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    • 4. 发明授权
    • Method of synthesizing 2-(2'-hydroxyphenyl) benzotriazole compounds
    • 合成2-(2'-羟基苯基)苯并三唑化合物的方法
    • US5670654A
    • 1997-09-23
    • US602946
    • 1996-02-16
    • Lal Chand Vishwakarma
    • Lal Chand Vishwakarma
    • C07D249/20
    • C07D249/20Y02P20/55
    • A method for preparing a compound of formula (VII): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are defined in the specification; the method comprising: protecting at least --XH on a compound of formula (IV) below to form a protected formula (IV) compound, by forming --X(PG) where PG is a group other than H which is not removed during a subsequent ring closure step: ##STR2## performing a ring closure by reacting the protected formula (IV) compound with a reducing agent to form a compound of formula (VI): ##STR3## wherein Z is H or a protecting group; deprotecting the compound of formula (VI) to form the compound of formula (VII) by replacing PG with H and, when Z is not H, also replacing Z with H.
    • (VII)化合物的制备方法:其中:R1,R2,R3,R4,R5,R6,R7和X在本说明书中定义; 所述方法包括:通过形成-X(PG),其中PG是除H之外的基团,在随后的其中不被除去的情况下,通过以下方式保护式(IV)化合物上至少-XH以形成受保护的式(IV)化合物 闭环步骤:(IV)通过使保护的式(IV)化合物与还原剂反应形成式(VI)化合物进行闭环:其中Z为H或保护基 组; 通过用H代替PG,并且当Z不为H时,用H代替Z,使式(VI)化合物脱保护形成式(VII)化合物。