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1. 发明授权

US5779673A Devices and methods for application of intraluminal photopolymerized gels 失效
标题翻译：用于腔内光聚合凝胶的装置和方法
公开(公告)号：US5779673A
公开(公告)日：1998-07-14
申请号：US494333
申请日：1995-06-26
申请人： Laurence A. Roth , Stephen J. Herman , Farhad Khosravi , David Melanson , Michael Dumont , Patrick K. Campbell , John C. Spiridigliozzi
发明人： Laurence A. Roth , Stephen J. Herman , Farhad Khosravi , David Melanson , Michael Dumont , Patrick K. Campbell , John C. Spiridigliozzi
IPC分类号： A61F2/958 , A61M25/00 , A61M35/00
CPC分类号： A61M25/1011 , A61M35/00 , A61M2025/1052 , A61M25/007 , A61M25/10
摘要： Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.
摘要翻译：公开了用于在体腔和空间的内表面上提供聚合物层的装置。该装置可以包括近端和远端阻塞元件以限定治疗空间，以及光发射器以提供用于光聚合程序的光。所述装置可以包括用于提供厚聚合物凝胶的模制构件。或者，可以使用没有模制构件的装置来进行界面聚合程序。

2. 发明授权

US08211104B2 Co-access bipolar ablation probe 有权
标题翻译：并联双极消融探头
公开(公告)号：US08211104B2
公开(公告)日：2012-07-03
申请号：US11030229
申请日：2005-01-06
申请人： Orla McCullagh , John C. Spiridigliozzi , David J. Sauvageau
发明人： Orla McCullagh , John C. Spiridigliozzi , David J. Sauvageau
IPC分类号： A61B18/18
CPC分类号： A61B18/148 , A61B17/3421 , A61B18/1477 , A61B2018/0016 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475
摘要： Medical probe kits and methods for treating tissue regions (e.g. tumors) are provided. The kit comprises a delivery cannula and an ablation probe. The delivery cannula comprises a shaft, a lumen extending through the shaft, and a plurality of windows formed through a wall of the shaft in communication with the cannula lumen. The ablation probe is configured to be removably disposed within the cannula lumen. The ablation probe has a shaft and proximal and distal arrays of electrodes that are deployable from the probe shaft. The electrodes of the proximal array are configured to be deployed out from the respective windows when the ablation probe is disposed within the cannula lumen. The electrodes of the distal array may be configured to be deployed out from an axial opening at the distal end of the cannula shaft when the ablation probe is disposed within the cannula lumen. The method may comprise introducing the cannula within a patient, introducing the ablation probe through the cannula, deploying the electrode arrays into contact with the tissue region, and conveying ablation energy to the ablation probe to ablate the tissue region within the electrode arrays.
摘要翻译：提供用于治疗组织区域（例如肿瘤）的医学探针试剂盒和方法。套件包括输送套管和消融探头。输送套管包括轴，延伸穿过轴的腔，以及通过与套管腔连通的轴的壁形成的多个窗。消融探针被配置为可移除地设置在套管内腔内。消融探针具有可从探针轴展开的轴和近端和远端的电极阵列。近端阵列的电极构造成当消融探针设置在套管腔内时从相应窗口部署出来。远端阵列的电极可被构造成当消融探针设置在套管内腔内时从插管轴的远端处的轴向开口部署出来。该方法可以包括将插管引入患者体内，通过套管引入消融探针，将电极阵列展开与组织区域接触，以及将消融能量输送到消融探针以烧蚀电极阵列内的组织区域。

3. 发明授权

US6121341A Redox and photoinitiator systems for priming and improved adherence of gels to substrates 失效
标题翻译：氧化还原和光引发剂体系，用于引发和改善凝胶对底物的粘附
公开(公告)号：US6121341A
公开(公告)日：2000-09-19
申请号：US973077
申请日：1997-10-10
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08K1/00 , A61F2/00
CPC分类号： C09D4/00 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/904
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". the polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译： PCT No.PCT / US96 / 03834 Sec。 371日期：1997年10月10日 102（e）日期1997年10月10日PCT提交1996年3月22日PCT公布。出版物WO96 / 29370 日期1996年9月26日披露了与施加的表面高粘附性的阻挡或药物递送系统，以及制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

4. 发明授权

US5800373A Initiator priming for improved adherence of gels to substrates 失效
标题翻译：引发剂引发，用于提高凝胶对底物的粘附性
公开(公告)号：US5800373A
公开(公告)日：1998-09-01
申请号：US410037
申请日：1995-03-23
申请人： David A. Melanson , Amarpreet S. Sawhney , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander
发明人： David A. Melanson , Amarpreet S. Sawhney , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F2/50 , C08F4/00 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , A61F13/00
CPC分类号： A61L24/0031 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D4/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/90 , Y10S602/904
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses.
摘要翻译：公开了一种改进的屏障或药物递送系统，其与其所应用的表面高粘附，以及用于制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一表面用引发剂预浸渍，并且在它们之间放置含有可凝胶单体的引发剂的薄层。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。

5. 发明授权

US06387977B1 Redox and photoinitiator systems for priming for improved adherence of gels to substrates 有权
标题翻译：氧化还原和光引发剂体系，用于引发凝胶以增强凝胶对底物的粘附性
公开(公告)号：US06387977B1
公开(公告)日：2002-05-14
申请号：US09616256
申请日：2000-07-14
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver , Marc A. Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder , Bradley C. Poff , Donald L. Elbert
IPC分类号： C09D400
CPC分类号： C09D4/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L2300/00 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C08L2666/02 , C09J151/00 , Y10S602/904 , C08L71/02 , C08L33/04 , C08F220/00
摘要： An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译：公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

6. 发明授权

US5749968A Device for priming for improved adherence of gels to substrates 失效
标题翻译：用于引发凝胶的装置用于改善凝胶对底物的附着力
公开(公告)号：US5749968A
公开(公告)日：1998-05-12
申请号：US472745
申请日：1995-06-07
申请人： David A. Melanson , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder
发明人： David A. Melanson , Marc Alan Levine , John C. Spiridigliozzi , Thomas S. Bromander , Dean M. Pichon , George Selecman , David J. Nedder
IPC分类号： A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/14 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/14 , C08F291/00 , C09D153/00 , C09J151/00 , C12N5/00 , C12N11/04 , B05C5/00
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D153/00 , C09J151/00 , C12N5/0012 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.
摘要翻译：公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。该方法在本文中称为“起动”。可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。第一表面和屏障或另一表面用引发剂预浸渍，并且在它们之间放置含有可凝胶单体的引发剂的薄层。在单体凝胶化时，在两个表面之间获得强粘合性。以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。描述了使用非光化学体系和组合化学/光化学体系的方法。

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