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1. 发明申请

WO2005016152A2 VASCULAR WOUND CLOSURE DEVICE 审中-公开
标题翻译：血管闭合装置
公开(公告)号：WO2005016152A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/026609
申请日：2004-08-16
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： ZHU, Yong, Hua , KIRSCH, Wolff, M.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/02 , A61B2017/00637 , A61B2017/00654
摘要： An apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
摘要翻译：用于闭合血管伤口的装置包括可以在导线上或与伤口相邻就位的导线上的装置。该装置包括在其中封闭止血材料的腔室。当根据需要将装置定位在伤口附近时，止血材料从腔室展开。血液接触止血材料，血液凝固优选由材料内的止血剂促进。因此，血管穿刺伤口被血块形成密封。

2. 发明申请

WO2015160719A3 CHITOSAN SHARDS FOR BIOMEDICAL APPLICATIONS 审中-公开
公开(公告)号：WO2015160719A3
公开(公告)日：2015-10-22
申请号：PCT/US2015/025605
申请日：2015-04-13
申请人： LOMA LINDA UNIVERSITY , LOMA LINDA UNIVERSITY MEDICAL CENTER , NORTH CAROLINA STATE UNIVERSITY
发明人： KIRSCH, Wolff, M. , HUDSON, Samuel, M. , CROFTON, Andrew
IPC分类号： A61K47/36 , A61F13/00
摘要： A thin chitosan-based material can be used for biomedical applications. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan material. A single or multiple such treatments may be employed. For example, the chitosan material may be irradiated under nitrogen using γ-irradiation, treated under a nitrogen plasma, or both. A thin chitosan material can be readily treated by surface modifying treatments such as irradiating under nitrogen using γ-irradiation, treating under a nitrogen plasma, or both.

3. 发明申请

WO1997020505A1 VASCULAR WOUND CLOSURE DEVICE 审中-公开
标题翻译：血管闭合装置
公开(公告)号：WO1997020505A1
公开(公告)日：1997-06-12
申请号：PCT/US1996019937
申请日：1996-12-05
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： LOMA LINDA UNIVERSITY MEDICAL CENTER , ZHU, Yong Hua , KIRSCH, Wolff, M.
IPC分类号： A61B17/00
CPC分类号： A61B17/0206 , A61B17/0057 , A61B17/128 , B29K2067/003
摘要： A device (100) which facilitates the closure of puncture wounds in the vasculature of a patient is used in conjunction with a guidewire, and helps locate and isolate the site of the puncture wound in the patient. The retractor (100) moves the surrounding tissue laterally when positioned in the patient, and acts as a guide for the physician in locating the exact site of the wound. A double-sleeved balloon can be used in conjunction with the retractor (100) to move the tissues laterally and form a tunnel from the surface of the patient's body to the puncture site. The retractor (100) is preferably used in combination with a surgical clip applicator which delivers clips to the site of the wound, but can also be used with other methods of wound closure such as suturing and stapling.
摘要翻译：促进关闭患者脉管系统中的穿刺伤口的装置（100）与导丝结合使用，并且有助于定位并隔离患者的穿刺伤口部位。当定位在患者体内时，牵开器（100）横向移动周围的组织，并且用作医生确定伤口确切位置的引导件。双袖气球可以与牵开器（100）一起使用，以横向移动组织，并形成从患者身体的表面到穿刺部位的隧道。收缩器（100）优选与将夹子输送到伤口部位的手术夹施加器组合使用，但也可以与其他伤口闭合方法一起使用，例如缝合和缝合。

4. 发明申请

WO2015021303A1 SYSTEMS AND METHODS FOR THE TREATMENT OF BLADDER CANCER 审中-公开
标题翻译：用于治疗乳腺癌的系统和方法
公开(公告)号：WO2015021303A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050188
申请日：2014-08-07
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , LOMA LINDA UNIVERSITY , NORTH CAROLINA STATE UNIVERSITY
发明人： KIRSCH, Wolff, M. , HUDSON, Samuel, M. , CROFTON, Andrew
IPC分类号： A61L2/08
CPC分类号： A61K41/0019 , A61K9/0019 , A61K9/0024 , A61K9/5161 , A61K38/208 , A61K47/36 , A61L2/0011 , A61L2/0035 , A61L2/08
摘要： A chitosan material is treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan, and the chitosan material is formulated into a hydrogel which can be utilized as a drug delivery vehicle for medicaments or therapeutic agents to treat certain conditions, such as cancers.
摘要翻译：通过施加能量以将脱乙酰壳多糖及其周围的氮离子化，将脱乙酰壳多糖材料配制成水凝胶，其可用作药物递送载体用于药物或治疗剂以治疗某些病症，例如作为癌症。

5. 发明申请

WO2011066471A1 CHITOSAN-BASED HEMOSTATIC TEXTILE 审中-公开
标题翻译：基于CHITOSAN的HEMOSTATIC TEXTILE
公开(公告)号：WO2011066471A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/058118
申请日：2010-11-24
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： KIRSCH, Wolff, M. , ZHU, Yong, Hua
IPC分类号： A61L15/28
CPC分类号： A61L15/28 , A61L2/081 , A61L2/14 , A61L2/20 , A61L15/42 , A61L24/0036 , A61L24/08 , A61L26/0023 , A61L31/042 , A61L33/08 , A61L2400/04 , C08L5/08
摘要： A microfibrillar high molecular weight chitosan-based textile can be used as a hemostat. The chitosan has been treated in a nitrogen field by applying energy to ionize nitrogen in and around the chitosan textile. A single or multiple such treatments may be employed. For example, the chitosan textile may be irradiated under nitrogen using γ- irradiation, treated under a nitrogen plasma, or both.
摘要翻译：微纤维高分子量壳聚糖为基础的织物可用作止血剂。壳聚糖通过施加能量以在壳聚糖纺织品中和周围离子化氮在氮气田中进行处理。可以使用单次或多次这样的治疗。例如，壳聚糖纺织品可以在氮气下用氮气照射，氮气等离子体处理或二者照射。

6. 发明申请

WO2007044510A1 VASCULAR WOUND CLOSURE DEVICE AND METHOD 审中-公开
标题翻译：血管闭合装置及方法
公开(公告)号：WO2007044510A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/039112
申请日：2006-10-05
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： ZHU, Young Hua , KIRSCH, Wolff, M.
IPC分类号： A61B17/00 , A61B17/02
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0206 , A61B17/3439 , A61B2017/00243 , A61B2017/00292 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00659 , A61B2017/00672 , A61B2017/00862 , A61B2017/00884 , A61B2017/00942 , A61B2090/037 , A61M25/0668 , A61M2025/0681
摘要： A method and apparatus for closing a vascular wound includes an apparatus that can be threaded over a guidewire into place at or adjacent the wound. The apparatus includes a chamber that encloses a hemostatic material therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. A blocking member distal of the hemostatic material functions as a barrier to prevent the hemostatic material from entering the wound. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
摘要翻译：用于闭合血管伤口的方法和装置包括可以在导线上或与伤口相邻就位的导线上穿过的装置。该装置包括在其中封闭止血材料的腔室。当根据需要将装置定位在伤口附近时，止血材料从腔室展开。止血材料远端的阻塞构件用作防止止血材料进入伤口的屏障。血液接触止血材料，血液凝固优选由材料内的止血剂促进。因此，血管穿刺伤口被血块形成密封。

7. 发明申请

WO2005041811A2 DEPLOYABLE HEMOSTATIC AGENT 审中-公开
标题翻译：可配药剂
公开(公告)号：WO2005041811A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/019043
申请日：2004-06-14
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , ZHU, Yong, Hua , KIRSCH, Wolff, M. , YANG, Chang, Zheng , DRAKE, James
发明人： ZHU, Yong, Hua , KIRSCH, Wolff, M. , YANG, Chang, Zheng , DRAKE, James
IPC分类号： A61F
CPC分类号： A61L15/225 , A61B17/0057 , A61B17/06166 , A61B2017/00654 , A61B2017/00884 , A61B2017/00898 , A61L26/0052 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.
摘要翻译：本发明涉及包含壳聚糖纤维的可部署止血材料，其上沉积有止血微孔多糖微球。止血材料适用于控制动脉和静脉撕裂的活动性出血，密封股动脉穿刺，以及控制组织渗出。

8. 发明申请

WO2003105697A1 VASCULAR WOUND CLOSURE DEVICE AND METHOD 审中-公开
标题翻译：血管闭合装置及方法
公开(公告)号：WO2003105697A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/019072
申请日：2003-06-16
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： ZHU, Yong, Hua , KIRSCH, Wolff, M.
IPC分类号： A61B17/00
CPC分类号： A61B17/085 , A61B17/00491 , A61B17/0057 , A61B17/0206 , A61B17/10 , A61B17/3439 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61B2017/00659 , A61B2090/037 , A61M25/00 , H04N7/08 , H04N7/088
摘要： A method and apparatus for closing a vascular wound includes a guidewire and/or other surgical implement extending from the wound. A hemostatic material is advanced over the surgical implement and into contact with an area of the blood vessel surrounding the wound. The surgical implement is removed. Blood soaks the hemostatic material, and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive can be applied to the hemostatic material, confining the blood flow to the material. Thus, the vascular puncture wound is sealed by natural blood clot formation.
摘要翻译：用于闭合血管伤口的方法和装置包括从伤口延伸的导丝和/或其它手术器械。止血材料在手术器具上前进并与围绕伤口的血管区域接触。手术器具被去除。血液浸泡止血材料，血液凝固由材料内的止血剂促进。粘合剂的密封层可以应用于止血材料，将血流限制在材料上。因此，血管穿刺伤口被天然血块形成密封。

9. 发明申请

WO2002009591A3 METHOD AND APPARATUS FOR CLOSING VASCULAR PUNCTURE 审中-公开
公开(公告)号：WO2002009591A3
公开(公告)日：2002-02-07
申请号：PCT/US2001/024462
申请日：2001-08-02
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER
发明人： ZHU, Yong, Hua , KIRSCH, Wolff, M.
IPC分类号： A61B17/00
摘要： A method and apparatus for closing a vascular wound includes a guidewire (58) and/or other surgical implement (32) extending from the wound (w). A sponge-like hemostatic material (80) is advanced over the surgical implement and into contact with an area of the blood vessel (94) surrounding the wound. The surgical implement (32) is removed. Blood (b) soaks the hemostatic material (80), and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive (106) can be applied to the sponge-like material (80), confining the blood flow to the sponge. Thus, the vascular puncture wound (w) is sealed by natural blood clot formation.

10. 发明申请

WO2003028546A3 METHOD AND DEVICE FOR CREATING MICROVASCULAR ANASTOMOSES 审中-公开
公开(公告)号：WO2003028546A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031787
申请日：2002-10-02
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , KIRSCH, Wolff, M. , DICKSON, Cindy , ZHU, Yong, Hua
发明人： KIRSCH, Wolff, M. , DICKSON, Cindy , ZHU, Yong, Hua
IPC分类号： A61B17/08
摘要： A coupler or a coupling vessel for creating an anastomosis between a first vessel and a second vessel, the coupler (10) comprising a proximal portion (12) comprising a tubular portion (16) having a proximal end (18), a distal end (20), an outer surface (22), an inner surface (24), and an axial lumen (26) defined by the inner surface (24) and extending between the proximal end (18) and the distal end (20), and a distal portion (14) comprising a flange (30) surrounding the distal end of the tubular portion (16). A method for creating an anastomosis between a first vessel and a second vessel, the method comprising selecting the first vessel and the second vessel, providing a coupler or a coupling vessel according to the present invention, and joining the first vessel to the coupler and joining the second vessel to the coupler.

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