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1. 发明申请

WO2009104051A2 COMBINATIONAL THERAPEUTICS FOR TREATMENT OF PROSTATE CANCER USING EPOXY ENCAPSULATED MAGNETIC PARTICLES AND RNAI MEDICINE 审中-公开
标题翻译：用环氧胶囊和RNAI药物治疗前列腺癌的联合治疗
公开(公告)号：WO2009104051A2
公开(公告)日：2009-08-27
申请号：PCT/IB2008003661
申请日：2008-12-31
申请人： LU PATRICK Y , GHIAS ASHGAR , EVANS DAVID
发明人： LU PATRICK Y , GHIAS ASHGAR , EVANS DAVID
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K47/6923 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12Y114/99001 , C12Y304/24024 , C12Y304/24035
摘要： The present invention provides compositions and methods for treatment of prostate cancer using siRNA cocktail sequences targeting multiple disease causing genes, and a combined regimen with both RNAi therapeutics and EEMP encapsulated magnetic nanoparticle therapeutics. The invention includes: 1) The algorithm for designing siRNA drug API (active pharmaceutical ingredient); 2)The compositions of multiple siRNA inhibiting expression of the multiple cancer causing genes; 3) The methods of designing siRNA duplexes with different lengths, different ends and to target the same genes from both human and mouse cells; 4) The methods of formulating various siRNA cocktail which are able to inhibit tumorigenic and angiogenesis; 5) The methods of using histidine-lysine copolymer (HKP), PAMAM dendrimer and Liposomal (DOTAP) carrier to enhance siRNA delivery into the cutaneous tissue; and 6) The methods of using two disease relevant mouse xenograft models to validate the siRNA cocktail for its efficacy on controlling tumor growth.
摘要翻译：本发明提供了使用靶向多种疾病引发基因的siRNA混合物序列治疗前列腺癌的组合物和方法，以及具有RNAi治疗剂和EEMP包封的磁性纳米颗粒治疗剂的组合方案。本发明包括：1）siRNA药物API（活性药物成分）的设计算法; 2）抑制多种癌症基因表达的多种siRNA的组成; 3）设计具有不同长度，不同末端的siRNA双链体并靶向来自人和小鼠细胞的相同基因的方法; 4）配制能够抑制致瘤和血管生成的各种siRNA混合物的方法; 5）使用组氨酸 - 赖氨酸共聚物（HKP），PAMAM树枝状大分子和脂质体（DOTAP）载体增强siRNA递送至皮肤组织的方法; 和6）使用两种疾病相关的小鼠异种移植模型来验证siRNA混合物以控制肿瘤生长的功效的方法。

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