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1. 发明授权

US08644571B1 Intensity-modulated proton therapy 有权
标题翻译：强度调制质子治疗
公开(公告)号：US08644571B1
公开(公告)日：2014-02-04
申请号：US13705903
申请日：2012-12-05
申请人： Loma Linda University Medical Center , Univeristy of South Australia
发明人： Reinhard W. Schulte , Regina Burachik , Yalcin Kaya
IPC分类号： G06K9/00
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1077 , A61N2005/1087
摘要： The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites.
摘要翻译：描述了使用强度调制质子治疗的患者的治疗方法。在一个示例中，提出了一种创建质子治疗计划的方法，其将感兴趣的体积分成子体积，对子体积施加剂量约束，找到质子治疗系统的一个或多个可行配置，并选择质子束改善或优化质子治疗的一个或多个方面的配置。在一些实现中，将卷分割成子卷的方法包括至少部分地基于与目标卷边界的接近度来创建分数子卷。在一些实施方式中，从一组可行配置中找到改进或最佳质子束配置的方法包括找到利用与治疗部位相关联的加权因子的成本函数的最小值。

2. 发明申请

US20160144201A1 INTENSITY-MODULATED PROTON THERAPY 有权
标题翻译：强度调节的PROTON治疗
公开(公告)号：US20160144201A1
公开(公告)日：2016-05-26
申请号：US14945214
申请日：2015-11-18
申请人： Loma Linda University Medical Center
发明人： Reinhard W. Schulte
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1077 , A61N2005/1087
摘要： The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites.
摘要翻译：描述了使用强度调制质子治疗的患者的治疗方法。在一个示例中，提出了一种创建质子治疗计划的方法，其将感兴趣的体积分成子体积，对子体积施加剂量约束，找到质子治疗系统的一个或多个可行配置，并选择质子束改善或优化质子治疗的一个或多个方面的配置。在一些实现中，将卷分割成子卷的方法包括至少部分地基于与目标卷边界的接近度来创建分数子卷。在一些实施方式中，从一组可行配置中找到改进或最佳质子束配置的方法包括找到利用与治疗部位相关联的加权因子的成本函数的最小值。

3. 发明申请

US20150198543A1 SYSTEMS, DEVICES AND METHODS RELATED TO CALIBRATION OF A PROTON COMPUTED TOMOGRAPHY SCANNER 有权
标题翻译：与计算机计算机扫描仪校准相关的系统，设备和方法
公开(公告)号：US20150198543A1
公开(公告)日：2015-07-16
申请号：US14492894
申请日：2014-09-22
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： Reinhard W. Schulte , R. Ford Hurley
IPC分类号： G01N23/04 , G01N35/00
CPC分类号： G01T7/005 , A61B6/032 , A61B6/035 , A61B6/4258 , A61B6/548 , A61B6/583 , A61B6/585 , G01N23/04 , G01N23/046 , G01N35/00693 , G01N2223/107 , G01T1/169 , G01T1/2985
摘要： Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.
摘要翻译：公开了与基于离子的成像装置如质子计算机断层摄影扫描仪的校准相关的系统，装置和方法。在一些实施方案中，具有已知水当量厚度（WET）值的能量降解板可被引入离子束以引入不同的能量降解设置。可以获得能量检测器对受到这种能量劣化设置影响的个体离子的响应。这些响应可以根据已知的WET值被归一化并且与离子的水当量路径长度（WEPL）相关。利用降解板的这种校准可以相对快速地进行，并且可以产生准确的WEPL值，其有助于基于对象的相对停止功率来估计例如CT图像。

4. 发明授权

US10180505B2 Systems and methodologies for proton computed tomography 有权
公开(公告)号：US10180505B2
公开(公告)日：2019-01-15
申请号：US14799910
申请日：2015-07-15
申请人： University of Haifa , University of Wollongong , Loma Linda University Medical Center
发明人： Yair Censor , Scott N. Penfold , Reinhard W. Schulte
IPC分类号： G01N33/48 , G01N33/50 , G01T1/29 , G06F19/12 , G06F19/24 , G01N23/046 , A61N5/10 , A61B6/03 , A61B6/00 , G06T11/00 , G01T1/17
摘要： Disclosed are systems, devices and methodologies relating to proton computed tomography. In some implementations, detection of protons can yield track information before and after an object for each proton so as to allow determination of a likely path of each proton within the object. Further, measurement of energy loss experienced by each proton allows determination that a given likely path results in a given energy loss. A collection of such data allows characterization of the object. In the context of energy loss, such a characterization can include an image map of relative stopping power of the object. Various reconstruction methodologies for obtaining such an image, including but not limited to superiorization of a merit function such as total variation, are disclosed. In some implementations, various forms of total variation superiorization methodology can yield excellent results while being computationally efficient and with reduced computing time. In some implementations, such a methodology can result in high quality proton CT images using relatively low dose of protons.

5. 发明申请

US20160245929A1 ION INDUCED IMPACT IONIZATION DETECTOR AND USES THEREOF 审中-公开
标题翻译：离子诱导的影响离子检测器及其用途
公开(公告)号：US20160245929A1
公开(公告)日：2016-08-25
申请号：US14966980
申请日：2015-12-11
申请人： Loma Linda University Medical Center
发明人： Vladimir Bashkirov , Reinhard W. Schulte
IPC分类号： G01T1/185
CPC分类号： G01T1/185 , G01T1/16 , G06F17/5009 , G16B5/00
摘要： Disclosed are systems, devices and methodologies relating to an ion induced impact ionization detector and uses thereof. In certain implementations, the detector can include a dielectric layer having one or more wells. An anode layer defining apertures to accommodate the openings of the wells can be disposed on one side of the dielectric layer, and a cathode such as a solid resistive cathode can be disposed on the other side so as to provide an electric field in each of the wells. Various design parameters such as well dimensions and operating parameters such as pressure and high voltage are disclosed. In certain implementations, such an ion detector can be coupled to a low pressure gas volume to detect ionization products such as positive ions. Such a system can be configured to provide single ion counting capability. Various example applications where the ion detector can be implemented are also disclosed.
摘要翻译：公开了与离子诱导的冲击电离检测器及其用途有关的系统，装置和方法。在某些实施方案中，检测器可以包括具有一个或多个孔的电介质层。限定孔的容纳孔的开口的阳极层可以设置在电介质层的一侧，并且诸如固体电阻阴极的阴极可以设置在另一侧上，以便在每一个中提供电场井。公开了各种设计参数，例如井尺寸和操作参数，例如压力和高电压。在某些实施方案中，这种离子检测器可以耦合到低压气体体积以检测电离产物如正离子。这样的系统可以被配置为提供单个离子计数能力。还公开了可以实现离子检测器的各种示例性应用。

6. 发明申请

US20160178769A1 SYSTEMS, DEVICES AND METHODS RELATED TO CALIBRATION OF A PROTON COMPUTED TOMOGRAPHY SCANNER 有权
公开(公告)号：US20160178769A1
公开(公告)日：2016-06-23
申请号：US15056694
申请日：2016-02-29
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： Reinhard W. Schulte , R. Ford Hurley
IPC分类号： G01T7/00 , A61B6/03 , A61B6/00 , G01T1/29
CPC分类号： G01T7/005 , A61B6/032 , A61B6/035 , A61B6/4258 , A61B6/548 , A61B6/583 , A61B6/585 , G01N23/04 , G01N23/046 , G01N35/00693 , G01N2223/107 , G01T1/169 , G01T1/2985
摘要： Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

7. 发明授权

US09213107B2 Ion induced impact ionization detector and uses thereof 有权
标题翻译：离子诱导冲击电离检测器及其用途
公开(公告)号：US09213107B2
公开(公告)日：2015-12-15
申请号：US14203124
申请日：2014-03-10
申请人： Loma Linda University Medical Center
发明人： Vladimir Bashkirov , Reinhard W. Schulte
IPC分类号： G01T1/185 , G01T1/16 , G06F17/50 , G06F19/12
CPC分类号： G01T1/185 , G01T1/16 , G06F17/5009 , G06F19/12
摘要： Disclosed are systems, devices and methodologies relating to an ion induced impact ionization detector and uses thereof. In certain implementations, the detector can include a dielectric layer having one or more wells. An anode layer defining apertures to accommodate the openings of the wells can be disposed on one side of the dielectric layer, and a cathode such as a solid resistive cathode can be disposed on the other side so as to provide an electric field in each of the wells. Various design parameters such as well dimensions and operating parameters such as pressure and high voltage are disclosed. In certain implementations, such an ion detector can be coupled to a low pressure gas volume to detect ionization products such as positive ions. Such a system can be configured to provide single ion counting capability. Various example applications where the ion detector can be implemented are also disclosed.
摘要翻译：公开了与离子诱导的冲击电离检测器及其用途有关的系统，装置和方法。在某些实施方案中，检测器可以包括具有一个或多个孔的电介质层。限定孔的容纳孔的开口的阳极层可以设置在电介质层的一侧，并且诸如固体电阻阴极的阴极可以设置在另一侧上，以便在每一个中提供电场井。公开了各种设计参数，例如井尺寸和操作参数，例如压力和高电压。在某些实施方案中，这种离子检测器可以耦合到低压气体体积以检测电离产物如正离子。这样的系统可以被配置为提供单个离子计数能力。还公开了可以实现离子检测器的各种示例性应用。

8. 发明授权

US09880301B2 Systems, devices and methods related to calibration of a proton computed tomography scanner 有权
公开(公告)号：US09880301B2
公开(公告)日：2018-01-30
申请号：US15056694
申请日：2016-02-29
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： Reinhard W. Schulte , R. Ford Hurley
IPC分类号： G01D18/00 , G01T7/00 , G01N23/04 , A61B6/03 , A61B6/00 , G01T1/169 , G01T1/29 , G01N35/00
CPC分类号： G01T7/005 , A61B6/032 , A61B6/035 , A61B6/4258 , A61B6/548 , A61B6/583 , A61B6/585 , G01N23/04 , G01N23/046 , G01N35/00693 , G01N2223/107 , G01T1/169 , G01T1/2985
摘要： Disclosed are systems, devices and methodologies related to calibration of an ion based imaging apparatus such as a proton computed tomography scanner. In some implementations, energy degrader plates having known water-equivalent thickness (WET) values can be introduced to an ion beam to introduce different energy degradation settings. Energy detector responses to individual ions subject to such energy degradation settings can be obtained. Such responses can be normalized and correlated to water-equivalent path lengths (WEPL) of the ions based on the known WET values. Such calibration utilizing degrader plates can be performed relatively quickly and can yield accurate WEPL values that facilitate estimation of, for example, a CT image based on relative stopping power of an object.

9. 发明授权

US09878180B2 Proton scattering analysis system 有权
公开(公告)号：US09878180B2
公开(公告)日：2018-01-30
申请号：US14802879
申请日：2015-07-17
申请人： Loma Linda University Medical Center
发明人： Reinhard W. Schulte , Vladimir A. Bashkirov
IPC分类号： A61N5/10 , A61B6/00 , G01N23/02
CPC分类号： A61N5/1071 , A61B6/54 , A61N5/103 , A61N5/1048 , A61N2005/1087 , G01N23/02
摘要： Disclosed are systems and methods for characterizing interactions or proton beams in tissues. In certain embodiments, charged particles emitted during passage of protons, such as those used for therapeutic and/or imaging purposes, can be detected at relatively large angles. In situations where beam intensity is relatively low, such as in certain imaging applications, characterization of the proton beam with charged particles can provide sufficient statistics for meaningful results while avoiding the beam itself. In situations where beam intensity is relatively high, such as in certain therapeutic applications, characterization of the proton beam with scattered primary protons and secondary protons can provide information such as differences in densities encountered by the beam as it traverses the tissue and dose deposited along the beam path. In certain situations, such beam characterizations can facilitate more accurate planning and monitoring of proton-based therapy.

10. 发明授权

US09220920B2 Intensity-modulated proton therapy 有权
标题翻译：强度调制质子治疗
公开(公告)号：US09220920B2
公开(公告)日：2015-12-29
申请号：US14171490
申请日：2014-02-03
申请人： Loma Linda University Medical Center , Yair Censor
发明人： Reinhard W. Schulte , Yair Censor
IPC分类号： G06K9/00 , A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1077 , A61N2005/1087
摘要： The therapeutic treatment of a patient using intensity-modulated proton therapy is described. In one example, a method of creating a proton treatment plan is presented that divides volumes of interest into sub-volumes, applies dose constraints to the sub-volumes, finds one or more feasible configurations of a proton therapy system, and selects a proton beam configuration that improves or optimizes one or more aspects of proton therapy. In some implementations, the method of dividing volumes into sub-volumes includes creating fractional sub-volumes based at least in part on proximity to a target volume boundary. In some implementations, the method of finding an improved or optimal proton beam configuration from a set of feasible configurations includes finding a minimum of a cost function that utilizes weighting factors associated with treatment sites.
摘要翻译：描述了使用强度调制质子治疗的患者的治疗方法。在一个示例中，提出了一种创建质子治疗计划的方法，其将感兴趣的体积分成子体积，对子体积施加剂量约束，找到质子治疗系统的一个或多个可行配置，并选择质子束改善或优化质子治疗的一个或多个方面的配置。在一些实现中，将卷分割成子卷的方法包括至少部分地基于与目标卷边界的接近度来创建分数子卷。在一些实施方式中，从一组可行配置中找到改进或最佳质子束配置的方法包括找到利用与治疗部位相关联的加权因子的成本函数的最小值。

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