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1. 发明申请

WO0051565A9 ENCAPSULATION OF BIOACTIVE COMPLEXES IN LIPOSOMES 审中-公开
标题翻译：脂质体中生物活性复合物的包封
公开(公告)号：WO0051565A9
公开(公告)日：2002-02-14
申请号：PCT/US0005395
申请日：2000-03-01
申请人： LIPOSOME CO INC , MEERS PAUL , SHANGGUAN TONG , CABRAL LILLY DONNA , JANOFF ANDREW , AHL PATRICK
发明人： MEERS PAUL , SHANGGUAN TONG , CABRAL-LILLY DONNA , JANOFF ANDREW , AHL PATRICK
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/1272 , A61K9/127
摘要： This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.
摘要翻译：本发明提供了一种制备脂质体包封的生物活性剂如核酸的方法，其包括在形成脂质体之前的反胶束中生物活性剂的复合，以及使用如此形成的脂质体和制剂将核酸递送至细胞的方法。

2. 发明申请

WO2008101214A2 FIXED DRUG RATIOS FOR TREATMENT OF HEMATOPOIETIC CANCERS AND PROLIFERATIVE DISORDERS 审中-公开
标题翻译：固定药物治疗造血系统肿瘤和增殖性疾病的比例
公开(公告)号：WO2008101214A2
公开(公告)日：2008-08-21
申请号：PCT/US2008054168
申请日：2008-02-15
申请人： CELATOR PHARMACEUTICALS INC , LOUIE ARTHUR , SWENSON CHRISTINE , MAYER LAWRENCE , JANOFF ANDREW
发明人： LOUIE ARTHUR , SWENSON CHRISTINE , MAYER LAWRENCE , JANOFF ANDREW
IPC分类号： A61K31/70 , A61K9/127 , A61P35/00
CPC分类号： A61K31/70 , A61K9/0019 , A61K9/127 , Y10T436/143333
摘要： Provided herein are methods for treating cancer by administering a pharmaceutical composition comprising a fixed, non-antagonistic molar ratio of cytarabine and an anthracycline. Such methods are particularly useful in the treatment of patients with advanced hematologic cancers or proliferative disorders.
摘要翻译：本文提供了通过施用包含固定的非拮抗摩尔比的阿糖胞苷和蒽环霉素的药物组合物来治疗癌症的方法。这些方法在治疗晚期血液癌症或增殖性疾病的患者中特别有用。

3. 发明申请

WO2007050784A3 FIXED RATIO DRUG COMBINATION TREATMENTS FOR SOLID TUMORS 审中-公开
标题翻译：固定比率药物联合治疗实体肿瘤
公开(公告)号：WO2007050784A3
公开(公告)日：2007-06-14
申请号：PCT/US2006041832
申请日：2006-10-25
申请人： CELATOR PHARMACEUTICALS INC , BATIST GERALD , MAYER LAWRENCE , SWENSON CHRISTINE , JANOFF ANDREW , GELMON KAREN
发明人： BATIST GERALD , MAYER LAWRENCE , SWENSON CHRISTINE , JANOFF ANDREW , GELMON KAREN
IPC分类号： A61K31/4745 , A61K31/505 , A61P35/00
CPC分类号： A61K31/4745 , A61K31/505
摘要： Provided herein are methods for treating cancer by administering a pharmaceutical composition comprising a fixed, non-antagonistic molar ratio of irinotecan and floxuridine. Such methods are particularly useful in the treatment of cancer patients with advanced solid tumors.
摘要翻译：本文提供了通过施用包含固定的非拮抗摩尔比的伊立替康和氟尿苷的药物组合物治疗癌症的方法。这种方法在治疗晚期实体瘤的癌症患者中特别有用。

4. 发明申请

WO0100247A9 PEPTIDE-LIPID CONJUGATES, LIPOSOMES AND LIPOSOMAL DRUG DELIVERY 审中-公开
标题翻译：肽类脂质结合物，脂质体和脂质体药物递送
公开(公告)号：WO0100247A9
公开(公告)日：2002-08-29
申请号：PCT/US0016248
申请日：2000-06-13
申请人： LIPOSOME CO INC
发明人： MEERS PAUL , PAK CHARLES , ALI SHAUKAT , JANOFF ANDREW , FRANKLIN J CRAIG , ERUKULLA RAVI , CABRAL-LILLY DONNA , AHL PATRICK
IPC分类号： A61K9/127 , A61K9/133 , A61K38/00 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/04 , A61K51/00 , A61P11/08 , A61P23/02 , A61P27/08 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P35/02 , C07K1/107 , C07K5/04 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K7/04 , C07K7/06 , C07K9/00 , C12N15/00 , C12N15/63 , C12N15/88
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1275 , A61K38/00 , A61K47/543 , A61K47/544 , A61K47/6911 , C07K1/1077 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/0819 , C07K5/0823 , C07K5/0827 , C07K5/1008 , C07K5/1013 , C07K5/1027 , C07K7/06 , C07K9/001
摘要： Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
摘要翻译：将肽 - 脂质缀合物掺入脂质体中，以选择性地使目标肽酶分泌细胞附近的脂质体不稳定，从而将脂质体递送至靶细胞附近或直接进入细胞。因此，脂质体可用于治疗哺乳动物疾病，病症或病症，例如肿瘤，微生物感染和炎症，其特征在于发生肽酶分泌细胞。

5. 发明公开

EP1079812A4 NOVEL PARTICULATE FORMULATIONS 审中-公开
标题翻译：新的特殊准备
公开(公告)号：EP1079812A4
公开(公告)日：2001-12-12
申请号：EP99925661
申请日：1999-05-19
申请人： LIPOSOME CO INC
发明人： PERKINS WALTER , LI XINGONG , HIRSCH DONALD , MAYHEW ERIC , AHMAD IMRAN , ALI SHAUKAT , JANOFF ANDREW
IPC分类号： A61K9/16 , A61K31/337 , A61K31/365 , A61K31/439 , A61K47/24 , A61K47/34 , A61K47/48
CPC分类号： A61K47/6929 , A61K47/542

6. 发明公开

EP1156783A4 ENCAPSULATION OF BIOACTIVE COMPLEXES IN LIPOSOMES 有权
标题翻译：包胶生物活性复合物在脂质体
公开(公告)号：EP1156783A4
公开(公告)日：2003-05-21
申请号：EP00915983
申请日：2000-03-01
申请人： LIPOSOME CO INC
发明人： MEERS PAUL , SHANGGUAN TONG , CABRAL-LILLY DONNA , JANOFF ANDREW , AHL PATRICK
IPC分类号： A61K9/127 , A61K9/133
CPC分类号： A61K9/1272 , A61K9/127
摘要： This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agents in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.

7. 发明专利

SK17422000A3 NOVEL PARTICULATE FORMULATIONS 未知
公开(公告)号：SK17422000A3
公开(公告)日：2001-09-11
申请号：SK17422000
申请日：1999-05-19
申请人： LIPOSOME CO INC
发明人： PERKINS WALTER , LI XINGONG , HIRSCH DONALD , MAYHEW ERIC , AHMAD IMRAN , ALI SHAUKAT , JANOFF ANDREW
IPC分类号： A61K9/16 , A61K31/337 , A61K31/365 , A61K31/439 , A61K47/24 , A61K47/34 , A61K47/48
摘要： This invention provides vehicles capable of delivering high concentrations of poorly hydrophilic/poorly lipophilic compounds to animals, by combining compounds having biocompatible hydrophobic domains with conjugates having both hydrophobic and hydrophilic regions. Such formulations are suitable for a number of uses in animals, particularly the administration thereto of high concentrations of therapeutically useful compound, without an undue level of side effects.

8. 发明专利

CA2362485A1 ENCAPSULATION OF BIOACTIVE COMPLEXES IN LIPOSOMES 未知
公开(公告)号：CA2362485A1
公开(公告)日：2000-09-08
申请号：CA2362485
申请日：2000-03-01
申请人： LIPOSOME CO INC
发明人： AHL PATRICK , JANOFF ANDREW , CABRAL-LILLY DONNA , SHANGGUAN TONG , MEERS PAUL
IPC分类号： A61K9/127 , A61K9/133
摘要： This invention provides a method to prepare liposome-encapsulated bioactive agents such as nucleic acids, comprising complexation of the bioactive agent s in reverse micelles prior to forming liposomes, as well as methods of using the liposomes so formed and formulations to deliver nucleic acids to cells.

9. 发明专利

DE69123568T2 未知
公开(公告)号：DE69123568T2
公开(公告)日：1997-05-28
申请号：DE69123568
申请日：1991-01-11
申请人： LIPOSOME CO INC
发明人： BONI LAWRENCE , JANOFF ANDREW , MINCHEY SHARMA , PERKINS WALTER , SWENSON CHRISTINE , AHL PATRICK
IPC分类号： A61K9/127 , A61K47/24 , A61K51/00 , B01J13/02 , A61K9/133
摘要： This invention relates to interdigitation-fusion (IF) liposomes and gels. These liposomes and gels capture high solute to lipid ratios, including bioactive agent. This invention also relates to the discovery that the fusion of liposomes to produce IF gel and liposomes according to the present invention is size dependent. The present invention also relates to a method for producing IF liposomes and gels. In the method of the present invention, sized liposomes formed by sonication, extrusion or alternative processes are fused in the presence of ethanol or other suitable inducer. This process results in a composition of the present invention in gel form. To produce liposomes, the gels are exposed to a temperature usually but not necessarily above the transition temperature (Tm) of the lipid used. The temperature required by the methods of the invention is that temperature which induces a change in the material properties of the mixture. The inducer may also be removed. The result is a composition comprising liposomes containing high solute to lipid ratios. The IF liposomes and gels of the present invention may be used in combination with numerous solutes, especially including bioactive agents.

10. 发明专利

DE68916956D1 未知
公开(公告)号：DE68916956D1
公开(公告)日：1994-08-25
申请号：DE68916956
申请日：1989-05-22
申请人： LIPOSOME CO INC
发明人： MINCHEY SHARMA , SWENSON CHRISTINE , JANOFF ANDREW , BONI LAWRENCE , STEWART KATHY , PERKINS WALTER
IPC分类号： A61K9/107 , A61K9/127 , A61K31/545 , A61K49/04 , A61P31/04 , B01J13/02 , A61K9/50 , A61K9/52

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