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1. 发明授权

US06537567B1 Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells 失效
标题翻译：具有周向取向的平滑肌细胞的组织工程管状构建体
公开(公告)号：US06537567B1
公开(公告)日：2003-03-25
申请号：US09109427
申请日：1998-07-02
申请人： Laura E. Niklason , Jinming Gao , Robert S. Langer
发明人： Laura E. Niklason , Jinming Gao , Robert S. Langer
IPC分类号： A61F200
CPC分类号： A61L27/507 , C12M21/08 , C12M23/06 , C12M23/26 , C12M25/14 , C12M29/14 , C12M35/04 , C12N5/0068 , C12N5/0691 , C12N2500/20 , C12N2500/32 , C12N2503/04 , C12N2509/00 , C12N2533/40
摘要： Improved methods for the production of tissue-engineered constructs, including muscular tissue constructs such as vascular constructs, are disclosed. The methods include the use of improved substrates for cell growth, improved cell culture media for cell growth, and the use of distensible bodies to impart pulsatile stretching force to lumens of constructs during growth. Also disclosed are improved products and methods for making those products, including substrates and cell culture media, for tissue engineering and tissue culture generally. Improved muscular tissue constructs, including vascular constructs, are also disclosed, which may be used in medicine for the repair or replacement of damaged natural structures. In an embodiment, a muscular, tubular tissue-engineered construct is prepared having a wall of mammalian smooth muscle cells oriented circumferentially about a lumen of the construct at a cell density of at least 107 cells/cc.
摘要翻译：公开了用于生产组织工程构建体（包括肌肉组织构建体如血管构建体）的改进方法。所述方法包括使用用于细胞生长的改良底物，用于细胞生长的改进的细胞培养基，以及使用扩张体在生长过程中对构建体的内腔赋予脉动拉伸力。还公开了通常用于组织工程和组织培养的用于制造包括底物和细胞培养基的那些产物的改进的产品和方法。还公开了改进的肌肉组织构建体，包括血管构建体，其可用于医学中用于修复或替换受损的天然结构。在一个实施方案中，制备肌肉，管状组织工程改造的构建体，其具有以至少107个细胞/ cc的细胞密度围绕构建体的内腔定向的哺乳动物平滑肌细胞壁。

2. 发明申请

US20110020271A1 ELASTIN FOR SOFT TISSUE AUGMENTATION 审中-公开
标题翻译：软组织补充
公开(公告)号：US20110020271A1
公开(公告)日：2011-01-27
申请号：US12784235
申请日：2010-05-20
申请人： Laura E. Niklason , Yuling Li , Heather Prichard , Shannon Dahl , Juliana Blum
发明人： Laura E. Niklason , Yuling Li , Heather Prichard , Shannon Dahl , Juliana Blum
IPC分类号： A61K38/20 , A61K38/39 , A61K35/12 , A61K38/18 , A61K38/19 , A61K38/21 , A61P43/00 , A61P29/00 , A61P23/00 , A61P39/06 , A61P17/10 , A61Q19/00
CPC分类号： A61K35/36 , A61K31/715 , A61K38/39 , A61K45/06 , A61L27/227 , A61L27/48 , A61L2400/06 , A61L2430/34 , A61K2300/00 , C08L89/00
摘要： The present invention provides compositions comprising isolated elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
摘要翻译：本发明提供包含分离的弹性蛋白和药学上可接受的载体的组合物，其中人弹性蛋白基本上不溶于分子量大于100kDa的水中。本发明还提供了用于软组织增强的方法和试剂盒。

3. 发明授权

US07498332B2 Therapy for cerebral vasospasm 失效
标题翻译：脑血管痉挛治疗
公开(公告)号：US07498332B2
公开(公告)日：2009-03-03
申请号：US10074250
申请日：2002-02-14
申请人： Laura E. Niklason , Andy McKee , Cecil Borel
发明人： Laura E. Niklason , Andy McKee , Cecil Borel
IPC分类号： A61K31/497 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： G01N33/5088 , A61K31/00 , A61K38/005 , A61K38/482 , A61K38/4886 , A61K2039/505 , C07K16/22 , C07K2317/73 , G01N2333/78
摘要： The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage.
摘要翻译：本发明涉及一种治疗或预防伴有蛛网膜下出血的脑血管痉挛的方法。

4. 发明授权

US5872828A Tomosynthesis system for breast imaging 失效
标题翻译：乳腺成像的体系合成系统
公开(公告)号：US5872828A
公开(公告)日：1999-02-16
申请号：US898058
申请日：1997-07-22
申请人： Loren T. Niklason , Laura E. Niklason , Daniel B. Kopans
发明人： Loren T. Niklason , Laura E. Niklason , Daniel B. Kopans
IPC分类号： A61B6/02 , A61B6/00
CPC分类号： A61B6/502 , A61B6/025 , A61B6/4233 , G06T11/006 , G06T2211/436
摘要： The invention includes both systems and methods for tomosynthesis x-ray imaging. An x-ray source is moved at various positions in an arc around an object, e.g., a breast, to illuminate a stationary digital detector (or its equivalent) placed at an image plane behind the object. A digital image data processor collects data from the detector and a motion controller moves the source around the object. As the source moves along the arc, the detector generates, for a succession of points along the arc, a corresponding succession of image data sets, each set being representative of the intensity of x-rays incident on the detector for the then current position of the source. The image data processor is responsive to the image data sets to generate an output image signal representative of the x-ray absorption of points within the object region. The processor transforms the image plane data to a form corresponding to that which would have been generated had the x-ray source moved in a linear motion in a source plane parallel to the image plane, rather than an arc. The resultant image data thus corresponds in form to that produced by a conventional linear motion, e.g., Twinning-type, system, so that conventional techniques and equipment may be used to produce a final representation of the x-ray absorption of the object region.
摘要翻译：本发明包括用于层析合成X射线成像的系统和方法。 X射线源在围绕物体（例如乳房）的弧中的各个位置移动，以照亮放置在物体后面的图像平面上的固定数字检测器（或其等效物）。数字图像数据处理器从检测器收集数据，并且运动控制器围绕物体移动源。当源沿着弧线移动时，检测器对于沿着弧的一系列点产生对应的连续的图像数据集，每组都代表入射在检测器上的X射线的强度，用于当前的位置来源。图像数据处理器响应于图像数据组以产生表示对象区域内的点的x射线吸收的输出图像信号。处理器将图像平面数据转换成与X射线源平行于图像平面的源平面中的线性运动而不是弧形而产生的图像平面数据相对应的形式。所得到的图像数据因此对应于通过常规线性运动产生的图像数据，例如，Twinning型系统，使得常规技术和设备可以用于产生对象区域的x射线吸收的最终表示。

5. 发明授权

US09556414B2 Tissue-engineered constructs 有权
标题翻译：组织工程结构
公开(公告)号：US09556414B2
公开(公告)日：2017-01-31
申请号：US13978422
申请日：2012-01-06
申请人： Shannon L. M. Dahl , Laura E. Niklason , Juliana Blum , Justin T. Strader , William E. Tente , Heather L. Prichard , Joseph J. Lundquist
发明人： Shannon L. M. Dahl , Laura E. Niklason , Juliana Blum , Justin T. Strader , William E. Tente , Heather L. Prichard , Joseph J. Lundquist
IPC分类号： C12N5/00 , A61F2/06 , A61F2/04 , B29C53/00 , B29C53/36 , A61L27/34 , B29K67/00 , B29K105/00 , B29L23/00 , B29L31/00
CPC分类号： C12N5/0068 , A61F2/04 , A61F2/06 , A61F2002/047 , A61F2002/048 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/3633 , A61L27/38 , A61L27/3895 , A61L27/54 , A61L27/58 , B29C53/005 , B29C53/36 , B29K2067/043 , B29K2105/256 , B29K2995/0056 , B29K2995/006 , B29L2023/00 , B29L2031/7532 , C12N2533/30 , C12N2533/40 , Y10T156/1038 , C08L67/04
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
摘要翻译：本发明提供了包括管状可生物降解聚乙醇酸支架的构建体，其中所述支架可以被包被细胞外基质蛋白质并且基本上是无细胞的。构建体可以用作动静脉移植物，冠状动脉移植物，外周动脉旁路导管或尿道。本发明还提供了生产这种构建体的方法。

6. 发明申请

US20130345824A1 TISSUED-ENGINEERED CONSTRUCTS 有权
标题翻译：组织工程结构
公开(公告)号：US20130345824A1
公开(公告)日：2013-12-26
申请号：US13978422
申请日：2012-01-06
申请人： Shannon L.M. Dahl , Laura E. Niklason , Juliana Blum , Justin T. Strader , William E. Tente , Heather L. Prichard , Joseph Lundquist
发明人： Shannon L.M. Dahl , Laura E. Niklason , Juliana Blum , Justin T. Strader , William E. Tente , Heather L. Prichard , Joseph Lundquist
IPC分类号： A61F2/04
CPC分类号： C12N5/0068 , A61F2/04 , A61F2/06 , A61F2002/047 , A61F2002/048 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/3633 , A61L27/38 , A61L27/3895 , A61L27/54 , A61L27/58 , B29C53/005 , B29C53/36 , B29K2067/043 , B29K2105/256 , B29K2995/0056 , B29K2995/006 , B29L2023/00 , B29L2031/7532 , C12N2533/30 , C12N2533/40 , Y10T156/1038 , C08L67/04
摘要： The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
摘要翻译：本发明提供了包括管状可生物降解聚乙醇酸支架的构建体，其中所述支架可以被包被细胞外基质蛋白质并且基本上是无细胞的。构建体可以用作动静脉移植物，冠状动脉移植物，外周动脉旁路导管或尿道。本发明还提供了生产这种构建体的方法。

7. 发明申请

US20120064050A1 Tissue Engineering of Lung 审中-公开
标题翻译：肺组织工程
公开(公告)号：US20120064050A1
公开(公告)日：2012-03-15
申请号：US13146605
申请日：2010-02-04
申请人： Elizabeth Calle , Laura E. Niklason , Thomas Peterson , Liqiong Gui
发明人： Elizabeth Calle , Laura E. Niklason , Thomas Peterson , Liqiong Gui
IPC分类号： A61K35/42 , A61P11/00 , C12Q1/68 , C12N5/071 , C12Q1/02
CPC分类号： A61K35/42 , C12N5/0688 , C12N2533/90
摘要： The present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natural lung tissue. The engineered tissue is useful for the study of lung developmental biology and pathology as well as drug discovery.
摘要翻译：本发明涉及包含脱细胞组织的组合物。本发明还提供显示天然肺组织特征的工程化三维肺组织。工程组织可用于研究肺发育生物学和病理学以及药物发现。

8. 发明授权

US07943378B2 Tissue engineering 有权
标题翻译：组织工程
公开(公告)号：US07943378B2
公开(公告)日：2011-05-17
申请号：US10388588
申请日：2003-03-17
申请人： Laura E. Niklason , J. Andrew McKee , Christopher M. Counter
发明人： Laura E. Niklason , J. Andrew McKee , Christopher M. Counter
IPC分类号： C12N15/63 , C12N5/00 , C12N5/08 , A61F13/00 , A61K48/00
CPC分类号： C12N9/1276 , A61K35/12 , A61K48/00 , C12N5/0691 , C12N2500/32 , C12N2510/04 , C12N2533/40
摘要： The present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering.
摘要翻译：本发明一般涉及组织工程，尤其涉及延长适用于血管工程的细胞寿命的方法。

9. 发明授权

US06443156B1 Separable double lumen endotracheal tube 有权
标题翻译：可分离双腔气管插管
公开(公告)号：US06443156B1
公开(公告)日：2002-09-03
申请号：US09630751
申请日：2000-08-02
申请人： Laura E. Niklason , Loren T. Niklason
发明人： Laura E. Niklason , Loren T. Niklason
IPC分类号： A61M1600
CPC分类号： A61M16/04 , A61M16/0404 , A61M16/0427 , A61M16/0434 , A61M16/0459 , A61M16/0486
摘要： A separable double lumen endotracheal tube is disclosed having a first lumen and a second lumen and which are removably affixed together to allow the first lumen to be separated from the second lumen of the double lumen endotracheal tube and, if desired, to be subsequently affixed together again. Either lumen of the double lumen endotracheal tube can function alone for positive pressure ventilation, but normally the bronchial lumen will be removed from a patient and the tracheal lumen left in place to function alone to provide positive pressure ventilation as required by a patient. The double lumen endotracheal tube will, however, function to allow the bronchial lumen to remain in a patient subsequent to removal of the tracheal lumen as a matter of choice during a medical procedure.
摘要翻译：公开了一种可分离的双腔气管插管，其具有第一腔和第二腔，并且可拆卸地固定在一起，以允许第一腔与双腔气管插管的第二腔分离，并且如果需要，随后将其固定在一起再次。双腔气管插管的管腔可以单独用于正压通气，但是通常将支气管腔从患者中移除，并且气管腔留置在适当位置以单独功能以根据患者的要求提供正压通气。然而，双管腔气管插管将用于在医疗过程中作为选择的事项在气管腔移除之后使支气管内腔保留在患者体内。

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