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2. 发明授权

US10406302B2 Inhalator 有权
公开(公告)号：US10406302B2
公开(公告)日：2019-09-10
申请号：US13992200
申请日：2011-12-05
申请人： Laura Andrade , Jose Ramon Ruiz , Celestino Ronchi , Alessandro Castellucci
发明人： Laura Andrade , Jose Ramon Ruiz , Celestino Ronchi , Alessandro Castellucci
IPC分类号： A61M15/00 , A61M15/08
摘要： An inhalator for the inhalation of powdered drug preparations from capsules which contain the powdered preparations. The inhalator has a mouthpiece or nosepiece and an assembly including: a capsule holder including a capsule chamber, the capsule chamber having an air inlet opening and an air outlet opening; a capsule opening device for opening a capsule; a finger-operable actuator. The inhalator further includes a rigid outer shell including a lower shell part hinged to an upper shell part so that the shell is openable and closable, the shell serving to cover and protect the assembly and the mouthpiece or nosepiece. The assembly and the mouthpiece or nosepiece are removable as a hinged unit from the open shell as a hinged unit without dismantling either unit, or the shell is arranged so that the contours of the rim of each shell part match the contours of the rim of the other around each shell part when the shell is in the closed condition, or the assembly is retained in the lower shell part and is not moveable in normal use with respect to the lower shell part.

3. 发明申请

US20130255679A1 INHALATOR 审中-公开
标题翻译：吸入器
公开(公告)号：US20130255679A1
公开(公告)日：2013-10-03
申请号：US13992200
申请日：2011-12-05
申请人： Laura Andrade , Jose Ramon Ruiz , Celestino Ronchi , Alessandro Castellucci
发明人： Laura Andrade , Jose Ramon Ruiz , Celestino Ronchi , Alessandro Castellucci
IPC分类号： A61M15/00 , A61M15/08
CPC分类号： A61M15/0028 , A61M15/0026 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0063 , A61M15/08 , A61M2202/064
摘要： An inhalator for the inhalation of powdered drug preparations from capsules which contain the powdered preparations. The inhalator has a mouthpiece or nosepiece and an assembly including: a capsule holder including a capsule chamber, the capsule chamber having an air inlet opening and an air outlet opening; a capsule opening device for opening a capsule; a finger-operable actuator. The inhalator further includes a rigid outer shell including a lower shell part hinged to an upper shell part so that the shell is openable and closable, the shell serving to cover and protect the assembly and the mouthpiece or nosepiece. The assembly and the mouthpiece or nosepiece are removable as a hinged unit from the open shell as a hinged unit without dismantling either unit, or the shell is arranged so that the contours of the rim of each shell part match the contours of the rim of the other around each shell part when the shell is in the closed condition, or the assembly is retained in the lower shell part and is not moveable in normal use with respect to the lower shell part.
摘要翻译：用于从含有粉末状制剂的胶囊吸入粉末药物制剂的吸入器。吸入器具有一个接口管或喷嘴和一个组件，它包括：胶囊保持器，其包括胶囊室，该胶囊腔室具有进气口和出气口; 用于打开胶囊的胶囊打开装置; 手指可操作的致动器。吸入器还包括刚性外壳，其包括铰接到上壳体部分的下壳体部分，使得壳体是可打开和可关闭的，壳体用于覆盖和保护组件和接口管或喷嘴。组件和接口管或鼻梁可作为铰链单元从打开的外壳作为铰接单元被移除，而不拆卸任一单元，或者壳体布置成使得每个外壳部分的边缘的轮廓与边缘的轮廓匹配当壳体处于关闭状态时，围绕每个壳体部分的其他部件，或者组件保持在下壳体部分中，并且相对于下壳体部件在正常使用中不可移动。

4. 发明授权

US09522259B2 Instrument for inserting a suppository 有权
标题翻译：用于插入栓剂的仪器
公开(公告)号：US09522259B2
公开(公告)日：2016-12-20
申请号：US14237031
申请日：2012-08-03
申请人： Gonzalo Hernández Herrero , Celestino Ronchi , Mauro Citterio , Lucas Sigman , Brett Mooney
发明人： Gonzalo Hernández Herrero , Celestino Ronchi , Mauro Citterio , Lucas Sigman , Brett Mooney
IPC分类号： A61M31/00 , A61F13/26 , A61M5/50
CPC分类号： A61M31/007 , A61F13/266 , A61M5/502 , F04C2270/0421
摘要： An instrument for inserting a suppository including a tube, having a first end adapted to receive the suppository and a second end, a plunger disposed in the tube and moveable therein to eject the suppository from the first end by causing an action of pushing the suppository from behind. Retaining tongues are splayed outwards for ejection of the suppository in response to movement of the plunger in the tube, via contacting cooperation between at least one part of the plunger and at least one part of the tube. Securement mechanism secure the plunger in the tube at first position in which the suppository is retained in the first end of the tube, while allowing a user to move the plunger to actuate the instrument, and to secure the plunger in the tube at a second position which is only achievable after the plunger has been moved to eject the suppository.
摘要翻译：一种用于插入包括管的栓剂的装置，其具有适于接收栓剂的第一端和第二端，设置在管中并可在其中移动的柱塞，从第一端喷出栓剂，通过引发栓剂从背后。通过柱塞的至少一部分与管的至少一部分之间的接合协作，向外张开保留舌片以响应柱塞在管中的运动而喷射栓剂。固定机构将栓塞固定在管中的第一位置，其中栓剂保持在管的第一端，同时允许使用者移动柱塞来致动器械，并将柱塞固定在管中的第二位置这仅在柱塞移动以便弹出栓剂之后才能实现。

5. 发明申请

US20140171882A1 INSTRUMENT FOR INSERTING A SUPPOSITORY 有权
标题翻译：插入支架的仪器
公开(公告)号：US20140171882A1
公开(公告)日：2014-06-19
申请号：US14237031
申请日：2012-08-03
申请人： Gonzalo Hernández Herrero , Celestino Ronchi , Mauro Citterio , Lucas Sigman , Brett Mooney
发明人： Gonzalo Hernández Herrero , Celestino Ronchi , Mauro Citterio , Lucas Sigman , Brett Mooney
IPC分类号： A61M31/00
CPC分类号： A61M31/007 , A61F13/266 , A61M5/502 , F04C2270/0421
摘要： An instrument for inserting a suppository which includes a tube, having a first end adapted to receive the suppository and a second end, and a plunger disposed in the tube and moveable therein to eject the suppository from the first end by causing an action of pushing the suppository from behind. Retaining tongues are splayed outwards for ejection of the suppository in response to movement of the plunger in the tube, via contacting cooperation between at least one part of the plunger and at least one part of the tube. Securement mechanism secure the plunger in the tube at first position in which the suppository is retained in the first end of the tube, while allowing a user to move the plunger to actuate the instrument, and to secure the plunger in the tube at a second position which is only achievable after the plunger has been moved to eject the suppository.
摘要翻译：一种用于插入栓剂的装置，所述栓剂包括管，所述管具有适于容纳所述栓剂的第一端和第二端，以及设置在所述管中并可在其中移动的柱塞，以从所述第一端喷射所述栓剂，栓从后面。通过柱塞的至少一部分与管的至少一部分之间的接合协作，向外张开保留舌片以响应柱塞在管中的运动而喷射栓剂。固定机构将栓塞固定在管中的第一位置，其中栓剂保持在管的第一端，同时允许使用者移动柱塞来致动器械，并将柱塞固定在管中的第二位置这仅在柱塞移动以便弹出栓剂之后才能实现。

6. 发明授权

US5656277A Nor- and homo- bile acids derivatives as absorption enhancers for medicaments 失效
标题翻译：非 - 和均酸衍生物作为药物的吸收促进剂
公开(公告)号：US5656277A
公开(公告)日：1997-08-12
申请号：US360833
申请日：1994-12-28
申请人： Fabio Berlati , Giancarlo Ceschel , Aldo Roda , Enrico Roda , Celestino Ronchi
发明人： Fabio Berlati , Giancarlo Ceschel , Aldo Roda , Enrico Roda , Celestino Ronchi
IPC分类号： A61K47/28 , C07J9/00 , A61K9/02 , A61K9/08 , A61K9/20 , A61K31/19
CPC分类号： A61K47/28
摘要： The use of nor- and homo-bile acids derivatives as absorption enhancers for medicaments is described. Said derivatives show the advantage of improving the absorption of medicaments through mucosae without being metabolized by the intestinal flora, thus allowing a fast excretion. Moreover, the derivatives of the invention have a negligible toxicity.
摘要翻译： PCT No.PCT / EP93 / 01508 Sec。 371日期1994年12月28日第 102（e）日期1994年12月28日PCT提交1993年6月15日PCT公布。出版物WO94 / 00155 日期1994年1月6日描述了使用正和胆汁酸衍生物作为药物的吸收促进剂。所述衍生物显示出通过粘膜改善药物吸收而不被肠道菌群代谢的优点，从而允许快速排泄。此外，本发明的衍生物具有可忽略的毒性。

7. 发明授权

US5124315A Liquid pharmaceutical composition for nasal administration containing a polypeptide as active ingredient 失效
标题翻译：用于鼻内给药的液体药物组合物，其含有多肽作为活性成分
公开(公告)号：US5124315A
公开(公告)日：1992-06-23
申请号：US716390
申请日：1991-06-17
申请人： Giancarlo Ceschel , Antonella M. Segu' , Celestino Ronchi
发明人： Giancarlo Ceschel , Antonella M. Segu' , Celestino Ronchi
IPC分类号： A61K9/00 , A61K9/48 , A61K38/23 , A61K47/12
CPC分类号： A61K9/0031 , A61K38/23 , A61K47/12 , A61K9/0043 , A61K9/4858 , Y10S514/80 , Y10S514/808
摘要： A liquid composition for nasal administration of polypeptide/s containing ammonium tartrate and a buffer together with optional adiuvants.
摘要翻译：用于鼻内给药含有酒石酸铵和缓冲液的多肽/液体组合物以及任选的附加物。

8. 发明授权

US09155700B2 Process for the preparation of pharmaceutical suspensions for inhalation 有权
标题翻译：用于制备吸入药物悬浮液的方法
公开(公告)号：US09155700B2
公开(公告)日：2015-10-13
申请号：US13332756
申请日：2011-12-21
申请人： Celestino Ronchi , Giancarlo Ceschel
发明人： Celestino Ronchi , Giancarlo Ceschel
IPC分类号： A61K9/10 , A61K9/00 , A61K31/56 , A61L2/00
CPC分类号： A61K9/10 , A61K9/0078 , A61L2/0017
摘要： Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 μm, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
摘要翻译：用于制备用于吸入的无菌悬浮液的方法，其包含不溶于水的活性成分，并且其中所述活性成分的至少80％的颗粒具有3至5μm的直径，包括以下阶段：将活性成分溶解在最小量醇溶剂，任选在多元醇存在下，并添加至少一种表面活性剂，通过灭菌过滤器过滤前一阶段获得的溶液，将超声处理阶段（b）的溶液加入到无菌水中直接获得悬浮液，其中颗粒具有减小的直径。

9. 发明申请

US20150258020A1 CHEWABLE TABLETS COMPRISING LEVONORGESTREL 审中-公开
标题翻译：包含LEVONORGESTREL的可检测图表
公开(公告)号：US20150258020A1
公开(公告)日：2015-09-17
申请号：US14215467
申请日：2014-03-17
申请人： Anekant Jain , Bruce Frank , Nagesh Nanda , Orazio Luca Strusi , Francisco Ferrer , Celestino Ronchi
发明人： Anekant Jain , Bruce Frank , Nagesh Nanda , Orazio Luca Strusi , Francisco Ferrer , Celestino Ronchi
IPC分类号： A61K9/00 , A61K9/20 , A61K31/57
CPC分类号： A61K9/0056 , A61K9/1635 , A61K9/2018 , A61K9/2077 , A61K31/567 , A61K31/57
摘要： The present invention relates to a chewable tablet comprising levonorgestrel and a pharmaceutically acceptable excipient for use in contraception, a method of use of same and a kit containing same.
摘要翻译：本发明涉及包含左炔诺孕酮和用于避孕的药学上可接受的赋形剂的咀嚼片，其使用方法和含有其的试剂盒。

10. 发明申请

US20050089476A1 Process for the preparation of pharmaceutical suspensions for inhalation 审中-公开
标题翻译：用于制备吸入药物悬浮液的方法
公开(公告)号：US20050089476A1
公开(公告)日：2005-04-28
申请号：US10971231
申请日：2004-10-22
申请人： Celestino Ronchi , Giancarlo Ceschel
发明人： Celestino Ronchi , Giancarlo Ceschel
IPC分类号： A61K9/00 , A61K9/10 , A61K9/12 , A61K47/10 , A61L9/04 , A61K31/56
CPC分类号： A61K9/10 , A61K9/0078 , A61L2/0017
摘要： Process for preparing sterile suspensions for inhalation comprising an active ingredient insoluble in water and wherein at least 80% of the particles of said active ingredient have a diameter between 3 and 5 μm, comprising the following stages: dissolving the active ingredient in the minimum quantity of an alcoholic solvent, optionally in the presence of a polyol and adding at least one surfactant, filtering the solution obtained in the previous stage through a sterilizing filter, adding the solution from stage (b) to sterile water under sonication to directly obtain a suspension wherein the particles have a reduced diameter.
摘要翻译：用于制备用于吸入的无菌悬浮液的方法，其包含不溶于水的活性成分，并且其中所述活性成分的至少80％的颗粒具有3至5μm的直径，包括以下阶段：将活性成分溶解在最小量醇溶剂，任选在多元醇存在下，并添加至少一种表面活性剂，通过灭菌过滤器过滤前一阶段获得的溶液，将超声处理阶段（b）的溶液加入到无菌水中直接获得悬浮液，其中颗粒具有减小的直径。

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