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1. 发明申请

WO2008127291A2 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING 审中-公开
标题翻译：高级药物开发与制造
公开(公告)号：WO2008127291A2
公开(公告)日：2008-10-23
申请号：PCT/US2007021888
申请日：2007-10-10
申请人： LOS ALAMOS NAT SECURITY LLC , CALDERA PHARMACEUTICALS INC , BIRNBAUM EVA R , KOPPISCH ANDREW T , BALDWIN SHARON M , WARNER BENJAMIN P , MCCLESKEY MARK T , BERGER JENNIFER A , STEWART JEFFREY J , HARRIS MICHAEL N , BURRELL ANTHONY K
发明人： BIRNBAUM EVA R , KOPPISCH ANDREW T , BALDWIN SHARON M , WARNER BENJAMIN P , MCCLESKEY MARK T , BERGER JENNIFER A , STEWART JEFFREY J , HARRIS MICHAEL N , BURRELL ANTHONY K
IPC分类号： G01N33/53 , G01N21/76 , G01N23/223 , G01N33/68
CPC分类号： G01N33/54373 , G21K7/00 , G21K2207/00
摘要： X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
摘要翻译：已经使用X射线荧光（XRF）光谱法检测结合事件并测量化学物质和受体之间的结合选择性。 XRF还可用于估计化学品的治疗指数，用于估计化学品与化学类似物的结合选择性，用于测量蛋白质的翻译后修饰和药物制造。

2. 发明专利

DK2084519T3 RØNTGENFLUORESCENS-ANALYSEFREMGANGSMÅDE 未知
公开(公告)号：DK2084519T3
公开(公告)日：2012-08-20
申请号：DK07874491
申请日：2007-10-10
申请人： LOS ALAMOS NAT SECURITY LLC , CALDERA PHARMACEUTICALS INC
发明人： BIRNBAUM EVA R , KOPPISCH ANDREW T , BALDWIN SHARON M , WARNER BENJAMIN P , MCCLESKEY MARK T , BERGER JENNIFER A , STEWART JEFFREY J , HARRIS MICHAEL N , BURRELL ANTHONY K
IPC分类号： G01N23/223 , C12Q1/00 , G01T1/36

3. 发明公开

EP2084519A4 ADVANCED DRUG DEVELOPMENT AND MANUFACTURING 有权转让
标题翻译：先进的药物开发与生产
公开(公告)号：EP2084519A4
公开(公告)日：2010-02-24
申请号：EP07874491
申请日：2007-10-10
申请人： LOS ALAMOS NAT SECURITY LLC , CALDERA PHARMACEUTICALS INC
发明人： BIRNBAUM EVA R , KOPPISCH ANDREW T , BALDWIN SHARON M , WARNER BENJAMIN P , MCCLESKEY MARK T , BERGER JENNIFER A , STEWART JEFFREY J , HARRIS MICHAEL N , BURRELL ANTHONY K
IPC分类号： G01N23/223 , C12Q1/00 , G01T1/36
CPC分类号： G01N33/54373 , G21K7/00 , G21K2207/00

4. 发明公开

EP2183644A4 WELL PLATE 有权转让
标题翻译： WHEN板
公开(公告)号：EP2183644A4
公开(公告)日：2012-01-18
申请号：EP08798006
申请日：2008-08-15
申请人： CALDERA PHARMACEUTICALS INC
发明人： BIRNBAUM EVA R , WARNER BENJAMIN P , BALDWIN SHARON M , BERGER JENNIFER A , MILLER REBECCA L E
IPC分类号： G03B42/02 , G01N23/22 , G03C5/16
CPC分类号： G01N23/2202 , G01N23/2204 , G01N23/223 , G01N2223/074 , G01N2223/076 , G01N2223/309 , G01N2223/64 , G03B42/02

5. 发明公开

EP2201353A4 METHOD AND APPARATUS FOR MEASURING PROTEIN POST-TRANSLATIONAL MODIFICATION 审中-公开
标题翻译：方法和设备测量翻译后的蛋白质修饰
公开(公告)号：EP2201353A4
公开(公告)日：2011-01-26
申请号：EP08833371
申请日：2008-09-26
申请人： CALDERA PHARMACEUTICALS INC
发明人： BIRNBAUM EVA R , WARNER BENJAMIN P , BALDWIN SHARON M , BERGER JENNIFER A , PETERSON-COURT LORI J , HARRIS MICHAEL N , MILLER REBECCA L E
IPC分类号： G01N23/223 , G01N33/68
CPC分类号： C12Q1/485 , C12Q1/37 , G01N21/75 , G01N23/223 , G01N33/20 , G01N33/6842 , G01N2223/076 , G01N2333/91215 , G01N2333/96441 , Y10T436/17 , Y10T436/200833
摘要： The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

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