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1. 发明申请

WO2004031168A3 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF OPTICALLY ACTIVE 3-AMINO-1-(2-THIENYL)-1-PROPANOL DERIVATIVES 审中-公开
标题翻译：制备光学活性3-氨基-1-（2-噻吩基）-1-丙醇衍生物的方法和中间体
公开(公告)号：WO2004031168A3
公开(公告)日：2004-08-26
申请号：PCT/EP0311073
申请日：2003-10-07
申请人： LONZA AG , FUCHS RUDOLF , MICHEL DOMINIQUE , BRIEDEN WALTER
发明人： FUCHS RUDOLF , MICHEL DOMINIQUE , BRIEDEN WALTER
IPC分类号： C07D333/20 , C07D493/14
CPC分类号： C07D493/14 , C07D333/20
摘要： Enantiomerically enriched 3-amino-1-(2-thienyl)-1-propanols of the formulae ((S)-I) or ((R)-I) wherein R and R independently denote H, C1-6-alkyl, C5-7-cycloalkyl, aralkyl or aryl, were prepared by reducing a 3-amino-1-(2-thienyl)-1-propanone of the formula (II) wherein R and R are defined as above, using a hydrogen donor in the presence of a metal catalyst, an optically active nitrogen-containing ligand and optionally a base.
摘要翻译：式（（S）-I）或（（R）-I）的对映体富集的3-氨基-1-（2-噻吩基）-1-丙醇其中R 1和R 2独立地表示H，Cl -6-烷基，C 5-7 - 环烷基，芳烷基或芳基，通过还原其中R 1和R 2的式（II）的3-氨基-1-（2-噻吩基）-1-丙酮 >如上定义，在金属催化剂，光学活性含氮配体和任选的碱的存在下使用氢供体。

2. 发明专利

JPH1171354A PRODUCTION OF ALKOXYPYRAZINE DERIVATIVE 失效
公开(公告)号：JPH1171354A
公开(公告)日：1999-03-16
申请号：JP18307598
申请日：1998-06-29
申请人： LONZA AG
发明人： FUCHS RUDOLF
IPC分类号： B01J31/02 , C07B61/00 , C07D241/18 , C07D241/20 , C07D241/24
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as an intermediate for synthesizing medicines, by reaction of a glyoxal derivative with an aminoimidate. SOLUTION: This new compound, an alkoxypyrazine derivative of formula I (R is H, an alkyl or allyl; R is H, an alkyl, CONH2 , COOR or C(NH)OR ; R is an alkyl or allyl; R is an alkyl), is obtained by reaction of a glyoxal derivative of formula II with an aminoimidate of formula III. The aminoimidate of formula III is prepared by reaction of aminonitrile in the presence of an alkali (alkaline earth) metal alkoxide, and then directly reacted, without isolation, with the compound of formula II to obtain the objective compound of formula I. The compound of formula I is e.g. (3-methoxy-5-methylpyrazine-2- carboxamide.

3. 发明授权

US774873A Portable folding seat. 失效
标题翻译：便携折叠座椅
公开(公告)号：US774873A
公开(公告)日：1904-11-15
申请号：US1904198454
申请日：1904-03-16
申请人： FUCHS RUDOLF
发明人： FUCHS RUDOLF
CPC分类号： A47C9/027 , A47C3/029 , A47C4/283 , A47C4/38 , A47C9/10

4. 发明专利

JPH11322699A PRODUCTION OF MALONONITRILE 失效
公开(公告)号：JPH11322699A
公开(公告)日：1999-11-24
申请号：JP7105599
申请日：1999-03-16
申请人： LONZA AG
发明人： CHEN PETER , HOFFNER JOHANNES DR , MUELLER ANDRE , FUCHS RUDOLF
IPC分类号： C07C253/30 , C07B61/00 , C07C253/00 , C07C255/04 , C07C255/09
摘要： PROBLEM TO BE SOLVED: To produce malononitrile useful as a starting substance and an intermediate for producing an active ingredient of medicines and agrochemicals according to a method practicable on an industrial scale by converting a specific isonitrile, as necessary, in the presence of a specified nitrile at a temperature within a specific range. SOLUTION: (A) An isonitrile represented by the formula R -NC (R is H, an alkyl or a cycloalkyl) is converted, as necessary, in the presence of (B) a nitrile represented by the formula R -NC (R is H, an alkyl or a cycloalkyl) at 700-1,000 deg.C, preferably at 800-950 deg.C usually in a tubular reactor generally for severals conversion time to produce the objective compound represented by the formula (R is H, an alkyl or a cycloalkyl). In the method, the component A is preferably methylisonitrile and the component B is preferably acetonitrile.

5. 发明专利

JPH1045726A PRODUCTION OF OPTICALLY ACTIVE PIPERAZINE-2-CARBOXYLIC ACID DERIVATIVE 失效
公开(公告)号：JPH1045726A
公开(公告)日：1998-02-17
申请号：JP9926297
申请日：1997-04-16
申请人： LONZA AG
发明人： FUCHS RUDOLF
IPC分类号： B01J31/24 , C07B61/00 , C07D241/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful as a synthetic intermediate for a substance having pharmacological activities by asymmetrically hydrogenating a corresponding pyrazinecarboxylic acid derivative. SOLUTION: A pyrazinecarboxylic acid derivative of formula II (X is hydroxyl, a 1-6C alkoxy or a group of the formula NR R ; R and R are each H, a 1-6C alkyl, a 3-6C cycloalkyl, an aryl, an amino-protecting group; R and R form a saturated hetero ring with a nitrogen atom) is asymmetrically hydrogenated in the presence of an optical active rhodium complex to give the objective compound of formula I. The rhodium complex compound is obtained by reacting RH(I) complex with optically active metallocenylphosphine. The compound of formula I is useful as a synthetic intermediate for a HIV protease inhibitor. The compound of formula I is obtained without requiring an expensive reagent since optical resolution of a racemic compound is not carried out.

6. 发明授权

US6291674B2 Process for preparing alkoxypyrazine derivatives 失效
标题翻译：制备烷氧基吡嗪衍生物的方法
公开(公告)号：US6291674B2
公开(公告)日：2001-09-18
申请号：US78525001
申请日：2001-02-20
申请人： LONZA AG
发明人： FUCHS RUDOLF
IPC分类号： B01J31/02 , C07B61/00 , C07D241/18 , C07D241/20 , C07D241/24
CPC分类号： C07D241/24 , C07D241/18 , C07D241/20
摘要： A process for preparing alkoxypyrazine derivatives of the general formula:These alkoxypyrazine derivatives are obtained by reacting a glyoxal derivative of the general formula:and an aminoimidate of the general formula:
摘要翻译：制备以下通式的烷氧基吡嗪衍生物的方法：这些烷氧基吡嗪衍生物通过使下列通式的乙二醛衍生物与下列通式的氨基亚氨酸酯反应获得：

7. 发明申请

WO2012025330A3 SYSTEM HAVING AT LEAST TWO OSCILLATION INSERT TOOLS 审中-公开
标题翻译：至少有两个OSZILLATIONSEINSATZWERKZEUGEN系统
公开(公告)号：WO2012025330A3
公开(公告)日：2012-04-26
申请号：PCT/EP2011063041
申请日：2011-07-28
申请人： BOSCH GMBH ROBERT , FUCHS RUDOLF
发明人： FUCHS RUDOLF
IPC分类号： B23D61/12 , B27B19/00
CPC分类号： B25F5/006 , B23D61/006 , B23D61/123 , B24B23/04 , B24B41/007 , B27B19/006
摘要： The invention relates to a system having at least one first oscillation insert tool (66, 68,70, 72) that can be effectively coupled to an oscillation hand power tool, and at least one second oscillation insert tool (66, 68, 70, 72) that differs from the first oscillation insert tool (66, 68, 70, 72) and can be effectively coupled to the oscillation hand power tool as an alternative to the first oscillation insert tool (66, 68, 70, 72), wherein at least one of the at least two oscillation insert tools (66, 68, 70, 72) comprises at least one compensating unit (88, 90, 92, 94) for at least substantially adapting a mass moment of inertia of the at least one oscillation insert tool (66, 68, 70, 72) to a mass moment of inertia of the at least one second oscillation tool (66, 68, 70, 72).
摘要翻译：它是具有至少其可操作地耦合到Oszillationshandwerkzeugmaschine第一Oszillationseinsatzwerkzeug（66，68，70，72）的系统，并且由所述第一振荡中的至少一个（66，68，70，72），第二Oszillationseinsatzwerkzeug（66不同，68，70，72），这是第一振荡（66，68，70，72）可操作地联接到Oszillationshandwerkzeugmaschine，所述至少两个Oszillationseinsatzwerkzeuge（66，68的其中至少一个，70％，72）的至少一个补偿单元（一个替代其被提供给的惯性矩88,90，92，94）至少（一个Oszillationseinsatzwerkzeugs 66，68,70，72）至所述至少第二Oszillationswerkzeugs（66，68，70，72）的惯性矩，以至少基本上适应建议。

8. 发明申请

WO2012116829A8 MACHINE TOOL SYSTEM 审中-公开
标题翻译：机床系统
公开(公告)号：WO2012116829A8
公开(公告)日：2013-09-26
申请号：PCT/EP2012000918
申请日：2012-03-02
申请人： BOSCH GMBH ROBERT , FUCHS RUDOLF
发明人： FUCHS RUDOLF
IPC分类号： B27B17/00
CPC分类号： B27B17/0083 , B23D57/023 , B27B17/02
摘要： The invention relates to a machine tool system having at least one machine tool separating device which has at least one cutting strand (18) and at least one guide unit (20) for guiding the cutting strand (18), which together form a self-contained system, and having at least one portable machine tool, which comprises a machine tool housing (12) and at least one coupling device (14) for coupling the machine tool separating device. According to the invention, the portable machine tool comprises at least one pad unit (22) to be placed on a workpiece, wherein the pad unit (22) and the machine tool housing (22) are mounted such that they can be moved relative to each other.
摘要翻译：本发明涉及一种具有具有用于引导所述切割条（18），它们一起形成一个封闭的系统中的至少一个切割线（18）和至少一个引导单元（20）的至少一个机床分离装置的机床系统，和至少一个便携式工具机具有用于机床分离器联接的工具壳体（12）和至少一个耦合装置（14）包括。它建议，所述便携式工具机，其包括至少一个支承部（22），用于放置在工件上，其中，所述支撑单元（22）和工具壳体（12）被可移动地相对于彼此安装。

9. 发明申请

WO2012052242A3 WORKING TOOL, IN PARTICULAR ELECTRIC TOOL 审中-公开
标题翻译：作业工具，特别是电动工具
公开(公告)号：WO2012052242A3
公开(公告)日：2012-06-28
申请号：PCT/EP2011066344
申请日：2011-09-20
申请人： BOSCH GMBH ROBERT , FUCHS RUDOLF , HESSE JUERGEN , REICH DORIS , HOHL ULRICH , LUTZ TOBIAS
发明人： FUCHS RUDOLF , HESSE JUERGEN , REICH DORIS , HOHL ULRICH , LUTZ TOBIAS
IPC分类号： B24B23/02 , B25F5/02
CPC分类号： B24B23/028 , B24B23/024 , B25F5/02
摘要： The invention relates to a working tool (10), in particular an electric tool, with a housing (12) which forms a handle (16) and in which a driving motor (18) for a working means (60) is provided, wherein the housing (12) defines a first axial device axis (26), and with a working shaft (28) which is driven in a rotating or oscillating manner, is intended for receiving the working means (44) and is formed transversely with respect to the first axial device axis (26). According to the invention, it is proposed that a rigid, in particular linear connecting element (32) which is inclined in relation to the first device axis (26) is provided between the handle end (I) of the motor housing (12) and a receptacle (34) for the working shaft (28).
摘要翻译：本发明涉及一种作业工具（10），特别是电动工具，具有一手柄（16）外壳（12），其中提供一个驱动马达（18），用于工作装置（60），其中所述壳体（12）包括第一成形装置轴向轴线（26）限定，并与用于接收横向形成在仪器（26）的第一轴向轴线的工作流体（44）的旋转或摆动的驱动的操作轴（28）。根据本发明，它提出了一个刚性的，特别是直链的，相对的倾斜的第一装置轴线（26）的连接元件（32）的电机壳体（12）和用于所述工作轴（28）的插座（34）的手柄端（I）之间。

10. 发明申请

WO2008138657A2 MOUNTING KIT 审中-公开
标题翻译： MONTAGESET
公开(公告)号：WO2008138657A2
公开(公告)日：2008-11-20
申请号：PCT/EP2008052939
申请日：2008-03-12
申请人： BOSCH GMBH ROBERT , FUCHS RUDOLF
发明人： FUCHS RUDOLF
IPC分类号： B25B13/56 , G09F3/00
CPC分类号： B25B13/56 , F16B1/0071 , G09F3/00
摘要： Components used for mounting purposes in conjunction with hand-held machine tools are combined to mounting kits. The invention is characterized in that the components are organized according to their size class in a mounting kit comprising components of one size class, and the components of one size class are encoded with a standard color and/or shape symbol.
摘要翻译：与用于组装目的分量被组合到安装台手持式工具一起，即布置在每种情况下根据尺寸级别的尺寸类部件的安装设置，并与一个颜色和/或形状的图标被均匀地编码尺寸类的组件。

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