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1. 发明申请

WO2006109323B1 PREPARATION OF [2-METHYL-5-PHENYL-3-(PIPERAZIN-1-YLMETHYL)] PYRROLE DERIVATIVES 审中-公开
标题翻译： [2-甲基-5-苯基-3-（哌嗪-1-基]乙基]]吡咯衍生物的制备
公开(公告)号：WO2006109323B1
公开(公告)日：2006-11-30
申请号：PCT/IN2006000115
申请日：2006-04-05
申请人： LUPIN LTD , ARORA SUDERSHAN KUMAR , SINHA NEELIMA , JAIN SANJAY , UPADHAYAYA RAM SHANKAR , TYAGI OM DUTT , NALAM VASANTH , CHAUHAN YOGENDRA KUMAR
发明人： ARORA SUDERSHAN KUMAR , SINHA NEELIMA , JAIN SANJAY , UPADHAYAYA RAM SHANKAR , TYAGI OM DUTT , NALAM VASANTH , CHAUHAN YOGENDRA KUMAR
IPC分类号： C07D207/50 , A61K31/4025 , A61P31/06
CPC分类号： C07D207/50 , C07D207/335 , C07D401/04 , C07D401/12
摘要： A process for the preparation of compounds of Formula (I) and their pharmaceutically acceptable acid addition salt wherein R 1 is phenyl or substituted phenyl, R 3 is selected from a group of formula (a), n = 0-2 and X = -NCH 3 , CH 2 , S, SO, or SO 2 wherein R 2 and R 5 are as defined herein.
摘要翻译：制备式（I）化合物及其药学上可接受的酸加成盐的方法，其中R 1是苯基或取代的苯基，R 3 3选自式（a），n = 0-2和X = -NCH 3，CH 2，S，SO或SO 2其中R R 2和R 5如本文所定义。

2. 发明申请

WO2006011157A2 A NOVEL METHOD FOR THE PREPARATION OF ARYL PIPERAZINYL-HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：一种制备芳基哌嗪类杂环化合物的新方法
公开(公告)号：WO2006011157A2
公开(公告)日：2006-02-02
申请号：PCT/IN2005000205
申请日：2005-06-16
申请人： LUPIN LTD , TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , CHAUHAN YOGENDRA KUMAR , NALAM VASANTH KUMAR
发明人： TYAGI OM DUTT , SRIVASTAVA TUSHAR KUMAR , CHAUHAN YOGENDRA KUMAR , NALAM VASANTH KUMAR
IPC分类号： C07D417/00
CPC分类号： C07D417/12
摘要： A novel method for preparing a compound of formula (I), which comprises of coupling the piperazine derivative of formula (II), with alkyl halide containing compound of the formula (III), by heating in solvent free conditions or, optionally, in a minimum quantity of non-aqueous suspending liquid, in presence of a catalyst and a neutralizing agent to neutralize the hydrohalic acid.
摘要翻译：一种制备式（I）化合物的新方法，其包括将式（II）的哌嗪衍生物与含烷基卤的式（III）化合物偶联，通过在无溶剂条件下加热，或任选地在在催化剂和中和剂存在下，最少量的非水悬浮液，以中和氢卤酸。

3. 发明申请

WO2005094800A3 A CO-PRECIPITATED CEFEPIME COMPOSITION AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：共沉淀的头峰组合物及其制备方法
公开(公告)号：WO2005094800A3
公开(公告)日：2005-11-24
申请号：PCT/IN2005000095
申请日：2005-03-30
申请人： LUPIN LTD , TYAGI OM DUTT , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR
发明人： TYAGI OM DUTT , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR
IPC分类号： A61K31/546 , C07D501/00
CPC分类号： A61K31/546
摘要： The present invention provides a stable and sterile composition of Cefepime with a pharmaceutically acceptable non-toxic organic and inorganic base in high purity which exhibits good thermal stability which is obtained by co precipitation of composition containing non-sterile Cefepime and non-sterile pharmaceutically acceptable base. The method of preparing the co-precipitated composition of Cefepime with pharmaceutically acceptable non-toxic base comprises of, i) dissolving a composition containing mixture of non sterile Cefepime and a non sterile pharmaceutically acceptable non-toxic organic or inorganic base in water to obtain a clear aqueous solution having a pH in the range of 3.5-7 and ii) filtration of aqueous solution through 0.2 micron membrane filter and then adding the clear aqueous solution to a suitable an organic solvent followed by stirring, filtration and drying.
摘要翻译：本发明提供了具有高纯度的药学上可接受的无毒有机和无机碱的稳定且无菌的头孢吡肟组合物，其显示出良好的热稳定性，其通过共沉淀包含非无菌头孢吡肟和非无菌药学上可接受的碱。制备头孢吡肟与药学上可接受的无毒碱的共沉淀组合物的方法包括：i）将含有非无菌头孢吡肟和非无菌药学上可接受的无毒有机或无机碱的混合物的组合物溶解于水中以获得澄清的pH值为3.5-7的水溶液，和ii）通过0.2微米膜过滤器过滤水溶液，然后将澄清的水溶液加入合适的有机溶剂中，随后搅拌，过滤并干燥。

4. 发明申请

WO2008152653A3 AN IMPROVED PROCESS FOR THE PREPARATION OF TAMSULOSIN HYDROCHLORIDE 审中-公开
标题翻译：一种改进制备TAMSULOSIN HYDROCHLORIDE的方法
公开(公告)号：WO2008152653A3
公开(公告)日：2010-04-29
申请号：PCT/IN2008000367
申请日：2008-06-10
申请人： MATRIX LAB LTD , TYAGI OM DUTT , RAY PURNA CHANDRA , RAO KONUDULA BABU , CHAUHAN YOGENDRA KUMAR , NARAYANA BANDLAMUDI VEERA , REDDY DOSARALA SIVA PRASAD
发明人： TYAGI OM DUTT , RAY PURNA CHANDRA , RAO KONUDULA BABU , CHAUHAN YOGENDRA KUMAR , NARAYANA BANDLAMUDI VEERA , REDDY DOSARALA SIVA PRASAD
IPC分类号： C07C311/37 , C07C209/08 , C07C209/16
CPC分类号： C07C311/37 , C07B2200/07 , C07C303/40
摘要： The invention relates an improved process for preparing the (R)-(-)5-[2-[[2-(2-ethoxyphenoxyethyl]amino]propyl]-2-methoxybenzenesulfonamide of Formula (I): and its pharmaceutically acceptable salts.
摘要翻译：本发明涉及制备式（I）所示的（R） - （ - ） - [ - （ - ） - [ - [ - （ - ） - [ - [ - （（2-乙氧基苯氧基乙基）氨基]丙基] -2-甲氧基苯磺酰胺及其药学上可接受的盐。

5. 发明申请

WO2008142706A3 NOVEL PROCESS FOR THE SYNTHESIS OF PIOGLITAZONE AND ITS SALTS THEREOF 审中-公开
标题翻译：用于合成PIOGLITAZONE及其盐的新方法
公开(公告)号：WO2008142706A3
公开(公告)日：2009-12-03
申请号：PCT/IN2008000315
申请日：2008-05-19
申请人： MATRIX LAB LTD , TYAGI OM DUTT , RAY PURNA CHANDRA , RAO KONUDULA BABU , CHAUHAN YOGENDRA KUMAR , NALLA RAJA MAHENDAR REDDY , PRASAD GADAMSETTY
发明人： TYAGI OM DUTT , RAY PURNA CHANDRA , RAO KONUDULA BABU , CHAUHAN YOGENDRA KUMAR , NALLA RAJA MAHENDAR REDDY , PRASAD GADAMSETTY
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： Present invention relates to an improved process for the preparation of thiazolidinedione derivatives. Further the invention provides the hydrogenation of acid addition salt of benzylidene compound with less reducing agent under low Hydrogen gas pressure to get substantially pure thiazolidinedione derivatives with improved yields.
摘要翻译：本发明涉及一种制备噻唑烷二酮衍生物的改进方法。此外，本发明提供了在低氢气压力下用较少还原剂氢化亚苄基化合物的酸加成盐，以获得基本上纯的噻唑烷二酮衍生物，其产率提高。

6. 发明申请

WO2009090544A2 PROCESS FOR PRODUCING AMORPHOUS ATORVASTATIN CALCIUM 审中-公开
标题翻译：生产无花果ATORVASTATIN钙的方法
公开(公告)号：WO2009090544A2
公开(公告)日：2009-07-23
申请号：PCT/IB2009000068
申请日：2009-01-15
申请人： MATRIX LAB LTD , RAO P V SRINIVAS , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR , RAY PURNA CHANDRA , TYAGI OM DUTT
发明人： RAO P V SRINIVAS , CHAUHAN YOGENDRA KUMAR , SRIVASTAVA TUSHAR KUMAR , RAY PURNA CHANDRA , TYAGI OM DUTT
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： Disclosed herein is an improved process for producing amorphous atorvastatin calcium and a method of packaging thereof.
摘要翻译：本文公开了一种生产无定形阿托伐他汀钙的改进方法及其包装方法。

7. 发明申请

WO2009125427A2 PROCESS FOR PREPARING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID 审中-公开
标题翻译：制备（S）-3-（氨基甲基）-5-甲基六氢叶酸的方法
公开(公告)号：WO2009125427A2
公开(公告)日：2009-10-15
申请号：PCT/IN2009000111
申请日：2009-02-18
申请人： MATRIX LAB LTD , KHAJA ATAHARODDIN , POTLA VENKATA SRINIVAS RAO , RAWAT GOVIND SINGH , KONUDULA BABU RAO , CHAUHAN YOGENDRA KUMAR , DATTA DEBASHISH
发明人： KHAJA ATAHARODDIN , POTLA VENKATA SRINIVAS RAO , RAWAT GOVIND SINGH , KONUDULA BABU RAO , CHAUHAN YOGENDRA KUMAR , DATTA DEBASHISH
IPC分类号： C07C227/34
CPC分类号： C07C227/34 , C07C229/08
摘要： Disclosed herein is a process for the preparing (S)-3-(aminomethyl)-5- methylhexanoic acid by optical resolution of (±)-3-(aminomethyl)-5-methylhexanoic acid and a resolving agent employing a suitable solvent.
摘要翻译：本文公开了通过（±）-3-（氨基甲基）-5-甲基己酸的光学拆分和使用合适溶剂的拆分剂制备（S）-3-（氨基甲基）-5-甲基己酸的方法。

8. 发明专利

CA2604388A1 PREPARATION OF [2-METHYL-5-PHENYL-3-(PIPERAZIN-1-YLMETHYL)] PYRROLE DERIVATIVES 未知
公开(公告)号：CA2604388A1
公开(公告)日：2006-10-19
申请号：CA2604388
申请日：2006-04-05
申请人： LUPIN LTD
发明人： CHAUHAN YOGENDRA KUMAR , NALAM VASANTH , TYAGI OM DUTT , UPADHAYAYA RAM SHANKAR , JAIN SANJAY , ARORA SUDERSHAN KUMAR , SINHA NEELIMA
IPC分类号： C07D207/50 , A61K31/4025 , A61P31/06
摘要： A process for the preparation of compounds of Formula (I) and their pharmaceutically acceptable acid addition salt wherein R1 is phenyl or substituted phenyl, R3 is selected from a group of formula (a), n = 0-2 and X = -NCH3, CH2, S, SO, or SO2 wherein R2 and R5 are as defined herein.

9. 发明专利

AU2006233943A1 Preparation of (2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)) pyrrole derivatives 未知
公开(公告)号：AU2006233943A1
公开(公告)日：2006-10-19
申请号：AU2006233943
申请日：2006-04-05
申请人： LUPIN LTD
发明人： NALAM VASANTH , CHAUHAN YOGENDRA KUMAR , UPADHAYAYA RAM SHANKAR , SINHA NEELIMA , JAIN SANJAY , TYAGI OM DUTT , ARORA SUDERSHAN KUMAR
IPC分类号： A61K31/4025 , A61P31/06 , C07D207/50
摘要： A process for the preparation of compounds of Formula I and their pharmaceutically acceptable acid addition salt wherein, R1 is phenyl or substituted phenyl R2 is selected from a group consisting of phenyl which is unsubstituted or substituted with 1 or 2 substituents, each independently selected from Cl, F, or pyridine, or naphthalene, or NHCOR4 wherein R4 is aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl. R3 is selected from a group of formula wherein R5 is phenyl which is unsubstituted or substituted with 1 or 2 substituents each independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, amino, haloalkyl, haloalkoxy etc.; unsubstituted or substituted benzyl; unsubstituted or substituted heteroaryl; unsubstituted or substituted heteroaroyl; unsubstituted or substituted diphenylmethyl, n=0-2 and X--NCH3, CH2, S, SO, or SO2 Such that when R2 is phenyl, which is unsubstituted or substituted with 1 or 2 substituents, each independently selected from Cl, F; R5 is not C1-C4 alkyl, or X is not -NCH3, CH2, S, SO, or SO2, when n=1, or X is not -CH2 when n=0; comprising the steps of (a) reacting compound of Formula II with a chlorinating agent in the presence or absence of catalytic amount of N,N-dimethylformamide to yield the compound of Formula III, (b) reacting the compound of Formula III with a compound of Formula R1H (R1 is as defined above), in presence of a Lewis acid to obtain the compound of Formula IV, (c) reacting the compound of Formula IV with a compound of Formula R2NH2 (R2 is as defined above) in presence of catalytic amounts of an aryl or alkyl sulphonic acid in an organic solvent to obtain the compound of Formula V, (d) reacting the compound of Formula V with various secondary amines of the Formula R3H (R3 is as defined above) in the presence of formaldehyde and acetic acid in acetonitrile followed by crystallization yield the compound of Formula I, (e) purifying the compound of Formula I by crystallization, (f) converting the purified compound of Formula I to a pharmaceutically acceptable acid addition salt.

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