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1. 发明授权

EP0996857B1 CANCER ASSOCIATED NUCLEIC ACIDS AND POLYPEPTIDES 失效
标题翻译： KREBSASSOZIIERTENUKLEINSÄUREUND PROTEINE
公开(公告)号：EP0996857B1
公开(公告)日：2009-09-09
申请号：EP98936860.0
申请日：1998-07-15
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , Sloan-Kettering Institute For Cancer Research , CORNELL RESEARCH FOUNDATION, INC.
发明人： OLD, Lloyd, J. , SCANLAN, Matthew, J. , STOCKERT, Elisabeth , GURE, Ali , CHEN, Yao-Tseng , GOUT, Ivan , O'HARE, Michael , OBATA, Yuichi , PFREUNDSCHUH, Michael , TURECI, Ozlem , SAHIN, Ugur
IPC分类号： G01N33/574 , C07K14/00
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

2. 发明申请

WO2002090986A1 COLON CANCER ANTIGEN PANEL 审中-公开
标题翻译：结肠癌抗原面板
公开(公告)号：WO2002090986A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/013994
申请日：2002-05-02
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , CORNELL RESEARCH FOUNDATION, INC. , CHEN, Yao-Tseng , OLD, Lloyd, J. , SCANLAN, Matthew, J. , STOCKERT, Elisabeth
发明人： CHEN, Yao-Tseng , OLD, Lloyd, J. , SCANLAN, Matthew, J. , STOCKERT, Elisabeth
IPC分类号： G01N33/53
CPC分类号： G01N33/57419 , A61K38/00 , C07K14/4748 , C07K16/3046 , C12Q1/6886 , C12Q2600/156
摘要： The invention provides methods for diagnosing cancer including colon cancer, based on the identification of certain colon cancer-associated polypeptides as antigens that elicit immune responses in colon cancer. The identified antigens can be utilized as markers for diagnosing colon cancer, and for following the course of treatment of colon cancer.
摘要翻译：本发明基于鉴定某些结肠癌相关多肽作为在结肠癌中引起免疫应答的抗原，提供诊断包括结肠癌的癌症的方法。所鉴定的抗原可用作诊断结肠癌的标志物，以及用于治疗结肠癌的过程。

3. 发明申请

WO2002078526A3 CANCER-TESTIS ANTIGENS 审中-公开
公开(公告)号：WO2002078526A3
公开(公告)日：2002-10-10
申请号：PCT/US2002/009808
申请日：2002-03-29
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , CORNELL RESEARCH FOUNDATION, INC , OLD, Lloyd, J. , SCANLAN, Matthew, J. , CHEN, Yao-Tseng
发明人： OLD, Lloyd, J. , SCANLAN, Matthew, J. , CHEN, Yao-Tseng
IPC分类号： A61K35/00
摘要： Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more CT antigens.

4. 发明申请

WO2002078526A2 CANCER-TESTIS ANTIGENS 审中-公开
标题翻译：癌症检测抗体
公开(公告)号：WO2002078526A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/009808
申请日：2002-03-29
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , CORNELL RESEARCH FOUNDATION, INC , OLD, Lloyd, J. , SCANLAN, Matthew, J. , CHEN, Yao-Tseng
发明人： OLD, Lloyd, J. , SCANLAN, Matthew, J. , CHEN, Yao-Tseng
IPC分类号： A61B
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K16/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N33/57407
摘要： Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more CT antigens.
摘要翻译：已经通过筛选在肿瘤组织和有限的正常组织中表达的转录本的公共数据库，或通过筛选在癌和睾丸组织（但不是其他正常组织）中表达的基因来鉴定癌 - 睾丸（CT）抗原。。本发明涉及在患有癌症的患者中表达的CT抗原的核酸和编码多肽。本发明提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种CT抗原表达为特征的病症。

5. 发明公开

EP1402261A1 COLON CANCER ANTIGEN PANEL 审中-公开
标题翻译： KOLONKARZINOM-ANTIGENTAFEL
公开(公告)号：EP1402261A1
公开(公告)日：2004-03-31
申请号：EP02736641.8
申请日：2002-05-02
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , CORNELL RESEARCH FOUNDATION, INC.
发明人： CHEN, Yao-Tseng , OLD, Lloyd, J. , SCANLAN, Matthew, J. , STOCKERT, Elisabeth
IPC分类号： G01N33/53 , C07K14/435 , C07K16/18 , C07K16/32 , C12N15/12 , C12Q1/68 , C12P19/34
CPC分类号： G01N33/57419 , A61K38/00 , C07K14/4748 , C07K16/3046 , C12Q1/6886 , C12Q2600/156
摘要： The invention provides methods for diagnosing cancer including colon cancer, based on the identification of certain colon cancer-associated polypeptides as antigens that elicit immune responses in colon cancer. The identified antigens can be utilized as markers for diagnosing colon cancer, and for following the course of treatment of colon cancer.

6. 发明授权

EP1005532B1 ISOLATED NUCLEIC ACID MOLECULES ENCODING SSX FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：分离与核酸分子的用途，其为家庭CODE SSX的成员
公开(公告)号：EP1005532B1
公开(公告)日：2002-12-04
申请号：EP98910056.5
申请日：1998-02-25
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , MEMORIAL SLOAN-KETTERING CANCER CENTER , CORNELL RESEARCH FOUNDATION, INC.
发明人： GURE, Ali, O. , TURECI, Ozlem , SAHIN, Ugur , TSANG, Solam , SCANLAN, Matthew, J. , KNUTH, Alexander , PFREUNDSCHUH, Michael , OLD, Lloyd, J. , CHEN, Yao-Tseng
IPC分类号： C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.

7. 发明公开

EP1259545A2 SMALL CELL LUNG CANCER ASSOCIATED ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：随着“非小细胞”肺癌相关抗原及其用途
公开(公告)号：EP1259545A2
公开(公告)日：2002-11-27
申请号：EP01942642.8
申请日：2001-01-19
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , MEMORIAL SLOAN-KETTERING CANCER CENTER , CORNELL RESEARCH FOUNDATION, INC.
发明人： STOCKERT, Elisabeth , SCANLAN, Matthew, J. , JAGER, Dirk , OLD, Lloyd, J. , GURE, Ali, O.,Cornell Univ. Med. College , CHEN, Yao-Tseng,New York Hosp.-Cornell Med. Cter
IPC分类号： C07K14/705
CPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , C07K14/4748 , G01N33/57423
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

8. 发明公开

EP1005532A1 ISOLATED NUCLEIC ACID MOLECULES ENCODING SSX FAMILY MEMBERS AND USES THEREOF 失效
标题翻译：分离与核酸分子的用途，其为家庭CODE SSX的成员
公开(公告)号：EP1005532A1
公开(公告)日：2000-06-07
申请号：EP98910056.5
申请日：1998-02-25
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , MEMORIAL SLOAN-KETTERING CANCER CENTER , CORNELL RESEARCH FOUNDATION, INC.
发明人： GURE, Ali, O. , TURECI, Ozlem , SAHIN, Ugur , TSANG, Solam , SCANLAN, Matthew, J. , KNUTH, Alexander , PFREUNDSCHUH, Michael , OLD, Lloyd, J. , CHEN, Yao-Tseng
IPC分类号： C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.

9. 发明申请

WO2004031354A2 HUMAN SARCOMA-ASSOCIATED ANTIGENS 审中-公开
标题翻译：人类SARCOMA相关抗原
公开(公告)号：WO2004031354A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/030870
申请日：2003-09-30
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , SCANLAN, Matthew, J. , LEE, Sang-Yull , OLD, Lloyd, J.
发明人： SCANLAN, Matthew, J. , LEE, Sang-Yull , OLD, Lloyd, J.
IPC分类号： C12N
CPC分类号： C07K14/4748 , C07H21/04 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/57488
摘要： The invention relates to sarcoma-associated antigens and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof associated with sarcoma in methods and compositions for the diagnosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of a novel cancer/testis (CT) antigen, NY-SAR-35.
摘要翻译：本发明涉及肉瘤相关抗原和编码它们的核酸分子。本发明进一步涉及与肉瘤相关的核酸分子，多肽及其片段在用于诊断和治疗诸如癌症的疾病的方法和组合物中的用途。更具体地，本发明涉及新型癌/睾丸（CT）抗原NY-SAR-35的发现。

10. 发明申请

WO1995029233A1 ISOLATED NUCLEIC ACID MOLECULE CODING FOR FIBROBLAST ACTIVATION PROTEIN 'alpha' AND USES THEREOF 审中-公开
标题翻译：纤维蛋白激活蛋白α的分离核酸分子编码及其用途
公开(公告)号：WO1995029233A1
公开(公告)日：1995-11-02
申请号：PCT/US1995004860
申请日：1995-04-19
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH
发明人： LUDWIG INSTITUTE FOR CANCER RESEARCH , RETTIG, Wolfgang, J. , SCANLAN, Matthew, J. , GARIN-CHESA, Pilar , OLD, Lloyd, J.
IPC分类号： C12N15/00
CPC分类号： C12N9/6424 , C07K14/705 , C07K14/70517 , C07K2319/00 , C12N9/48 , C12N2799/026 , C12P21/06
摘要： The invention describes the identification and isolation of nucleic acid molecules which code for fibroblast activation protein alpha, or "FAP alpha ". Various applications of the isolated molecules are also described.
摘要翻译：本发明描述了编码成纤维细胞激活蛋白α或“FAPα”的核酸分子的鉴定和分离。还描述了分离的分子的各种应用。

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