , Charles Patrick Collier
发明人： Lawrence A. Wade , Charles Patrick Collier
IPC分类号： G01N1/28 , C12N13/00
CPC分类号： G01Q60/42 , G01Q80/00
摘要： The invention is a device including array of aciive regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region and a silane material overlying the surface region. A first active region overlies a first portion of the silane material. The first region has a first dimension of less than 1 micron in size and has first molecules capable of binding to the first portion of the silane material. A second active region overlies a second portion of the silane material. The second region has a second dimension of less than 1 micron in size, second molecules capable of binding to the second portion of the active region, and a spatial distance separates the first active region and the second active region.
摘要翻译：本发明是一种装置，其包括用于在顺序过程（例如顺序反应）中使至少两个活性区域中的一种或多种物质反应的活性区域的阵列。该装置具有透明基板部件，该基板部件具有覆盖在表面区域上的表面区域和硅烷材料。第一活性区域覆盖硅烷材料的第一部分。第一区域具有尺寸小于1微米的第一尺寸，并且具有能够结合硅烷材料的第一部分的第一分子。第二活性区域覆盖硅烷材料的第二部分。第二区域具有尺寸小于1微米的第二尺寸，能够结合有源区域的第二部分的第二分子，以及空间距离分离第一有源区域和第二有源区域。

5. 发明申请

US20080216565A1 PROBE TIPS 审中-公开
标题翻译：探索提示
公开(公告)号：US20080216565A1
公开(公告)日：2008-09-11
申请号：US12045412
申请日：2008-03-10
申请人： Donato Ceres , Yoshie Narui , Charles Patrick Collier
发明人： Donato Ceres , Yoshie Narui , Charles Patrick Collier
IPC分类号： G01B5/28 , G01D21/00
CPC分类号： G01Q60/40 , G01Q70/12
摘要： Probe tips comprising tips and coatings are described. The tips and coatings may be selected to provide various probe-tip features, including, but not limited to, high reproducibility, high reliability, low cost, ultra-sharpness, high conductivity and/or simultaneous critical dimension imaging and sidewall roughness analysis.
摘要翻译：描述了包括尖端和涂层的探针尖端。可以选择尖端和涂层以提供各种探针尖端特征，包括但不限于高再现性，高可靠性，低成本，超清晰度，高导电性和/或同时临界尺寸成像和侧壁粗糙度分析。

6. 发明授权

US06198655B1 Electrically addressable volatile non-volatile molecular-based switching devices 有权
标题翻译：电可寻址挥发性非挥发性分子基开关器件
公开(公告)号：US06198655B1
公开(公告)日：2001-03-06
申请号：US09459246
申请日：1999-12-10
申请人： James Richard Heath , Charles Patrick Collier , Gunter Mattersteig , Francisco M. Raymo , James Fraser Stoddart , Eric Wong
发明人： James Richard Heath , Charles Patrick Collier , Gunter Mattersteig , Francisco M. Raymo , James Fraser Stoddart , Eric Wong
IPC分类号： G11C1300
CPC分类号： G11C13/0014 , B82Y10/00 , G11C13/02 , G11C2213/14 , G11C2213/77 , G11C2213/81 , H01L27/28 , H01L51/0595
摘要： Volatile and non-volatile solid state molecular switching devices which are electrically addressable and may be used in memory cells, routing circuits, inverters and field programmable devices which may or may not be designed to exhibit diode behavior. The molecular switching devices include certain [2] catenanes as bistable molecules which are sandwiched between two switch terminals. The switches are extremely small and have dimensions which range from several microns down to a few nanometers.
摘要翻译：挥发性和非挥发性固态分子开关器件，其可电寻址并且可用于存储器单元，布线电路，反相器和现场可编程器件，其可被设计为表现出二极管性能。分子切换装置包括夹在两个开关端子之间的双稳态分子的某些[2]连胺。开关非常小，尺寸范围从几微米到几纳米。

7. 发明申请

US20120322162A1 GENERATION OF MONODISPERSE DROPLETS BY SHAPE-INDUCED SHEAR AND INTERFACIAL CONTROLLED FUSION OF INDIVIDUAL DROPLETS ON-DEMAND 有权
标题翻译：通过形状诱导的剪切和单独控制的个体滴灌的融合产生单体滴灌
公开(公告)号：US20120322162A1
公开(公告)日：2012-12-20
申请号：US13161080
申请日：2011-06-15
申请人： Charles Patrick Collier , Scott T. Retterer , Seung-Yong Jung
发明人： Charles Patrick Collier , Scott T. Retterer , Seung-Yong Jung
IPC分类号： G01N21/76 , F15C1/06
CPC分类号： B01F3/0807 , B01F13/0071 , B01F15/0241 , B01L3/0268 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2400/02 , B01L2400/0406 , Y10T137/0329 , Y10T137/218 , Y10T137/2191 , Y10T137/2218 , Y10T137/2224
摘要： A microfluidic device for generation of monodisperse droplets and initiating a chemical reaction is provided. The microfluidic device includes a first input microchannel having a first dimension and including a first phase located therein. The device also includes a second input microchannel having a second dimension and including a second phase located therein. In accordance with the present disclosure, the second dimension is different from the first dimension and the first phase is immiscible in the second phase. A microchannel junction is also present and is in communication with the first input microchannel and the second input microchannel. The device further includes an output channel in communication with the microchannel junction and set to receive a monodisperse droplet. In the present disclosure, the difference in the first dimension and the second dimension creates an interfacial tension induced force at the microchannel junction which forms the monodisperse droplet.
摘要翻译：提供了用于产生单分散液滴和引发化学反应的微流体装置。微流体装置包括具有第一尺寸并且包括位于其中的第一相的第一输入微通道。该装置还包括具有第二尺寸并且包括位于其中的第二相的第二输入微通道。根据本公开，第二维度与第一维度不同，并且第一相位在第二阶段中是不混溶的。微通道结也存在并且与第一输入微通道和第二输入微通道连通。该装置还包括与微通道结连通并设置为接收单分散液滴的输出通道。在本公开中，第一尺寸和第二尺寸的差异在微通道结处产生界面张力诱导力，其形成单分散液滴。

8. 发明授权

US08944083B2 Generation of monodisperse droplets by shape-induced shear and interfacial controlled fusion of individual droplets on-demand 有权
标题翻译：通过形状诱导的剪切和单个液滴的界面控制融合来生成单分散液滴
公开(公告)号：US08944083B2
公开(公告)日：2015-02-03
申请号：US13161080
申请日：2011-06-15
申请人： Charles Patrick Collier , Scott T. Retterer , Seung-Yong Jung
发明人： Charles Patrick Collier , Scott T. Retterer , Seung-Yong Jung
IPC分类号： E03B1/00 , B01F3/08 , B01L3/00 , B01F13/00 , B01F15/02 , B01L3/02
CPC分类号： B01F3/0807 , B01F13/0071 , B01F15/0241 , B01L3/0268 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2400/02 , B01L2400/0406 , Y10T137/0329 , Y10T137/218 , Y10T137/2191 , Y10T137/2218 , Y10T137/2224
摘要： A microfluidic device for generation of monodisperse droplets and initiating a chemical reaction is provided. The microfluidic device includes a first input microchannel having a first dimension and including a first phase located therein. The device also includes a second input microchannel having a second dimension and including a second phase located therein. In accordance with the present disclosure, the second dimension is different from the first dimension and the first phase is immiscible in the second phase. A microchannel junction is also present and is in communication with the first input microchannel and the second input microchannel. The device further includes an output channel in communication with the microchannel junction and set to receive a monodisperse droplet. In the present disclosure, the difference in the first dimension and the second dimension creates an interfacial tension induced force at the microchannel junction which forms the monodisperse droplet.
摘要翻译：提供了用于产生单分散液滴和引发化学反应的微流体装置。微流体装置包括具有第一尺寸并且包括位于其中的第一相的第一输入微通道。该装置还包括具有第二尺寸并且包括位于其中的第二相的第二输入微通道。根据本公开，第二维度与第一维度不同，并且第一相位在第二阶段中是不混溶的。微通道结也存在并且与第一输入微通道和第二输入微通道连通。该装置还包括与微通道结连通并设置为接收单分散液滴的输出通道。在本公开中，第一尺寸和第二尺寸的差异在微通道结处产生界面张力诱导力，其形成单分散液滴。

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