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1. 发明申请

US20210024615A1 CHIMERIC FC RECEPTOR BINDING PROTEINS AND USES THEREOF 有权
公开(公告)号：US20210024615A1
公开(公告)日：2021-01-28
申请号：US16981111
申请日：2019-03-15
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： Richard John Pleass , Patricia Ann Blundell
IPC分类号： C07K16/00
摘要： The present invention relates to chimeric proteins, to compositions comprising such proteins and to the medical uses of such proteins and compositions. In particular the proteins or compositions of the invention may be used in the prevention or treatment of autoimmune diseases or inflammatory diseases, or for the prevention or treatment of diseases mediated through binding of sialic acid dependent receptors, or as vaccines or as anti-cancer agents. One aspect of the invention relates to a chimeric Fc receptor binding protein which comprises two chimeric polypeptide chains, wherein each chimeric polypeptide chain comprises an immunoglobulin G heavy chain constant region, a tailpiece region and a hinge region, wherein the amino acid sequence of each polypeptide chain possess a sugar moiety at or close to the N-terminus and a sugar moiety at or close to the C-terminus, and their use in the treatment or prevention of a disease mediated by a pathogen that relies on sialic acid receptors interactions.

2. 发明申请

US20180086797A1 IMMUNOMODULATORY PROTEINS 审中-公开
公开(公告)号：US20180086797A1
公开(公告)日：2018-03-29
申请号：US15725894
申请日：2017-10-05
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： Richard John Pleass
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K39/0008 , A61K2039/505 , C07K16/00 , C07K16/283 , C07K16/46 , C07K2317/52 , C07K2317/64 , C07K2317/92 , C07K2319/74
摘要： A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.

3. 发明申请

US20180362600A1 IMMUNOMODULATORY PROTEINS 审中-公开
公开(公告)号：US20180362600A1
公开(公告)日：2018-12-20
申请号：US16017967
申请日：2018-06-25
申请人： Liverpool school of tropical medicine
发明人： Richard John Pleass
IPC分类号： C07K14/47 , C07K16/46 , A61K39/00 , C07K16/00 , C07K16/28 , A61K38/00
摘要： A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.

4. 发明申请

US20150218236A1 IMMUNOMODULATORY PROTEINS 审中-公开
标题翻译：免疫调节蛋白
公开(公告)号：US20150218236A1
公开(公告)日：2015-08-06
申请号：US14436427
申请日：2012-10-17
申请人： LIVERPOOL SCHOOL OF TROPICAL MEDICINE
发明人： Richard John Pleass
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K39/0008 , A61K2039/505 , C07K16/00 , C07K16/283 , C07K16/46 , C07K2317/52 , C07K2317/64 , C07K2317/92 , C07K2319/74
摘要： A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.
摘要翻译：一种用于治疗哺乳动物受试者自身免疫性或炎性疾病的方法，所述方法包括：向哺乳动物受试者施用有效量的包含5,6或7个多肽单体单元的聚合蛋白; 其中每个多肽单体单元包含包含两个免疫球蛋白G重链恒定区的Fc受体结合部分; 其中每个免疫球蛋白G重链恒定区包含通过二硫键与相邻多肽单体单元的免疫球蛋白G重链恒定区的半胱氨酸残基连接的半胱氨酸残基; 其中所述聚合蛋白不包含另外的免疫调节部分; 或当向哺乳动物受试者施用时引起抗原特异性免疫抑制的抗原部分。

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