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1. 发明申请

US20110045498A1 On-Site Liquid Production 审中-公开
标题翻译：现场液体生产
公开(公告)号：US20110045498A1
公开(公告)日：2011-02-24
申请号：US12675232
申请日：2008-08-25
申请人： Martin Lindberg , Lars Winther
发明人： Martin Lindberg , Lars Winther
IPC分类号： G01N33/567 , C12M1/02 , C12M1/36
CPC分类号： G01N35/00029 , G01N2035/00138 , G01N2035/00217 , G01N2035/00544
摘要： A biological sample processing system for on-site liquid production comprises a processing apparatus for processing of biological samples arranged on microscope slides, and a production unit connected to the apparatus. The production unit comprises a first ingredient source, a second ingredient source, and a mixer station. The mixer station is configured to mix ingredients to produce a liquid product. Supply conduits are arranged to supply an amount of a first ingredient and an amount of a second ingredient from the first and second ingredient sources to the mixer station. A delivery conduit is provided for transportation of an amount of the liquid product from the mixer station. A production controller is arranged in communication with the production unit, and is configured to control the operation of the production unit.
摘要翻译：用于现场液体生产的生物样品处理系统包括用于处理布置在显微镜载片上的生物样品的处理装置和连接到该装置的生产单元。生产单元包括第一成分源，第二成分源和混合站。搅拌站配置成混合成分以产生液体产品。供应管道被布置成将一定量的第一成分和第二成分的量从第一和第二成分源提供给混合器站。输送管道用于运输来自混合站的液体产品的量。生产控制器被布置成与生产单元通信，并且被配置为控制生产单元的操作。

2. 发明申请

US20090155907A1 Removal of Embedding Medium 审中-公开
标题翻译：去除嵌入介质
公开(公告)号：US20090155907A1
公开(公告)日：2009-06-18
申请号：US12095432
申请日：2006-11-24
申请人： Lars Winther , Martin Lindberg
发明人： Lars Winther , Martin Lindberg
IPC分类号： C12N5/06 , C12M1/00 , C12M1/36
CPC分类号： G01N1/30 , G01N1/312 , G01N1/36 , G01N2001/307 , G01N2035/00881
摘要： A method, apparatus and system for automated removal of an embedding medium from an embedded biological sample. The method comprising the steps of: providing an automated sample processing apparatus having an automated process operation capability that causes automated process operation events through robotic sample process functions; providing a clearing solvent, e.g. an organic solvent, capable of lowering the melting point of an embedding medium and/or dissolving an embedding medium; loading a plurality of carriers with embedded biological samples in the automated sample processing apparatus; exposing an embedded biological sample to the clearing solvent, whereby the embedding medium is liquefied; and providing a washing solution capable of removing the clearing solvent and the liquefied embedded medium from said biological sample, said clearing solvent and said washing solution being immiscible.
摘要翻译：一种用于从嵌入式生物样品中自动去除嵌入介质的方法，装置和系统。该方法包括以下步骤：提供具有自动化处理操作能力的自动化样品处理设备，其通过机器人样品处理功能引起自动过程操作事件; 提供清除溶剂，例如能够降低嵌入介质的熔点和/或溶解嵌入介质的有机溶剂; 在自动化样品处理装置中加载具有嵌入式生物样品的多个载体; 将嵌入的生物样品暴露于清除溶剂，由此嵌入介质液化; 并且提供能够从所述生物样品中除去清除溶剂和液化的嵌入介质的洗涤溶液，所述清除溶剂和所述洗涤溶液是不混溶的。

3. 发明申请

US20060040341A1 Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device 有权
公开(公告)号：US20060040341A1
公开(公告)日：2006-02-23
申请号：US11168987
申请日：2005-06-28
申请人： Loren Bland , Marc Key , Lars Winther , David Stanforth , Martin Lindberg
发明人： Loren Bland , Marc Key , Lars Winther , David Stanforth , Martin Lindberg
IPC分类号： G01N1/30 , G01N33/48 , G06F19/00 , G01N33/50
CPC分类号： G01N1/30 , B01L3/545 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G01N1/312 , G01N35/00732 , G01N2035/00782 , Y10T436/255
摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

4. 发明申请

US20120259105A1 HUMAN PAPILLOMA VIRUS PROBES FOR THE DIAGNOSIS OF CANCER 有权
标题翻译：人类PAPILLOMA病毒检测癌症的诊断
公开(公告)号：US20120259105A1
公开(公告)日：2012-10-11
申请号：US13527489
申请日：2012-06-19
申请人： Miu Fun Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
发明人： Miu Fun Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
IPC分类号： C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q1/708 , C12Q2600/158
摘要： In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.
摘要翻译：在一个实施方案中，本发明涉及使用高风险人乳头状瘤病毒的至少三种基因组克隆或其片段的组合来检测宫颈癌和其它类型的癌症的方法。例如，本发明涉及包含高风险人乳头状瘤病毒的至少三个全长基因组克隆或其片段的组合物。

5. 发明授权

US5851794A Collagen binding protein as well as its preparation 失效
标题翻译：胶原蛋白结合蛋白及其制备
公开(公告)号：US5851794A
公开(公告)日：1998-12-22
申请号：US447031
申请日：1995-05-22
申请人： Bengt Guss , Magnus Hook , Hans Jonsson , Martin Lindberg , Joseph Patti , Christer Signas , Lech Switalski
发明人： Bengt Guss , Magnus Hook , Hans Jonsson , Martin Lindberg , Joseph Patti , Christer Signas , Lech Switalski
IPC分类号： A61K38/00 , A61K39/00 , C07K14/31 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/09
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to a new recombinant DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having collagen binding properties.
摘要翻译：本发明涉及包含编码蛋白质的金黄色葡萄球菌的核苷酸序列或具有胶原结合特性的多肽的新的重组DNA分子。

6. 发明授权

US08513398B2 Human papilloma virus probes for the diagnosis of cancer 有权
标题翻译：人乳头瘤病毒探针用于诊断癌症
公开(公告)号：US08513398B2
公开(公告)日：2013-08-20
申请号：US13527489
申请日：2012-06-19
申请人： Miu Fun Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
发明人： Miu Fun Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
IPC分类号： C07H21/04
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q1/708 , C12Q2600/158
摘要： In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.
摘要翻译：在一个实施方案中，本发明涉及使用高风险人乳头状瘤病毒的至少三种基因组克隆或其片段的组合来检测宫颈癌和其它类型的癌症的方法。例如，本发明涉及包含高风险人乳头状瘤病毒的至少三个全长基因组克隆或其片段的组合物。

7. 发明授权

US6100055A DNA encoding f.alpha.-2m-binding protein and protein encoded thereby 失效
标题翻译：编码fα-2m结合蛋白的DNA和由此编码的蛋白质
公开(公告)号：US6100055A
公开(公告)日：2000-08-08
申请号：US669408
申请日：1996-07-03
申请人： Bengt Guss , Hans Jonsson , Martin Lindberg , Hans-Peter Mueller , Liisa K. Rantamaki
发明人： Bengt Guss , Hans Jonsson , Martin Lindberg , Hans-Peter Mueller , Liisa K. Rantamaki
IPC分类号： A61K38/00 , C07K14/315 , C07K14/735 , C12N15/11 , C12N15/63
CPC分类号： C07K14/315 , C07K14/70535 , A61K38/00
摘要： DNA molecules and methods for producing proteins, or fragments thereof, having binding activity for the fast form of .alpha..sub.2 -macroglobulins as exemplified for the streptococcal surface proteins MIG, MAG and ZAG.
摘要翻译： PCT No.PCT / SE94 / 00826 Sec。 371日期：1996年7月3日 102（e）日期1996年7月3日PCT 1994年9月6日PCT公布。公开号WO95 / 07296 日期1995年3月16日用于制备蛋白质或其片段的DNA分子和方法，其具有针对链球菌表面蛋白MIG，MAG和ZAG所例示的α2-巨球蛋白快速形式的结合活性。

8. 发明授权

US08221970B2 Human papilloma virus probes for the diagnosis of cancer 有权
标题翻译：人乳头瘤病毒探针用于诊断癌症
公开(公告)号：US08221970B2
公开(公告)日：2012-07-17
申请号：US10959175
申请日：2004-10-07
申请人： Miu Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
发明人： Miu Chau , Kirsten Bisgaard-Franzen , Jone Lin , Ole Feldballe Rasmussen , Zunde Wang , Jason Lusk , Martin Lindberg , Sienna Yoast
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q1/708 , C12Q2600/158
摘要： In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.
摘要翻译：在一个实施方案中，本发明涉及使用高风险人乳头状瘤病毒的至少三种基因组克隆或其片段的组合来检测宫颈癌和其它类型的癌症的方法。例如，本发明涉及包含高风险人乳头状瘤病毒的至少三个全长基因组克隆或其片段的组合物。

9. 发明授权

US06733758B1 Fibrinogen binding protein originating from coagulase-negative staphylococcus 有权
标题翻译：来自凝固酶阴性葡萄球菌的纤维蛋白原结合蛋白
公开(公告)号：US06733758B1
公开(公告)日：2004-05-11
申请号：US09147405
申请日：1999-04-01
申请人： Bengt Guss , Martin Nilsson , Lars Frykberg , Jan-Ingmar Flock , Martin Lindberg
发明人： Bengt Guss , Martin Nilsson , Lars Frykberg , Jan-Ingmar Flock , Martin Lindberg
IPC分类号： A61K30085
CPC分类号： C07K14/31 , A61K38/00 , A61K2039/51 , C07K2319/00 , Y10S530/825
摘要： A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.
摘要翻译：来自凝固酶阴性葡萄球菌的新的纤维蛋白原结合蛋白或多肽，用于产生具有纤维蛋白原结合活性的蛋白质或多肽的生物技术方法和编码该蛋白质（或其片段）的重组DNA分子和含有该蛋白质的微生物（包括病毒）重组DNA分子。本发明还包括蛋白质和/或DNA的治疗和诊断用途，例如用于确定凝固酶阴性葡萄球菌的存在和/或类型的诊断试剂盒和包含蛋白质或DNA的疫苗组合物。

10. 发明授权

US07160990B2 Antibodies to a fibrinogen binding protein of staphylococcus epidermidis 有权
标题翻译：对表皮葡萄球菌纤维蛋白原结合蛋白的抗体
公开(公告)号：US07160990B2
公开(公告)日：2007-01-09
申请号：US10806288
申请日：2004-03-23
申请人： Bengt Guss , Martin Nilsson , Lars Frykberg , Jan-Ingmar Flock , Martin Lindberg
发明人： Bengt Guss , Martin Nilsson , Lars Frykberg , Jan-Ingmar Flock , Martin Lindberg
IPC分类号： C07K16/00 , A61K38/16 , A61K39/40 , A61K39/395
CPC分类号： C07K14/31 , A61K38/00 , A61K2039/51 , C07K2319/00 , Y10S530/825
摘要： A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.
摘要翻译：来自凝固酶阴性葡萄球菌的新的纤维蛋白原结合蛋白或多肽，用于产生具有纤维蛋白原结合活性的蛋白质或多肽的生物技术方法和编码该蛋白质（或其片段）的重组DNA分子和含有该蛋白质的微生物（包括病毒）重组DNA分子。本发明还包括蛋白质和/或DNA的治疗和诊断用途，例如用于确定凝固酶阴性葡萄球菌的存在和/或类型的诊断试剂盒和包含蛋白质或DNA的疫苗组合物。

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