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1. 发明申请

WO2015066266A1 SCALE AND ASSOCIATED METRIC FOR TREATMENT OF FACIAL WRINKLES AND RELATED CONDITIONS 审中-公开
标题翻译：用于治疗面部皱纹的比例和相关的公制及相关条件
公开(公告)号：WO2015066266A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063048
申请日：2014-10-30
申请人： LIVING PROOF, INC.
发明人： YU, Betty , BIESMAN, Brian
IPC分类号： A61B5/00
CPC分类号： A61B5/442 , A61B5/4878 , A61K8/0208 , A61K2800/805 , A61Q19/08 , G06F19/00 , G16H50/20
摘要： This invention provides assessment scale devices and methods for assessing the severity of wrinkles and facial swelling and puffiness. Wrinkle and facial swelling/puffiness assessment using the devices, methods, and assessment scales of the invention can be performed in a clinical setting for the purpose of simply characterizing a wrinkle or facial swelling/puffiness, or as part of a treatment plan or course that varies according to the severity of the wrinkle or facial swelling/puffiness. Thus, this invention also provides methods of reducing the appearance of wrinkles and/or facial puffiness, and kits comprising for evaluating and treating wrinkles and/or facial puffiness. Additionally, the present disclosure relates to a devices, methods, and assessment scales for managing expectations of the given treatment plan or course for human facial wrinkles and facial puffiness.
摘要翻译：本发明提供了用于评估皱纹和面部肿胀和浮肿的严重程度的评估尺度装置和方法。为了简单地表征皱纹或面部肿胀/浮肿的目的，或者作为治疗计划或疗程的一部分，可以在临床设置中使用本发明的装置，方法和评估量表进行皱纹和面部肿胀/浮肿评估根据皱纹或面部肿胀/浮肿的严重程度而变化。因此，本发明还提供了减少皱纹和/或面部浮肿的外观的方法以及包含用于评估和治疗皱纹和/或面部浮肿的试剂盒。此外，本公开涉及用于管理针对人类面部皱纹和面部浮肿的给定治疗计划或疗程的期望的装置，方法和评估尺度。

2. 发明申请

WO2012030993A2 SKIN COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：皮肤组合物及其使用方法
公开(公告)号：WO2012030993A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050016
申请日：2011-08-31
申请人： LIVING PROOF, INC. , YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
IPC分类号： A61K31/74 , A61K31/795 , A61K8/89 , A61P17/02 , A61Q19/00
CPC分类号： A61K31/765 , A61K8/0204 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/585 , A61K8/891 , A61K8/894 , A61K8/895 , A61K2800/412 , A61K2800/43 , A61K2800/58 , A61K2800/5922 , A61K2800/884 , A61K2800/95 , A61L26/0019 , A61L26/0095 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C08L83/04
摘要： Provided are therapeutic formulations and methods of use thereof.
摘要翻译：提供治疗剂型及其使用方法。

3. 发明申请

WO2013044098A1 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF COMPROMISED SKIN BARRIER FUNCTION 审中-公开
标题翻译：用于治疗皮肤屏障功能障碍的组合物和方法
公开(公告)号：WO2013044098A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056667
申请日：2012-09-21
申请人： LIVING PROOF, INC.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-young , ADAMS, Benjamin, W.
IPC分类号： A61K9/00 , A61K8/891 , A61K47/24 , A61P17/02
CPC分类号： A61K31/80 , A61K9/0014 , A61K9/7015 , A61K45/06 , A61K2300/00
摘要： Compositions and methods of treating conditions of compromised skin barrier function are described.
摘要翻译：描述了治疗受损皮肤屏障功能状况的组合物和方法。

4. 发明申请

WO2012030984A2 SKIN COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：皮肤组合物及其使用方法
公开(公告)号：WO2012030984A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050003
申请日：2011-08-31
申请人： LIVING PROOF, INC. , YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
IPC分类号： A61K8/89 , A61K31/74 , A61K31/795 , A61Q19/00 , A61P17/00
CPC分类号： A61K31/765 , A61K8/0204 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/585 , A61K8/891 , A61K8/894 , A61K8/895 , A61K2800/412 , A61K2800/43 , A61K2800/58 , A61K2800/5922 , A61K2800/884 , A61K2800/95 , A61L26/0019 , A61L26/0095 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C08L83/04
摘要： Provided are body corrective cosmetic formulations and methods of use thereof.
摘要翻译：提供身体矫正化妆品制剂及其使用方法。

5. 发明申请

WO2008134712A2 USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE 审中-公开
标题翻译：在皮肤护理中使用基质金属蛋白酶抑制剂
公开(公告)号：WO2008134712A2
公开(公告)日：2008-11-06
申请号：PCT/US2008/061992
申请日：2008-04-30
申请人： LIVING PROOF, INC. , YU, Betty , NASHAT, Amir , ANDERSON, Daniel, Griffith , PUERTA, David, Thomas , ADAMS, Benjamin , CLARK, Scott , KIM, Yushan , SPENGLER, Eric, George , MCLAUGHLIN, Ronald, P. , BEDFORD, Susan, Eilidh , LI, Zhi
发明人： YU, Betty , NASHAT, Amir , ANDERSON, Daniel, Griffith , PUERTA, David, Thomas , ADAMS, Benjamin , CLARK, Scott , KIM, Yushan , SPENGLER, Eric, George , MCLAUGHLIN, Ronald, P. , BEDFORD, Susan, Eilidh , LI, Zhi
CPC分类号： A61K8/062 , A61K8/0212 , A61K8/0229 , A61K8/064 , A61K8/14 , A61K8/498 , A61K2800/31 , A61K2800/782 , A61Q17/04 , A61Q19/00 , A61Q19/005 , A61Q19/08
摘要： The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).
摘要翻译：基质金属蛋白酶（MMP）抑制剂对皮肤的应用抑制皮肤中发现的蛋白质的降解，包括胶原蛋白，弹性蛋白，以及其他基底膜和细胞外基质蛋白质。 MMP抑制剂可用于化妆品组合物和用于皮肤应用的药物组合物中。 MMP抑制剂与美容上合适的载体或药学上可接受的赋形剂一起配制，用于作为乳膏，洗剂，软膏，溶液，面罩等应用于皮肤。作为化妆品，将本发明的MMP抑制剂组合物施用于皮肤以预防或减少皱纹的出现，色素沉着变化，丧失弹性或与老化或太阳损伤有关的其他影响。作为药物，本发明的MMP抑制剂组合物也可以施用于皮肤以治疗或预防皮肤疾病（例如增殖性疾病，炎性疾病）。

6. 发明申请

WO2013158844A2 COLOR CORRECTING COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：颜色校正组合物及其使用方法
公开(公告)号：WO2013158844A2
公开(公告)日：2013-10-24
申请号：PCT/US2013/037116
申请日：2013-04-18
申请人： LIVING PROOF, INC.
发明人： LOMAKIN, Joseph , KANG, Soo-young , YU, Betty , PILKENTON, Morgan
IPC分类号： A61K8/25
CPC分类号： A61K8/895 , A61K8/25 , A61K8/585 , A61K2800/884 , A61K2800/95 , A61Q1/02 , A61Q17/04
摘要： Compositions and methods of for changing the color of skin or body described.
摘要翻译：改变皮肤或身体颜色的组成和方法。

7. 发明公开

EP2758032A1 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS OF COMPROMISED SKIN BARRIER FUNCTION 有权转让
标题翻译：成分和方法与皮肤屏障功能受损疾病治疗
公开(公告)号：EP2758032A1
公开(公告)日：2014-07-30
申请号：EP12775090.9
申请日：2012-09-21
申请人： Living Proof, Inc.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-young , ADAMS, Benjamin, W.
IPC分类号： A61K9/00 , A61K8/891 , A61K47/24 , A61P17/02
CPC分类号： A61K31/80 , A61K9/0014 , A61K9/7015 , A61K45/06 , A61K2300/00
摘要： This invention relates to compositions and methods useful in treating dermatological disorders. In particular, the methods include applying a composition that includes a reactive reinforcing component; and a cross-linking component; in which the cross-linking component facilitates in situ cross-linking of the reactive reinforcing component, such that a film is formed on skin, thereby treating the dermatological disorder.

8. 发明公开

EP2337544A2 USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE 审中-公开
标题翻译：使用基质金属蛋白酶抑制剂在皮肤护理
公开(公告)号：EP2337544A2
公开(公告)日：2011-06-29
申请号：EP08747168.6
申请日：2008-04-30
申请人： Living Proof, Inc.
发明人： YU, Betty , NASHAT, Amir , ANDERSON, Daniel, Griffith , PUERTA, David, Thomas , ADAMS, Benjamin , CLARK, Scott , KIM, Yushan , SPENGLER, Eric, George , MCLAUGHLIN, Ronald, P. , BEDFORD, Susan, Eilidh , LI, Zhi
IPC分类号： A61K8/00
CPC分类号： A61K8/062 , A61K8/0212 , A61K8/0229 , A61K8/064 , A61K8/14 , A61K8/498 , A61K2800/31 , A61K2800/782 , A61Q17/04 , A61Q19/00 , A61Q19/005 , A61Q19/08
摘要： The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease).

9. 发明公开

EP2611413A2 SKIN COMPOSITIONS AND METHODS OF USE THEREOF 有权转让
标题翻译： HAUTZUSAMMENSETZUNGEN UND VERWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2611413A2
公开(公告)日：2013-07-10
申请号：EP11822576.2
申请日：2011-08-31
申请人： Living Proof, Inc.
发明人： YU, Betty , LOMAKIN, Joseph , KANG, Soo-Young , ADAMS, Benjamin, W.
IPC分类号： A61K8/89 , A61K31/74 , A61K31/795 , A61Q19/00 , A61P17/00
CPC分类号： A61K31/765 , A61K8/0204 , A61K8/19 , A61K8/25 , A61K8/29 , A61K8/345 , A61K8/585 , A61K8/891 , A61K8/894 , A61K8/895 , A61K2800/412 , A61K2800/43 , A61K2800/58 , A61K2800/5922 , A61K2800/884 , A61K2800/95 , A61L26/0019 , A61L26/0095 , A61Q1/02 , A61Q1/14 , A61Q19/00 , A61Q19/06 , A61Q19/08 , C08L83/04
摘要： Provided are body corrective cosmetic formulations and methods of use thereof.
摘要翻译：提供身体矫正化妆品制剂及其使用方法。

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