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1. 发明申请

US20100159446A1 Detection Assays and Use Thereof 审中-公开
标题翻译：检测分析及其用途
公开(公告)号：US20100159446A1
公开(公告)日：2010-06-24
申请号：US12176798
申请日：2008-07-21
申请人： Lawrence A. Haff , Yumei Huang , Richard A. Martinelli , Benjamin A. Seigal , David J. Livingston , Wei-Chuan Sun
发明人： Lawrence A. Haff , Yumei Huang , Richard A. Martinelli , Benjamin A. Seigal , David J. Livingston , Wei-Chuan Sun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/485 , C12Q1/6804 , G01N2333/705 , G01N2333/91215 , G01N2333/95 , G01N2500/02 , C12Q2565/101 , C12Q2563/179
摘要： The invention provides compositions and methods for the detection and/or quantification of biological targets (e.g., nucleic acids and proteins) by the nucleic acid-templated creation of one or more reaction products, for example, epitopes, enzyme substrates, enzyme activators, and ligands. The reaction products can be detected and/or quantitated after signal amplification using an amplification system.
摘要翻译：本发明提供用于通过核酸模板产生一种或多种反应产物，例如表位，酶底物，酶活化剂和/或生物学靶标的检测和/或定量生物学靶标（例如核酸和蛋白质）的组合物和方法配体。可以使用扩增系统在信号放大后检测和/或定量反应产物。

2. 发明申请

US20100159455A1 RECEPTOR FAMILY PROFILING 审中-公开
标题翻译：受体家族简介
公开(公告)号：US20100159455A1
公开(公告)日：2010-06-24
申请号：US12441672
申请日：2007-09-18
申请人： Tanya Landsman , David J. Livingston , Richard A. Martinelli , Yumei Huang , Benjamin Adam Seigal , Dingxue Yan , James M. Coull , Andrew M. Stern
发明人： Tanya Landsman , David J. Livingston , Richard A. Martinelli , Yumei Huang , Benjamin Adam Seigal , Dingxue Yan , James M. Coull , Andrew M. Stern
IPC分类号： C12Q1/68
CPC分类号： G01N33/542 , C12Q1/6804 , G01N33/566 , G01N2333/71 , C12Q2565/101 , C12Q2563/179 , C12Q2563/131
摘要： The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics.
摘要翻译：本发明提供组合物和方法，例如测定技术及其在生物检测和诊断中的应用。更具体地，本发明提供了基于生物检测和受体（及其家族）和蛋白质（及其家族）的生物检测和分析的核酸模板化学的组合物和方法，以及其在诊断中的用途。

3. 发明申请

US20130084561A1 BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY 审中-公开
标题翻译：通过核酸化学化学的生物防治
公开(公告)号：US20130084561A1
公开(公告)日：2013-04-04
申请号：US13467698
申请日：2012-05-09
申请人： James M. Coull , Andrew M. Stern , Lawrence A. Haff , Barbara S. Fox , Yumei Huang
发明人： James M. Coull , Andrew M. Stern , Lawrence A. Haff , Barbara S. Fox , Yumei Huang
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6818 , C12Q1/6823 , G01N33/532 , G01N33/58 , C12Q2565/501 , C12Q2523/101
摘要： The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.
摘要翻译：本发明提供了通过核酸模板化学，例如通过产生荧光，化学发光和/或发色信号来检测生物学靶标（例如核酸和蛋白质）的组合物和方法。

4. 发明申请

US20110059458A1 COMPOSITIONS AND METHODS FOR CATALYZING DNA-PROGRAMMED CHEMISTRY 审中-公开
标题翻译：用于催化DNA编程化学的组合物和方法
公开(公告)号：US20110059458A1
公开(公告)日：2011-03-10
申请号：US12918708
申请日：2009-02-20
申请人： Yumei Huang , James M. Coull , David J. Livingston
发明人： Yumei Huang , James M. Coull , David J. Livingston
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6816 , C12N15/1068 , C12Q2563/155 , C12Q2563/131
摘要： The present invention relates compositions and methods that are useful in catalyzing DNA-Programmed Chemistry (or Nucleic Acid-templated chemistry) for use in therapeutic and diagnostic applications.
摘要翻译：本发明涉及可用于催化用于治疗和诊断应用的DNA程序化学（或核酸模板化学）的组合物和方法。

5. 发明授权

US09168625B2 Computer numerical control machine tool for grinding two sides of a plane by shifting self-rotation and ultrasonic vibration 有权
标题翻译：计算机数控机床用于通过自转和超声波振动来研磨平面的两侧
公开(公告)号：US09168625B2
公开(公告)日：2015-10-27
申请号：US13820975
申请日：2011-09-08
申请人： Yumei Huang , Wen Yan , Feng Gao , Hao Jiang
发明人： Yumei Huang , Wen Yan , Feng Gao , Hao Jiang
IPC分类号： B24B1/04 , B24B37/08 , B24B7/17 , B24B41/06
CPC分类号： B24B1/04 , B24B7/17 , B24B37/08 , B24B41/067
摘要： A computer numerical control machine tool for grinding two sides of a plane by shifting self-rotation ultrasonic vibration, wherein a pillar (3) is provided on the tool body (1) of the machine tool, a Y axis movement assembly (12) is provided on the platform of the tool body (1), with a lower revolving movement assembly (11), which revolves about a Z coordinate axis, being mounted on the upper surface of the Y axis movement assembly (12), and a lower grinding plate (10) being mounted coaxially above the lower revolving movement assembly (11); an ultrasonic vibration assembly (2) is mounted fixedly on the pillar (3), with a separation plate (8) for clamping a workpiece assembly (9) being provided on the ultrasonic vibration assembly (2); an X axis movement assembly (4) is mounted on the upper part of the pillar (3), a Z axis movement assembly (5) is mounted on the upright face of the X axis movement assembly (4), with an upper revolving movement assembly (6), which revolves about the Z coordinate axis, being provided on the Z axis movement assembly (5), and an upper grinding plate (7) being mounted coaxially on the revolving axis of the upper revolving movement assembly (6). The present invention enhances the time variation of grinding movement tracks, the uniformity of grinding speed distribution, machining efficiency and machining precision.
摘要翻译：一种用于通过移动自旋超声波振动来研磨平面的两侧的计算机数字控制机床，其中在机床的工具主体（1）上设置有支柱（3），Y轴运动组件（12）是设置在工具主体（1）的平台上，具有安装在Y轴运动组件（12）的上表面上的围绕Z坐标轴转动的下旋转运动组件（11），以及下磨板（10）同轴地安装在下旋转运动组件（11）的上方; 超声波振动组件（2）固定地安装在支柱（3）上，具有用于夹紧设置在超声波振动组件（2）上的工件组件（9）的分隔板（8）。 X轴运动组件（4）安装在支柱（3）的上部，Z轴运动组件（5）安装在X轴运动组件（4）的直立面上，上运动组件围绕Z坐标轴旋转的组件（6）设置在Z轴移动组件（5）上，以及同轴地安装在上部旋转运动组件（6）的旋转轴上的上部研磨板（7）。本发明增加了研磨运动轨迹的时间变化，磨削速度分布的均匀性，加工效率和加工精度。

6. 发明授权

US09121799B2 Multi-axle joint shifting loading apparatus for processing center and detection method for static stiffness distribution 有权
标题翻译：用于加工中心的多轴关节移动装载装置和静刚度分布的检测方法
公开(公告)号：US09121799B2
公开(公告)日：2015-09-01
申请号：US13811257
申请日：2011-08-04
申请人： Yumei Huang , Xingang Yang , Ye Hui , Rui Zhao
发明人： Yumei Huang , Xingang Yang , Ye Hui , Rui Zhao
IPC分类号： G01N3/40 , G01M99/00 , B23Q17/00
CPC分类号： G01N3/40 , B23Q17/00 , B23Q2230/002 , G01M99/007
摘要： Disclosed is an operating position changeable loading apparatus with multi-axis joint movement used on machining center. The apparatus consists of a load-receiving test piece and a load-exerting component. Moving the load-exerting component and the load-receiving test piece to a preset loading position according to a multi-axis joint movement, with the displacement value measured by displacement sensors and the amount of simulated load measured by a force sensor of the loaded-exerting component, a stiffness of the load-exertion position under a simulated load can be derived. Changing the load-exertion position, repeating in sequence the previous steps, a stiffness distribution under the simulated load can be derived.
摘要翻译：公开了一种在加工中心上使用的具有多轴关节运动的操作位置可变装载装置。该装置由负载接收试验片和负载施加部件组成。根据多轴关节运动将负载施加部件和承载试验片移动到预设加载位置，通过位移传感器测量的位移值和由负载传感器的力传感器测量的模拟负载量，可以得出在模拟载荷下载荷运动位置的刚度。改变载荷消耗位置，依次重复前述步骤，可以得出模拟载荷下的刚度分布。

7. 发明申请

US20130111981A1 MULTI-AXLE JOINT SHIFTING LOADING APPARATUS FOR PROCESSING CENTER AND DETECTION METHOD FOR STATIC STIFFNESS DISTRIBUTION 有权
标题翻译：用于加工中心的多轴联轴器移载装置和静态分布的检测方法
公开(公告)号：US20130111981A1
公开(公告)日：2013-05-09
申请号：US13811257
申请日：2011-08-04
申请人： Yumei Huang , Xingang Yang , Ye Hui , Rui Zhao
发明人： Yumei Huang , Xingang Yang , Ye Hui , Rui Zhao
IPC分类号： G01N3/40
CPC分类号： G01N3/40 , B23Q17/00 , B23Q2230/002 , G01M99/007
摘要： Disclosed is a processing center multi-axis joint deflection loading apparatus comprising a load-receiving test piece and a load-exerting component. The load-exerting component is constituted by a steel ball, a cap, a ball socket, a bent board, a force sensor, a connection component A, and a connection component B. The connection component A is fixedly connected to a blade handle of the processing center; the blade handle is pulled tight within a bored hole on a main axle; and the connection component A is connected to a main housing via the connection component B. In a method using the apparatus for an inspection of static stiffness distribution, by means of a multi-axle joint movement, moving the load-exerting component and the load-receiving test piece to a preset loading position, allowing the normal at a load-receiving point on a load-receiving face of the load-receiving piece to be aligned with the axis of the ball socket; with the amount of shift measured by position-shift sensors fitted on the main axle, the main axle housing, and a working platform, and the amount of simulated load measured by the force sensor of the loaded-exerting component, deriving a stiffness measurement of the load-exertion position under a simulated load; changing the load-exertion position by means of a multi-axle joint movement, repeating in sequence the previous steps, thus deriving a stiffness distribution under the simulated load.
摘要翻译：公开了一种加工中心多轴接合偏转加载装置，其包括承载试验片和载荷施加部件。负载施加部件由钢球，盖，球窝，弯曲板，力传感器，连接部件A和连接部件B构成。连接部件A固定地连接到加工中心; 刀柄在主轴上的钻孔内被拉紧; 并且连接部件A经由连接部件B连接到主壳体。在使用用于检查静刚度分布的装置的方法中，通过多轴关节运动，使负载施加部件和负载接收试件到预设加载位置，允许负载接收件的承载面上的载荷接收点处的法线与球窝的轴线对齐; 通过安装在主轴，主轴壳体和工作平台上的位置换档传感器测量的换档量以及由负载运动部件的力传感器测量的模拟负载量，导出刚度测量值模拟载荷下的载荷作用位置; 通过多轴关节运动改变载荷消耗位置，依次重复先前的步骤，从而导出模拟载荷下的刚度分布。

8. 发明授权

US09366327B2 Serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device 有权
标题翻译：串联滚珠丝杠对和压电执行机构宏微驱动引导装置
公开(公告)号：US09366327B2
公开(公告)日：2016-06-14
申请号：US14001896
申请日：2011-10-26
申请人： Yumei Huang , Hongyan Liu , Xingang Yang , Yong Yang
发明人： Yumei Huang , Hongyan Liu , Xingang Yang , Yong Yang
IPC分类号： F16H25/22 , B23Q1/30 , B23Q5/40
CPC分类号： F16H25/2204 , B23Q1/30 , B23Q5/40 , Y10T74/18656
摘要： A serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device includes, from the bottom to the top, a sliding seat (1), a ball screw pair, a sliding table guide rail pairs, a nut seat (6), a piezoelectric actuator (7), a micro-moving table, a nut seat guide rail pairs and a sliding table (1). The axis of a ball screw is symmetric with respect to two sliding table rail pairs, a nut (3) of the ball screw pair is fixedly mounted into the nut seat (6), one end of the piezoelectric actuator (7) is fixedly connected with the nut seat (6) and the other end thereof is fixedly connected with the micro-moving table (8), the axis of the piezoelectric actuator is symmetric relative to two sliding table rail pairs, an upper surface of the micro-moving table is fixedly mounted to a lower surface of the sliding table, and two nut rail pairs are symmetric relative to the axis of the ball screw. The ultra precision feeding in a long stroke within a full journey can be achieved; and the piezoelectric actuator only endures the driving force without enduring the driving torque generated by the driving force of the ball screw pair, thus, so that the piezoelectric actuator is in a good stressed status, which is applicable to a large-load ultra-precision feed system.
摘要翻译：一个串联连接的滚珠丝杠对和压电执行器宏观微型驱动和引导装置，包括从底部到顶部的滑动座（1），滚珠丝杠对，滑动台导轨对，螺母座（6 ），压电致动器（7），微移动台，螺母座导轨对和滑动台（1）。滚珠丝杠的轴线相对于两个滑动台轨对对称，滚珠丝杠对的螺母（3）固定地安装在螺母座（6）中，压电致动器（7）的一端固定连接与螺母座（6）的另一端与微动台（8）固定连接，压电致动器的轴线相对于两个滑台轨对，微动台的上表面对称固定地安装在滑动台的下表面，两个螺母导轨对相对于滚珠丝杠的轴线对称。可以在全程内实现长时间的超精密进给; 并且压电致动器仅承受驱动力而不会承受由滚珠丝杠对的驱动力产生的驱动力矩，使得压电致动器处于良好的应力状态，这适用于大负载超精度饲料系统

9. 发明申请

US20150300910A1 DEVICE AND METHOD FOR TESTING RIGIDITY AND NON-LINEAR RELATIONSHIP OF COUPLING INTERFACE FOR CYLINDRICAL FITTING 有权
标题翻译：用于测试圆柱形接头的耦合接口的刚度和非线性关系的装置和方法
公开(公告)号：US20150300910A1
公开(公告)日：2015-10-22
申请号：US14237336
申请日：2011-10-27
申请人： Yumei Huang , Yao Liu , Ye Hui , Guangpeng Zhang , Chuang Gao
发明人： Yumei Huang , Yao Liu , Ye Hui , Guangpeng Zhang , Chuang Gao
IPC分类号： G01M5/00
CPC分类号： G01M5/0075
摘要： A device and a method for testing the rigidity and non-linear relationship of the coupling interface for cylindrical fitting including an axial loading assembly which is provided along a horizontal central line within a side wall of a frame test bench and contacting with the test-piece shaft via a steel ball, a radial loading assembly downward provided along a vertical central line of top board of the frame test bench, a tip of a perpendicular loading part of the radial loading assembly extending into the outer housing of the test-piece housing fixed on an upper plane of a bottom wall of the frame test bench, with the test-piece shaft and the test-piece housing fitted and connected to each other via a coupling interface for cylindrical fitting; a plurality of displacement sensors fixed on the test-piece housing, and test heads of respective displacement sensor assembly aiming at the test-piece shaft.
摘要翻译：一种用于测试用于圆柱形接头的联接接口的刚度和非线性关系的装置和方法，包括沿着框架试验台的侧壁内的水平中心线设置的轴向加载组件，并与试验片轴，其沿着框架测试台的顶板的垂直中心线向下设置的径向加载组件，所述径向加载组件的垂直装载部分的尖端延伸到所述试件壳体固定的外壳体中在框架试验台的底壁的上平面上，试件轴和试件壳体通过用于圆柱形配合的联接接口彼此配合和连接; 固定在试件壳体上的多个位移传感器和针对试验轴的各个位移传感器组件的测试头。

10. 发明申请

US20150040703A1 SERIALLY-CONNECTED BALL SCREW PAIR AND PIEZOELECTRIC ACTUATOR MACRO-MICRO DRIVING AND GUIDING DEVICE 有权
标题翻译：串联连接球螺丝对和压电致动器微型驱动和导向装置
公开(公告)号：US20150040703A1
公开(公告)日：2015-02-12
申请号：US14001896
申请日：2011-10-26
申请人： Yumei Huang
发明人： Yumei Huang
IPC分类号： F16H25/22
CPC分类号： F16H25/2204 , B23Q1/30 , B23Q5/40 , Y10T74/18656
摘要： A serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device includes, from the bottom to the top, a sliding seat (1), a ball screw pair, a sliding table guide rail pairs, a nut seat (6), a piezoelectric actuator (7), a micro-moving table, a nut seat guide rail pairs and a sliding table (1). The axis of a ball screw is symmetric with respect to two sliding table rail pairs, a nut (3) of the ball screw pair is fixedly mounted into the nut seat (6), one end of the piezoelectric actuator (7) is fixedly connected with the nut seat (6) and the other end thereof is fixedly connected with the micro-moving table (8), the axis of the piezoelectric actuator is symmetric relative to two sliding table rail pairs, an upper surface of the micro-moving table is fixedly mounted to a lower surface of the sliding table, and two nut rail pairs are symmetric relative to the axis of the ball screw. The ultra precision feeding in a long stroke within a full journey can be achieved; and the piezoelectric actuator only endures the driving force without enduring the driving torque generated by the driving force of the ball screw pair, thus, so that the piezoelectric actuator is in a good stressed status, which is applicable to a large-load ultra-precision feed system.
摘要翻译：一个串联连接的滚珠丝杠对和压电执行器宏观微型驱动和引导装置，包括从底部到顶部的滑动座（1），滚珠丝杠对，滑动台导轨对，螺母座（6 ），压电致动器（7），微移动台，螺母座导轨对和滑动台（1）。滚珠丝杠的轴线相对于两个滑动台轨对对称，滚珠丝杠对的螺母（3）固定地安装在螺母座（6）中，压电致动器（7）的一端固定连接与螺母座（6）的另一端与微动台（8）固定连接，压电致动器的轴线相对于两个滑台轨对，微动台的上表面对称固定地安装在滑动台的下表面，两个螺母导轨对相对于滚珠丝杠的轴线对称。可以在全程内实现长时间的超精密进给; 并且压电致动器仅承受驱动力而不会承受由滚珠丝杠对的驱动力产生的驱动力矩，使得压电致动器处于良好的应力状态，这适用于大负载超精度饲料系统

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